| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Darolutamide perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Darolutamide_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.120985 |
| ASPH | aspartate beta-hydroxylase | 0.0987351 |
| PTMA | prothymosin, alpha | 0.0945835 |
| HMGB2 | high mobility group box 2 | 0.0821759 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0745496 |
| TMSB4X | thymosin beta 4, X-linked | 0.0743691 |
| LAMC2 | laminin, gamma 2 | 0.0673225 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0656431 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0645454 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0637999 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0630563 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0552994 |
| SLC38A1 | solute carrier family 38, member 1 | 0.053032 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0462244 |
| DSPP | dentin sialophosphoprotein | 0.0443362 |
| MYO6 | myosin VI | 0.0443214 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0439347 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0434725 |
| S100A6 | S100 calcium binding protein A6 | 0.0433646 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0429937 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0428194 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0409672 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0390951 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0374281 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0369492 |
| SQSTM1 | sequestosome 1 | 0.0366265 |
| EPCAM | epithelial cell adhesion molecule | 0.0359521 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0358072 |
| FAM13A | family with sequence similarity 13, member A | 0.0356733 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0353116 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.035232 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0347224 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0342725 |
| CALR | calreticulin | 0.0339358 |
| PGK1 | phosphoglycerate kinase 1 | 0.0330222 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0328941 |
| LAMB3 | laminin, beta 3 | 0.0327164 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0324607 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0324173 |
| OGA | O-GlcNAcase | 0.0323463 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0316624 |
| RBM39 | RNA binding motif protein 39 | 0.031646 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0312422 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0308807 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0307988 |
| CAVIN1 | caveolae associated protein 1 | 0.0302769 |
| PLAU | plasminogen activator, urokinase | 0.0300925 |
| LMO7 | LIM domain 7 | 0.0298632 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0298438 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0295444 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0285227 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | 0.0282944 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0280185 |
| YTHDC1 | YTH domain containing 1 | 0.0277944 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0277441 |
| SERINC1 | serine incorporator 1 | 0.0276501 |
| WAC | WW domain containing adaptor with coiled-coil | 0.027565 |
| TPM3 | tropomyosin 3 | 0.026486 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0264271 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0263852 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0262498 |
| MATR3 | matrin 3 | 0.0260653 |
| MORF4L1 | mortality factor 4 like 1 | 0.0260455 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0259824 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0258294 |
| SDC4 | syndecan 4 | 0.0254098 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0251676 |
| NCKAP1 | NCK-associated protein 1 | 0.0250587 |
| SLMAP | sarcolemma associated protein | 0.0249901 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0248317 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0248273 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.024751 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0245322 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0244559 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0244038 |
| KRT18 | keratin 18, type I | 0.0243945 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0242959 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.02426 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0238273 |
| TPR | translocated promoter region, nuclear basket protein | 0.0237582 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0237448 |
| CD2AP | CD2-associated protein | 0.0236832 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0235976 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.023555 |
| KIF5B | kinesin family member 5B | 0.023499 |
| ATP13A3 | ATPase type 13A3 | 0.0234502 |
| CCDC47 | coiled-coil domain containing 47 | 0.0233125 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0232448 |
| CDC73 | cell division cycle 73 | 0.0228799 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0227398 |
| CANX | calnexin | 0.022706 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0226468 |
| COPA | coatomer protein complex, subunit alpha | 0.0226183 |
| MKRN1 | makorin ring finger protein 1 | 0.0223714 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0223457 |
| TKT | transketolase | 0.0223277 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0222483 |
| TMEM263 | transmembrane protein 263 | 0.0221404 |
| SET | SET nuclear proto-oncogene | 0.021829 |
| ANXA2 | annexin A2 | 0.021519 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.456318 |
| NDRG1 | N-myc downstream regulated 1 | -0.23794 |
| FTL | ferritin, light polypeptide | -0.17915 |
| HMGA1 | high mobility group AT-hook 1 | -0.145384 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.105898 |
| MT2A | metallothionein 2A | -0.0906233 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0770192 |
| TMSB10 | thymosin beta 10 | -0.0698606 |
| RPS19 | ribosomal protein S19 | -0.0609405 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.060458 |
| ACTG1 | actin gamma 1 | -0.0586823 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0561956 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0539949 |
| EFNA5 | ephrin-A5 | -0.0514172 |
| RPL8 | ribosomal protein L8 | -0.0509351 |
| PKM | pyruvate kinase, muscle | -0.0459946 |
| FN1 | fibronectin 1 | -0.0449472 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.043547 |
| TAPBP | TAP binding protein (tapasin) | -0.0434952 |
| BRD2 | bromodomain containing 2 | -0.0434171 |
| EGR1 | early growth response 1 | -0.0422657 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0406361 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0405745 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0403428 |
| RPS29 | ribosomal protein S29 | -0.0395972 |
| RPS23 | ribosomal protein S23 | -0.0389787 |
| FOSL1 | FOS-like antigen 1 | -0.0378778 |
| RPL34 | ribosomal protein L34 | -0.0378505 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0361611 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0355294 |
| GOLGA4 | golgin A4 | -0.0341918 |
| RPLP1 | ribosomal protein, large, P1 | -0.0331517 |
| NAV2 | neuron navigator 2 | -0.032842 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0327577 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0325001 |
| RPL28 | ribosomal protein L28 | -0.0321728 |
| UPP1 | uridine phosphorylase 1 | -0.0321401 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.031849 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.031174 |
| G0S2 | G0/G1 switch 2 | -0.0309849 |
| RPS13 | ribosomal protein S13 | -0.0309675 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0308551 |
| MUC1 | mucin 1, cell surface associated | -0.0303105 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0301187 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0299911 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0296708 |
| DTNA | dystrobrevin, alpha | -0.0296412 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0294788 |
| RPS5 | ribosomal protein S5 | -0.0292682 |
| RPS15 | ribosomal protein S15 | -0.0291657 |
| RPLP2 | ribosomal protein, large, P2 | -0.0282673 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.028134 |
| CLDN4 | claudin 4 | -0.0277777 |
| VEGFA | vascular endothelial growth factor A | -0.0275368 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.0272459 |
| RPS6 | ribosomal protein S6 | -0.0270777 |
| FHIT | fragile histidine triad | -0.0270742 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0267294 |
| BBX | bobby sox homolog (Drosophila) | -0.0263153 |
| RPL5 | ribosomal protein L5 | -0.0262816 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0260497 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0259673 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0259477 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0256057 |
| TUBA1C | tubulin, alpha 1c | -0.0252389 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0251971 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0250254 |
| RPS14 | ribosomal protein S14 | -0.0248412 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0246001 |
| RPS10 | ribosomal protein S10 | -0.0244952 |
| RPL32 | ribosomal protein L32 | -0.0240129 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0236834 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0235596 |
| TXNIP | thioredoxin interacting protein | -0.0234862 |
| CDCP1 | CUB domain containing protein 1 | -0.0233474 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0232487 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0225329 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0223938 |
| S100A9 | S100 calcium binding protein A9 | -0.0223112 |
| HLA-B | major histocompatibility complex, class I, B | -0.0222839 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0220723 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0220634 |
| MAP1B | microtubule-associated protein 1B | -0.0219783 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0218711 |
| RPL30 | ribosomal protein L30 | -0.0217636 |
| RPS11 | ribosomal protein S11 | -0.0216363 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0216026 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0213835 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0213669 |
| PFN1 | profilin 1 | -0.0212768 |
| RPS25 | ribosomal protein S25 | -0.0212225 |
| ANKRD37 | ankyrin repeat domain 37 | -0.0211112 |
| RPL9 | ribosomal protein L9 | -0.0211083 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.021039 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0203776 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.0202018 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0200994 |
| RHOA | ras homolog family member A | -0.0198845 |
| DDX24 | DEAD (Asp-Glu-Ala-Asp) box helicase 24 | -0.0198062 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0197447 |
