| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Darolutamide perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Darolutamide_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0458755 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0397119 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0297817 |
| NEK7 | NIMA-related kinase 7 | 0.0296137 |
| PTMA | prothymosin, alpha | 0.0262023 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0247112 |
| RPS12 | ribosomal protein S12 | 0.0228415 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0219789 |
| RPL12 | ribosomal protein L12 | 0.0196792 |
| RPL9 | ribosomal protein L9 | 0.0193833 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0191895 |
| FAM13A | family with sequence similarity 13, member A | 0.017993 |
| CTSC | cathepsin C | 0.0177964 |
| PCBP2 | poly(rC) binding protein 2 | 0.017355 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.016489 |
| ANXA1 | annexin A1 | 0.0163126 |
| NRCAM | neuronal cell adhesion molecule | 0.0157559 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0154249 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.0151977 |
| OGA | O-GlcNAcase | 0.01491 |
| RNF145 | ring finger protein 145 | 0.0148578 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0147171 |
| ASPH | aspartate beta-hydroxylase | 0.014489 |
| XPO1 | exportin 1 | 0.0140705 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0138382 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0128542 |
| RPS3 | ribosomal protein S3 | 0.0121754 |
| TNPO1 | transportin 1 | 0.0120965 |
| CENPF | centromere protein F, 350/400kDa | 0.0120773 |
| RPL23 | ribosomal protein L23 | 0.0120458 |
| RPS17 | ribosomal protein S17 | 0.0119429 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0118612 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0117744 |
| CNOT8 | CCR4-NOT transcription complex, subunit 8 | 0.0114232 |
| RPL3 | ribosomal protein L3 | 0.0113588 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0112494 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0112301 |
| MT2A | metallothionein 2A | 0.0112068 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.011189 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.011017 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.0109622 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0108568 |
| RPL37A | ribosomal protein L37a | 0.0108245 |
| SET | SET nuclear proto-oncogene | 0.0107735 |
| PRDX1 | peroxiredoxin 1 | 0.0105603 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.0104606 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0103627 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0101911 |
| PTGR1 | prostaglandin reductase 1 | 0.0100643 |
| TPM3 | tropomyosin 3 | 0.0100276 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.00992801 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 0.00982932 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.00980179 |
| RPL35A | ribosomal protein L35a | 0.00977538 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.00974527 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.00974022 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0096236 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.00959075 |
| ANLN | anillin, actin binding protein | 0.00946281 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.00935667 |
| ITGAV | integrin, alpha V | 0.00918496 |
| SP3 | Sp3 transcription factor | 0.00916856 |
| MSN | moesin | 0.00916527 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.00892454 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.00892107 |
| ARRDC3 | arrestin domain containing 3 | 0.00889491 |
| BDNF | brain-derived neurotrophic factor | 0.0088866 |
| INSIG2 | insulin induced gene 2 | 0.00886159 |
| RBM25 | RNA binding motif protein 25 | 0.00884977 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.00883727 |
| ZNF292 | zinc finger protein 292 | 0.00883064 |
| POTEF | POTE ankyrin domain family, member F | 0.00881535 |
| MXI1 | MAX interactor 1, dimerization protein | 0.00874994 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0087421 |
| NGLY1 | N-glycanase 1 | 0.00873085 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.00872101 |
| KIF5B | kinesin family member 5B | 0.00870152 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.00867012 |
| RAI1 | retinoic acid induced 1 | 0.00862285 |
| PHIP | pleckstrin homology domain interacting protein | 0.00858297 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.00839301 |
| FOSL1 | FOS-like antigen 1 | 0.0083291 |
| CCNL1 | cyclin L1 | 0.00821519 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.00818871 |
| HSPA8 | heat shock 70kDa protein 8 | 0.00816892 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.00816658 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.00814557 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) | 0.00812051 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.00811702 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.00803236 |
| USP3 | ubiquitin specific peptidase 3 | 0.00790477 |
| ATP13A3 | ATPase type 13A3 | 0.00789934 |
| COX7B | cytochrome c oxidase subunit VIIb | 0.00776923 |
| HMGB2 | high mobility group box 2 | 0.00776414 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.00769741 |
| NAV2 | neuron navigator 2 | 0.0075983 |
| RPS27 | ribosomal protein S27 | 0.00759218 |
| YTHDC1 | YTH domain containing 1 | 0.0075504 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.00753662 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.00748159 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.301716 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.27028 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.166024 |
| FN1 | fibronectin 1 | -0.151139 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.128151 |
| PDE10A | phosphodiesterase 10A | -0.113568 |
| EFNA5 | ephrin-A5 | -0.0987939 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0886717 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0770274 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.074984 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0733156 |
| KYNU | kynureninase | -0.06932 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0670036 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.06618 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0657389 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0647454 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.06185 |
| GDA | guanine deaminase | -0.0606929 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0592787 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0581753 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0559443 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0539427 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0523643 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0503357 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.050109 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0470264 |
| SMAD2 | SMAD family member 2 | -0.0468888 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0468374 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0467584 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0446483 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0438526 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0418806 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0417382 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0410667 |
| CDH13 | cadherin 13 | -0.0400353 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.038933 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0388861 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.038675 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0381841 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.037401 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0369065 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0355746 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.034604 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0344658 |
| ABLIM1 | actin binding LIM protein 1 | -0.0336194 |
| CD44 | CD44 molecule (Indian blood group) | -0.0335328 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0334541 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0333615 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.033333 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0326507 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0324929 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.032387 |
| COL5A2 | collagen, type V, alpha 2 | -0.0319437 |
| MCL1 | myeloid cell leukemia 1 | -0.0317319 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0307796 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.030488 |
| UBC | ubiquitin C | -0.0303908 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0295714 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.029213 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0287429 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.0280761 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0280547 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0280487 |
| SPAG9 | sperm associated antigen 9 | -0.0280293 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0279151 |
| EGR1 | early growth response 1 | -0.027909 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.0277262 |
| CANX | calnexin | -0.0275549 |
| DOCK5 | dedicator of cytokinesis 5 | -0.027197 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0271689 |
| GNAS | GNAS complex locus | -0.0268353 |
| INTS6 | integrator complex subunit 6 | -0.0266945 |
| ACTG1 | actin gamma 1 | -0.0266174 |
| HDLBP | high density lipoprotein binding protein | -0.0266031 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0265791 |
| IL6 | interleukin 6 | -0.026518 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0265142 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0262012 |
| SMYD3 | SET and MYND domain containing 3 | -0.0259477 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0258612 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0256689 |
| ANTXR1 | anthrax toxin receptor 1 | -0.025478 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0252476 |
| VCL | vinculin | -0.0252042 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0250784 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0250427 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0249016 |
| CTIF | CBP80/20-dependent translation initiation factor | -0.0248457 |
| AUTS2 | autism susceptibility candidate 2 | -0.0246829 |
| OSMR | oncostatin M receptor | -0.0245517 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0244892 |
| INHBA | inhibin, beta A | -0.0244532 |
| ASTN2 | astrotactin 2 | -0.0242523 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -0.0242486 |
| CUX1 | cut-like homeobox 1 | -0.0241647 |
| CHL1 | cell adhesion molecule L1-like | -0.0238766 |
| LAMA1 | laminin, alpha 1 | -0.0237105 |
| PYGL | phosphorylase, glycogen, liver | -0.0236806 |
| NFX1 | nuclear transcription factor, X-box binding 1 | -0.0231405 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0228745 |
