| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Darolutamide perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Darolutamide_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.172616 |
| VIM | vimentin | 0.157919 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.134231 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.113375 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.107171 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.105529 |
| POTEF | POTE ankyrin domain family, member F | 0.0760433 |
| PTMA | prothymosin, alpha | 0.0740002 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0737765 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0621161 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.059918 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0548238 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0534694 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0515631 |
| TMSB4X | thymosin beta 4, X-linked | 0.0511612 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0479548 |
| PCBP2 | poly(rC) binding protein 2 | 0.0477292 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0446898 |
| PFN1 | profilin 1 | 0.0444255 |
| ANXA2 | annexin A2 | 0.0436576 |
| CALR | calreticulin | 0.0427729 |
| LDHA | lactate dehydrogenase A | 0.0419689 |
| CAVIN1 | caveolae associated protein 1 | 0.0410449 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0409984 |
| THBS1 | thrombospondin 1 | 0.0405986 |
| CENPF | centromere protein F, 350/400kDa | 0.0392767 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0378177 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0377507 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0368349 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.035683 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0353919 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0348136 |
| CCN2 | cellular communication network factor 2 | 0.0347858 |
| ZC3H15 | zinc finger CCCH-type containing 15 | 0.0346911 |
| CANX | calnexin | 0.033363 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0331852 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0330486 |
| PGK1 | phosphoglycerate kinase 1 | 0.0327207 |
| SFRP4 | secreted frizzled-related protein 4 | 0.0323515 |
| XPO1 | exportin 1 | 0.032048 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.0310466 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0305404 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0305146 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0304779 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0292209 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0289675 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0288077 |
| TPM3 | tropomyosin 3 | 0.0285463 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0282753 |
| ENO1 | enolase 1, (alpha) | 0.0282013 |
| SPAG9 | sperm associated antigen 9 | 0.0279834 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0269306 |
| DST | dystonin | 0.0269107 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0267495 |
| ABCF1 | ATP-binding cassette, sub-family F (GCN20), member 1 | 0.0266889 |
| KIF5B | kinesin family member 5B | 0.0265853 |
| SERINC1 | serine incorporator 1 | 0.0264524 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0263385 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0262312 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0262172 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0259758 |
| SRP54 | signal recognition particle 54kDa | 0.0256403 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0256303 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0255464 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0255425 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0254784 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0253503 |
| MDN1 | MDN1, midasin homolog (yeast) | 0.0252898 |
| SERINC3 | serine incorporator 3 | 0.0252159 |
| TOP1 | topoisomerase (DNA) I | 0.0251317 |
| CSNK1G3 | casein kinase 1, gamma 3 | 0.0246586 |
| PUM1 | pumilio RNA-binding family member 1 | 0.024475 |
| KIF1C | kinesin family member 1C | 0.0244242 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0242045 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0240818 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0238695 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0235219 |
| VDAC1 | voltage-dependent anion channel 1 | 0.0234823 |
| MORF4L1 | mortality factor 4 like 1 | 0.0232364 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0232348 |
| SNX6 | sorting nexin 6 | 0.0231994 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.0231789 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0230543 |
| ARHGAP11A | Rho GTPase activating protein 11A | 0.0229971 |
| SON | SON DNA binding protein | 0.0228217 |
| TPX2 | TPX2, microtubule-associated | 0.0227951 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.0226527 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0226483 |
| MTF2 | metal response element binding transcription factor 2 | 0.0225771 |
| FN1 | fibronectin 1 | 0.0225745 |
| TCP1 | t-complex 1 | 0.022521 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0222712 |
| DKC1 | dyskeratosis congenita 1, dyskerin | 0.0219565 |
| TPR | translocated promoter region, nuclear basket protein | 0.0219526 |
| NOP58 | NOP58 ribonucleoprotein | 0.0219081 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0218945 |
| RPS12 | ribosomal protein S12 | 0.0217542 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.021667 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0216148 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0213897 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CADM2 | cell adhesion molecule 2 | -0.185141 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.181815 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.181161 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.105273 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.103508 |
| TENM3 | teneurin transmembrane protein 3 | -0.0970901 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.093875 |
| COL11A1 | collagen, type XI, alpha 1 | -0.0775118 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.07666 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0670603 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0642897 |
| FOXP2 | forkhead box P2 | -0.063 |
| LRRC4C | leucine rich repeat containing 4C | -0.0627679 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0626722 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0607418 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0597598 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0552157 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0548425 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.052356 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.052142 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0507176 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0504368 |
| PCDH9 | protocadherin 9 | -0.050076 |
| PHIP | pleckstrin homology domain interacting protein | -0.0453923 |
| RAD51B | RAD51 paralog B | -0.0442849 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0420666 |
| ZNF292 | zinc finger protein 292 | -0.0409348 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0402025 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0395937 |
| METAP2 | methionyl aminopeptidase 2 | -0.0374804 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0368557 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0367596 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0366949 |
| PRTG | protogenin | -0.0363865 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.035103 |
| GPC3 | glypican 3 | -0.0348925 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0332997 |
| HMCN1 | hemicentin 1 | -0.0332585 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0320662 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0320502 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0309322 |
| TOX | thymocyte selection-associated high mobility group box | -0.0306794 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0299805 |
| USH2A | Usher syndrome 2A (autosomal recessive, mild) | -0.0297167 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0297086 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0294354 |
| TRIM2 | tripartite motif containing 2 | -0.0294112 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0294107 |
| EXOC4 | exocyst complex component 4 | -0.0292848 |
| RBM20 | RNA binding motif protein 20 | -0.0292455 |
| CUX1 | cut-like homeobox 1 | -0.0283873 |
| PRELID2 | PRELI domain containing 2 | -0.02731 |
| H1-0 | H1.0 linker histone | -0.0269999 |
| NHSL1 | NHS-like 1 | -0.0267633 |
| ANK2 | ankyrin 2, neuronal | -0.0267305 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0267029 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.026318 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0260812 |
| SMYD3 | SET and MYND domain containing 3 | -0.0260706 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0260236 |
| NPAS3 | neuronal PAS domain protein 3 | -0.025657 |
| PDGFC | platelet derived growth factor C | -0.0252277 |
| JMJD1C | jumonji domain containing 1C | -0.025225 |
| MAP4 | microtubule-associated protein 4 | -0.0245832 |
| TCF12 | transcription factor 12 | -0.0243356 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0241811 |
| RPS16 | ribosomal protein S16 | -0.0236953 |
| ZNF385D | zinc finger protein 385D | -0.0230214 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0228876 |
| HDAC9 | histone deacetylase 9 | -0.0228215 |
| RPL35A | ribosomal protein L35a | -0.0227209 |
| RASAL2 | RAS protein activator like 2 | -0.0219745 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0214515 |
| CCDC102B | coiled-coil domain containing 102B | -0.0211957 |
| SHROOM3 | shroom family member 3 | -0.0210408 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0208706 |
| TBL1X | transducin (beta)-like 1X-linked | -0.020218 |
| LRRN3 | leucine rich repeat neuronal 3 | -0.0200273 |
| RPL34 | ribosomal protein L34 | -0.0200167 |
| CDH19 | cadherin 19, type 2 | -0.0199554 |
| SP3 | Sp3 transcription factor | -0.0199284 |
| MACROD2 | MACRO domain containing 2 | -0.0199143 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0197722 |
| MED12L | mediator complex subunit 12-like | -0.0195795 |
| ZNF217 | zinc finger protein 217 | -0.0194171 |
| EPHA5 | EPH receptor A5 | -0.0191326 |
| MEIS2 | Meis homeobox 2 | -0.0191018 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | -0.0189511 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0189328 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0188386 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.0187851 |
| RFX7 | regulatory factor X, 7 | -0.018785 |
| RPL19 | ribosomal protein L19 | -0.0185862 |
| IRAK1BP1 | interleukin-1 receptor-associated kinase 1 binding protein 1 | -0.0184661 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0184428 |
| LIN28B | lin-28 homolog B (C. elegans) | -0.0183702 |
| RPS8 | ribosomal protein S8 | -0.0179812 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0177953 |
| ABI2 | abl-interactor 2 | -0.0177647 |
| PGPEP1L | pyroglutamyl-peptidase I-like | -0.0176902 |
