Darolutamide_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Darolutamide perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Darolutamide_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.134123
TGFBI transforming growth factor, beta-induced, 68kDa 0.120312
ERRFI1 ERBB receptor feedback inhibitor 1 0.100086
CDH13 cadherin 13 0.0756476
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0724837
TMSB10 thymosin beta 10 0.0677963
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0677181
COL6A3 collagen, type VI, alpha 3 0.0626124
F3 coagulation factor III (thromboplastin, tissue factor) 0.0606707
CD44 CD44 molecule (Indian blood group) 0.0586415
FTH1 ferritin, heavy polypeptide 1 0.0585428
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0556793
COL6A1 collagen, type VI, alpha 1 0.0550427
ENO1 enolase 1, (alpha) 0.0537042
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0527125
TMEM165 transmembrane protein 165 0.0508418
STC1 stanniocalcin 1 0.0486655
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0480385
PRSS23 protease, serine, 23 0.0462419
HLA-B major histocompatibility complex, class I, B 0.0454353
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0447853
TRIO trio Rho guanine nucleotide exchange factor 0.0447511
LIMS1 LIM and senescent cell antigen-like domains 1 0.042713
TIMP3 TIMP metallopeptidase inhibitor 3 0.0425826
HMGA2 high mobility group AT-hook 2 0.0417849
COL5A1 collagen, type V, alpha 1 0.0403301
ANXA2 annexin A2 0.0403282
SQSTM1 sequestosome 1 0.0399622
KYNU kynureninase 0.0399611
WNT5A wingless-type MMTV integration site family, member 5A 0.0390952
PTMA prothymosin, alpha 0.0386836
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0383148
MYO10 myosin X 0.0380535
RPL34 ribosomal protein L34 0.0373688
MT2A metallothionein 2A 0.0373366
STK4 serine/threonine kinase 4 0.0371593
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0370695
HMGB2 high mobility group box 2 0.0370688
CAPN2 calpain 2, (m/II) large subunit 0.0369006
RPLP2 ribosomal protein, large, P2 0.0368016
BZW1 basic leucine zipper and W2 domains 1 0.0364912
CXCL8 chemokine (C-X-C motif) ligand 8 0.0364259
LOX lysyl oxidase 0.036024
HDLBP high density lipoprotein binding protein 0.0358657
GARS1 glycyl-tRNA synthetase 1 0.0358463
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0358419
DLG1 discs, large homolog 1 (Drosophila) 0.0354568
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0351918
POTEF POTE ankyrin domain family, member F 0.0350406
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0348112
NAP1L1 nucleosome assembly protein 1-like 1 0.0341583
PICALM phosphatidylinositol binding clathrin assembly protein 0.0338703
CALU calumenin 0.0337092
ITCH itchy E3 ubiquitin protein ligase 0.0336168
DSCAM Down syndrome cell adhesion molecule 0.0334833
EXT1 exostosin glycosyltransferase 1 0.0327724
LOXL2 lysyl oxidase-like 2 0.0316938
CEMIP cell migration inducing protein, hyaluronan binding 0.0312973
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0312726
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0310805
PLAUR plasminogen activator, urokinase receptor 0.0310257
GOLGB1 golgin B1 0.0308311
RPL35A ribosomal protein L35a 0.0303688
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0303459
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0301828
KMT2C lysine (K)-specific methyltransferase 2C 0.0297391
CTSB cathepsin B 0.0296647
B2M beta-2-microglobulin 0.0296241
KIF5B kinesin family member 5B 0.0295995
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0295912
FAM20C family with sequence similarity 20, member C 0.0294237
NOTCH2 notch 2 0.029064
AAK1 AP2 associated kinase 1 0.0289186
TMEM14B transmembrane protein 14B 0.0289181
PDIA4 protein disulfide isomerase family A, member 4 0.0286425
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0283215
ALK anaplastic lymphoma receptor tyrosine kinase 0.0283
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0281723
UBA6 ubiquitin-like modifier activating enzyme 6 0.0281491
RBM25 RNA binding motif protein 25 0.0281293
VCL vinculin 0.0280484
ATF4 activating transcription factor 4 0.0274956
RPL26 ribosomal protein L26 0.0272761
COL6A2 collagen, type VI, alpha 2 0.0268926
EIF1 eukaryotic translation initiation factor 1 0.0267398
KDM4C lysine (K)-specific demethylase 4C 0.0265942
PRELID2 PRELI domain containing 2 0.0261214
RPS8 ribosomal protein S8 0.0260538
CLMP CXADR-like membrane protein 0.0259876
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0259607
RPS3 ribosomal protein S3 0.0259538
RPL32 ribosomal protein L32 0.025943
TMSB4X thymosin beta 4, X-linked 0.0258931
PSD3 pleckstrin and Sec7 domain containing 3 0.0256492
RAD21 RAD21 homolog (S. pombe) 0.0256309
CTBP2 C-terminal binding protein 2 0.0253964
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0253603
GLIS3 GLIS family zinc finger 3 0.0253434
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0252385
MORF4L2 mortality factor 4 like 2 0.0250741

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.184771
PDIA3 protein disulfide isomerase family A, member 3 -0.0598465
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.059538
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0564187
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0554936
PKM pyruvate kinase, muscle -0.0536577
ASPH aspartate beta-hydroxylase -0.0483736
MATR3 matrin 3 -0.0480009
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0478447
NAMPT nicotinamide phosphoribosyltransferase -0.0460132
FNDC3A fibronectin type III domain containing 3A -0.0453409
FNDC3B fibronectin type III domain containing 3B -0.0438718
MEF2A myocyte enhancer factor 2A -0.0413726
IGFBP3 insulin-like growth factor binding protein 3 -0.0403368
SPAG9 sperm associated antigen 9 -0.0402525
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0390507
QKI QKI, KH domain containing, RNA binding -0.0385486
NDRG1 N-myc downstream regulated 1 -0.0370924
FN1 fibronectin 1 -0.0368756
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.036523
SEC24B SEC24 family member B -0.036202
CADM1 cell adhesion molecule 1 -0.0359085
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0355621
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0349316
MAP1B microtubule-associated protein 1B -0.0349026
PDE10A phosphodiesterase 10A -0.0332924
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0329989
SRP54 signal recognition particle 54kDa -0.032997
IRF1 interferon regulatory factor 1 -0.0329874
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0326309
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.032382
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0322562
EGR1 early growth response 1 -0.0306983
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0306824
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0304028
TSC22D2 TSC22 domain family, member 2 -0.0296768
CCNL1 cyclin L1 -0.029551
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0294548
ENO2 enolase 2 (gamma, neuronal) -0.0289454
RTN4 reticulon 4 -0.0288248
UGCG UDP-glucose ceramide glucosyltransferase -0.0286361
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0279623
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0279313
KRIT1 KRIT1, ankyrin repeat containing -0.0278299
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0278235
UBC ubiquitin C -0.0275646
IWS1 IWS1 homolog (S. cerevisiae) -0.0273065
BRWD1 bromodomain and WD repeat domain containing 1 -0.0263701
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0262554
GPC6 glypican 6 -0.0262417
INSIG2 insulin induced gene 2 -0.0259555
EXOC4 exocyst complex component 4 -0.0259391
SDC4 syndecan 4 -0.0257285
PRRC1 proline-rich coiled-coil 1 -0.0255318
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0254602
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0252579
UBE2O ubiquitin-conjugating enzyme E2O -0.0252392
DMTF1 cyclin D binding myb-like transcription factor 1 -0.0252193
TAGLN2 transgelin 2 -0.0252011
ESYT2 extended synaptotagmin-like protein 2 -0.0251081
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0248235
PRPF8 pre-mRNA processing factor 8 -0.0246457
DOT1L DOT1-like histone H3K79 methyltransferase -0.0246392
RBM39 RNA binding motif protein 39 -0.0246268
NUP153 nucleoporin 153kDa -0.0242468
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0240074
NCOR1 nuclear receptor corepressor 1 -0.0239941
AFAP1 actin filament associated protein 1 -0.0238251
RAB1A RAB1A, member RAS oncogene family -0.0238056
STRN3 striatin, calmodulin binding protein 3 -0.0237717
TOP1 topoisomerase (DNA) I -0.0236909
TIMP1 TIMP metallopeptidase inhibitor 1 -0.023578
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0235728
SEC62 SEC62 homolog (S. cerevisiae) -0.0235153
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0234475
MYH9 myosin, heavy chain 9, non-muscle -0.0231025
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0230626
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0230047
MSI2 musashi RNA-binding protein 2 -0.0229009
VEGFA vascular endothelial growth factor A -0.0228591
INSIG1 insulin induced gene 1 -0.022743
MAP2K4 mitogen-activated protein kinase kinase 4 -0.0227012
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0225961
PIAS1 protein inhibitor of activated STAT, 1 -0.0224881
H3-3B H3.3 histone B -0.0223601
MRPS6 mitochondrial ribosomal protein S6 -0.022145
SOD2 superoxide dismutase 2, mitochondrial -0.0219604
TXNRD1 thioredoxin reductase 1 -0.0218945
HBP1 HMG-box transcription factor 1 -0.021832
CCNK cyclin K -0.0217773
CACUL1 CDK2-associated, cullin domain 1 -0.0215894
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -0.021543
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0215091
ZC3H11A zinc finger CCCH-type containing 11A -0.0214996
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0214968
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0214192
DPYSL2 dihydropyrimidinase-like 2 -0.0213999
MRTFA myocardin related transcription factor A -0.0213798
SOCS5 suppressor of cytokine signaling 5 -0.0213505
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0213242