Darolutamide_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Darolutamide perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Darolutamide_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.130188
VIM vimentin 0.115179
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0767903
NAP1L1 nucleosome assembly protein 1-like 1 0.0756546
TPX2 TPX2, microtubule-associated 0.0706367
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0653784
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0627147
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0556345
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.053119
CENPF centromere protein F, 350/400kDa 0.0492863
SMC4 structural maintenance of chromosomes 4 0.0487659
SMYD3 SET and MYND domain containing 3 0.0483507
RPS3 ribosomal protein S3 0.0469105
TPI1 triosephosphate isomerase 1 0.0429804
CSNK1A1 casein kinase 1, alpha 1 0.0402156
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0394928
RPL23 ribosomal protein L23 0.0393827
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0392753
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0386381
ECT2 epithelial cell transforming 2 0.038524
NUP58 nucleoporin 58 0.0384606
KIF5B kinesin family member 5B 0.0384178
RPLP0 ribosomal protein, large, P0 0.0381769
GNAS GNAS complex locus 0.0380835
RPL12 ribosomal protein L12 0.0375236
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0372975
CALR calreticulin 0.0365022
SET SET nuclear proto-oncogene 0.0343735
MYH9 myosin, heavy chain 9, non-muscle 0.0341474
PRRC2C proline-rich coiled-coil 2C 0.0324209
TMSB10 thymosin beta 10 0.0322698
RPL7 ribosomal protein L7 0.0318856
RNF145 ring finger protein 145 0.0312498
IL6ST interleukin 6 signal transducer 0.0310349
HMGB2 high mobility group box 2 0.0304552
NAMPT nicotinamide phosphoribosyltransferase 0.0303098
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0301851
ARHGAP5 Rho GTPase activating protein 5 0.0297664
RACK1 receptor for activated C kinase 1 0.0287971
EIF4A1 eukaryotic translation initiation factor 4A1 0.0287131
INTS6 integrator complex subunit 6 0.0286282
MIS18BP1 MIS18 binding protein 1 0.0284069
SDC4 syndecan 4 0.0280671
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0279891
XPO1 exportin 1 0.0279832
PUM2 pumilio RNA-binding family member 2 0.0274596
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0273431
BRD2 bromodomain containing 2 0.0266972
CANX calnexin 0.0265921
TRA2A transformer 2 alpha homolog (Drosophila) 0.0263439
CALU calumenin 0.0263288
CSDE1 cold shock domain containing E1, RNA-binding 0.0263163
LCORL ligand dependent nuclear receptor corepressor-like 0.0262116
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0261532
TUBA1B tubulin, alpha 1b 0.0260391
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0260244
YME1L1 YME1-like 1 ATPase 0.0256194
HSPA8 heat shock 70kDa protein 8 0.0255593
PGK1 phosphoglycerate kinase 1 0.025535
SKP1 S-phase kinase-associated protein 1 0.025342
MKI67 marker of proliferation Ki-67 0.0250919
MBNL1 muscleblind-like splicing regulator 1 0.0250746
YAP1 Yes-associated protein 1 0.0250284
BZW1 basic leucine zipper and W2 domains 1 0.0249917
CEP250 centrosomal protein 250kDa 0.0245572
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0243755
BICD1 bicaudal D homolog 1 (Drosophila) 0.0242189
AHNAK AHNAK nucleoprotein 0.0241994
GSK3B glycogen synthase kinase 3 beta 0.0241901
RPS17 ribosomal protein S17 0.0241319
OGA O-GlcNAcase 0.0239682
RDX radixin 0.0239019
STAU1 staufen double-stranded RNA binding protein 1 0.0236462
TXNRD1 thioredoxin reductase 1 0.0234728
TOP2B topoisomerase (DNA) II beta 180kDa 0.0232812
RAD21 RAD21 homolog (S. pombe) 0.0232332
RBM39 RNA binding motif protein 39 0.0232293
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0230667
NAP1L4 nucleosome assembly protein 1-like 4 0.0230414
C6ORF62 chromosome 6 open reading frame 62 0.0230092
CXCL8 chemokine (C-X-C motif) ligand 8 0.0228686
COPB1 coatomer protein complex, subunit beta 1 0.0226799
PTMA prothymosin, alpha 0.0226736
RPS12 ribosomal protein S12 0.0226666
APLP2 amyloid beta (A4) precursor-like protein 2 0.0224972
KDM3A lysine (K)-specific demethylase 3A 0.0224967
ANLN anillin, actin binding protein 0.0221678
DCAF7 DDB1 and CUL4 associated factor 7 0.0220612
PDE4D phosphodiesterase 4D, cAMP-specific 0.0219292
RPS8 ribosomal protein S8 0.0218943
MED13L mediator complex subunit 13-like 0.0218739
EHBP1 EH domain binding protein 1 0.0218674
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0218436
BIRC3 baculoviral IAP repeat containing 3 0.021792
KIF4A kinesin family member 4A 0.0217557
RPS20 ribosomal protein S20 0.021706
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.0216226
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.021602
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0212644
RPL36 ribosomal protein L36 0.0212605

decreased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B -0.12801
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.11179
IGFBP3 insulin-like growth factor binding protein 3 -0.0908206
ESYT2 extended synaptotagmin-like protein 2 -0.0550188
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0528683
ANGPTL4 angiopoietin-like 4 -0.0512862
IGF2 insulin-like growth factor 2 -0.0497751
NDRG1 N-myc downstream regulated 1 -0.0497278
MACF1 microtubule-actin crosslinking factor 1 -0.0487607
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0482474
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0479036
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.046716
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0426806
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0426746
DNER delta/notch-like EGF repeat containing -0.0414569
EFNA5 ephrin-A5 -0.0414026
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.04021
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0401855
RIGI RNA sensor RIG-I -0.0395552
MYO9B myosin IXB -0.0394944
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0379855
AKAP12 A kinase (PRKA) anchor protein 12 -0.0377955
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0376927
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0374756
ATXN1 ataxin 1 -0.0371898
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0371499
CAPRIN2 caprin family member 2 -0.0370413
FMNL2 formin-like 2 -0.0370099
UGCG UDP-glucose ceramide glucosyltransferase -0.0365591
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0362238
ZMYND8 zinc finger, MYND-type containing 8 -0.0358831
FNIP1 folliculin interacting protein 1 -0.0353845
SETD5 SET domain containing 5 -0.0349134
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0335291
MAP1B microtubule-associated protein 1B -0.0333789
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0323436
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0322034
FLNB filamin B, beta -0.0320366
HILPDA hypoxia inducible lipid droplet-associated -0.0316095
ASPH aspartate beta-hydroxylase -0.0313558
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0310398
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0308809
NALCN sodium leak channel, non selective -0.0307446
GPC5 glypican 5 -0.0298468
ANKRD12 ankyrin repeat domain 12 -0.0294199
TPT1 tumor protein, translationally-controlled 1 -0.0293605
ERBIN erbb2 interacting protein -0.0292795
PPP4R4 protein phosphatase 4, regulatory subunit 4 -0.0289116
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0289063
BPTF bromodomain PHD finger transcription factor -0.0287529
LDHA lactate dehydrogenase A -0.0285439
DERA deoxyribose-phosphate aldolase (putative) -0.0284521
PDGFA platelet-derived growth factor alpha polypeptide -0.028268
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0278166
SASH1 SAM and SH3 domain containing 1 -0.0276417
DGKH diacylglycerol kinase, eta -0.0276291
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0276109
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0274987
NPAS2 neuronal PAS domain protein 2 -0.0269531
EGFR epidermal growth factor receptor -0.0268832
NCOR2 nuclear receptor corepressor 2 -0.0268315
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0259851
FNDC3A fibronectin type III domain containing 3A -0.0255196
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0252543
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0251504
EGR1 early growth response 1 -0.0248631
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0246153
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0242768
PRKCA protein kinase C, alpha -0.0241607
FN1 fibronectin 1 -0.0236759
KIAA1671 KIAA1671 -0.0234687
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0234078
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0230526
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0229518
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.02289
TENT2 terminal nucleotidyltransferase 2 -0.0222531
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.02225
BRWD1 bromodomain and WD repeat domain containing 1 -0.0221658
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0221497
FOSL1 FOS-like antigen 1 -0.0220447
NHSL1 NHS-like 1 -0.0219851
WARS1 tryptophanyl-tRNA synthetase 1 -0.0217522
PAWR PRKC, apoptosis, WT1, regulator -0.0217453
JUN jun proto-oncogene -0.0217115
RIN2 Ras and Rab interactor 2 -0.0216566
PTK2 protein tyrosine kinase 2 -0.0215888
ITGB5 integrin, beta 5 -0.0215656
ITGAV integrin, alpha V -0.0215199
DENND1A DENN/MADD domain containing 1A -0.0213932
DGKD diacylglycerol kinase, delta 130kDa -0.0213701
MAP4 microtubule-associated protein 4 -0.0211865
ITGB4 integrin, beta 4 -0.0211667
CPNE8 copine VIII -0.0211122
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -0.0210701
CAMK4 calcium/calmodulin-dependent protein kinase IV -0.0210159
SPNS1 spinster homolog 1 (Drosophila) -0.0208698
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0208315
YEATS2 YEATS domain containing 2 -0.0207667
TRAM2 translocation associated membrane protein 2 -0.0206793
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0206645