Dasatinib Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/3062316
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Genes

199 proteins with high or low expression in Dasatinib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
NR4A2 nuclear receptor subfamily 4, group A, member 2 1.88
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.82
VGF VGF nerve growth factor inducible 1.34
PTPRD protein tyrosine phosphatase, receptor type, D 1.34
LIPH lipase, member H 1.32
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 1.31
OTX1 orthodenticle homeobox 1 1.3
DEPTOR DEP domain containing MTOR-interacting protein 1.29
GDF15 growth differentiation factor 15 1.29
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 1.28
GJC1 gap junction protein, gamma 1, 45kDa 1.25
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 1.23
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.19
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.18
NIPSNAP3A nipsnap homolog 3A (C. elegans) 1.17
TSPAN3 tetraspanin 3 1.16
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1.15
GATA2 GATA binding protein 2 1.11
FOXC1 forkhead box C1 1.11
RREB1 ras responsive element binding protein 1 1.1
SARDH sarcosine dehydrogenase 1.07
PDLIM3 PDZ and LIM domain 3 1.07
PGPEP1 pyroglutamyl-peptidase I 1.06
GREB1 growth regulation by estrogen in breast cancer 1 1.05
CCDC158 coiled-coil domain containing 158 1.04
PTPRF protein tyrosine phosphatase, receptor type, F 1.02
DHRS2 dehydrogenase/reductase (SDR family) member 2 1.02
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 1.01
HSH2D hematopoietic SH2 domain containing 1.0
CES3 carboxylesterase 3 0.97
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 0.96
DENND5B DENN/MADD domain containing 5B 0.93
CREG1 cellular repressor of E1A-stimulated genes 1 0.9
PTPRS protein tyrosine phosphatase, receptor type, S 0.89
MSRB2 methionine sulfoxide reductase B2 0.88
NIBAN1 niban apoptosis regulator 1 0.87
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.87
PSPH phosphoserine phosphatase 0.87
EPN3 epsin 3 0.86
IGFBP3 insulin-like growth factor binding protein 3 0.86
RAB27B RAB27B, member RAS oncogene family 0.85
ADD3 adducin 3 (gamma) 0.85
TRIM2 tripartite motif containing 2 0.84
FAM117A family with sequence similarity 117, member A 0.83
CLDN3 claudin 3 0.83
BCAM basal cell adhesion molecule (Lutheran blood group) 0.82
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 0.81
TMEM59 transmembrane protein 59 0.81
CD63 CD63 molecule 0.81
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 0.81
NQO1 NAD(P)H dehydrogenase, quinone 1 0.8
MLXIPL MLX interacting protein-like 0.8
HKDC1 hexokinase domain containing 1 0.8
MSX1 msh homeobox 1 0.79
NRXN3 neurexin 3 0.79
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.79
CTHRC1 collagen triple helix repeat containing 1 0.78
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.78
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.78
PTPRU protein tyrosine phosphatase, receptor type, U 0.78
SAYSD1 SAYSVFN motif domain containing 1 0.77
FOXO1 forkhead box O1 0.77
ARG2 arginase 2 0.76
THSD4 thrombospondin, type I, domain containing 4 0.76
PSAT1 phosphoserine aminotransferase 1 0.75
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.75
PLCD1 phospholipase C, delta 1 0.74
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.74
IFI35 interferon-induced protein 35 0.73
ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 0.73
SYTL1 synaptotagmin-like 1 0.73
CYHR1 cysteine/histidine-rich 1 0.72
FBXL2 F-box and leucine-rich repeat protein 2 0.72
NOTCH3 notch 3 0.72
DUSP4 dual specificity phosphatase 4 0.71
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 0.7
HOXB9 homeobox B9 0.7
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 0.7
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.7
DNASE2 deoxyribonuclease II, lysosomal 0.69
CTH cystathionine gamma-lyase 0.69
CBR1 carbonyl reductase 1 0.69
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.69
INPP5J inositol polyphosphate-5-phosphatase J 0.68
HYKK hydroxylysine kinase 0.68
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.67
IRF9 interferon regulatory factor 9 0.67
MAN1A1 mannosidase, alpha, class 1A, member 1 0.67
ABHD14A abhydrolase domain containing 14A 0.66
MPZL2 myelin protein zero-like 2 0.66
STAT2 signal transducer and activator of transcription 2, 113kDa 0.66
IQGAP2 IQ motif containing GTPase activating protein 2 0.66
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.66
H1-0 H1.0 linker histone 0.65
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.65
NEBL nebulette 0.65
TMEM51 transmembrane protein 51 0.65
PRSS8 protease, serine, 8 0.65
TMEM135 transmembrane protein 135 0.65

low expression

Symbol Name Standardized Value
SEMG1 semenogelin I -4.61
CPA4 carboxypeptidase A4 -1.99
SYTL3 synaptotagmin-like 3 -1.66
RND3 Rho family GTPase 3 -1.56
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A -1.54
GEM GTP binding protein overexpressed in skeletal muscle -1.46
F3 coagulation factor III (thromboplastin, tissue factor) -1.46
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -1.32
UBE2S ubiquitin-conjugating enzyme E2S -1.29
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -1.25
CDCA4 cell division cycle associated 4 -1.23
NAV2 neuron navigator 2 -1.19
TRIB1 tribbles pseudokinase 1 -1.18
FOSL1 FOS-like antigen 1 -1.09
UBE2C ubiquitin-conjugating enzyme E2C -1.07
F2RL1 coagulation factor II (thrombin) receptor-like 1 -1.0
PLK1 polo-like kinase 1 -0.96
NAV3 neuron navigator 3 -0.96
CDC20 cell division cycle 20 -0.96
UGCG UDP-glucose ceramide glucosyltransferase -0.95
PLD6 phospholipase D family, member 6 -0.94
CCNB1 cyclin B1 -0.92
AXL AXL receptor tyrosine kinase -0.92
SEMG2 semenogelin II -0.92
TEC tec protein tyrosine kinase -0.89
PBX3 pre-B-cell leukemia homeobox 3 -0.89
DDN dendrin -0.89
BCL2L12 BCL2-like 12 (proline rich) -0.88
EGR1 early growth response 1 -0.88
ANLN anillin, actin binding protein -0.87
TMEM219 transmembrane protein 219 -0.86
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) -0.85
SFXN5 sideroflexin 5 -0.85
IFFO2 intermediate filament family orphan 2 -0.85
WNT16 wingless-type MMTV integration site family, member 16 -0.85
PRC1 protein regulator of cytokinesis 1 -0.84
TACSTD2 tumor-associated calcium signal transducer 2 -0.84
GAS6 growth arrest-specific 6 -0.84
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.84
SMTN smoothelin -0.83
MICA MHC class I polypeptide-related sequence A -0.83
LRRC58 leucine rich repeat containing 58 -0.83
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -0.83
SH3RF1 SH3 domain containing ring finger 1 -0.81
ADGRF1 adhesion G protein-coupled receptor F1 -0.8
LAMB3 laminin, beta 3 -0.8
TPX2 TPX2, microtubule-associated -0.79
UBE2T ubiquitin-conjugating enzyme E2T -0.79
KIF1B kinesin family member 1B -0.79
BDNF brain-derived neurotrophic factor -0.78
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -0.78
BCAR3 breast cancer anti-estrogen resistance 3 -0.78
CRTC2 CREB regulated transcription coactivator 2 -0.78
NFE2L1 nuclear factor, erythroid 2-like 1 -0.78
GAS2L3 growth arrest-specific 2 like 3 -0.78
TOP2A topoisomerase (DNA) II alpha 170kDa -0.78
RRM2 ribonucleotide reductase M2 -0.77
JUNB jun B proto-oncogene -0.76
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) -0.75
FBXO41 F-box protein 41 -0.75
WSB2 WD repeat and SOCS box containing 2 -0.74
GTSE1 G-2 and S-phase expressed 1 -0.74
PDE7A phosphodiesterase 7A -0.74
ZFP36L1 ZFP36 ring finger protein-like 1 -0.73
VIM vimentin -0.73
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.73
ALPK3 alpha-kinase 3 -0.71
PARG poly (ADP-ribose) glycohydrolase -0.71
HMGXB3 HMG box domain containing 3 -0.71
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -0.71
KIF22 kinesin family member 22 -0.71
SHCBP1 SHC SH2-domain binding protein 1 -0.71
PIMREG PICALM interacting mitotic regulator -0.71
AURKA aurora kinase A -0.71
NOCT nocturnin -0.7
CCNA2 cyclin A2 -0.7
DUSP7 dual specificity phosphatase 7 -0.7
TCTEX1D2 Tctex1 domain containing 2 -0.7
CEP55 centrosomal protein 55kDa -0.7
CDC25B cell division cycle 25B -0.7
CDCA2 cell division cycle associated 2 -0.69
RHOBTB3 Rho-related BTB domain containing 3 -0.68
AEN apoptosis enhancing nuclease -0.68
FAM111B family with sequence similarity 111, member B -0.68
KCTD5 potassium channel tetramerization domain containing 5 -0.68
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 -0.68
MOSPD1 motile sperm domain containing 1 -0.68
TTLL4 tubulin tyrosine ligase-like family member 4 -0.68
KIF20A kinesin family member 20A -0.67
RAD54B RAD54 homolog B (S. cerevisiae) -0.67
RELT RELT tumor necrosis factor receptor -0.67
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor -0.67
IRX4 iroquois homeobox 4 -0.67
MLPH melanophilin -0.67
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -0.67
LIMK1 LIM domain kinase 1 -0.66
PER1 period circadian clock 1 -0.66
TRIM14 tripartite motif containing 14 -0.66
KIF2C kinesin family member 2C -0.65
AURKB aurora kinase B -0.65