Deadenylation-dependent mRNA decay Gene Set

Dataset Reactome Pathways
Category structural or functional annotations
Type pathway
Description A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability. (Gene Ontology, GO_0000288)
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-429914
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Genes

49 proteins participating in the Deadenylation-dependent mRNA decay pathway from the Reactome Pathways dataset.

Symbol Name
CNOT1 CCR4-NOT transcription complex, subunit 1
CNOT10 CCR4-NOT transcription complex, subunit 10
CNOT11 CCR4-NOT transcription complex, subunit 11
CNOT2 CCR4-NOT transcription complex, subunit 2
CNOT3 CCR4-NOT transcription complex, subunit 3
CNOT4 CCR4-NOT transcription complex, subunit 4
CNOT6 CCR4-NOT transcription complex, subunit 6
CNOT6L CCR4-NOT transcription complex, subunit 6-like
CNOT7 CCR4-NOT transcription complex, subunit 7
CNOT8 CCR4-NOT transcription complex, subunit 8
DCP1A decapping mRNA 1A
DCP1B decapping mRNA 1B
DCP2 decapping mRNA 2
DCPS decapping enzyme, scavenger
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
EDC3 enhancer of mRNA decapping 3
EDC4 enhancer of mRNA decapping 4
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4A2 eukaryotic translation initiation factor 4A2
EIF4A3 eukaryotic translation initiation factor 4A3
EIF4B eukaryotic translation initiation factor 4B
EIF4E eukaryotic translation initiation factor 4E
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EXOSC1 exosome component 1
EXOSC2 exosome component 2
EXOSC3 exosome component 3
EXOSC4 exosome component 4
EXOSC5 exosome component 5
EXOSC6 exosome component 6
EXOSC7 exosome component 7
EXOSC8 exosome component 8
EXOSC9 exosome component 9
LSM1 LSM1, U6 small nuclear RNA associated
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
PABPC1 poly(A) binding protein, cytoplasmic 1
PAIP1 poly(A) binding protein interacting protein 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAN3 PAN3 poly(A) specific ribonuclease subunit
PARN poly(A)-specific ribonuclease
PATL1 protein associated with topoisomerase II homolog 1 (yeast)
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
TNKS1BP1 tankyrase 1 binding protein 1, 182kDa
XRN1 5'-3' exoribonuclease 1
Funding