Death Receptor Signaling Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
External Link https://reactome.org/PathwayBrowser/#/R-HSA-73887
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Genes

155 proteins participating in the Death Receptor Signaling pathway from the Reactome Pathways 2024 dataset.

Symbol Name
AATF apoptosis antagonizing transcription factor
ABR active BCR-related
ADAM17 ADAM metallopeptidase domain 17
AKAP13 A kinase (PRKA) anchor protein 13
APH1A APH1A gamma secretase subunit
APH1B APH1B gamma secretase subunit
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARHGEF33 Rho guanine nucleotide exchange factor (GEF) 33
ARHGEF35 Rho guanine nucleotide exchange factor (GEF) 35
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
BAD BCL2-associated agonist of cell death
BAG4 BCL2-associated athanogene 4
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BEX3 brain expressed X-linked 3
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CFLAR CASP8 and FADD-like apoptosis regulator
CHUK conserved helix-loop-helix ubiquitous kinase
CLIP3 CAP-GLY domain containing linker protein 3
CYLD cylindromatosis (turban tumor syndrome)
ECT2 epithelial cell transforming 2
FADD Fas (TNFRSF6)-associated via death domain
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FGD1 FYVE, RhoGEF and PH domain containing 1
FGD2 FYVE, RhoGEF and PH domain containing 2
FGD3 FYVE, RhoGEF and PH domain containing 3
FGD4 FYVE, RhoGEF and PH domain containing 4
GNA13 guanine nucleotide binding protein (G protein), alpha 13
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IRAK1 interleukin-1 receptor-associated kinase 1
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
ITSN1 intersectin 1 (SH3 domain protein)
KALRN kalirin, RhoGEF kinase
LINGO1 leucine rich repeat and Ig domain containing 1
MADD MAP-kinase activating death domain
MAG myelin associated glycoprotein
MAGED1 melanoma antigen family D1
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK8 mitogen-activated protein kinase 8
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MCF2 MCF.2 cell line derived transforming sequence
MCF2L MCF.2 cell line derived transforming sequence-like
MIB2 mindbomb E3 ubiquitin protein ligase 2
MYD88 myeloid differentiation primary response 88
NCSTN nicastrin
NET1 neuroepithelial cell transforming 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGEF neuronal guanine nucleotide exchange factor
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OMG oligodendrocyte myelin glycoprotein
OPTN optineurin
OTUD1 OTU deubiquitinase 1
OTUD7B OTU deubiquitinase 7B
OTULIN OTU deubiquitinase with linear linkage specificity
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5
PRDM4 PR domain containing 4
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PRKCI protein kinase C, iota
PSEN1 presenilin 1
PSEN2 presenilin 2
PSENEN presenilin enhancer gamma secretase subunit
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RACK1 receptor for activated C kinase 1
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOA ras homolog family member A
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK2 receptor-interacting serine-threonine kinase 2
RNF31 ring finger protein 31
RPS27A ribosomal protein S27a
RTN4 reticulon 4
RTN4R reticulon 4 receptor
SHARPIN SHANK-associated RH domain interactor
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
SORCS3 sortilin-related VPS10 domain containing receptor 3
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SPATA2 spermatogenesis associated 2
SPPL2A signal peptide peptidase like 2A
SPPL2B signal peptide peptidase like 2B
SQSTM1 sequestosome 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBK1 TANK-binding kinase 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TIAM2 T-cell lymphoma invasion and metastasis 2
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRADD TNFRSF1A-associated via death domain
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIO trio Rho guanine nucleotide exchange factor
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D2 ubiquitin-conjugating enzyme E2D 2
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2L3 ubiquitin-conjugating enzyme E2L 3
ULK1 unc-51 like autophagy activating kinase 1
USP2 ubiquitin specific peptidase 2
USP21 ubiquitin specific peptidase 21
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon