| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/66555680 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Debio-1347 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 2.43 |
| TP53 | tumor protein p53 | 2.2 |
| TP53I3 | tumor protein p53 inducible protein 3 | 2.17 |
| DNAH6 | dynein, axonemal, heavy chain 6 | 1.78 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 1.72 |
| SMTN | smoothelin | 1.42 |
| SULF2 | sulfatase 2 | 1.23 |
| FAS | Fas cell surface death receptor | 1.16 |
| POLH | polymerase (DNA directed), eta | 1.14 |
| LAMC2 | laminin, gamma 2 | 1.14 |
| WNT10B | wingless-type MMTV integration site family, member 10B | 1.14 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 1.14 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 1.13 |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 | 1.11 |
| HECW2 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 | 1.1 |
| RASSF3 | Ras association (RalGDS/AF-6) domain family member 3 | 1.06 |
| E2F7 | E2F transcription factor 7 | 1.05 |
| RRN3 | RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) | 1.01 |
| CAPRIN2 | caprin family member 2 | 0.97 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.97 |
| CPA4 | carboxypeptidase A4 | 0.96 |
| TGM2 | transglutaminase 2 | 0.96 |
| NGFR | nerve growth factor receptor | 0.95 |
| MGLL | monoglyceride lipase | 0.93 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.92 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.9 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | 0.88 |
| CCND1 | cyclin D1 | 0.88 |
| LAMA3 | laminin, alpha 3 | 0.88 |
| RINL | Ras and Rab interactor-like | 0.88 |
| TP73 | tumor protein p73 | 0.88 |
| DUSP4 | dual specificity phosphatase 4 | 0.87 |
| LAMB3 | laminin, beta 3 | 0.87 |
| CD82 | CD82 molecule | 0.86 |
| MT-CO1 | cytochrome c oxidase subunit I | 0.86 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.85 |
| NUDT14 | nudix (nucleoside diphosphate linked moiety X)-type motif 14 | 0.84 |
| STK17A | serine/threonine kinase 17a | 0.84 |
| UPP1 | uridine phosphorylase 1 | 0.82 |
| SLC12A4 | solute carrier family 12 (potassium/chloride transporter), member 4 | 0.82 |
| DGKA | diacylglycerol kinase, alpha 80kDa | 0.82 |
| CCND3 | cyclin D3 | 0.8 |
| NRP1 | neuropilin 1 | 0.8 |
| TROAP | trophinin associated protein | 0.8 |
| TNS1 | tensin 1 | 0.79 |
| PTPDC1 | protein tyrosine phosphatase domain containing 1 | 0.78 |
| FHL2 | four and a half LIM domains 2 | 0.78 |
| FOSL2 | FOS-like antigen 2 | 0.77 |
| FDXR | ferredoxin reductase | 0.76 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.76 |
| IKBIP | IKBKB interacting protein | 0.76 |
| TMEM40 | transmembrane protein 40 | 0.75 |
| PLD6 | phospholipase D family, member 6 | 0.75 |
| PLIN2 | perilipin 2 | 0.75 |
| PRKD3 | protein kinase D3 | 0.74 |
| SLC39A3 | solute carrier family 39 (zinc transporter), member 3 | 0.73 |
| CDCA5 | cell division cycle associated 5 | 0.73 |
| RAB27B | RAB27B, member RAS oncogene family | 0.71 |
| FSTL3 | follistatin-like 3 (secreted glycoprotein) | 0.71 |
| SGO1 | shugoshin 1 | 0.7 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | 0.7 |
| VAMP4 | vesicle-associated membrane protein 4 | 0.7 |
| PAAF1 | proteasomal ATPase-associated factor 1 | 0.69 |
| SFN | stratifin | 0.69 |
| LRR1 | leucine rich repeat protein 1 | 0.69 |
| SYTL3 | synaptotagmin-like 3 | 0.69 |
| EPN3 | epsin 3 | 0.69 |
| RAET1G | retinoic acid early transcript 1G | 0.68 |
| ITPKA | inositol-trisphosphate 3-kinase A | 0.67 |
| RRM2 | ribonucleotide reductase M2 | 0.67 |
| DUOX1 | dual oxidase 1 | 0.67 |
| APOBEC3C | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C | 0.66 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.66 |
| ANLN | anillin, actin binding protein | 0.66 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.66 |
| C18ORF32 | chromosome 18 open reading frame 32 | 0.65 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.64 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 0.64 |
| INAVA | innate immunity activator | 0.63 |
| ANKRD2 | ankyrin repeat domain 2 (stretch responsive muscle) | 0.63 |
| COQ8A | coenzyme Q8A | 0.63 |
| CRYBG2 | crystallin beta-gamma domain containing 2 | 0.62 |
| DUSP5 | dual specificity phosphatase 5 | 0.62 |
| CKAP2 | cytoskeleton associated protein 2 | 0.62 |
| ZBTB5 | zinc finger and BTB domain containing 5 | 0.62 |
| INPP5J | inositol polyphosphate-5-phosphatase J | 0.62 |
| RBM4B | RNA binding motif protein 4B | 0.62 |
| PSTPIP2 | proline-serine-threonine phosphatase interacting protein 2 | 0.62 |
| FOXM1 | forkhead box M1 | 0.61 |
| CKAP2L | cytoskeleton associated protein 2-like | 0.61 |
| B3GNT3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | 0.61 |
| MAPKBP1 | mitogen-activated protein kinase binding protein 1 | 0.61 |
| P2RX4 | purinergic receptor P2X, ligand gated ion channel, 4 | 0.61 |
| ATXN7L2 | ataxin 7-like 2 | 0.6 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.6 |
| LRRCC1 | leucine rich repeat and coiled-coil centrosomal protein 1 | 0.6 |
| PLAU | plasminogen activator, urokinase | 0.6 |
| MORC4 | MORC family CW-type zinc finger 4 | 0.6 |
| SGSH | N-sulfoglucosamine sulfohydrolase | 0.6 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ODC1 | ornithine decarboxylase 1 | -2.43 |
| RPS19BP1 | ribosomal protein S19 binding protein 1 | -1.8 |
| EREG | epiregulin | -1.73 |
| WDR46 | WD repeat domain 46 | -1.72 |
| UTP11 | UTP11 small subunit processome component | -1.66 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -1.55 |
| ZNF770 | zinc finger protein 770 | -1.49 |
| TIGD5 | tigger transposable element derived 5 | -1.49 |
| NOP53 | NOP53 ribosome biogenesis factor | -1.46 |
| RPF1 | ribosome production factor 1 homolog (S. cerevisiae) | -1.41 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -1.38 |
| NSA2 | NSA2 ribosome biogenesis homolog (S. cerevisiae) | -1.35 |
| RRP36 | ribosomal RNA processing 36 homolog (S. cerevisiae) | -1.35 |
| FCF1 | FCF1 rRNA-processing protein | -1.34 |
| SURF6 | surfeit 6 | -1.34 |
| CBX6 | chromobox homolog 6 | -1.32 |
| UTP14A | UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) | -1.29 |
| DCAF13 | DDB1 and CUL4 associated factor 13 | -1.29 |
| UTP6 | UTP6, small subunit (SSU) processome component, homolog (yeast) | -1.24 |
| CCDC59 | coiled-coil domain containing 59 | -1.21 |
| NOL7 | nucleolar protein 7, 27kDa | -1.17 |
| RPL7L1 | ribosomal protein L7-like 1 | -1.13 |
| FAM207A | family with sequence similarity 207, member A | -1.09 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -1.07 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -1.07 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -1.05 |
| RSL1D1 | ribosomal L1 domain containing 1 | -1.03 |
| STC2 | stanniocalcin 2 | -1.02 |
| PDCD11 | programmed cell death 11 | -0.97 |
| SLC38A2 | solute carrier family 38, member 2 | -0.96 |
| ZCCHC9 | zinc finger, CCHC domain containing 9 | -0.96 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | -0.94 |
| CDC6 | cell division cycle 6 | -0.93 |
| ZFHX4 | zinc finger homeobox 4 | -0.93 |
| RGN | regucalcin | -0.93 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | -0.92 |
| ZNF580 | zinc finger protein 580 | -0.91 |
| DDX24 | DEAD (Asp-Glu-Ala-Asp) box helicase 24 | -0.91 |
| SMIM19 | small integral membrane protein 19 | -0.89 |
| VGF | VGF nerve growth factor inducible | -0.89 |
| TSSC4 | tumor suppressing subtransferable candidate 4 | -0.89 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.88 |
| MIDN | midnolin | -0.85 |
| AZIN1 | antizyme inhibitor 1 | -0.85 |
| ANKRD36C | ankyrin repeat domain 36C | -0.85 |
| DERPC | DERPC proline and glycine rich nuclear protein | -0.84 |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa | -0.84 |
| TCTEX1D2 | Tctex1 domain containing 2 | -0.84 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | -0.84 |
| SLC35F3 | solute carrier family 35, member F3 | -0.83 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | -0.82 |
| E2F2 | E2F transcription factor 2 | -0.82 |
| ATF6B | activating transcription factor 6 beta | -0.82 |
| PNO1 | partner of NOB1 homolog (S. cerevisiae) | -0.81 |
| DDX52 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 | -0.81 |
| NECTIN3 | nectin cell adhesion molecule 3 | -0.81 |
| FAAP24 | FA core complex associated protein 24 | -0.8 |
| ZKSCAN2 | zinc finger with KRAB and SCAN domains 2 | -0.8 |
| DDX27 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 | -0.8 |
| KMT5A | lysine methyltransferase 5A | -0.79 |
| CCDC137 | coiled-coil domain containing 137 | -0.79 |
| ANKRD13D | ankyrin repeat domain 13 family, member D | -0.79 |
| WDR74 | WD repeat domain 74 | -0.78 |
| CDT1 | chromatin licensing and DNA replication factor 1 | -0.78 |
| ORC1 | origin recognition complex, subunit 1 | -0.77 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.77 |
| NOP16 | NOP16 nucleolar protein | -0.77 |
| DDX49 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 | -0.77 |
| DUSP6 | dual specificity phosphatase 6 | -0.76 |
| ZNF276 | zinc finger protein 276 | -0.75 |
| RIOK2 | RIO kinase 2 | -0.74 |
| RBM19 | RNA binding motif protein 19 | -0.73 |
| BYSL | bystin-like | -0.73 |
| HOXA7 | homeobox A7 | -0.73 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.73 |
| CEP70 | centrosomal protein 70kDa | -0.72 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | -0.72 |
| RBM34 | RNA binding motif protein 34 | -0.72 |
| AMD1 | adenosylmethionine decarboxylase 1 | -0.72 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.72 |
| ANKRD52 | ankyrin repeat domain 52 | -0.71 |
| RPL22L1 | ribosomal protein L22-like 1 | -0.71 |
| UTP20 | UTP20, small subunit (SSU) processome component, homolog (yeast) | -0.7 |
| ZNF431 | zinc finger protein 431 | -0.7 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.7 |
| PTMA | prothymosin, alpha | -0.7 |
| ZNF302 | zinc finger protein 302 | -0.7 |
| ZNF354A | zinc finger protein 354A | -0.69 |
| SRFBP1 | serum response factor binding protein 1 | -0.69 |
| TSPYL1 | TSPY-like 1 | -0.69 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.69 |
| KCNAB2 | potassium channel, voltage gated subfamily A regulatory beta subunit 2 | -0.69 |
| SMAD3 | SMAD family member 3 | -0.69 |
| NIFK | nucleolar protein interacting with the FHA domain of MKI67 | -0.69 |
| BMS1 | BMS1 ribosome biogenesis factor | -0.69 |
| DDX54 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 | -0.68 |
| EBNA1BP2 | EBNA1 binding protein 2 | -0.68 |
| SYT1 | synaptotagmin I | -0.68 |
| C1ORF131 | chromosome 1 open reading frame 131 | -0.68 |
| EYS | eyes shut homolog (Drosophila) | -0.67 |
