Decitabine_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Decitabine perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Decitabine_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.100769
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0953802
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0882968
ASPH aspartate beta-hydroxylase 0.0819528
EHBP1 EH domain binding protein 1 0.0719983
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0709214
HMGA2 high mobility group AT-hook 2 0.0688102
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0673202
MMP12 matrix metallopeptidase 12 0.0616228
PTMA prothymosin, alpha 0.0586073
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0575584
CALR calreticulin 0.0554807
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0551672
VMP1 vacuole membrane protein 1 0.0549457
NHSL1 NHS-like 1 0.0546301
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0540332
TPT1 tumor protein, translationally-controlled 1 0.0534692
MACF1 microtubule-actin crosslinking factor 1 0.0530301
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0522559
TAS2R14 taste receptor, type 2, member 14 0.0521965
LOC112694756 uncharaterized LOC112694756 0.0516325
TPM3 tropomyosin 3 0.0513688
RPL3 ribosomal protein L3 0.0509047
YEATS2 YEATS domain containing 2 0.0502471
NAP1L1 nucleosome assembly protein 1-like 1 0.0498792
RPL37 ribosomal protein L37 0.0489944
RPS12 ribosomal protein S12 0.0478915
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0476352
USP34 ubiquitin specific peptidase 34 0.0467283
ACTG1 actin gamma 1 0.045843
AHNAK AHNAK nucleoprotein 0.0448262
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.043797
NEBL nebulette 0.0429591
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0424553
ANXA1 annexin A1 0.0422338
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0400059
NLGN1 neuroligin 1 0.0399278
RRM2 ribonucleotide reductase M2 0.0398026
HSPA8 heat shock 70kDa protein 8 0.0394559
BCHE butyrylcholinesterase 0.0392531
EEF2 eukaryotic translation elongation factor 2 0.0382465
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0379751
AKAP12 A kinase (PRKA) anchor protein 12 0.0368547
RPL37A ribosomal protein L37a 0.0368177
EZR ezrin 0.0359785
MYH9 myosin, heavy chain 9, non-muscle 0.0354948
RPS27A ribosomal protein S27a 0.0346662
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0343372
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0343368
RABGAP1L RAB GTPase activating protein 1-like 0.034208
CANX calnexin 0.0335623
MKI67 marker of proliferation Ki-67 0.0333377
ANKRD28 ankyrin repeat domain 28 0.0329539
MTAP methylthioadenosine phosphorylase 0.0326464
R3HDM2 R3H domain containing 2 0.0324364
CUX1 cut-like homeobox 1 0.0321825
TPM4 tropomyosin 4 0.0318381
LRMDA leucine rich melanocyte differentiation associated 0.031323
PDGFC platelet derived growth factor C 0.0312674
SMYD3 SET and MYND domain containing 3 0.0309701
RAD51B RAD51 paralog B 0.0308259
ATP9A ATPase, class II, type 9A 0.0306179
EIF4B eukaryotic translation initiation factor 4B 0.0305372
RPS3 ribosomal protein S3 0.0304397
VCAN versican 0.0301016
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0298549
FNIP1 folliculin interacting protein 1 0.029677
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0290982
TRIO trio Rho guanine nucleotide exchange factor 0.028755
BABAM2 BRISC and BRCA1 A complex member 2 0.0287544
TMEM41B transmembrane protein 41B 0.0287172
YAP1 Yes-associated protein 1 0.0284747
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0283898
FGFR1 fibroblast growth factor receptor 1 0.028339
SPATS2 spermatogenesis associated, serine-rich 2 0.0282132
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0279232
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.027882
XPOT exportin, tRNA 0.0278085
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0272791
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0271425
ENO1 enolase 1, (alpha) 0.026972
CCT7 chaperonin containing TCP1, subunit 7 (eta) 0.0268684
KDM4C lysine (K)-specific demethylase 4C 0.0267204
PDIA3 protein disulfide isomerase family A, member 3 0.0266611
MTCL1 microtubule crosslinking factor 1 0.0266437
RPL26 ribosomal protein L26 0.026502
TNRC18 trinucleotide repeat containing 18 0.0262838
RPL38 ribosomal protein L38 0.0262487
WDPCP WD repeat containing planar cell polarity effector 0.0262408
SMC1A structural maintenance of chromosomes 1A 0.0261446
WWOX WW domain containing oxidoreductase 0.026069
SPIRE1 spire-type actin nucleation factor 1 0.0259203
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0258634
EXOC4 exocyst complex component 4 0.0255449
PLEC plectin 0.0250826
FDPS farnesyl diphosphate synthase 0.0249897
H1-4 H1.4 linker histone, cluster member 0.0247619
CLIP1 CAP-GLY domain containing linker protein 1 0.0247163
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0247055
PDS5A PDS5 cohesin associated factor A 0.0242323

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0895831
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0833902
AREG amphiregulin -0.0707195
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0700299
CELF2 CUGBP, Elav-like family member 2 -0.0629929
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0591294
FTL ferritin, light polypeptide -0.0575375
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.054998
TSC22D2 TSC22 domain family, member 2 -0.0528208
OXR1 oxidation resistance 1 -0.0527579
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0467893
EDN1 endothelin 1 -0.0433009
PCBP2 poly(rC) binding protein 2 -0.0426262
PFN1 profilin 1 -0.0417434
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0411378
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0401585
BIRC3 baculoviral IAP repeat containing 3 -0.0383845
NEK7 NIMA-related kinase 7 -0.0383697
HMGA1 high mobility group AT-hook 1 -0.0373416
PEG10 paternally expressed 10 -0.0371894
CXADR coxsackie virus and adenovirus receptor -0.036179
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0355815
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0352693
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0341721
MED13L mediator complex subunit 13-like -0.0339816
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0328395
AXIN2 axin 2 -0.031962
CBX3 chromobox homolog 3 -0.0315539
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0314425
MPG N-methylpurine-DNA glycosylase -0.0313364
CCNL1 cyclin L1 -0.0312818
PUM2 pumilio RNA-binding family member 2 -0.0310839
ARHGAP12 Rho GTPase activating protein 12 -0.0297829
MEF2C myocyte enhancer factor 2C -0.029467
YBX1 Y box binding protein 1 -0.0292973
VIM vimentin -0.0291379
POTEF POTE ankyrin domain family, member F -0.0290218
CENPF centromere protein F, 350/400kDa -0.0289533
NIPBL Nipped-B homolog (Drosophila) -0.0287279
WDR43 WD repeat domain 43 -0.0283184
QKI QKI, KH domain containing, RNA binding -0.0282506
CNRIP1 cannabinoid receptor interacting protein 1 -0.0279924
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0279688
UBE2B ubiquitin-conjugating enzyme E2B -0.0278978
GSK3B glycogen synthase kinase 3 beta -0.0278236
CCND1 cyclin D1 -0.0275782
GPBP1 GC-rich promoter binding protein 1 -0.0273642
CHD1 chromodomain helicase DNA binding protein 1 -0.027238
USP15 ubiquitin specific peptidase 15 -0.0271082
ATP5F1B ATP synthase F1 subunit beta -0.0269602
XPO1 exportin 1 -0.0264476
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0264034
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -0.0261873
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0261766
KMT2E lysine (K)-specific methyltransferase 2E -0.0259766
KIF2A kinesin heavy chain member 2A -0.0255748
DCAF7 DDB1 and CUL4 associated factor 7 -0.0255625
NCEH1 neutral cholesterol ester hydrolase 1 -0.025499
AKAP9 A kinase (PRKA) anchor protein 9 -0.0254282
HSPB1 heat shock 27kDa protein 1 -0.0252929
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0252139
RPLP1 ribosomal protein, large, P1 -0.0251512
CCDC88A coiled-coil domain containing 88A -0.0250571
TXNRD1 thioredoxin reductase 1 -0.0248848
ATP11A ATPase, class VI, type 11A -0.0247224
PRRC2C proline-rich coiled-coil 2C -0.0245005
MBNL1 muscleblind-like splicing regulator 1 -0.0244185
WBP11 WW domain binding protein 11 -0.0243498
KIF5B kinesin family member 5B -0.0241881
ADAM17 ADAM metallopeptidase domain 17 -0.0240601
TFG TRK-fused gene -0.0240185
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -0.0238023
ERBIN erbb2 interacting protein -0.0237953
PIBF1 progesterone immunomodulatory binding factor 1 -0.0232919
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0232852
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.02316
DUSP6 dual specificity phosphatase 6 -0.0231009
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0229618
AHR aryl hydrocarbon receptor -0.0229323
MON2 MON2 homolog (S. cerevisiae) -0.0228366
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0226842
TMSB10 thymosin beta 10 -0.0226219
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0220837
TMEM131 transmembrane protein 131 -0.0220504
SEC62 SEC62 homolog (S. cerevisiae) -0.0215685
RPL35A ribosomal protein L35a -0.0215363
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0215252
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.0215115
MARCHF6 membrane associated ring-CH-type finger 6 -0.0214452
RLF rearranged L-myc fusion -0.0212802
PLK2 polo-like kinase 2 -0.0210818
COG5 component of oligomeric golgi complex 5 -0.0209848
RAB1A RAB1A, member RAS oncogene family -0.0207629
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0205274
ZNF148 zinc finger protein 148 -0.0203967
FBXO11 F-box protein 11 -0.0202986
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0202787
AFTPH aftiphilin -0.0202042
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0201303
SON SON DNA binding protein -0.0200668