Decitabine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Decitabine perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Decitabine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.107998
HELZ helicase with zinc finger 0.104889
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0969413
RPL3 ribosomal protein L3 0.0869813
EEF2 eukaryotic translation elongation factor 2 0.0820509
SEPTIN9 septin 9 0.0810367
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0751203
FAM13A family with sequence similarity 13, member A 0.066292
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0601929
LOC112694756 uncharaterized LOC112694756 0.0591321
LPIN1 lipin 1 0.0567459
KMT2C lysine (K)-specific methyltransferase 2C 0.0562585
PKM pyruvate kinase, muscle 0.0549117
MYH9 myosin, heavy chain 9, non-muscle 0.0547702
SREBF2 sterol regulatory element binding transcription factor 2 0.0521933
DTNA dystrobrevin, alpha 0.0513613
WDR45B WD repeat domain 45B 0.0511567
MSI2 musashi RNA-binding protein 2 0.0504184
NAMPT nicotinamide phosphoribosyltransferase 0.0488773
HSPA8 heat shock 70kDa protein 8 0.0477927
ZMIZ1 zinc finger, MIZ-type containing 1 0.0473211
TRIB2 tribbles pseudokinase 2 0.0470413
DSCAM Down syndrome cell adhesion molecule 0.0467273
MED13 mediator complex subunit 13 0.0465244
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0453426
KDM3A lysine (K)-specific demethylase 3A 0.0438931
H1-4 H1.4 linker histone, cluster member 0.0433242
NPEPPS aminopeptidase puromycin sensitive 0.0428369
KTN1 kinectin 1 (kinesin receptor) 0.0416346
SPAG9 sperm associated antigen 9 0.041592
PHIP pleckstrin homology domain interacting protein 0.0408327
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0405894
DDIT4 DNA-damage-inducible transcript 4 0.0404478
AHNAK AHNAK nucleoprotein 0.0403676
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0394541
RHOA ras homolog family member A 0.0386148
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0382321
GOLGA4 golgin A4 0.0381281
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0380208
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0377471
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0373075
COL1A1 collagen, type I, alpha 1 0.0369867
TPI1 triosephosphate isomerase 1 0.0369169
RPL4 ribosomal protein L4 0.0369168
VGF VGF nerve growth factor inducible 0.0368594
BIRC6 baculoviral IAP repeat containing 6 0.0367084
ZNF148 zinc finger protein 148 0.0366018
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0360644
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0350815
PRRC2C proline-rich coiled-coil 2C 0.034927
RUNX1 runt-related transcription factor 1 0.0338614
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0331088
PELI1 pellino E3 ubiquitin protein ligase 1 0.0328797
APP amyloid beta (A4) precursor protein 0.0327532
BBX bobby sox homolog (Drosophila) 0.0325326
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0321219
PRPF8 pre-mRNA processing factor 8 0.0319997
ZMYM2 zinc finger, MYM-type 2 0.0317787
CADM1 cell adhesion molecule 1 0.031369
WAC WW domain containing adaptor with coiled-coil 0.0309302
PNISR PNN-interacting serine/arginine-rich protein 0.0307712
WSB1 WD repeat and SOCS box containing 1 0.030504
HOOK2 hook microtubule-tethering protein 2 0.0304316
KDM6A lysine (K)-specific demethylase 6A 0.0301183
CASC3 cancer susceptibility candidate 3 0.0293392
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.0292927
MYO6 myosin VI 0.0292916
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0292873
XPO1 exportin 1 0.0292383
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0285564
SLC38A2 solute carrier family 38, member 2 0.0284931
AKAP12 A kinase (PRKA) anchor protein 12 0.0283358
CSNK1A1 casein kinase 1, alpha 1 0.0282969
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0277456
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0277045
USP9X ubiquitin specific peptidase 9, X-linked 0.0275908
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0275353
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.027453
MARCHF6 membrane associated ring-CH-type finger 6 0.0268844
SET SET nuclear proto-oncogene 0.0268618
RBM25 RNA binding motif protein 25 0.026797
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0267199
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0258939
OGA O-GlcNAcase 0.0258045
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0258005
PLEC plectin 0.0257149
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0254626
DNMBP dynamin binding protein 0.0251613
TNRC6A trinucleotide repeat containing 6A 0.0250085
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.0248368
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0247216
MMP2 matrix metallopeptidase 2 0.0246983
MSMO1 methylsterol monooxygenase 1 0.0246591
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0246529
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.0246506
BCLAF1 BCL2-associated transcription factor 1 0.0246251
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0245447
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0245205
POTEF POTE ankyrin domain family, member F 0.0244914
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0244825

decreased expression

Symbol Name Standardized Value
LSAMP limbic system-associated membrane protein -0.184642
NRG1 neuregulin 1 -0.153771
SYT1 synaptotagmin I -0.102679
EXT1 exostosin glycosyltransferase 1 -0.084743
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0833048
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0791062
VCL vinculin -0.0720534
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.065368
PTPRD protein tyrosine phosphatase, receptor type, D -0.0649841
NALF1 NALCN channel auxiliary factor 1 -0.0641007
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0638825
FRMD4A FERM domain containing 4A -0.0626665
NCAM2 neural cell adhesion molecule 2 -0.0622796
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0599165
GPC5 glypican 5 -0.0581693
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0570752
DLC1 DLC1 Rho GTPase activating protein -0.0533591
PTMA prothymosin, alpha -0.0532965
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0503818
IGFBP3 insulin-like growth factor binding protein 3 -0.0470899
PCDH9 protocadherin 9 -0.0441601
MBTD1 mbt domain containing 1 -0.0403173
BCAS3 breast carcinoma amplified sequence 3 -0.0390359
PHF3 PHD finger protein 3 -0.0384793
MBD5 methyl-CpG binding domain protein 5 -0.0381497
PRKCA protein kinase C, alpha -0.0371999
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.036616
EGR1 early growth response 1 -0.0364439
DNAH14 dynein, axonemal, heavy chain 14 -0.0363165
RPLP1 ribosomal protein, large, P1 -0.0361745
UNC5C unc-5 homolog C (C. elegans) -0.0359236
EGFR epidermal growth factor receptor -0.0357956
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0357587
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0353507
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0350594
B2M beta-2-microglobulin -0.0349741
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0347419
DKK2 dickkopf WNT signaling pathway inhibitor 2 -0.0345109
ADGRB3 adhesion G protein-coupled receptor B3 -0.0344853
ITGA1 integrin, alpha 1 -0.0343411
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0342439
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0341697
RPL19 ribosomal protein L19 -0.0339317
COL4A6 collagen, type IV, alpha 6 -0.033579
VIM vimentin -0.0335744
GREM2 gremlin 2, DAN family BMP antagonist -0.0335216
FTL ferritin, light polypeptide -0.0328537
IER3 immediate early response 3 -0.0327899
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0326837
MAPK10 mitogen-activated protein kinase 10 -0.0323563
KCNT2 potassium channel, sodium activated subfamily T, member 2 -0.0317857
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0314408
AEBP2 AE binding protein 2 -0.0312792
CADM2 cell adhesion molecule 2 -0.0310665
INTS6 integrator complex subunit 6 -0.0308396
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0305536
CUX1 cut-like homeobox 1 -0.030494
RPL31 ribosomal protein L31 -0.0296483
KDM2A lysine (K)-specific demethylase 2A -0.0295317
BTG1 B-cell translocation gene 1, anti-proliferative -0.029243
MCL1 myeloid cell leukemia 1 -0.028979
NREP neuronal regeneration related protein -0.028666
RPL35A ribosomal protein L35a -0.0285996
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0285317
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0282114
HDX highly divergent homeobox -0.0278966
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0278697
RPL36 ribosomal protein L36 -0.0278497
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0275235
TRPS1 trichorhinophalangeal syndrome I -0.0273868
STXBP4 syntaxin binding protein 4 -0.0272409
RPS24 ribosomal protein S24 -0.0267801
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0267449
ZNF804A zinc finger protein 804A -0.0266159
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0259694
RPL28 ribosomal protein L28 -0.02579
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0257013
AHR aryl hydrocarbon receptor -0.0253909
CEMIP cell migration inducing protein, hyaluronan binding -0.0253139
PLPP1 phospholipid phosphatase 1 -0.0252508
RPL12 ribosomal protein L12 -0.0251242
PLAT plasminogen activator, tissue -0.0250912
MAML2 mastermind-like 2 (Drosophila) -0.0249985
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0248386
ATRNL1 attractin-like 1 -0.0246969
GARS1 glycyl-tRNA synthetase 1 -0.024444
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.02441
SP100 SP100 nuclear antigen -0.0243844
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.024362
HM13 histocompatibility (minor) 13 -0.0242219
NBEA neurobeachin -0.0240857
LRRC7 leucine rich repeat containing 7 -0.0238091
STC1 stanniocalcin 1 -0.0237745
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0237038
PDLIM5 PDZ and LIM domain 5 -0.0235561
EIF1 eukaryotic translation initiation factor 1 -0.0235055
KCNIP4 Kv channel interacting protein 4 -0.0234875
TBC1D19 TBC1 domain family, member 19 -0.0232504
GOLGB1 golgin B1 -0.023052
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0229965