Decitabine_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Decitabine perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Decitabine_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.266109
PLEC plectin 0.205009
MYH9 myosin, heavy chain 9, non-muscle 0.179598
AHNAK AHNAK nucleoprotein 0.151002
LOC112694756 uncharaterized LOC112694756 0.142177
FLNA filamin A, alpha 0.0803658
H1-0 H1.0 linker histone 0.0740121
RPL3 ribosomal protein L3 0.0681654
KRT17 keratin 17, type I 0.0644044
TMSB4X thymosin beta 4, X-linked 0.0638443
MSN moesin 0.0632207
NAMPT nicotinamide phosphoribosyltransferase 0.0631818
MYOF myoferlin 0.0628001
BCL2L1 BCL2-like 1 0.0573626
EZR ezrin 0.0570244
TRIO trio Rho guanine nucleotide exchange factor 0.0559022
TNIP1 TNFAIP3 interacting protein 1 0.0551801
OGA O-GlcNAcase 0.0551703
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.054345
MACF1 microtubule-actin crosslinking factor 1 0.0535206
APP amyloid beta (A4) precursor protein 0.0532035
HDLBP high density lipoprotein binding protein 0.0520267
SMAD3 SMAD family member 3 0.0491709
KIAA1217 KIAA1217 0.0486652
FOXO1 forkhead box O1 0.0469229
ANLN anillin, actin binding protein 0.0461724
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0453692
CTNND1 catenin (cadherin-associated protein), delta 1 0.0437733
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0434643
NCOR2 nuclear receptor corepressor 2 0.0432149
EPHA2 EPH receptor A2 0.0409437
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0396971
ANKRD33B ankyrin repeat domain 33B 0.0396404
EEF2 eukaryotic translation elongation factor 2 0.0392302
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0391322
HOOK2 hook microtubule-tethering protein 2 0.0390975
ARRDC3 arrestin domain containing 3 0.0389627
RIN2 Ras and Rab interactor 2 0.038238
CEMIP cell migration inducing protein, hyaluronan binding 0.0381667
CD59 CD59 molecule, complement regulatory protein 0.0376212
DOCK5 dedicator of cytokinesis 5 0.0374356
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0372712
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0372598
APLP2 amyloid beta (A4) precursor-like protein 2 0.0371183
BLCAP bladder cancer associated protein 0.036293
NAV2 neuron navigator 2 0.0360549
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0358598
ITGA6 integrin, alpha 6 0.0355788
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0354902
SEPTIN9 septin 9 0.035358
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0349246
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0346918
MYO10 myosin X 0.0342582
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0339279
EIF4H eukaryotic translation initiation factor 4H 0.0332125
GOLGA2 golgin A2 0.0327649
EHBP1L1 EH domain binding protein 1-like 1 0.0325863
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0324922
PLAT plasminogen activator, tissue 0.0323893
CEP250 centrosomal protein 250kDa 0.0318445
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0313275
PODXL podocalyxin-like 0.0309659
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0306689
ITCH itchy E3 ubiquitin protein ligase 0.0304299
KDM3A lysine (K)-specific demethylase 3A 0.0302573
NCOA3 nuclear receptor coactivator 3 0.0301349
CUL4B cullin 4B 0.0300945
RASA3 RAS p21 protein activator 3 0.0299907
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0296485
SDC4 syndecan 4 0.0293791
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0293065
CAVIN1 caveolae associated protein 1 0.0291929
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.029105
ESYT2 extended synaptotagmin-like protein 2 0.0290134
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0281434
SLC45A4 solute carrier family 45, member 4 0.0280719
MARCHF6 membrane associated ring-CH-type finger 6 0.0275327
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.027472
RAB14 RAB14, member RAS oncogene family 0.0273731
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0269743
ARGLU1 arginine and glutamate rich 1 0.0267982
RBM39 RNA binding motif protein 39 0.0267106
BCAR3 breast cancer anti-estrogen resistance 3 0.0267032
ARHGAP23 Rho GTPase activating protein 23 0.0265525
CAPRIN2 caprin family member 2 0.0262999
ACTN4 actinin, alpha 4 0.026202
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0261845
AHNAK2 AHNAK nucleoprotein 2 0.0260604
NUMA1 nuclear mitotic apparatus protein 1 0.0260417
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0260232
CSDE1 cold shock domain containing E1, RNA-binding 0.0260028
MEGF6 multiple EGF-like-domains 6 0.0257773
PGK1 phosphoglycerate kinase 1 0.0252975
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0251649
BHLHE40 basic helix-loop-helix family, member e40 0.0248478
ARHGAP29 Rho GTPase activating protein 29 0.024728
MCL1 myeloid cell leukemia 1 0.0247082
SERINC3 serine incorporator 3 0.0246386
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0242525
EMP1 epithelial membrane protein 1 0.0242409

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.245504
TIMP3 TIMP metallopeptidase inhibitor 3 -0.111197
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0992405
PDE4D phosphodiesterase 4D, cAMP-specific -0.08066
DPYD dihydropyrimidine dehydrogenase -0.0784019
LMO7 LIM domain 7 -0.0762179
FTH1 ferritin, heavy polypeptide 1 -0.0661841
RPS8 ribosomal protein S8 -0.0635093
POTEF POTE ankyrin domain family, member F -0.0607614
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0597682
RPS6 ribosomal protein S6 -0.0595671
MT2A metallothionein 2A -0.0592113
PDLIM5 PDZ and LIM domain 5 -0.0574373
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0557579
B2M beta-2-microglobulin -0.0556575
ALCAM activated leukocyte cell adhesion molecule -0.0523653
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0517632
IFITM3 interferon induced transmembrane protein 3 -0.0516332
RPS19 ribosomal protein S19 -0.0495361
RPLP1 ribosomal protein, large, P1 -0.0493411
TMSB10 thymosin beta 10 -0.0482932
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0481721
FTL ferritin, light polypeptide -0.0478092
RASAL2 RAS protein activator like 2 -0.0473628
INTS6 integrator complex subunit 6 -0.0462766
RPS21 ribosomal protein S21 -0.0443551
RPLP2 ribosomal protein, large, P2 -0.0442099
RPL35A ribosomal protein L35a -0.0428085
RPS13 ribosomal protein S13 -0.0417278
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0404489
HSPG2 heparan sulfate proteoglycan 2 -0.0400006
RPS25 ribosomal protein S25 -0.038427
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0382216
S100A9 S100 calcium binding protein A9 -0.0370879
ANXA1 annexin A1 -0.0366884
MBNL2 muscleblind-like splicing regulator 2 -0.0343641
KLF5 Kruppel-like factor 5 (intestinal) -0.0341964
HMGA1 high mobility group AT-hook 1 -0.0334032
RABGAP1L RAB GTPase activating protein 1-like -0.0331831
RPS14 ribosomal protein S14 -0.0329696
EGR1 early growth response 1 -0.0325713
PLS3 plastin 3 -0.0320842
RPS23 ribosomal protein S23 -0.0320143
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0316972
HLA-B major histocompatibility complex, class I, B -0.0309896
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0307321
RPL37A ribosomal protein L37a -0.0299853
IFI44L interferon-induced protein 44-like -0.0293069
IFITM1 interferon induced transmembrane protein 1 -0.0293053
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0288118
EFNA5 ephrin-A5 -0.0286757
JMJD1C jumonji domain containing 1C -0.0285638
RPL34 ribosomal protein L34 -0.0281904
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.027801
RPL21 ribosomal protein L21 -0.0276567
RAI14 retinoic acid induced 14 -0.027244
CALB1 calbindin 1, 28kDa -0.0270134
PFN1 profilin 1 -0.0268562
RPL31 ribosomal protein L31 -0.0268279
PALLD palladin, cytoskeletal associated protein -0.0265937
RPL37 ribosomal protein L37 -0.0262889
IFI27 interferon, alpha-inducible protein 27 -0.0261877
RPL12 ribosomal protein L12 -0.0261559
TPT1 tumor protein, translationally-controlled 1 -0.0260654
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0256267
RPL36 ribosomal protein L36 -0.0255954
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0251717
HMGA2 high mobility group AT-hook 2 -0.0251421
EXT1 exostosin glycosyltransferase 1 -0.0251224
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0249515
LDHA lactate dehydrogenase A -0.0247396
GOLGB1 golgin B1 -0.0246031
RPL11 ribosomal protein L11 -0.0245356
CNTNAP3 contactin associated protein-like 3 -0.0241479
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.024127
ASTN2 astrotactin 2 -0.0240544
RPL28 ribosomal protein L28 -0.0240138
RPL32 ribosomal protein L32 -0.0239709
ATF4 activating transcription factor 4 -0.0235505
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0235232
RPL9 ribosomal protein L9 -0.0234217
S100A11 S100 calcium binding protein A11 -0.0234069
RPS27 ribosomal protein S27 -0.02301
ABI3BP ABI family, member 3 (NESH) binding protein -0.0226715
MT1E metallothionein 1E -0.0226579
CAV2 caveolin 2 -0.0224422
ACTG1 actin gamma 1 -0.0222967
SLC35F3 solute carrier family 35, member F3 -0.0221827
S100A10 S100 calcium binding protein A10 -0.0221161
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0220549
RPS29 ribosomal protein S29 -0.022014
RNF217 ring finger protein 217 -0.0220039
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0214366
RPL39 ribosomal protein L39 -0.0213977
PTMA prothymosin, alpha -0.0213816
RAB7A RAB7A, member RAS oncogene family -0.0211804
RPS15 ribosomal protein S15 -0.0210708
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0210401
NDRG1 N-myc downstream regulated 1 -0.0209323
RPS27A ribosomal protein S27a -0.0208833