Decitabine_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Decitabine perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Decitabine_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.159081
LOC112694756 uncharaterized LOC112694756 0.138642
MUC6 mucin 6, oligomeric mucus/gel-forming 0.119277
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.10681
EEF2 eukaryotic translation elongation factor 2 0.104485
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0985885
RPL3 ribosomal protein L3 0.0850423
PIGR polymeric immunoglobulin receptor 0.0846381
TXNIP thioredoxin interacting protein 0.0833152
DSPP dentin sialophosphoprotein 0.0829838
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0828525
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0794873
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0793982
ITGA6 integrin, alpha 6 0.0791877
ANXA2 annexin A2 0.0780587
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0761717
FTH1 ferritin, heavy polypeptide 1 0.0758684
AHNAK AHNAK nucleoprotein 0.0731704
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0697983
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0631816
KRT8 keratin 8, type II 0.0630013
PTBP3 polypyrimidine tract binding protein 3 0.0629385
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.06171
EPCAM epithelial cell adhesion molecule 0.0615252
KIF5B kinesin family member 5B 0.061036
FAT1 FAT atypical cadherin 1 0.0598293
ABHD2 abhydrolase domain containing 2 0.0597705
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0564199
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0555385
RNF43 ring finger protein 43 0.0525492
KRT18 keratin 18, type I 0.0518324
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0514648
GOLGA4 golgin A4 0.0495906
TMSB4X thymosin beta 4, X-linked 0.0492524
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0472822
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0458867
RREB1 ras responsive element binding protein 1 0.0457552
MED13L mediator complex subunit 13-like 0.044765
PKM pyruvate kinase, muscle 0.0442825
LDHA lactate dehydrogenase A 0.0442206
PTMA prothymosin, alpha 0.0437748
CEMIP cell migration inducing protein, hyaluronan binding 0.04375
WDR45B WD repeat domain 45B 0.0433979
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0427276
PELI1 pellino E3 ubiquitin protein ligase 1 0.0426281
MATR3 matrin 3 0.0425232
ENO1 enolase 1, (alpha) 0.0424106
UBE2H ubiquitin-conjugating enzyme E2H 0.0423708
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0422217
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0421101
FAM13A family with sequence similarity 13, member A 0.0418922
H1-0 H1.0 linker histone 0.0415908
CANX calnexin 0.0414381
HDLBP high density lipoprotein binding protein 0.0412702
EREG epiregulin 0.0411854
PRSS3 protease, serine, 3 0.0410588
DSCAM Down syndrome cell adhesion molecule 0.0408084
GPHN gephyrin 0.0407154
KMT2E lysine (K)-specific methyltransferase 2E 0.0400479
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0399774
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0397679
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0397503
RPS6 ribosomal protein S6 0.0395397
IQGAP1 IQ motif containing GTPase activating protein 1 0.038992
ANKRD11 ankyrin repeat domain 11 0.0389766
RNF145 ring finger protein 145 0.0388931
KTN1 kinectin 1 (kinesin receptor) 0.0387768
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0381195
TXNRD1 thioredoxin reductase 1 0.0381139
WAC WW domain containing adaptor with coiled-coil 0.0374819
DSG2 desmoglein 2 0.0374195
S100A6 S100 calcium binding protein A6 0.0369979
TPD52 tumor protein D52 0.0367478
TNS4 tensin 4 0.0366725
TPM3 tropomyosin 3 0.0365987
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0365768
APP amyloid beta (A4) precursor protein 0.0363981
SERINC5 serine incorporator 5 0.0363148
RAD21 RAD21 homolog (S. pombe) 0.0362617
PTPRR protein tyrosine phosphatase, receptor type, R 0.0361694
EHF ets homologous factor 0.0357834
CD46 CD46 molecule, complement regulatory protein 0.0356768
PRRC2C proline-rich coiled-coil 2C 0.0350021
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.034768
CDK6 cyclin-dependent kinase 6 0.0347614
ATP5F1B ATP synthase F1 subunit beta 0.0346446
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0345918
UBA6 ubiquitin-like modifier activating enzyme 6 0.0340207
PNISR PNN-interacting serine/arginine-rich protein 0.0338068
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0333421
PDIA3 protein disulfide isomerase family A, member 3 0.0330381
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0325653
TPI1 triosephosphate isomerase 1 0.0324238
TMEM123 transmembrane protein 123 0.0322684
FERMT1 fermitin family member 1 0.0317747
EZR ezrin 0.0315876
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0315381
KDM3A lysine (K)-specific demethylase 3A 0.0313955
ACTN4 actinin, alpha 4 0.0313327
MYO10 myosin X 0.0312825

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.101868
VCL vinculin -0.0827579
RPS3 ribosomal protein S3 -0.0754857
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0696203
RPL37A ribosomal protein L37a -0.0682012
RPS29 ribosomal protein S29 -0.0673346
RPLP2 ribosomal protein, large, P2 -0.0644727
EXT1 exostosin glycosyltransferase 1 -0.0636773
RPS12 ribosomal protein S12 -0.0636288
RPS19 ribosomal protein S19 -0.0633774
GMDS GDP-mannose 4,6-dehydratase -0.0572016
S100P S100 calcium binding protein P -0.0526629
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0458625
RPL31 ribosomal protein L31 -0.0450952
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0413244
BTBD9 BTB (POZ) domain containing 9 -0.0397994
RPS13 ribosomal protein S13 -0.0396676
RPL36 ribosomal protein L36 -0.0388982
POF1B premature ovarian failure, 1B -0.0385227
PTPRB protein tyrosine phosphatase, receptor type, B -0.0379998
FTL ferritin, light polypeptide -0.0366846
ISG15 ISG15 ubiquitin-like modifier -0.0365458
RPS11 ribosomal protein S11 -0.0359911
PDLIM5 PDZ and LIM domain 5 -0.0352391
PTPRK protein tyrosine phosphatase, receptor type, K -0.0350718
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0349318
RPS23 ribosomal protein S23 -0.0349258
RPS27A ribosomal protein S27a -0.0340519
INTS6 integrator complex subunit 6 -0.0334719
RPS24 ribosomal protein S24 -0.0323752
TMSB10 thymosin beta 10 -0.0321622
RPS17 ribosomal protein S17 -0.0320184
RPL28 ribosomal protein L28 -0.0317543
RPL26 ribosomal protein L26 -0.0316791
RPL18 ribosomal protein L18 -0.031641
EFNB2 ephrin-B2 -0.0302029
LAMA4 laminin, alpha 4 -0.0298692
RPL13A ribosomal protein L13a -0.0294376
USP53 ubiquitin specific peptidase 53 -0.0290976
RPL7A ribosomal protein L7a -0.0290697
RPL37 ribosomal protein L37 -0.0287738
RPS25 ribosomal protein S25 -0.0285084
IFRD1 interferon-related developmental regulator 1 -0.028383
MAML3 mastermind-like 3 (Drosophila) -0.0282709
EGFR epidermal growth factor receptor -0.0275956
MBNL1 muscleblind-like splicing regulator 1 -0.0274564
RPL32 ribosomal protein L32 -0.0274048
CDK13 cyclin-dependent kinase 13 -0.0271077
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0269558
RPL27 ribosomal protein L27 -0.0268364
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0267772
ASPH aspartate beta-hydroxylase -0.0262197
NDRG1 N-myc downstream regulated 1 -0.0259254
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0254688
RPL23 ribosomal protein L23 -0.0253244
IER3 immediate early response 3 -0.0252725
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0251215
CATSPERB catsper channel auxiliary subunit beta -0.0250848
RPS15 ribosomal protein S15 -0.0247996
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0247638
TTC3 tetratricopeptide repeat domain 3 -0.0245088
RPL36A ribosomal protein L36a -0.0243695
ATXN1 ataxin 1 -0.0242877
MT2A metallothionein 2A -0.0241354
EGR1 early growth response 1 -0.0237503
S100A10 S100 calcium binding protein A10 -0.0237074
FNIP1 folliculin interacting protein 1 -0.0236124
CADPS2 Ca++-dependent secretion activator 2 -0.0235703
MBD5 methyl-CpG binding domain protein 5 -0.0226841
MARCHF3 membrane associated ring-CH-type finger 3 -0.0226036
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0221296
SLC38A2 solute carrier family 38, member 2 -0.0219507
COG6 component of oligomeric golgi complex 6 -0.0217347
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0216214
SLC35F3 solute carrier family 35, member F3 -0.0212677
RPL38 ribosomal protein L38 -0.0211872
RPL9 ribosomal protein L9 -0.0206973
NABP1 nucleic acid binding protein 1 -0.0206228
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.020547
SAMD4A sterile alpha motif domain containing 4A -0.0201691
AEBP2 AE binding protein 2 -0.0200507
ANXA1 annexin A1 -0.019861
ENO2 enolase 2 (gamma, neuronal) -0.0198432
MRPS6 mitochondrial ribosomal protein S6 -0.0197707
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0194621
BACE2 beta-site APP-cleaving enzyme 2 -0.0193684
CCSER1 coiled-coil serine-rich protein 1 -0.0189011
SLC10A7 solute carrier family 10, member 7 -0.0187865
TUFT1 tuftelin 1 -0.0182057
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0181101
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0178477
RNF217 ring finger protein 217 -0.0177351
MYO1E myosin IE -0.0175594
RPL5 ribosomal protein L5 -0.0175558
IARS1 isoleucyl-tRNA synthetase 1 -0.0174415
KLF5 Kruppel-like factor 5 (intestinal) -0.0172755
RAD51B RAD51 paralog B -0.0171313
NPAS2 neuronal PAS domain protein 2 -0.0170309
KDM4C lysine (K)-specific demethylase 4C -0.0169369
LARP1B La ribonucleoprotein domain family, member 1B -0.0168111