Decitabine_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Decitabine perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Decitabine_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.105748
MYH9 myosin, heavy chain 9, non-muscle 0.0830926
LOC112694756 uncharaterized LOC112694756 0.0730417
EEF2 eukaryotic translation elongation factor 2 0.070719
RPL3 ribosomal protein L3 0.0702509
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0680339
ZMYND8 zinc finger, MYND-type containing 8 0.064145
SMAD3 SMAD family member 3 0.0631476
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0578695
AHNAK AHNAK nucleoprotein 0.0575963
AKAP12 A kinase (PRKA) anchor protein 12 0.0508629
APP amyloid beta (A4) precursor protein 0.0503573
EIF4H eukaryotic translation initiation factor 4H 0.0483859
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0466634
KDM3A lysine (K)-specific demethylase 3A 0.0464944
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0449936
SEPTIN9 septin 9 0.0437716
ENO1 enolase 1, (alpha) 0.0430343
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0419832
TPT1 tumor protein, translationally-controlled 1 0.041773
TNIP1 TNFAIP3 interacting protein 1 0.0393225
HDLBP high density lipoprotein binding protein 0.0389842
FLNB filamin B, beta 0.0378356
TMSB4X thymosin beta 4, X-linked 0.0369112
RPL4 ribosomal protein L4 0.0368515
NPC1 Niemann-Pick disease, type C1 0.0348471
NAP1L1 nucleosome assembly protein 1-like 1 0.0341871
TRIO trio Rho guanine nucleotide exchange factor 0.0338827
PRELID2 PRELI domain containing 2 0.0334108
OGA O-GlcNAcase 0.0331861
USP34 ubiquitin specific peptidase 34 0.0323779
CEP250 centrosomal protein 250kDa 0.0322548
CXCL5 chemokine (C-X-C motif) ligand 5 0.0321201
HSPA8 heat shock 70kDa protein 8 0.0307975
MCL1 myeloid cell leukemia 1 0.0301533
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0297549
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0296047
NAV2 neuron navigator 2 0.0294764
PFKP phosphofructokinase, platelet 0.0291201
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0289827
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0289443
HOOK2 hook microtubule-tethering protein 2 0.0287155
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0280039
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0280002
MARS1 methionyl-tRNA synthetase 1 0.0279536
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0278739
WDR45B WD repeat domain 45B 0.0276108
CTNND1 catenin (cadherin-associated protein), delta 1 0.0275991
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.027012
ARRDC3 arrestin domain containing 3 0.0270025
SUN1 Sad1 and UNC84 domain containing 1 0.0268418
FLNA filamin A, alpha 0.0267102
ANKRD11 ankyrin repeat domain 11 0.0266877
PKM pyruvate kinase, muscle 0.0266093
PGK1 phosphoglycerate kinase 1 0.0265535
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0265241
ACTN4 actinin, alpha 4 0.0263124
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0258902
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0252977
RPS24 ribosomal protein S24 0.0250978
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0249964
FAM20C family with sequence similarity 20, member C 0.0249401
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0245866
TPI1 triosephosphate isomerase 1 0.0243449
IFI6 interferon, alpha-inducible protein 6 0.0241347
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0238397
PLEC plectin 0.0238188
MSN moesin 0.0236642
SLC38A2 solute carrier family 38, member 2 0.0236207
SRRM2 serine/arginine repetitive matrix 2 0.0234196
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0230933
TXNRD1 thioredoxin reductase 1 0.0228369
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0227982
RPL14 ribosomal protein L14 0.0225342
ANGPTL4 angiopoietin-like 4 0.022348
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0222779
SERINC1 serine incorporator 1 0.0222061
MAP2K1 mitogen-activated protein kinase kinase 1 0.0221253
ZFAND3 zinc finger, AN1-type domain 3 0.0221196
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.022102
TM4SF1 transmembrane 4 L six family member 1 0.0219192
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0218046
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0213527
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0212315
MACF1 microtubule-actin crosslinking factor 1 0.0207047
MLPH melanophilin 0.0206623
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0206291
NAMPT nicotinamide phosphoribosyltransferase 0.020624
HLA-B major histocompatibility complex, class I, B 0.0203914
LAMB3 laminin, beta 3 0.0203866
RPS11 ribosomal protein S11 0.0202616
GYS1 glycogen synthase 1 (muscle) 0.0200878
RHOA ras homolog family member A 0.0200792
ECE1 endothelin converting enzyme 1 0.0198584
BIRC2 baculoviral IAP repeat containing 2 0.0197908
RAD51B RAD51 paralog B 0.0197213
ESYT2 extended synaptotagmin-like protein 2 0.0194962
PDIA4 protein disulfide isomerase family A, member 4 0.01947
OPTN optineurin 0.0194656
NFE2L1 nuclear factor, erythroid 2-like 1 0.0194352

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.125569
IGFBP3 insulin-like growth factor binding protein 3 -0.103035
FTH1 ferritin, heavy polypeptide 1 -0.0857764
PDE4D phosphodiesterase 4D, cAMP-specific -0.0825834
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0819987
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0804118
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0711184
TMSB10 thymosin beta 10 -0.0684325
FTL ferritin, light polypeptide -0.0602869
MT2A metallothionein 2A -0.0545722
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0529944
NRG1 neuregulin 1 -0.0513786
MEF2A myocyte enhancer factor 2A -0.0509407
RAB1A RAB1A, member RAS oncogene family -0.0506167
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0483497
PCBP2 poly(rC) binding protein 2 -0.047542
KDM2A lysine (K)-specific demethylase 2A -0.0467498
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0443504
EGR1 early growth response 1 -0.0433159
LMAN1 lectin, mannose-binding, 1 -0.0428617
BASP1 brain abundant, membrane attached signal protein 1 -0.0413782
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.040202
PFN1 profilin 1 -0.0399527
LOX lysyl oxidase -0.0393639
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0387479
NDRG1 N-myc downstream regulated 1 -0.0372379
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.036896
DPYD dihydropyrimidine dehydrogenase -0.0367094
ZSWIM6 zinc finger, SWIM-type containing 6 -0.036516
RBM39 RNA binding motif protein 39 -0.0361898
ANKRD28 ankyrin repeat domain 28 -0.0360443
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0346717
MRPS6 mitochondrial ribosomal protein S6 -0.034501
GRB10 growth factor receptor-bound protein 10 -0.0333456
GPC6 glypican 6 -0.0325584
DDIT3 DNA-damage-inducible transcript 3 -0.0309236
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0308073
BLZF1 basic leucine zipper nuclear factor 1 -0.0303113
HMGA1 high mobility group AT-hook 1 -0.0302029
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0301668
SEC31A SEC31 homolog A (S. cerevisiae) -0.0294947
SRP54 signal recognition particle 54kDa -0.0293788
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0291524
KMT2E lysine (K)-specific methyltransferase 2E -0.0289374
PDLIM5 PDZ and LIM domain 5 -0.0288071
GLCCI1 glucocorticoid induced 1 -0.0283102
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0276315
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0265143
MBNL1 muscleblind-like splicing regulator 1 -0.0264461
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0264108
RPS19 ribosomal protein S19 -0.0261469
STC1 stanniocalcin 1 -0.0259454
ARF4 ADP-ribosylation factor 4 -0.0255469
AADAC arylacetamide deacetylase -0.0247255
NF1 neurofibromin 1 -0.0244594
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0239815
TENT5A terminal nucleotidyltransferase 5A -0.0238073
NTN4 netrin 4 -0.0235697
PDIA3 protein disulfide isomerase family A, member 3 -0.0235131
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.023241
VEGFC vascular endothelial growth factor C -0.0230274
MYADM myeloid-associated differentiation marker -0.02292
C15ORF48 chromosome 15 open reading frame 48 -0.0225583
RPL32 ribosomal protein L32 -0.0221185
MSRB3 methionine sulfoxide reductase B3 -0.0220646
MORF4L2 mortality factor 4 like 2 -0.0219414
RPL18 ribosomal protein L18 -0.0216375
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0216304
VMP1 vacuole membrane protein 1 -0.0215031
SEC24A SEC24 family member A -0.0213655
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0213145
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0211714
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0209613
GREB1L growth regulation by estrogen in breast cancer-like -0.0207242
SSBP2 single-stranded DNA binding protein 2 -0.0206016
SYAP1 synapse associated protein 1 -0.0205891
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.020544
GLIS3 GLIS family zinc finger 3 -0.0203814
TGFB1 transforming growth factor, beta 1 -0.0200889
HMGA2 high mobility group AT-hook 2 -0.0200755
HILPDA hypoxia inducible lipid droplet-associated -0.0198026
VIM vimentin -0.0197257
PHF21A PHD finger protein 21A -0.0195682
BIRC3 baculoviral IAP repeat containing 3 -0.0195619
GOLGA4 golgin A4 -0.0195536
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0194929
NCOA7 nuclear receptor coactivator 7 -0.0193807
NLK nemo-like kinase -0.019234
PRR16 proline rich 16 -0.0191756
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0190574
RAB5A RAB5A, member RAS oncogene family -0.019003
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0188551
DNER delta/notch-like EGF repeat containing -0.0185579
CCDC88A coiled-coil domain containing 88A -0.0185004
RND3 Rho family GTPase 3 -0.018494
VRK2 vaccinia related kinase 2 -0.018408
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0183827
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0182819
EXOC6B exocyst complex component 6B -0.0180415
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0179752