Decitabine_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Decitabine perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Decitabine_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.209797
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.187803
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.139461
NDRG1 N-myc downstream regulated 1 0.125063
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.112735
FN1 fibronectin 1 0.1047
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.101354
CDH13 cadherin 13 0.0943128
LOC112694756 uncharaterized LOC112694756 0.0919889
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0850116
FAM13A family with sequence similarity 13, member A 0.0839109
PDE10A phosphodiesterase 10A 0.0821243
VIM vimentin 0.0780641
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0734549
KYNU kynureninase 0.0734442
SPAG9 sperm associated antigen 9 0.0703211
FNDC3B fibronectin type III domain containing 3B 0.068719
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0653922
ERRFI1 ERBB receptor feedback inhibitor 1 0.0651736
HOOK2 hook microtubule-tethering protein 2 0.0611345
TMSB4X thymosin beta 4, X-linked 0.0610024
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0604324
ITPRID2 ITPR interacting domain containing 2 0.0604305
HELZ helicase with zinc finger 0.0598132
BACE2 beta-site APP-cleaving enzyme 2 0.0590843
DST dystonin 0.0589306
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0577957
RUNX1 runt-related transcription factor 1 0.0573962
LAMB3 laminin, beta 3 0.0554871
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0554863
SND1 staphylococcal nuclease and tudor domain containing 1 0.0546702
STC1 stanniocalcin 1 0.0546596
ESYT2 extended synaptotagmin-like protein 2 0.0533953
MYOF myoferlin 0.0530846
COL6A3 collagen, type VI, alpha 3 0.0524199
NKD1 naked cuticle homolog 1 (Drosophila) 0.0514836
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0504346
ARRDC3 arrestin domain containing 3 0.0489072
BZW1 basic leucine zipper and W2 domains 1 0.0477199
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0475141
AFF4 AF4/FMR2 family, member 4 0.0475087
AKAP9 A kinase (PRKA) anchor protein 9 0.0472744
CANX calnexin 0.0469449
ARHGAP5 Rho GTPase activating protein 5 0.0465097
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0464647
LOX lysyl oxidase 0.04531
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0444257
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0434969
ELL2 elongation factor, RNA polymerase II, 2 0.0427133
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.042545
ADAM9 ADAM metallopeptidase domain 9 0.0421289
ANO6 anoctamin 6 0.0416636
MT2A metallothionein 2A 0.0412329
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0409341
GLS2 glutaminase 2 (liver, mitochondrial) 0.0408873
SPIRE1 spire-type actin nucleation factor 1 0.040837
DTNA dystrobrevin, alpha 0.0407198
KMT2C lysine (K)-specific methyltransferase 2C 0.0406469
INHBA inhibin, beta A 0.0401006
HILPDA hypoxia inducible lipid droplet-associated 0.0398374
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0391744
NGLY1 N-glycanase 1 0.0391562
GARS1 glycyl-tRNA synthetase 1 0.0385873
TENT2 terminal nucleotidyltransferase 2 0.038406
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0382959
SOD2 superoxide dismutase 2, mitochondrial 0.0382693
USP3 ubiquitin specific peptidase 3 0.0373366
ZNF292 zinc finger protein 292 0.0367333
PDE4D phosphodiesterase 4D, cAMP-specific 0.0365547
RORA RAR-related orphan receptor A 0.036448
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0360608
MYO10 myosin X 0.0359925
PIAS1 protein inhibitor of activated STAT, 1 0.0357031
RPL3 ribosomal protein L3 0.0356836
SDC4 syndecan 4 0.0353481
COL8A1 collagen, type VIII, alpha 1 0.035336
SMAD3 SMAD family member 3 0.0353126
ERBIN erbb2 interacting protein 0.0351585
CCNY cyclin Y 0.0346446
KRT17 keratin 17, type I 0.0339567
COG5 component of oligomeric golgi complex 5 0.0338442
XPO1 exportin 1 0.0336045
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0334926
CELF1 CUGBP, Elav-like family member 1 0.0328776
MYH9 myosin, heavy chain 9, non-muscle 0.0326544
SMAP1 small ArfGAP 1 0.0324437
ZFAND3 zinc finger, AN1-type domain 3 0.0323568
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0318075
JMJD1C jumonji domain containing 1C 0.0312661
CD59 CD59 molecule, complement regulatory protein 0.0312391
PDIA4 protein disulfide isomerase family A, member 4 0.0310099
PDIA3 protein disulfide isomerase family A, member 3 0.0308571
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0305258
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0300346
HDLBP high density lipoprotein binding protein 0.0299204
LIMCH1 LIM and calponin homology domains 1 0.0295797
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0295749
PTPRM protein tyrosine phosphatase, receptor type, M 0.0295429
RTN4 reticulon 4 0.0295391
RBM39 RNA binding motif protein 39 0.029507

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.130799
FTL ferritin, light polypeptide -0.110309
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0789286
RPL19 ribosomal protein L19 -0.0672916
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0642053
IGF2 insulin-like growth factor 2 -0.0639534
C6ORF132 chromosome 6 open reading frame 132 -0.0639509
SLC38A1 solute carrier family 38, member 1 -0.0617056
RPS8 ribosomal protein S8 -0.0593248
RPS21 ribosomal protein S21 -0.0588366
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0570171
MUC13 mucin 13, cell surface associated -0.0549566
MMP1 matrix metallopeptidase 1 -0.0546152
RPL7A ribosomal protein L7a -0.0545872
MED13L mediator complex subunit 13-like -0.0535017
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.053232
IER3 immediate early response 3 -0.0515497
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0512857
TMSB10 thymosin beta 10 -0.0499385
RPL31 ribosomal protein L31 -0.0498784
NUP98 nucleoporin 98kDa -0.0493047
BBX bobby sox homolog (Drosophila) -0.0486198
PTMA prothymosin, alpha -0.0480799
FAT1 FAT atypical cadherin 1 -0.048033
IFI6 interferon, alpha-inducible protein 6 -0.0475947
RPL36 ribosomal protein L36 -0.0474807
FHIT fragile histidine triad -0.0471589
KRT8 keratin 8, type II -0.047052
GCLC glutamate-cysteine ligase, catalytic subunit -0.0466703
SLC38A2 solute carrier family 38, member 2 -0.0460218
ZNFX1 zinc finger, NFX1-type containing 1 -0.0453945
MSI2 musashi RNA-binding protein 2 -0.0452078
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0450724
TSC22D1 TSC22 domain family, member 1 -0.0448529
FOXP1 forkhead box P1 -0.0448312
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.043669
NAV2 neuron navigator 2 -0.0432512
RPL15 ribosomal protein L15 -0.043146
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0428267
DNM2 dynamin 2 -0.0428052
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0425002
RPLP1 ribosomal protein, large, P1 -0.0422499
ZEB1 zinc finger E-box binding homeobox 1 -0.0422184
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0420612
RPS15 ribosomal protein S15 -0.0417494
DICER1 dicer 1, ribonuclease type III -0.0415558
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0407642
MAML2 mastermind-like 2 (Drosophila) -0.0403487
STK24 serine/threonine kinase 24 -0.0401888
NSRP1 nuclear speckle splicing regulatory protein 1 -0.0400975
B2M beta-2-microglobulin -0.0400868
TNRC6B trinucleotide repeat containing 6B -0.0392992
RPL12 ribosomal protein L12 -0.0390639
SLTM SAFB-like, transcription modulator -0.0383771
LMO7 LIM domain 7 -0.0383218
CRADD CASP2 and RIPK1 domain containing adaptor with death domain -0.0380257
HIPK2 homeodomain interacting protein kinase 2 -0.0380203
HMGB1 high mobility group box 1 -0.0380021
EPSTI1 epithelial stromal interaction 1 (breast) -0.0379411
ZBTB20 zinc finger and BTB domain containing 20 -0.0377192
GPBP1 GC-rich promoter binding protein 1 -0.0376558
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.037607
PGK1 phosphoglycerate kinase 1 -0.0372557
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0371768
ARHGAP32 Rho GTPase activating protein 32 -0.0370949
RPS19 ribosomal protein S19 -0.0369459
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0362102
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0359424
PKP4 plakophilin 4 -0.0358036
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0355113
ENO1 enolase 1, (alpha) -0.0354836
FAM107B family with sequence similarity 107, member B -0.0354141
RPS13 ribosomal protein S13 -0.035352
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0353402
RPS11 ribosomal protein S11 -0.0353142
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0351243
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.034978
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0347833
RBM15 RNA binding motif protein 15 -0.034621
SDK1 sidekick cell adhesion molecule 1 -0.0345062
METTL15 methyltransferase like 15 -0.0344158
RPL35A ribosomal protein L35a -0.0343493
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0343148
H3-3B H3.3 histone B -0.0342523
NCOA3 nuclear receptor coactivator 3 -0.034125
SRPK2 SRSF protein kinase 2 -0.0340352
CUX1 cut-like homeobox 1 -0.0338287
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0333607
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0328159
RIOK3 RIO kinase 3 -0.0327247
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0325651
RSRC1 arginine/serine-rich coiled-coil 1 -0.0323757
MAP7 microtubule-associated protein 7 -0.0322294
RBM25 RNA binding motif protein 25 -0.0320871
IFITM3 interferon induced transmembrane protein 3 -0.0320196
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0319295
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0318998
ETNK1 ethanolamine kinase 1 -0.0313842
VGF VGF nerve growth factor inducible -0.031294
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0312794