Decitabine_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Decitabine perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Decitabine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.172229
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.14819
EEF2 eukaryotic translation elongation factor 2 0.123918
TPI1 triosephosphate isomerase 1 0.0792228
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0634334
CSDE1 cold shock domain containing E1, RNA-binding 0.0592399
RPL3 ribosomal protein L3 0.0567471
RPS3 ribosomal protein S3 0.049229
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.046061
TPM3 tropomyosin 3 0.0460103
MYH9 myosin, heavy chain 9, non-muscle 0.0457175
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0403952
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0394603
RPL37 ribosomal protein L37 0.0392605
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0389635
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0376909
LOC112694756 uncharaterized LOC112694756 0.0374731
UBC ubiquitin C 0.0327774
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0316994
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0308178
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0308154
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0305272
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0296296
PLEC plectin 0.0286701
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0285031
EIF4A1 eukaryotic translation initiation factor 4A1 0.0279724
KRT18 keratin 18, type I 0.0278006
FLNA filamin A, alpha 0.0270418
SET SET nuclear proto-oncogene 0.0266919
CAMTA1 calmodulin binding transcription activator 1 0.0263389
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0259396
RPL32 ribosomal protein L32 0.0255766
COPA coatomer protein complex, subunit alpha 0.0255704
NCAPD2 non-SMC condensin I complex, subunit D2 0.0252538
PKM pyruvate kinase, muscle 0.0250825
NCKAP1 NCK-associated protein 1 0.0250126
ENO1 enolase 1, (alpha) 0.024111
PDIA4 protein disulfide isomerase family A, member 4 0.0240792
RPS12 ribosomal protein S12 0.0238777
RPL4 ribosomal protein L4 0.0237749
EEF1G eukaryotic translation elongation factor 1 gamma 0.0234599
RPS18 ribosomal protein S18 0.023154
SRRM2 serine/arginine repetitive matrix 2 0.0228055
MKI67 marker of proliferation Ki-67 0.0227474
HSPA8 heat shock 70kDa protein 8 0.0216405
RHOA ras homolog family member A 0.0216167
RPS4X ribosomal protein S4, X-linked 0.0215088
CCT7 chaperonin containing TCP1, subunit 7 (eta) 0.0214842
FKBP4 FK506 binding protein 4, 59kDa 0.0213945
HOOK2 hook microtubule-tethering protein 2 0.0213725
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0212801
UBE2H ubiquitin-conjugating enzyme E2H 0.0211712
RPL5 ribosomal protein L5 0.0209421
HDGF hepatoma-derived growth factor 0.0201808
PGK1 phosphoglycerate kinase 1 0.019713
LDHB lactate dehydrogenase B 0.0196078
LDHA lactate dehydrogenase A 0.0195957
H1-10 H1.10 linker histone 0.0193779
RPL23 ribosomal protein L23 0.0192361
TPX2 TPX2, microtubule-associated 0.0190627
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0189269
NACA nascent polypeptide-associated complex alpha subunit 0.0186349
TPM2 tropomyosin 2 (beta) 0.0184458
H1-0 H1.0 linker histone 0.0184341
CALR calreticulin 0.018042
PRPF8 pre-mRNA processing factor 8 0.0178223
IQGAP3 IQ motif containing GTPase activating protein 3 0.0173024
PCBP2 poly(rC) binding protein 2 0.0172624
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.0172426
AHNAK AHNAK nucleoprotein 0.017215
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0171527
ZFC3H1 zinc finger, C3H1-type containing 0.017022
BRD2 bromodomain containing 2 0.0169772
RPS11 ribosomal protein S11 0.0168801
ADAR adenosine deaminase, RNA-specific 0.0168442
RACK1 receptor for activated C kinase 1 0.0168225
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0166132
MSH6 mutS homolog 6 0.0163085
GPX4 glutathione peroxidase 4 0.0162415
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0162196
CHD4 chromodomain helicase DNA binding protein 4 0.0161173
PHIP pleckstrin homology domain interacting protein 0.0157095
PDIA6 protein disulfide isomerase family A, member 6 0.0156576
STMN1 stathmin 1 0.0156395
RLIM ring finger protein, LIM domain interacting 0.0156274
ACIN1 apoptotic chromatin condensation inducer 1 0.0155688
HDLBP high density lipoprotein binding protein 0.0153393
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0152306
KDM3A lysine (K)-specific demethylase 3A 0.015226
CLTC clathrin, heavy chain (Hc) 0.0151457
RPL8 ribosomal protein L8 0.015122
EIF4H eukaryotic translation initiation factor 4H 0.0150023
NCAPG2 non-SMC condensin II complex, subunit G2 0.0147998
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0147083
H1-4 H1.4 linker histone, cluster member 0.0146396
PER1 period circadian clock 1 0.0146378
RPLP2 ribosomal protein, large, P2 0.0145839
TLN1 talin 1 0.0145022
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0144971
RPL18 ribosomal protein L18 0.0144959

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.177362
THSD4 thrombospondin, type I, domain containing 4 -0.0564648
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0474245
TFPI2 tissue factor pathway inhibitor 2 -0.0472799
OSMR oncostatin M receptor -0.0466407
GRAMD1B GRAM domain containing 1B -0.0448475
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0414964
TAS2R14 taste receptor, type 2, member 14 -0.0388714
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0378448
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0356832
YBX3 Y box binding protein 3 -0.0355176
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0353699
RIMS2 regulating synaptic membrane exocytosis 2 -0.0352349
ZBTB20 zinc finger and BTB domain containing 20 -0.0337927
VIM vimentin -0.0333932
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0332023
HMGA2 high mobility group AT-hook 2 -0.0326016
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0309204
EXOC4 exocyst complex component 4 -0.0305248
IFI6 interferon, alpha-inducible protein 6 -0.0296512
PDE4D phosphodiesterase 4D, cAMP-specific -0.0293659
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0289743
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0284838
NCOA7 nuclear receptor coactivator 7 -0.0284657
EXT1 exostosin glycosyltransferase 1 -0.0273341
DNAH14 dynein, axonemal, heavy chain 14 -0.0267934
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.026652
RPL35A ribosomal protein L35a -0.0259205
DOCK5 dedicator of cytokinesis 5 -0.0258032
HLA-B major histocompatibility complex, class I, B -0.0258024
AFF3 AF4/FMR2 family, member 3 -0.0257608
NF1 neurofibromin 1 -0.0250055
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0242508
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0241729
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0232901
FBXO11 F-box protein 11 -0.0232204
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0231781
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0229838
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0229707
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0229104
PRH1 proline-rich protein HaeIII subfamily 1 -0.0228209
ACTG1 actin gamma 1 -0.022444
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0222984
NABP1 nucleic acid binding protein 1 -0.0220294
STC1 stanniocalcin 1 -0.021825
IGF1R insulin-like growth factor 1 receptor -0.0216944
WNT2B wingless-type MMTV integration site family, member 2B -0.0211022
NIPBL Nipped-B homolog (Drosophila) -0.0210411
PDE10A phosphodiesterase 10A -0.0210331
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0206101
PHF14 PHD finger protein 14 -0.0204515
IFIH1 interferon induced with helicase C domain 1 -0.02038
ATG7 autophagy related 7 -0.0203242
EGFR epidermal growth factor receptor -0.0202432
PMP22 peripheral myelin protein 22 -0.0200875
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0194459
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0194201
PLSCR1 phospholipid scramblase 1 -0.0193754
IER3 immediate early response 3 -0.019179
BPTF bromodomain PHD finger transcription factor -0.0191597
ARB2A ARB2 cotranscriptional regulator A -0.0185766
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0185532
ZNF638 zinc finger protein 638 -0.0183972
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0183929
ZFAND3 zinc finger, AN1-type domain 3 -0.018113
FMNL2 formin-like 2 -0.0181043
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.017819
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0177077
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0176251
VCL vinculin -0.0176098
PDLIM5 PDZ and LIM domain 5 -0.0173652
INTS6 integrator complex subunit 6 -0.0173046
LOC102724023 ES1 protein homolog, mitochondrial -0.0171073
MBD5 methyl-CpG binding domain protein 5 -0.0169532
MCL1 myeloid cell leukemia 1 -0.0169132
SPIDR scaffolding protein involved in DNA repair -0.0166689
EGR1 early growth response 1 -0.0166029
KTN1 kinectin 1 (kinesin receptor) -0.0161076
PATJ PATJ crumbs cell polarity complex component -0.0159894
CLIP1 CAP-GLY domain containing linker protein 1 -0.0158295
CLDN1 claudin 1 -0.0157693
JMJD1C jumonji domain containing 1C -0.0157502
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0156581
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0156081
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0156081
DIAPH2 diaphanous-related formin 2 -0.0155223
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0154022
ELL2 elongation factor, RNA polymerase II, 2 -0.0153832
CAVIN1 caveolae associated protein 1 -0.0153329
CDK13 cyclin-dependent kinase 13 -0.0153014
R3HDM2 R3H domain containing 2 -0.0151934
RIGI RNA sensor RIG-I -0.0150633
RAB7A RAB7A, member RAS oncogene family -0.0147251
TRIM56 tripartite motif containing 56 -0.0146537
FAF1 Fas (TNFRSF6) associated factor 1 -0.0146187
AEBP2 AE binding protein 2 -0.0144389
GPHN gephyrin -0.0143669
ZNF207 zinc finger protein 207 -0.0143642
RABGAP1L RAB GTPase activating protein 1-like -0.0143381
ZNF644 zinc finger protein 644 -0.0143379