Decitabine_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Decitabine perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Decitabine_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.165139
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.150113
PLEC plectin 0.118638
FN1 fibronectin 1 0.115112
LOC112694756 uncharaterized LOC112694756 0.115081
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.103236
NDRG1 N-myc downstream regulated 1 0.098627
EEF2 eukaryotic translation elongation factor 2 0.094545
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0871257
RPL3 ribosomal protein L3 0.0818683
HSPA8 heat shock 70kDa protein 8 0.0649929
MSN moesin 0.0640056
CALR calreticulin 0.0565882
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0561297
ARRDC3 arrestin domain containing 3 0.0549798
APLP2 amyloid beta (A4) precursor-like protein 2 0.0539272
UBC ubiquitin C 0.0537971
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.051988
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0461269
LAMC2 laminin, gamma 2 0.0456801
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0436941
H1-4 H1.4 linker histone, cluster member 0.0432113
AHNAK AHNAK nucleoprotein 0.0422517
FLNA filamin A, alpha 0.0418339
MT2A metallothionein 2A 0.0407821
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0402931
MKI67 marker of proliferation Ki-67 0.0402345
TMSB4X thymosin beta 4, X-linked 0.0392865
DSPP dentin sialophosphoprotein 0.0369281
PKM pyruvate kinase, muscle 0.0359853
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0353366
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0351193
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0349851
TPI1 triosephosphate isomerase 1 0.0331801
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0330227
RPL4 ribosomal protein L4 0.0329492
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0322254
ENO1 enolase 1, (alpha) 0.03207
TPM3 tropomyosin 3 0.0317927
EIF4H eukaryotic translation initiation factor 4H 0.0313113
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.031168
RHOA ras homolog family member A 0.0299162
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0298244
HSPA1B heat shock 70kDa protein 1B 0.029161
POTEF POTE ankyrin domain family, member F 0.0286612
TUBB4B tubulin, beta 4B class IVb 0.0285313
NAV2 neuron navigator 2 0.0267068
CTSB cathepsin B 0.0263069
SEPTIN9 septin 9 0.0261725
ATP5F1B ATP synthase F1 subunit beta 0.0256434
RPS6 ribosomal protein S6 0.0242757
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0241589
HDLBP high density lipoprotein binding protein 0.0238364
HMGN2 high mobility group nucleosomal binding domain 2 0.0235915
SDC4 syndecan 4 0.0234882
TACSTD2 tumor-associated calcium signal transducer 2 0.0228497
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0227444
PABPN1 poly(A) binding protein, nuclear 1 0.0226908
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0225092
H1-10 H1.10 linker histone 0.0223963
KTN1 kinectin 1 (kinesin receptor) 0.022384
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0220449
RPS4X ribosomal protein S4, X-linked 0.021789
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0215248
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0215239
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0208219
SET SET nuclear proto-oncogene 0.0206487
TNIP1 TNFAIP3 interacting protein 1 0.0204475
BRD2 bromodomain containing 2 0.0202166
DDIT4 DNA-damage-inducible transcript 4 0.0199437
RPS18 ribosomal protein S18 0.0198997
EIF4A1 eukaryotic translation initiation factor 4A1 0.0198735
MUC1 mucin 1, cell surface associated 0.0198718
CD9 CD9 molecule 0.0197346
UPP1 uridine phosphorylase 1 0.0196554
RPL29 ribosomal protein L29 0.0195889
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0195289
YBX1 Y box binding protein 1 0.0194941
NACA nascent polypeptide-associated complex alpha subunit 0.0189937
SPINT2 serine peptidase inhibitor, Kunitz type, 2 0.0188978
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0186752
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0183746
TXNIP thioredoxin interacting protein 0.0181119
TUBA1B tubulin, alpha 1b 0.018064
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0179875
RPL14 ribosomal protein L14 0.0179488
HSPA1A heat shock 70kDa protein 1A 0.0179099
SMC4 structural maintenance of chromosomes 4 0.0176412
HDGF hepatoma-derived growth factor 0.0176337
NONO non-POU domain containing, octamer-binding 0.0175548
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0174162
CENPF centromere protein F, 350/400kDa 0.0173135
KIAA1217 KIAA1217 0.0172877
EPCAM epithelial cell adhesion molecule 0.0171282
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0171091
SSRP1 structure specific recognition protein 1 0.017055
TUBA1C tubulin, alpha 1c 0.0169909
RPL23A ribosomal protein L23a 0.0167199
PLAUR plasminogen activator, urokinase receptor 0.0165857
FHIT fragile histidine triad 0.0164965

decreased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B -0.0984735
ACTG1 actin gamma 1 -0.0952656
TSC22D2 TSC22 domain family, member 2 -0.0862538
TMSB10 thymosin beta 10 -0.0794037
KMT2E lysine (K)-specific methyltransferase 2E -0.0763337
ALCAM activated leukocyte cell adhesion molecule -0.0735192
LMO7 LIM domain 7 -0.072997
TRIO trio Rho guanine nucleotide exchange factor -0.0660808
FAM13A family with sequence similarity 13, member A -0.0648789
PTMA prothymosin, alpha -0.0639215
ANXA2 annexin A2 -0.0617473
GRB10 growth factor receptor-bound protein 10 -0.0600761
PTK2 protein tyrosine kinase 2 -0.0560653
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0556248
LPP LIM domain containing preferred translocation partner in lipoma -0.0551115
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0526981
CSTB cystatin B (stefin B) -0.05224
ASPH aspartate beta-hydroxylase -0.0515534
STRN3 striatin, calmodulin binding protein 3 -0.050705
GPBP1 GC-rich promoter binding protein 1 -0.0506419
EXT1 exostosin glycosyltransferase 1 -0.0505746
ZNF292 zinc finger protein 292 -0.0483758
BHLHE40 basic helix-loop-helix family, member e40 -0.04794
MARCHF6 membrane associated ring-CH-type finger 6 -0.0479141
PDLIM5 PDZ and LIM domain 5 -0.0469867
LIMCH1 LIM and calponin homology domains 1 -0.046536
CD2AP CD2-associated protein -0.0461085
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0457997
KDM5B lysine (K)-specific demethylase 5B -0.0454997
RBM39 RNA binding motif protein 39 -0.0452576
ZFAND3 zinc finger, AN1-type domain 3 -0.0452379
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0447252
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0446795
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0444084
RAB1A RAB1A, member RAS oncogene family -0.0434818
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0427608
TPT1 tumor protein, translationally-controlled 1 -0.0425049
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0424566
ERBIN erbb2 interacting protein -0.0412014
IGFBP3 insulin-like growth factor binding protein 3 -0.0405964
COPA coatomer protein complex, subunit alpha -0.0402452
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0401368
RLF rearranged L-myc fusion -0.0400334
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0400089
RPS3 ribosomal protein S3 -0.0385052
JMJD1C jumonji domain containing 1C -0.0382942
RASA2 RAS p21 protein activator 2 -0.038256
RNF145 ring finger protein 145 -0.0381359
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0378703
FTL ferritin, light polypeptide -0.0377923
NIPBL Nipped-B homolog (Drosophila) -0.0376398
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0374669
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0371064
NAMPT nicotinamide phosphoribosyltransferase -0.0363074
SAMD4A sterile alpha motif domain containing 4A -0.0362719
RPL35A ribosomal protein L35a -0.0361594
TMEM263 transmembrane protein 263 -0.0361019
PARD3 par-3 family cell polarity regulator -0.0355937
RASAL2 RAS protein activator like 2 -0.0355135
LCORL ligand dependent nuclear receptor corepressor-like -0.0352314
NPEPPS aminopeptidase puromycin sensitive -0.0351545
FBXO32 F-box protein 32 -0.0346563
KMT2C lysine (K)-specific methyltransferase 2C -0.0333816
MEF2A myocyte enhancer factor 2A -0.0327711
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0325033
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.032336
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0321785
TM4SF1 transmembrane 4 L six family member 1 -0.0319503
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0317138
WASF2 WAS protein family, member 2 -0.0316893
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0314043
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0311846
PUM2 pumilio RNA-binding family member 2 -0.030835
NR3C2 nuclear receptor subfamily 3, group C, member 2 -0.0308078
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0307991
IFRD1 interferon-related developmental regulator 1 -0.0307898
TFG TRK-fused gene -0.0307824
SH3KBP1 SH3-domain kinase binding protein 1 -0.0303844
FBXO11 F-box protein 11 -0.0303812
RPL37A ribosomal protein L37a -0.030194
CERT1 ceramide transporter 1 -0.0299318
MYO6 myosin VI -0.0299146
USP15 ubiquitin specific peptidase 15 -0.0298862
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0297684
SLC38A1 solute carrier family 38, member 1 -0.029752
SEC24D SEC24 family member D -0.0293766
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0292451
CDC73 cell division cycle 73 -0.0292089
RYBP RING1 and YY1 binding protein -0.0287783
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0287753
ZNF207 zinc finger protein 207 -0.028764
GARS1 glycyl-tRNA synthetase 1 -0.0286736
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0286215
S100A10 S100 calcium binding protein A10 -0.0284321
SENP6 SUMO1/sentrin specific peptidase 6 -0.0283206
TRA2A transformer 2 alpha homolog (Drosophila) -0.0282809
RAB10 RAB10, member RAS oncogene family -0.0281924
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0280248
IFITM3 interferon induced transmembrane protein 3 -0.0278313
RPS29 ribosomal protein S29 -0.0277387