Decitabine_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Decitabine perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Decitabine_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL3 ribosomal protein L3 0.124805
EEF2 eukaryotic translation elongation factor 2 0.114325
AHNAK AHNAK nucleoprotein 0.113672
LOC112694756 uncharaterized LOC112694756 0.112273
PRELID2 PRELI domain containing 2 0.0697229
PDE4B phosphodiesterase 4B, cAMP-specific 0.0685877
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0611637
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0554643
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0554045
H1-4 H1.4 linker histone, cluster member 0.053701
PDE4D phosphodiesterase 4D, cAMP-specific 0.0533822
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0531947
FLNB filamin B, beta 0.0527728
TMSB4X thymosin beta 4, X-linked 0.0504823
EZR ezrin 0.0469746
MYOF myoferlin 0.0468558
SOX6 SRY (sex determining region Y)-box 6 0.0461833
SLC38A2 solute carrier family 38, member 2 0.045835
TBC1D22A TBC1 domain family, member 22A 0.043765
PDGFC platelet derived growth factor C 0.0412414
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0407654
HSPA8 heat shock 70kDa protein 8 0.0387051
FHIT fragile histidine triad 0.0385693
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0372885
PKM pyruvate kinase, muscle 0.0372365
CAMTA1 calmodulin binding transcription activator 1 0.0359769
EGFR epidermal growth factor receptor 0.0358816
RPS18 ribosomal protein S18 0.034263
ENO1 enolase 1, (alpha) 0.0339259
VCL vinculin 0.0338122
ADAM10 ADAM metallopeptidase domain 10 0.0317795
GSE1 Gse1 coiled-coil protein 0.0315707
SRRM2 serine/arginine repetitive matrix 2 0.0313048
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0312199
NPAS2 neuronal PAS domain protein 2 0.0309653
TPI1 triosephosphate isomerase 1 0.0309329
APLP2 amyloid beta (A4) precursor-like protein 2 0.0309286
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0297316
ANKRD36 ankyrin repeat domain 36 0.0295357
SDK1 sidekick cell adhesion molecule 1 0.0294023
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0291732
TTC28 tetratricopeptide repeat domain 28 0.0291332
RHOA ras homolog family member A 0.0290927
EBNA1BP2 EBNA1 binding protein 2 0.0288237
BMP10 bone morphogenetic protein 10 0.0279358
LOXL3 lysyl oxidase-like 3 0.0279191
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.0277997
PRPF38B pre-mRNA processing factor 38B 0.026945
MYH9 myosin, heavy chain 9, non-muscle 0.0267938
KLF3 Kruppel-like factor 3 (basic) 0.0260096
MKI67 marker of proliferation Ki-67 0.0255717
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0254186
GLI2 GLI family zinc finger 2 0.0251028
HDLBP high density lipoprotein binding protein 0.0247082
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0239358
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0238096
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0234628
TMEM65 transmembrane protein 65 0.023359
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0231388
CEP250 centrosomal protein 250kDa 0.0229974
UBC ubiquitin C 0.0226349
FNIP1 folliculin interacting protein 1 0.0225541
ANKRD12 ankyrin repeat domain 12 0.0224526
FAT1 FAT atypical cadherin 1 0.0221549
TGFBR3 transforming growth factor, beta receptor III 0.0220389
RPL4 ribosomal protein L4 0.021783
EIF4H eukaryotic translation initiation factor 4H 0.0214355
YEATS2 YEATS domain containing 2 0.0208911
TNIP1 TNFAIP3 interacting protein 1 0.020853
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0207588
NACA nascent polypeptide-associated complex alpha subunit 0.0206858
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0205613
SBF2 SET binding factor 2 0.0203692
MYO5C myosin VC 0.0201863
SEPTIN9 septin 9 0.0201114
CHSY1 chondroitin sulfate synthase 1 0.0197095
RAB27B RAB27B, member RAS oncogene family 0.0196387
ANKRD36B ankyrin repeat domain 36B 0.0194288
MACF1 microtubule-actin crosslinking factor 1 0.0190807
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0190242
AMOTL2 angiomotin like 2 0.0187108
ENOSF1 enolase superfamily member 1 0.0185877
HM13 histocompatibility (minor) 13 0.0185735
SET SET nuclear proto-oncogene 0.0183377
RPL23A ribosomal protein L23a 0.0182923
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0181965
USP34 ubiquitin specific peptidase 34 0.0181844
EIF4A2 eukaryotic translation initiation factor 4A2 0.0181785
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0181599
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0176833
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0175689
CD47 CD47 molecule 0.0174137
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0171114
MSN moesin 0.0171
ANXA3 annexin A3 0.0170807
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0170436
BRD2 bromodomain containing 2 0.0169783
MACROD2 MACRO domain containing 2 0.0169195
FBLN2 fibulin 2 0.0168993
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0167587

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.146357
PTMA prothymosin, alpha -0.114408
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0959269
SSBP2 single-stranded DNA binding protein 2 -0.0857359
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0704166
RPL35A ribosomal protein L35a -0.0604036
ZNF292 zinc finger protein 292 -0.0581454
QKI QKI, KH domain containing, RNA binding -0.0519329
NAMPT nicotinamide phosphoribosyltransferase -0.0488295
RBM39 RNA binding motif protein 39 -0.0474833
EIF1 eukaryotic translation initiation factor 1 -0.0458698
KMT2E lysine (K)-specific methyltransferase 2E -0.0453924
RTN4 reticulon 4 -0.0439148
GARS1 glycyl-tRNA synthetase 1 -0.0437672
ZEB1 zinc finger E-box binding homeobox 1 -0.0435202
KDM3A lysine (K)-specific demethylase 3A -0.0418781
NBEA neurobeachin -0.04058
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0405768
ZFAND3 zinc finger, AN1-type domain 3 -0.0392113
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0386838
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.035184
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0341058
CDC73 cell division cycle 73 -0.0340145
RPS19 ribosomal protein S19 -0.0332279
B2M beta-2-microglobulin -0.0328017
RNF145 ring finger protein 145 -0.0326948
RPL34 ribosomal protein L34 -0.0326263
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0322969
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0321736
DLG1 discs, large homolog 1 (Drosophila) -0.0314241
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0312587
WAC WW domain containing adaptor with coiled-coil -0.0303945
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0302951
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0301472
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.029779
MATR3 matrin 3 -0.0294965
IARS1 isoleucyl-tRNA synthetase 1 -0.0292047
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0290375
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0289852
STRN3 striatin, calmodulin binding protein 3 -0.0289834
TCF12 transcription factor 12 -0.0289485
PNISR PNN-interacting serine/arginine-rich protein -0.0287366
RPL12 ribosomal protein L12 -0.0286344
TFG TRK-fused gene -0.02846
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0279793
ACTG1 actin gamma 1 -0.0279357
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0279083
USP3 ubiquitin specific peptidase 3 -0.0273539
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0272463
RPLP1 ribosomal protein, large, P1 -0.0271651
S100A6 S100 calcium binding protein A6 -0.027112
RHEB Ras homolog enriched in brain -0.0269166
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0268177
FBXO11 F-box protein 11 -0.0267997
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0266911
RPS6 ribosomal protein S6 -0.0263778
DPYD dihydropyrimidine dehydrogenase -0.02627
RPS8 ribosomal protein S8 -0.0261511
RSL1D1 ribosomal L1 domain containing 1 -0.0259045
JMJD1C jumonji domain containing 1C -0.0257424
TMEM41B transmembrane protein 41B -0.0256644
MEF2A myocyte enhancer factor 2A -0.0254328
MT2A metallothionein 2A -0.0244575
EML4 echinoderm microtubule associated protein like 4 -0.0239979
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0239705
RPS13 ribosomal protein S13 -0.0237804
CCNL1 cyclin L1 -0.0236661
ECT2 epithelial cell transforming 2 -0.0235735
EXOC6B exocyst complex component 6B -0.0234703
WDR43 WD repeat domain 43 -0.0234136
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0232244
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0227794
RLF rearranged L-myc fusion -0.0223522
PRDX2 peroxiredoxin 2 -0.0221127
HSPB1 heat shock 27kDa protein 1 -0.0220655
YBX1 Y box binding protein 1 -0.0215081
LCORL ligand dependent nuclear receptor corepressor-like -0.0212534
HMGA1 high mobility group AT-hook 1 -0.0211752
TXNRD1 thioredoxin reductase 1 -0.0211237
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.0211134
PIAS1 protein inhibitor of activated STAT, 1 -0.0210278
RAD21 RAD21 homolog (S. pombe) -0.0210062
PUM2 pumilio RNA-binding family member 2 -0.0209063
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0208014
NMD3 NMD3 ribosome export adaptor -0.0207008
MARCHF6 membrane associated ring-CH-type finger 6 -0.0205064
MED13 mediator complex subunit 13 -0.020493
PFN1 profilin 1 -0.0204663
KIF5B kinesin family member 5B -0.0201764
NOP58 NOP58 ribonucleoprotein -0.0201122
NIPBL Nipped-B homolog (Drosophila) -0.0198698
TPR translocated promoter region, nuclear basket protein -0.019772
HMGB1 high mobility group box 1 -0.0196445
BRWD1 bromodomain and WD repeat domain containing 1 -0.0195959
TRA2A transformer 2 alpha homolog (Drosophila) -0.0192566
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0189321
KPNB1 karyopherin (importin) beta 1 -0.0188709
PARD3 par-3 family cell polarity regulator -0.0187865
ANXA1 annexin A1 -0.0187723
RAB1A RAB1A, member RAS oncogene family -0.018756