Decitabine_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Decitabine perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Decitabine_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.126801
LOC112694756 uncharaterized LOC112694756 0.12411
COL6A3 collagen, type VI, alpha 3 0.100812
MYH9 myosin, heavy chain 9, non-muscle 0.0902302
LOX lysyl oxidase 0.0838016
AHNAK AHNAK nucleoprotein 0.0809424
UBC ubiquitin C 0.0767103
HOOK2 hook microtubule-tethering protein 2 0.0754711
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0657407
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0653722
SEPTIN9 septin 9 0.0615989
CD44 CD44 molecule (Indian blood group) 0.0561488
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0534226
FLNA filamin A, alpha 0.0498271
EEF2 eukaryotic translation elongation factor 2 0.0498249
ATP13A3 ATPase type 13A3 0.0468279
ACTN1 actinin, alpha 1 0.0467683
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0462426
CSDE1 cold shock domain containing E1, RNA-binding 0.0450302
PDIA4 protein disulfide isomerase family A, member 4 0.0431546
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0418982
CALR calreticulin 0.0417951
SMAD3 SMAD family member 3 0.0406211
IGFBP7 insulin-like growth factor binding protein 7 0.0406
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.0405694
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0389216
ACTN4 actinin, alpha 4 0.0365628
PABPC1 poly(A) binding protein, cytoplasmic 1 0.036522
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0363032
COL6A2 collagen, type VI, alpha 2 0.0360913
COL5A2 collagen, type V, alpha 2 0.035947
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0356227
TNIP1 TNFAIP3 interacting protein 1 0.0351005
TPI1 triosephosphate isomerase 1 0.034806
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0336725
ELL2 elongation factor, RNA polymerase II, 2 0.0334433
RICTOR RPTOR independent companion of MTOR, complex 2 0.0333073
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0329918
CD59 CD59 molecule, complement regulatory protein 0.0328555
TLN1 talin 1 0.0324624
MYO9B myosin IXB 0.0319654
OGA O-GlcNAcase 0.0309007
RLIM ring finger protein, LIM domain interacting 0.0306766
PLEC plectin 0.0305292
SPRED1 sprouty-related, EVH1 domain containing 1 0.0302956
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0302441
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.029566
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0294098
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.028925
TMSB4X thymosin beta 4, X-linked 0.028777
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.028719
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.02867
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0283323
UBE2H ubiquitin-conjugating enzyme E2H 0.0282486
RPL15 ribosomal protein L15 0.0282197
MSN moesin 0.0279468
RPS12 ribosomal protein S12 0.0278743
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0275909
KMT2A lysine (K)-specific methyltransferase 2A 0.0275537
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0272661
ATXN1 ataxin 1 0.0271232
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0270749
TRIP12 thyroid hormone receptor interactor 12 0.0270682
TPM3 tropomyosin 3 0.0268497
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0264577
SYNJ2 synaptojanin 2 0.0264053
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.026358
TMED9 transmembrane emp24 protein transport domain containing 9 0.0261938
CHSY1 chondroitin sulfate synthase 1 0.0260167
RYBP RING1 and YY1 binding protein 0.0259505
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0258451
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0258408
SDC4 syndecan 4 0.0257675
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0256172
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0256082
PTK2 protein tyrosine kinase 2 0.0254536
MBNL1 muscleblind-like splicing regulator 1 0.0254276
MYO10 myosin X 0.0253863
ERRFI1 ERBB receptor feedback inhibitor 1 0.0252556
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.025213
HSPA8 heat shock 70kDa protein 8 0.0251875
TRRAP transformation/transcription domain-associated protein 0.025165
DENND5A DENN/MADD domain containing 5A 0.025162
NAV1 neuron navigator 1 0.0251372
COL5A1 collagen, type V, alpha 1 0.0248555
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0246781
MACF1 microtubule-actin crosslinking factor 1 0.0245819
SRRM2 serine/arginine repetitive matrix 2 0.0242972
DNPEP aspartyl aminopeptidase 0.0242112
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0241351
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0238251
PTPRF protein tyrosine phosphatase, receptor type, F 0.0237808
RAB14 RAB14, member RAS oncogene family 0.023755
B2M beta-2-microglobulin 0.0237445
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0236329
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0236286
FAT1 FAT atypical cadherin 1 0.023356
NCKAP1 NCK-associated protein 1 0.0233522
NAMPT nicotinamide phosphoribosyltransferase 0.0233445
RPL3 ribosomal protein L3 0.0232623

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.198524
TMSB10 thymosin beta 10 -0.0875544
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0817109
F3 coagulation factor III (thromboplastin, tissue factor) -0.0747246
MT2A metallothionein 2A -0.0701699
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0627691
FTL ferritin, light polypeptide -0.0572194
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0558946
IL6 interleukin 6 -0.0481198
LMAN1 lectin, mannose-binding, 1 -0.0471993
TENT5A terminal nucleotidyltransferase 5A -0.0454644
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -0.0454333
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0453038
CADM1 cell adhesion molecule 1 -0.0425809
TRA2A transformer 2 alpha homolog (Drosophila) -0.0418918
DPYD dihydropyrimidine dehydrogenase -0.0407792
POTEF POTE ankyrin domain family, member F -0.0401413
TGFBI transforming growth factor, beta-induced, 68kDa -0.0399131
PSD3 pleckstrin and Sec7 domain containing 3 -0.0397651
SEC31A SEC31 homolog A (S. cerevisiae) -0.03857
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0370758
CBX3 chromobox homolog 3 -0.0360647
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0343576
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0331948
FOSL1 FOS-like antigen 1 -0.0325048
STC1 stanniocalcin 1 -0.0322403
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0317173
EGR1 early growth response 1 -0.0316917
VIM vimentin -0.030879
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0306811
KTN1 kinectin 1 (kinesin receptor) -0.0306072
RPL11 ribosomal protein L11 -0.0305812
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0299885
LOXL2 lysyl oxidase-like 2 -0.0297385
DCAF10 DDB1 and CUL4 associated factor 10 -0.0297039
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0296019
VEGFA vascular endothelial growth factor A -0.0293836
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0290689
COL1A2 collagen, type I, alpha 2 -0.0290119
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0286216
RPS6 ribosomal protein S6 -0.0284541
HLA-B major histocompatibility complex, class I, B -0.028361
RBM39 RNA binding motif protein 39 -0.0283412
RPL35A ribosomal protein L35a -0.0277767
PDIA3 protein disulfide isomerase family A, member 3 -0.0277181
FNDC3A fibronectin type III domain containing 3A -0.0276401
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0276197
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0273005
MORF4L2 mortality factor 4 like 2 -0.0272237
TTC3 tetratricopeptide repeat domain 3 -0.0271587
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0267968
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0267131
TBCA tubulin folding cofactor A -0.0265682
SOS1 son of sevenless homolog 1 (Drosophila) -0.0263574
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0262631
FUS FUS RNA binding protein -0.0257775
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0256945
LSAMP limbic system-associated membrane protein -0.0253071
ERBIN erbb2 interacting protein -0.0252686
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0252103
SYNPO synaptopodin -0.0252013
IFRD1 interferon-related developmental regulator 1 -0.0251954
HILPDA hypoxia inducible lipid droplet-associated -0.0251906
RAB2A RAB2A, member RAS oncogene family -0.0251649
VEGFC vascular endothelial growth factor C -0.0249805
RPS8 ribosomal protein S8 -0.0249104
ANXA5 annexin A5 -0.0247855
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0246719
RAB6A RAB6A, member RAS oncogene family -0.0245379
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0243171
CALD1 caldesmon 1 -0.0240395
RPS14 ribosomal protein S14 -0.0238852
IARS1 isoleucyl-tRNA synthetase 1 -0.0236055
TUBA1B tubulin, alpha 1b -0.0235362
ZNF395 zinc finger protein 395 -0.0234316
S100A6 S100 calcium binding protein A6 -0.0233116
GPBP1 GC-rich promoter binding protein 1 -0.0232906
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0232747
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0227676
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0227628
ATF4 activating transcription factor 4 -0.0226139
CLINT1 clathrin interactor 1 -0.0225927
HDAC9 histone deacetylase 9 -0.0225903
AK1 adenylate kinase 1 -0.0225242
PALLD palladin, cytoskeletal associated protein -0.0223834
EGFR epidermal growth factor receptor -0.0222309
MON2 MON2 homolog (S. cerevisiae) -0.0222113
KIAA1217 KIAA1217 -0.0217119
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0216772
TRIM56 tripartite motif containing 56 -0.0216407
RAB7A RAB7A, member RAS oncogene family -0.0214852
FAM13A family with sequence similarity 13, member A -0.0213523
KLHDC10 kelch domain containing 10 -0.0211768
COPB1 coatomer protein complex, subunit beta 1 -0.0211721
BLZF1 basic leucine zipper nuclear factor 1 -0.0209169
TAS2R14 taste receptor, type 2, member 14 -0.0208665
CDH13 cadherin 13 -0.0208274
NBAS neuroblastoma amplified sequence -0.0208075
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0207402
RPS23 ribosomal protein S23 -0.0207316