Decitabine_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Decitabine perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Decitabine_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.134655
NAMPT nicotinamide phosphoribosyltransferase 0.0593445
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0577117
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0536288
PTMA prothymosin, alpha 0.0478635
LOC112694756 uncharaterized LOC112694756 0.045785
MYH9 myosin, heavy chain 9, non-muscle 0.0387647
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.038442
MT2A metallothionein 2A 0.0356859
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0356411
VIM vimentin 0.0350936
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0324028
TRIO trio Rho guanine nucleotide exchange factor 0.0315652
TPI1 triosephosphate isomerase 1 0.03043
TMSB4X thymosin beta 4, X-linked 0.0302716
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0300358
CANX calnexin 0.0296997
SQSTM1 sequestosome 1 0.0292741
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0289954
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0283291
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.027909
PKM pyruvate kinase, muscle 0.0272142
PRRC2C proline-rich coiled-coil 2C 0.0264172
B2M beta-2-microglobulin 0.0259183
CXCL8 chemokine (C-X-C motif) ligand 8 0.0257949
NAP1L1 nucleosome assembly protein 1-like 1 0.0257726
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0255947
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0246362
NDRG1 N-myc downstream regulated 1 0.0245723
EEF2 eukaryotic translation elongation factor 2 0.0244523
CALR calreticulin 0.0243493
SFTPA2 surfactant protein A2 0.0240958
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0236433
S100A6 S100 calcium binding protein A6 0.0231704
RPS6 ribosomal protein S6 0.0229274
UBC ubiquitin C 0.0228427
RPS12 ribosomal protein S12 0.0224844
TPT1 tumor protein, translationally-controlled 1 0.0223762
HILPDA hypoxia inducible lipid droplet-associated 0.0221396
ENO1 enolase 1, (alpha) 0.0211403
TXNIP thioredoxin interacting protein 0.0202856
APP amyloid beta (A4) precursor protein 0.020216
WDR45B WD repeat domain 45B 0.0202046
HLA-B major histocompatibility complex, class I, B 0.0201002
S100A10 S100 calcium binding protein A10 0.0200608
RPL3 ribosomal protein L3 0.0199974
MKI67 marker of proliferation Ki-67 0.0197609
OGA O-GlcNAcase 0.019685
FAM13A family with sequence similarity 13, member A 0.01963
FLNA filamin A, alpha 0.0195707
PGK1 phosphoglycerate kinase 1 0.0194761
RPL26 ribosomal protein L26 0.0192052
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0189694
FNDC3B fibronectin type III domain containing 3B 0.0187901
APLP2 amyloid beta (A4) precursor-like protein 2 0.018725
RACK1 receptor for activated C kinase 1 0.0187248
RPL23 ribosomal protein L23 0.0182837
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0180654
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0176904
TNIP1 TNFAIP3 interacting protein 1 0.0172591
EIF4A1 eukaryotic translation initiation factor 4A1 0.0171119
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0167594
SOD2 superoxide dismutase 2, mitochondrial 0.0167091
HDLBP high density lipoprotein binding protein 0.0166532
FTL ferritin, light polypeptide 0.0164057
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0160956
RPS27A ribosomal protein S27a 0.0160806
DDIT4 DNA-damage-inducible transcript 4 0.0160132
AHNAK AHNAK nucleoprotein 0.015974
SPAG9 sperm associated antigen 9 0.0159531
RPL37 ribosomal protein L37 0.0157811
HDGF hepatoma-derived growth factor 0.0157654
KTN1 kinectin 1 (kinesin receptor) 0.0157161
LMNA lamin A/C 0.0157142
CD63 CD63 molecule 0.0155117
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0155012
TPM3 tropomyosin 3 0.0151384
ARRDC3 arrestin domain containing 3 0.0149279
RPS3 ribosomal protein S3 0.0147688
RPS11 ribosomal protein S11 0.0147207
RPL31 ribosomal protein L31 0.0145635
RPL37A ribosomal protein L37a 0.0145156
RPS8 ribosomal protein S8 0.0145065
RPL11 ribosomal protein L11 0.0143997
CD109 CD109 molecule 0.0143901
PLEC plectin 0.014234
CSDE1 cold shock domain containing E1, RNA-binding 0.0141234
KDM3A lysine (K)-specific demethylase 3A 0.0140053
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0137807
RPL38 ribosomal protein L38 0.013708
H1-0 H1.0 linker histone 0.0136368
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0135973
SUCO SUN domain containing ossification factor 0.0135496
RPL19 ribosomal protein L19 0.0135326
RPS5 ribosomal protein S5 0.0134992
INSIG2 insulin induced gene 2 0.0134258
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0133705
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.013232
MACF1 microtubule-actin crosslinking factor 1 0.0132086
ZNF292 zinc finger protein 292 0.0131832

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.0412301
EXT1 exostosin glycosyltransferase 1 -0.0308321
HMGA2 high mobility group AT-hook 2 -0.0291387
GLIS3 GLIS family zinc finger 3 -0.0276079
VCL vinculin -0.0235591
SYT1 synaptotagmin I -0.0226677
FTH1 ferritin, heavy polypeptide 1 -0.0199764
NTN4 netrin 4 -0.0197467
NRP1 neuropilin 1 -0.0144054
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0141698
KSR1 kinase suppressor of ras 1 -0.0129876
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0121915
MBD5 methyl-CpG binding domain protein 5 -0.0120376
PALLD palladin, cytoskeletal associated protein -0.0119919
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0118362
AHRR aryl-hydrocarbon receptor repressor -0.0100992
PDLIM5 PDZ and LIM domain 5 -0.00992686
FHL2 four and a half LIM domains 2 -0.00956754
EGR1 early growth response 1 -0.00939257
RAB31 RAB31, member RAS oncogene family -0.00936691
RAI14 retinoic acid induced 14 -0.00918089
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.00891738
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.00864168
EFNA5 ephrin-A5 -0.0084651
ITGA1 integrin, alpha 1 -0.00829088
NCOA7 nuclear receptor coactivator 7 -0.00783706
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.00741653
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.00736396
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.00726105
EPC2 enhancer of polycomb homolog 2 (Drosophila) -0.00720147
AEBP2 AE binding protein 2 -0.00717505
RASAL2 RAS protein activator like 2 -0.00706299
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.00672523
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.00667526
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.00649039
ZBTB20 zinc finger and BTB domain containing 20 -0.00648884
TMEM165 transmembrane protein 165 -0.00645161
DNAH5 dynein, axonemal, heavy chain 5 -0.00621614
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.00621176
VEGFC vascular endothelial growth factor C -0.00612829
GLCCI1 glucocorticoid induced 1 -0.00611872
VMP1 vacuole membrane protein 1 -0.00610737
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.00608087
NBEA neurobeachin -0.00607595
GPATCH2L G patch domain containing 2-like -0.00607553
DPYD dihydropyrimidine dehydrogenase -0.00602831
SOS1 son of sevenless homolog 1 (Drosophila) -0.00595884
IFI44L interferon-induced protein 44-like -0.00585854
FNDC3A fibronectin type III domain containing 3A -0.00584972
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.00582788
PTPRK protein tyrosine phosphatase, receptor type, K -0.00570654
INTS6 integrator complex subunit 6 -0.00566106
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0055753
RBPMS RNA binding protein with multiple splicing -0.00556229
RAB10 RAB10, member RAS oncogene family -0.00552807
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.00545827
TMEM156 transmembrane protein 156 -0.00541978
CCDC138 coiled-coil domain containing 138 -0.00540417
LOC102724023 ES1 protein homolog, mitochondrial -0.00536187
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.00530414
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.00528398
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.00528119
RANBP17 RAN binding protein 17 -0.00526786
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.00526467
ETV6 ets variant 6 -0.00516482
PRH1 proline-rich protein HaeIII subfamily 1 -0.00510808
CCDC91 coiled-coil domain containing 91 -0.00507913
TTC28 tetratricopeptide repeat domain 28 -0.00507811
AOPEP aminopeptidase O (putative) -0.00503242
TUFT1 tuftelin 1 -0.00496401
ANKRD28 ankyrin repeat domain 28 -0.00493358
DLG1 discs, large homolog 1 (Drosophila) -0.00491918
UBASH3B ubiquitin associated and SH3 domain containing B -0.00481718
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.00481264
BICC1 BicC family RNA binding protein 1 -0.00479379
HIPK2 homeodomain interacting protein kinase 2 -0.00476222
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.00468943
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.00461547
DUSP16 dual specificity phosphatase 16 -0.00460477
VCAN versican -0.00457974
NPAS2 neuronal PAS domain protein 2 -0.00457495
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.00453243
ZNF644 zinc finger protein 644 -0.00453168
RDH10 retinol dehydrogenase 10 (all-trans) -0.00448123
RIGI RNA sensor RIG-I -0.00440474
TMEM178B transmembrane protein 178B -0.00439482
STAU2 staufen double-stranded RNA binding protein 2 -0.00438484
ENO2 enolase 2 (gamma, neuronal) -0.00435671
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.00434398
ZCCHC7 zinc finger, CCHC domain containing 7 -0.00431359
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.00427897
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.00426429
RUNX2 runt-related transcription factor 2 -0.00422531
TAS2R14 taste receptor, type 2, member 14 -0.00422446
GOLGB1 golgin B1 -0.00417446
ATOSA atos homolog A -0.00411217
UBAP1 ubiquitin associated protein 1 -0.0040935
AKAP9 A kinase (PRKA) anchor protein 9 -0.00408802
TSC22D1 TSC22 domain family, member 1 -0.00400899
IL1R1 interleukin 1 receptor, type I -0.00397843