Delamanid_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Delamanid perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Delamanid_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.153056
FBN1 fibrillin 1 0.0921416
LOXL2 lysyl oxidase-like 2 0.0813326
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0759441
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0657906
APP amyloid beta (A4) precursor protein 0.0650423
C1D C1D nuclear receptor corepressor 0.0571491
FNDC3B fibronectin type III domain containing 3B 0.0546474
MT2A metallothionein 2A 0.0526704
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0525368
THBS2 thrombospondin 2 0.0521836
NFE2L1 nuclear factor, erythroid 2-like 1 0.0519558
TMSB4X thymosin beta 4, X-linked 0.0515498
CALR calreticulin 0.051345
COL3A1 collagen, type III, alpha 1 0.050889
FLNA filamin A, alpha 0.0497211
CTSB cathepsin B 0.0483624
PODXL podocalyxin-like 0.0476568
DPYSL3 dihydropyrimidinase-like 3 0.04148
EEF2 eukaryotic translation elongation factor 2 0.0413441
TNIP1 TNFAIP3 interacting protein 1 0.0408664
NAV2 neuron navigator 2 0.0408556
AUTS2 autism susceptibility candidate 2 0.0402877
SOD2 superoxide dismutase 2, mitochondrial 0.0400005
LOX lysyl oxidase 0.0399916
PSD3 pleckstrin and Sec7 domain containing 3 0.0396165
FLNB filamin B, beta 0.0396148
MYH9 myosin, heavy chain 9, non-muscle 0.0390723
HLA-B major histocompatibility complex, class I, B 0.0378092
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0377963
BHLHE40 basic helix-loop-helix family, member e40 0.0375821
SEPTIN9 septin 9 0.035911
UBC ubiquitin C 0.0355166
COL1A2 collagen, type I, alpha 2 0.0347565
SDC4 syndecan 4 0.0340705
SLC22A23 solute carrier family 22, member 23 0.0332047
NAV1 neuron navigator 1 0.0318583
SFTPA2 surfactant protein A2 0.0317171
SRRM2 serine/arginine repetitive matrix 2 0.0313802
ADM adrenomedullin 0.0313313
TMOD1 tropomodulin 1 0.0298933
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0298383
GPC6 glypican 6 0.0295628
ANXA2 annexin A2 0.0292822
SBF2 SET binding factor 2 0.0271949
STC1 stanniocalcin 1 0.0269332
EIF4H eukaryotic translation initiation factor 4H 0.0266738
COL6A2 collagen, type VI, alpha 2 0.0260768
CD44 CD44 molecule (Indian blood group) 0.0258061
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0251438
ANKRD36 ankyrin repeat domain 36 0.0249047
OGA O-GlcNAcase 0.024786
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0246733
PRELID2 PRELI domain containing 2 0.0241055
OPTN optineurin 0.0236426
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0233783
MYOF myoferlin 0.0233674
ARL15 ADP-ribosylation factor-like 15 0.0232053
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.02304
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0229383
HLA-C major histocompatibility complex, class I, C 0.0226142
CLU clusterin 0.022218
WTAP Wilms tumor 1 associated protein 0.0220639
WDFY1 WD repeat and FYVE domain containing 1 0.021706
WWTR1 WW domain containing transcription regulator 1 0.0214301
DENND5A DENN/MADD domain containing 5A 0.0214094
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0211823
CDK18 cyclin-dependent kinase 18 0.0211768
KIAA1217 KIAA1217 0.0211333
ATP13A3 ATPase type 13A3 0.0208971
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0198624
ARRDC3 arrestin domain containing 3 0.0194046
TRIM22 tripartite motif containing 22 0.0194017
IQGAP1 IQ motif containing GTPase activating protein 1 0.0193989
SVIL supervillin 0.0193877
NOTCH2 notch 2 0.0193244
KDM3A lysine (K)-specific demethylase 3A 0.0192936
RPN1 ribophorin I 0.0192915
GOLM1 golgi membrane protein 1 0.0190324
LRRC49 leucine rich repeat containing 49 0.0187462
FMNL2 formin-like 2 0.0186941
DCAF6 DDB1 and CUL4 associated factor 6 0.0186515
SETD5 SET domain containing 5 0.0186335
COL7A1 collagen, type VII, alpha 1 0.0183997
MPRIP myosin phosphatase Rho interacting protein 0.0182357
PLAT plasminogen activator, tissue 0.0181903
ZEB2 zinc finger E-box binding homeobox 2 0.0179959
RASA2 RAS p21 protein activator 2 0.0179168
PRPF8 pre-mRNA processing factor 8 0.0177529
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0177222
STEAP3 STEAP family member 3, metalloreductase 0.0175274
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0173414
BACE2 beta-site APP-cleaving enzyme 2 0.0173229
FRMD5 FERM domain containing 5 0.0172329
AHNAK2 AHNAK nucleoprotein 2 0.0171957
NT5C2 5'-nucleotidase, cytosolic II 0.0171763
L1CAM L1 cell adhesion molecule 0.0170907
GLS2 glutaminase 2 (liver, mitochondrial) 0.0170832
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.016925
ANXA6 annexin A6 0.0166306

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.219354
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.136302
IGFBP3 insulin-like growth factor binding protein 3 -0.0917392
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0906812
CDH13 cadherin 13 -0.0775203
NDRG1 N-myc downstream regulated 1 -0.075372
MAP1B microtubule-associated protein 1B -0.0746464
S100A6 S100 calcium binding protein A6 -0.0703016
CSTB cystatin B (stefin B) -0.0659798
TMSB10 thymosin beta 10 -0.0646844
ABI3BP ABI family, member 3 (NESH) binding protein -0.0617397
POTEF POTE ankyrin domain family, member F -0.058172
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0575703
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0544762
FN1 fibronectin 1 -0.0535342
TRIO trio Rho guanine nucleotide exchange factor -0.0527144
S100A10 S100 calcium binding protein A10 -0.0523164
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0520877
DCLK2 doublecortin-like kinase 2 -0.0509588
TPM4 tropomyosin 4 -0.0497472
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0497061
SLC38A1 solute carrier family 38, member 1 -0.0492389
CCND1 cyclin D1 -0.0489579
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0488767
SLC39A11 solute carrier family 39, member 11 -0.0476107
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0462913
EGFR epidermal growth factor receptor -0.0431458
CANX calnexin -0.0425831
PFN1 profilin 1 -0.0418528
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0415319
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0402157
TAGLN2 transgelin 2 -0.0394643
SAMD9 sterile alpha motif domain containing 9 -0.0390042
PBX3 pre-B-cell leukemia homeobox 3 -0.0389041
LMNA lamin A/C -0.0383711
MEIS2 Meis homeobox 2 -0.036331
SUCNR1 succinate receptor 1 -0.0362384
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0358247
PKM pyruvate kinase, muscle -0.0355724
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0338976
PRSS23 protease, serine, 23 -0.0336852
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0334212
SPDL1 spindle apparatus coiled-coil protein 1 -0.031739
ZMYND8 zinc finger, MYND-type containing 8 -0.0314411
PDIA3 protein disulfide isomerase family A, member 3 -0.0313788
ENO1 enolase 1, (alpha) -0.0311919
SORBS2 sorbin and SH3 domain containing 2 -0.0309562
MSI2 musashi RNA-binding protein 2 -0.0303884
MX2 MX dynamin-like GTPase 2 -0.0299544
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -0.0298109
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0295291
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0294079
RIGI RNA sensor RIG-I -0.0292296
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0291019
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0285045
CDK6 cyclin-dependent kinase 6 -0.0281576
CUX1 cut-like homeobox 1 -0.0277862
EFNA5 ephrin-A5 -0.0273596
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0272429
IL7R interleukin 7 receptor -0.0272207
SEPTIN7 septin 7 -0.0266834
IARS1 isoleucyl-tRNA synthetase 1 -0.0264568
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.026127
FLT1 fms-related tyrosine kinase 1 -0.0259038
RRBP1 ribosome binding protein 1 -0.025839
FTL ferritin, light polypeptide -0.0258229
TPM1 tropomyosin 1 (alpha) -0.0248324
LRRC17 leucine rich repeat containing 17 -0.0245022
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0242951
S100A11 S100 calcium binding protein A11 -0.0241349
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0235382
COL5A1 collagen, type V, alpha 1 -0.0234278
RPL35A ribosomal protein L35a -0.0233428
ISG15 ISG15 ubiquitin-like modifier -0.0231736
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0231714
IFITM3 interferon induced transmembrane protein 3 -0.0231499
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0229861
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0228752
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.0228547
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0228145
KPNB1 karyopherin (importin) beta 1 -0.0227436
CENPF centromere protein F, 350/400kDa -0.0224356
DGKG diacylglycerol kinase, gamma 90kDa -0.0223696
LDHA lactate dehydrogenase A -0.022188
SEC61G Sec61 gamma subunit -0.0219603
KRT81 keratin 81, type II -0.0217128
ASPH aspartate beta-hydroxylase -0.0214126
GOLGA4 golgin A4 -0.0213623
S100A4 S100 calcium binding protein A4 -0.021222
SMC4 structural maintenance of chromosomes 4 -0.0211098
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0207773
MBNL1 muscleblind-like splicing regulator 1 -0.020651
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0204005
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0202529
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0202454
MACF1 microtubule-actin crosslinking factor 1 -0.0202273
HILPDA hypoxia inducible lipid droplet-associated -0.0202074
LOC112694756 uncharaterized LOC112694756 -0.0201927
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0201842
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0199519