| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Delamanid perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Delamanid_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.376681 |
| COL6A3 | collagen, type VI, alpha 3 | 0.250376 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0942723 |
| CALR | calreticulin | 0.0881751 |
| LOXL2 | lysyl oxidase-like 2 | 0.0766462 |
| VEGFA | vascular endothelial growth factor A | 0.0698616 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0654668 |
| TMSB4X | thymosin beta 4, X-linked | 0.0565954 |
| PLEC | plectin | 0.0564018 |
| ATP13A3 | ATPase type 13A3 | 0.0554081 |
| SMAD3 | SMAD family member 3 | 0.0550569 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0540552 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0484281 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0477984 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0451179 |
| APP | amyloid beta (A4) precursor protein | 0.0429747 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0415673 |
| STC1 | stanniocalcin 1 | 0.0378434 |
| SPAG9 | sperm associated antigen 9 | 0.0371632 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0366873 |
| NAV2 | neuron navigator 2 | 0.0355398 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0353515 |
| ADM | adrenomedullin | 0.0352882 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0348511 |
| RPN1 | ribophorin I | 0.0324272 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0293841 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0290195 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0285251 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.02815 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0280344 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0279514 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0272666 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0260048 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0255056 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0254604 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0254019 |
| COL5A1 | collagen, type V, alpha 1 | 0.0247309 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0246676 |
| FMNL2 | formin-like 2 | 0.024311 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0239062 |
| FLNB | filamin B, beta | 0.023819 |
| SDC4 | syndecan 4 | 0.0233546 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0230583 |
| AHNAK | AHNAK nucleoprotein | 0.0229578 |
| ANTXR2 | anthrax toxin receptor 2 | 0.022491 |
| RASA2 | RAS p21 protein activator 2 | 0.0224346 |
| HLA-C | major histocompatibility complex, class I, C | 0.0223897 |
| COL6A2 | collagen, type VI, alpha 2 | 0.022316 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0222852 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.0222588 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0222051 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0219926 |
| RASA3 | RAS p21 protein activator 3 | 0.0219056 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.0218821 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0216436 |
| HAS2 | hyaluronan synthase 2 | 0.0215718 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0212357 |
| OGA | O-GlcNAcase | 0.0212066 |
| CAVIN1 | caveolae associated protein 1 | 0.021059 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0210179 |
| ECT2 | epithelial cell transforming 2 | 0.0208898 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0207758 |
| MKI67 | marker of proliferation Ki-67 | 0.0206985 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0201665 |
| ANXA2 | annexin A2 | 0.0201181 |
| YEATS2 | YEATS domain containing 2 | 0.0193753 |
| CTSB | cathepsin B | 0.0188842 |
| FLNA | filamin A, alpha | 0.0188163 |
| THRAP3 | thyroid hormone receptor associated protein 3 | 0.0187849 |
| ARRDC3 | arrestin domain containing 3 | 0.0187255 |
| MYO9B | myosin IXB | 0.0185021 |
| COPG1 | coatomer protein complex, subunit gamma 1 | 0.0184509 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.018124 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0180896 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0177586 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0172109 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0170774 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | 0.0168918 |
| TPR | translocated promoter region, nuclear basket protein | 0.0166956 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | 0.0162216 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0161637 |
| ENTPD4 | ectonucleoside triphosphate diphosphohydrolase 4 | 0.0161154 |
| TNS1 | tensin 1 | 0.015877 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0157538 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0156661 |
| EIF3D | eukaryotic translation initiation factor 3, subunit D | 0.0154564 |
| SEPTIN9 | septin 9 | 0.0153747 |
| STK4 | serine/threonine kinase 4 | 0.0153561 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0153357 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0152888 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0151711 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0151677 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0151032 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0150598 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0150257 |
| STX1A | syntaxin 1A (brain) | 0.0150155 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0149796 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0148172 |
| CASC3 | cancer susceptibility candidate 3 | 0.0148049 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0147971 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.180716 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.141251 |
| VIM | vimentin | -0.13326 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.128773 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.128016 |
| NDRG1 | N-myc downstream regulated 1 | -0.113772 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0982421 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0952836 |
| CDH13 | cadherin 13 | -0.0908489 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0883564 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0786116 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0771821 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0724574 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0710525 |
| COL1A2 | collagen, type I, alpha 2 | -0.0702019 |
| TMSB10 | thymosin beta 10 | -0.0696222 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0693899 |
| ENO1 | enolase 1, (alpha) | -0.0685795 |
| FBN1 | fibrillin 1 | -0.0634952 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.06306 |
| FTL | ferritin, light polypeptide | -0.0626117 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0623082 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0578294 |
| IL6ST | interleukin 6 signal transducer | -0.0548604 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0535686 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.05344 |
| MT2A | metallothionein 2A | -0.0528586 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0519298 |
| LDHA | lactate dehydrogenase A | -0.0509321 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0498765 |
| CALD1 | caldesmon 1 | -0.0495989 |
| RPS6 | ribosomal protein S6 | -0.0490136 |
| COL1A1 | collagen, type I, alpha 1 | -0.0486246 |
| VCAN | versican | -0.0484981 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0480169 |
| CADM1 | cell adhesion molecule 1 | -0.0469069 |
| EGR1 | early growth response 1 | -0.0469056 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0465584 |
| RPS8 | ribosomal protein S8 | -0.0451438 |
| ASPH | aspartate beta-hydroxylase | -0.0450062 |
| DSTN | destrin (actin depolymerizing factor) | -0.0447532 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0445872 |
| CLIC4 | chloride intracellular channel 4 | -0.0442993 |
| TPM4 | tropomyosin 4 | -0.043087 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0426142 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.041583 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0410719 |
| POTEF | POTE ankyrin domain family, member F | -0.0406146 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0402683 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0401919 |
| CNTN5 | contactin 5 | -0.039999 |
| CD44 | CD44 molecule (Indian blood group) | -0.039426 |
| EGFR | epidermal growth factor receptor | -0.0393279 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0390554 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0386898 |
| TAPBP | TAP binding protein (tapasin) | -0.0375644 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0369791 |
| VCL | vinculin | -0.0368711 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0368702 |
| PFN1 | profilin 1 | -0.0360065 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0357351 |
| RPL35A | ribosomal protein L35a | -0.0344355 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0341548 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0340351 |
| HMGA1 | high mobility group AT-hook 1 | -0.034004 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0337472 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0328193 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0322433 |
| PKM | pyruvate kinase, muscle | -0.0321983 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0307926 |
| TRAM1 | translocation associated membrane protein 1 | -0.0306452 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.030258 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0302207 |
| GLIS3 | GLIS family zinc finger 3 | -0.0293219 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.028977 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0288314 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0287231 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0282117 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0281213 |
| S100A9 | S100 calcium binding protein A9 | -0.027959 |
| BBX | bobby sox homolog (Drosophila) | -0.0278308 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0277254 |
| RPLP0 | ribosomal protein, large, P0 | -0.027672 |
| RPS12 | ribosomal protein S12 | -0.0275432 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0275231 |
| RACK1 | receptor for activated C kinase 1 | -0.0272781 |
| RPL28 | ribosomal protein L28 | -0.027248 |
| SQSTM1 | sequestosome 1 | -0.0262822 |
| TENM3 | teneurin transmembrane protein 3 | -0.0261777 |
| EXOC4 | exocyst complex component 4 | -0.026172 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0261267 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0258708 |
| IL6 | interleukin 6 | -0.0256562 |
| TPM1 | tropomyosin 1 (alpha) | -0.0256017 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0255376 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0254444 |
| RPL8 | ribosomal protein L8 | -0.0250029 |
| CANX | calnexin | -0.0249196 |
| NEK10 | NIMA-related kinase 10 | -0.0248908 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0247943 |
