Delamanid_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Delamanid perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Delamanid_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.463671
EEF2 eukaryotic translation elongation factor 2 0.151005
SDC4 syndecan 4 0.147954
SPTBN1 spectrin, beta, non-erythrocytic 1 0.147704
AKAP12 A kinase (PRKA) anchor protein 12 0.137191
PEG3 paternally expressed 3 0.12261
SAMD4A sterile alpha motif domain containing 4A 0.104988
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.102686
FBF1 Fas (TNFRSF6) binding factor 1 0.0950176
DDIT4 DNA-damage-inducible transcript 4 0.0876811
FTH1 ferritin, heavy polypeptide 1 0.0721132
VEGFA vascular endothelial growth factor A 0.0666632
TNS1 tensin 1 0.0636427
BHLHE40 basic helix-loop-helix family, member e40 0.062589
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0618801
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0611024
ERRFI1 ERBB receptor feedback inhibitor 1 0.0576527
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0568658
SMAD3 SMAD family member 3 0.0557866
DSCAM Down syndrome cell adhesion molecule 0.0522384
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0509873
CALR calreticulin 0.0506456
EIF4B eukaryotic translation initiation factor 4B 0.0491466
ASPH aspartate beta-hydroxylase 0.0460606
HOOK2 hook microtubule-tethering protein 2 0.0452571
DSPP dentin sialophosphoprotein 0.0442812
AFDN afadin, adherens junction formation factor 0.0442041
MYH9 myosin, heavy chain 9, non-muscle 0.0440802
EXT1 exostosin glycosyltransferase 1 0.0438445
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0430668
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0429895
CTSB cathepsin B 0.0427287
PLEC plectin 0.0404542
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0403784
FAT1 FAT atypical cadherin 1 0.0402985
KDM3A lysine (K)-specific demethylase 3A 0.0386728
RPL3 ribosomal protein L3 0.0379726
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0379616
KRT8 keratin 8, type II 0.0376851
JAG1 jagged 1 0.0374124
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0372988
APOA1 apolipoprotein A-I 0.0370799
ATXN1 ataxin 1 0.0368102
FMNL2 formin-like 2 0.0362259
FAM107B family with sequence similarity 107, member B 0.0358313
MACF1 microtubule-actin crosslinking factor 1 0.0357057
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0354637
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0354279
ACTG1 actin gamma 1 0.0352875
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0350582
IGF1R insulin-like growth factor 1 receptor 0.0340701
RPL7A ribosomal protein L7a 0.0334331
IQSEC1 IQ motif and Sec7 domain 1 0.0331415
NFE2L1 nuclear factor, erythroid 2-like 1 0.0331309
ZMIZ1 zinc finger, MIZ-type containing 1 0.0326334
HSPA8 heat shock 70kDa protein 8 0.0323065
FLNB filamin B, beta 0.031689
EFNA1 ephrin-A1 0.0315551
EIF4A2 eukaryotic translation initiation factor 4A2 0.0311136
SRRM2 serine/arginine repetitive matrix 2 0.0308802
SVIL supervillin 0.0308348
TRIO trio Rho guanine nucleotide exchange factor 0.0307506
GRB10 growth factor receptor-bound protein 10 0.0301689
ADM adrenomedullin 0.0301106
CLTB clathrin, light chain B 0.0300371
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0295378
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0293116
LPP LIM domain containing preferred translocation partner in lipoma 0.0289535
ZFAND3 zinc finger, AN1-type domain 3 0.0288619
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0284054
NKD1 naked cuticle homolog 1 (Drosophila) 0.0283156
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0278791
MCL1 myeloid cell leukemia 1 0.0278694
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0276166
ARHGAP5 Rho GTPase activating protein 5 0.0265952
COL7A1 collagen, type VII, alpha 1 0.0264759
DTNA dystrobrevin, alpha 0.0262713
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0251926
TPT1 tumor protein, translationally-controlled 1 0.0249435
CAMTA1 calmodulin binding transcription activator 1 0.0245627
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0242668
CCNL2 cyclin L2 0.0240482
RPL4 ribosomal protein L4 0.0233983
NACA nascent polypeptide-associated complex alpha subunit 0.0233293
INTS6 integrator complex subunit 6 0.0231704
SFTPA2 surfactant protein A2 0.0230362
VCL vinculin 0.0228102
EEF1G eukaryotic translation elongation factor 1 gamma 0.0228021
ANXA5 annexin A5 0.0221874
FNIP1 folliculin interacting protein 1 0.0218353
RPL23 ribosomal protein L23 0.0218046
ARHGAP9 Rho GTPase activating protein 9 0.021466
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.021452
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.021179
RNF213 ring finger protein 213 0.0211778
ACTN4 actinin, alpha 4 0.0210888
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0207922
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0207852
RPN1 ribophorin I 0.02056
FLNA filamin A, alpha 0.0205583

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.278217
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.180781
APOB apolipoprotein B -0.144007
EML4 echinoderm microtubule associated protein like 4 -0.067756
RPS6 ribosomal protein S6 -0.0554251
EHBP1 EH domain binding protein 1 -0.052869
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0470442
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0461867
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0455372
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0451614
JMJD1C jumonji domain containing 1C -0.0431424
LYZ lysozyme -0.0422859
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0418998
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0407783
PERP PERP, TP53 apoptosis effector -0.0404531
ITGA1 integrin, alpha 1 -0.0393433
VMP1 vacuole membrane protein 1 -0.0391332
TRIM26 tripartite motif containing 26 -0.0383802
MAML2 mastermind-like 2 (Drosophila) -0.0375273
A2M alpha-2-macroglobulin -0.0343932
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.032722
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.032685
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0323042
RPS2 ribosomal protein S2 -0.0322465
ZBTB20 zinc finger and BTB domain containing 20 -0.0317304
MBNL3 muscleblind-like splicing regulator 3 -0.0311356
NAP1L1 nucleosome assembly protein 1-like 1 -0.0298837
RRBP1 ribosome binding protein 1 -0.0290117
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0276587
PCBP2 poly(rC) binding protein 2 -0.025936
SOS1 son of sevenless homolog 1 (Drosophila) -0.0258148
RPLP0 ribosomal protein, large, P0 -0.0257388
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0251194
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0248535
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0247668
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0245315
PDIA3 protein disulfide isomerase family A, member 3 -0.0242227
FTL ferritin, light polypeptide -0.0239662
PEG10 paternally expressed 10 -0.0238743
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0235756
GMDS GDP-mannose 4,6-dehydratase -0.0235358
ADGRG6 adhesion G protein-coupled receptor G6 -0.0232357
DENND4A DENN/MADD domain containing 4A -0.022673
CDK6 cyclin-dependent kinase 6 -0.0224617
PTPRM protein tyrosine phosphatase, receptor type, M -0.0222869
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0222805
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0221807
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0221508
NFIA nuclear factor I/A -0.0216396
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0214092
CST3 cystatin C -0.0213943
SESTD1 SEC14 and spectrin domains 1 -0.021382
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0212988
SMAD5 SMAD family member 5 -0.0211415
GPC6 glypican 6 -0.0210705
TXNRD1 thioredoxin reductase 1 -0.0210477
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.020919
RPS12 ribosomal protein S12 -0.0209165
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0208717
CYB5R3 cytochrome b5 reductase 3 -0.0207159
MYADM myeloid-associated differentiation marker -0.020543
HP1BP3 heterochromatin protein 1, binding protein 3 -0.020536
RBM39 RNA binding motif protein 39 -0.0202984
RPL10A ribosomal protein L10a -0.0201144
PDGFB platelet-derived growth factor beta polypeptide -0.0201122
MATN3 matrilin 3 -0.0198802
TRA2A transformer 2 alpha homolog (Drosophila) -0.0197842
APOH apolipoprotein H (beta-2-glycoprotein I) -0.019622
BCLAF1 BCL2-associated transcription factor 1 -0.0196216
TMEM123 transmembrane protein 123 -0.0194948
AKAP9 A kinase (PRKA) anchor protein 9 -0.0193821
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0191602
SELENOP selenoprotein P -0.0190528
ZMYND8 zinc finger, MYND-type containing 8 -0.0190223
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.018821
USP34 ubiquitin specific peptidase 34 -0.0185996
CADM1 cell adhesion molecule 1 -0.0185957
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.0184947
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0184157
APOA2 apolipoprotein A-II -0.018369
RPL7 ribosomal protein L7 -0.0181336
PDS5A PDS5 cohesin associated factor A -0.0180321
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0175633
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0175023
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.0174568
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0174364
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0171785
MATR3 matrin 3 -0.0171728
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like -0.0170555
FGL1 fibrinogen-like 1 -0.0170362
RPL21 ribosomal protein L21 -0.0169181
ACYP2 acylphosphatase 2, muscle type -0.0168781
FAM135A family with sequence similarity 135, member A -0.016817
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0167057
PNISR PNN-interacting serine/arginine-rich protein -0.0167023
SOX6 SRY (sex determining region Y)-box 6 -0.0165827
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0165208
TRAM1 translocation associated membrane protein 1 -0.0164754
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0164188
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0164022