Delamanid_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Delamanid perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Delamanid_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.235025
FTH1 ferritin, heavy polypeptide 1 0.223526
TMSB4X thymosin beta 4, X-linked 0.184046
PLEC plectin 0.117257
MYH9 myosin, heavy chain 9, non-muscle 0.11544
FLNA filamin A, alpha 0.113507
SMAD3 SMAD family member 3 0.105947
PODXL podocalyxin-like 0.103972
AHNAK AHNAK nucleoprotein 0.0916949
IGFBP6 insulin-like growth factor binding protein 6 0.0819366
HSPG2 heparan sulfate proteoglycan 2 0.0804261
BCL2L1 BCL2-like 1 0.078696
EHBP1L1 EH domain binding protein 1-like 1 0.0763669
RPL7A ribosomal protein L7a 0.0751251
PTMA prothymosin, alpha 0.071305
MYOF myoferlin 0.0692895
NAV2 neuron navigator 2 0.0609405
FN1 fibronectin 1 0.0607341
BHLHE40 basic helix-loop-helix family, member e40 0.0603194
SRRM2 serine/arginine repetitive matrix 2 0.0568358
CALR calreticulin 0.0549913
MEGF6 multiple EGF-like-domains 6 0.0532538
EEF2 eukaryotic translation elongation factor 2 0.052373
ADM adrenomedullin 0.0506186
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0489965
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0485259
EMP1 epithelial membrane protein 1 0.0483297
ACTG1 actin gamma 1 0.0479857
RPL4 ribosomal protein L4 0.0461346
APP amyloid beta (A4) precursor protein 0.0435034
LAMA5 laminin, alpha 5 0.0433097
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0422095
TMSB10 thymosin beta 10 0.0420712
CAPRIN2 caprin family member 2 0.0386156
MPRIP myosin phosphatase Rho interacting protein 0.0382795
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0379855
NTSR1 neurotensin receptor 1 (high affinity) 0.0377708
EIF4H eukaryotic translation initiation factor 4H 0.0376333
HLA-B major histocompatibility complex, class I, B 0.0375021
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0374645
PCDH1 protocadherin 1 0.0363656
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0362984
PRELID2 PRELI domain containing 2 0.0362688
AHNAK2 AHNAK nucleoprotein 2 0.0360099
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0359885
HLA-C major histocompatibility complex, class I, C 0.0358954
ZMIZ1 zinc finger, MIZ-type containing 1 0.0352628
BLCAP bladder cancer associated protein 0.0351015
RPL23 ribosomal protein L23 0.0349973
AMOTL1 angiomotin like 1 0.0348266
CEP250 centrosomal protein 250kDa 0.0344138
JAG1 jagged 1 0.0344006
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0342351
NCOR2 nuclear receptor corepressor 2 0.0337791
RPL3 ribosomal protein L3 0.033666
KIAA1217 KIAA1217 0.0332433
COL17A1 collagen, type XVII, alpha 1 0.0330406
MKI67 marker of proliferation Ki-67 0.0329014
RPL12 ribosomal protein L12 0.0327627
TSPAN3 tetraspanin 3 0.0325124
OSMR oncostatin M receptor 0.0320866
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0319184
ANO1 anoctamin 1, calcium activated chloride channel 0.0314981
PRRC2C proline-rich coiled-coil 2C 0.0311166
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0306844
EIF3D eukaryotic translation initiation factor 3, subunit D 0.0297504
ZC3H13 zinc finger CCCH-type containing 13 0.0295927
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.0295747
SH3PXD2A SH3 and PX domains 2A 0.0291517
RPL19 ribosomal protein L19 0.0291324
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0286499
EPHA2 EPH receptor A2 0.0285741
TNS4 tensin 4 0.0284798
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0284308
HSPA8 heat shock 70kDa protein 8 0.0282071
C1D C1D nuclear receptor corepressor 0.0277041
DOCK5 dedicator of cytokinesis 5 0.0277018
YBX1 Y box binding protein 1 0.027558
KRT17 keratin 17, type I 0.0274494
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0271149
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0268975
SEPTIN9 septin 9 0.0266688
SOX13 SRY (sex determining region Y)-box 13 0.0264276
TBC1D22A TBC1 domain family, member 22A 0.0263896
LAMC2 laminin, gamma 2 0.0262714
TPM3 tropomyosin 3 0.0262542
SDC4 syndecan 4 0.0257924
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0253501
TMED9 transmembrane emp24 protein transport domain containing 9 0.0247308
BCAR3 breast cancer anti-estrogen resistance 3 0.0243989
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0242908
MYO10 myosin X 0.0239302
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0237242
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 0.0237104
EIF4A2 eukaryotic translation initiation factor 4A2 0.0235821
RASA3 RAS p21 protein activator 3 0.0235533
EIF4B eukaryotic translation initiation factor 4B 0.0234128
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0229497
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0228813
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0224946

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.213178
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.12233
LDHA lactate dehydrogenase A -0.0828777
ENO1 enolase 1, (alpha) -0.0809591
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0783628
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0777955
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0768407
PGK1 phosphoglycerate kinase 1 -0.0577811
GOLGA4 golgin A4 -0.0558331
MEF2A myocyte enhancer factor 2A -0.0556329
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0551428
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0538635
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0527956
CANX calnexin -0.0496727
STC1 stanniocalcin 1 -0.0486792
SEC31A SEC31 homolog A (S. cerevisiae) -0.0486086
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0475179
SQLE squalene epoxidase -0.04624
DSTN destrin (actin depolymerizing factor) -0.0432389
PDIA3 protein disulfide isomerase family A, member 3 -0.0401562
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0389143
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0381379
FNDC3B fibronectin type III domain containing 3B -0.037823
PLS3 plastin 3 -0.0378131
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0376033
CAV1 caveolin 1, caveolae protein, 22kDa -0.0367927
ZNF292 zinc finger protein 292 -0.0363526
NAMPT nicotinamide phosphoribosyltransferase -0.0362269
TAGLN2 transgelin 2 -0.0359384
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0358466
PKM pyruvate kinase, muscle -0.0355905
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0353933
RPS13 ribosomal protein S13 -0.0350721
RBM39 RNA binding motif protein 39 -0.0344498
RPLP0 ribosomal protein, large, P0 -0.033871
COPB1 coatomer protein complex, subunit beta 1 -0.033722
RAI14 retinoic acid induced 14 -0.0334153
UBE2H ubiquitin-conjugating enzyme E2H -0.0329899
SAMD9 sterile alpha motif domain containing 9 -0.0326203
XPO1 exportin 1 -0.0326195
TRAM1 translocation associated membrane protein 1 -0.0324018
WASF2 WAS protein family, member 2 -0.0321144
SQSTM1 sequestosome 1 -0.0314051
PDE4D phosphodiesterase 4D, cAMP-specific -0.0312161
AKAP9 A kinase (PRKA) anchor protein 9 -0.0311748
MYADM myeloid-associated differentiation marker -0.0310485
RPL21 ribosomal protein L21 -0.030989
RIOK3 RIO kinase 3 -0.0309566
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0306892
PFN1 profilin 1 -0.0304941
TMEM123 transmembrane protein 123 -0.0299659
CSDE1 cold shock domain containing E1, RNA-binding -0.0299388
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0298156
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0297659
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.029612
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -0.029072
JMJD1C jumonji domain containing 1C -0.0289629
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0289173
S100A9 S100 calcium binding protein A9 -0.0288558
S100A6 S100 calcium binding protein A6 -0.0286841
ARF4 ADP-ribosylation factor 4 -0.0286501
HLA-E major histocompatibility complex, class I, E -0.0281875
LMAN1 lectin, mannose-binding, 1 -0.0280984
FNDC3A fibronectin type III domain containing 3A -0.0278117
DENND4C DENN/MADD domain containing 4C -0.0277118
TXNIP thioredoxin interacting protein -0.0274366
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0273109
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0272675
QKI QKI, KH domain containing, RNA binding -0.0270555
RTN3 reticulon 3 -0.026949
SRP54 signal recognition particle 54kDa -0.0268591
BIRC6 baculoviral IAP repeat containing 6 -0.0267775
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0266572
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0266546
TFG TRK-fused gene -0.0266223
SDCBP syndecan binding protein (syntenin) -0.0265342
ESYT2 extended synaptotagmin-like protein 2 -0.0259878
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0254633
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0248978
RPL5 ribosomal protein L5 -0.024777
TGM2 transglutaminase 2 -0.024721
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0246986
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.024698
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0246204
RPL27A ribosomal protein L27a -0.0246008
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0245759
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0243217
SPINK5 serine peptidase inhibitor, Kazal type 5 -0.0242922
DPYD dihydropyrimidine dehydrogenase -0.024241
PRRC1 proline-rich coiled-coil 1 -0.0241387
ZMYND8 zinc finger, MYND-type containing 8 -0.0239839
SPAG9 sperm associated antigen 9 -0.0239706
PDIA6 protein disulfide isomerase family A, member 6 -0.0238494
RPS21 ribosomal protein S21 -0.0237455
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0237209
RPS8 ribosomal protein S8 -0.0232824
ITCH itchy E3 ubiquitin protein ligase -0.0230773
MBNL1 muscleblind-like splicing regulator 1 -0.0230394
LNPEP leucyl/cystinyl aminopeptidase -0.0228145
TAPBP TAP binding protein (tapasin) -0.0227841