Delamanid_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Delamanid perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Delamanid_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.173785
VEGFA vascular endothelial growth factor A 0.117472
EZR ezrin 0.109719
SPTBN1 spectrin, beta, non-erythrocytic 1 0.107219
FAT1 FAT atypical cadherin 1 0.100231
TMSB4X thymosin beta 4, X-linked 0.0990605
AREG amphiregulin 0.0990084
LMO7 LIM domain 7 0.0946825
ONECUT3 one cut homeobox 3 0.0732839
CALR calreticulin 0.0712376
FAM13A family with sequence similarity 13, member A 0.0711605
MYH9 myosin, heavy chain 9, non-muscle 0.0670148
KRT8 keratin 8, type II 0.063736
RPL3 ribosomal protein L3 0.061262
MYO1E myosin IE 0.0597814
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0572173
B2M beta-2-microglobulin 0.0541513
DDIT4 DNA-damage-inducible transcript 4 0.0526536
MYO5B myosin VB 0.0516403
HSPA8 heat shock 70kDa protein 8 0.0500972
FLNB filamin B, beta 0.0488262
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0453276
MUC13 mucin 13, cell surface associated 0.044919
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0440686
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0433315
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0431563
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0428874
KLF5 Kruppel-like factor 5 (intestinal) 0.0417198
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0415372
APP amyloid beta (A4) precursor protein 0.0414769
KDM3A lysine (K)-specific demethylase 3A 0.0410263
CTNND1 catenin (cadherin-associated protein), delta 1 0.0404694
PRELID2 PRELI domain containing 2 0.0394918
ITGA6 integrin, alpha 6 0.0393167
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0393056
ANXA2 annexin A2 0.0381366
NDRG1 N-myc downstream regulated 1 0.0380759
EIF4A2 eukaryotic translation initiation factor 4A2 0.0380666
DSCAM Down syndrome cell adhesion molecule 0.0380151
TXNIP thioredoxin interacting protein 0.0379139
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0364592
ANXA11 annexin A11 0.0363009
SDC4 syndecan 4 0.0361739
ITPRID2 ITPR interacting domain containing 2 0.0357206
MCL1 myeloid cell leukemia 1 0.0353174
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0348531
EPHA2 EPH receptor A2 0.0347374
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.034702
MACF1 microtubule-actin crosslinking factor 1 0.0340317
EXT1 exostosin glycosyltransferase 1 0.034
GRB10 growth factor receptor-bound protein 10 0.0338649
SPAG9 sperm associated antigen 9 0.0336947
KMT2E lysine (K)-specific methyltransferase 2E 0.033547
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0333468
PIGR polymeric immunoglobulin receptor 0.0329687
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0323912
FTH1 ferritin, heavy polypeptide 1 0.0323683
MPRIP myosin phosphatase Rho interacting protein 0.0309277
EREG epiregulin 0.0307677
MYH14 myosin, heavy chain 14, non-muscle 0.0304735
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.0304199
PLAUR plasminogen activator, urokinase receptor 0.0303379
MBNL1 muscleblind-like splicing regulator 1 0.0302412
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0301901
NUMA1 nuclear mitotic apparatus protein 1 0.0298339
AFF1 AF4/FMR2 family, member 1 0.0297278
NCOR2 nuclear receptor corepressor 2 0.029665
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0296324
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0295744
FDXR ferredoxin reductase 0.029188
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 0.0287784
CTSB cathepsin B 0.0287529
WDR45B WD repeat domain 45B 0.0287093
FHL2 four and a half LIM domains 2 0.0279776
MINK1 misshapen-like kinase 1 0.0276621
RPN1 ribophorin I 0.0276275
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0275709
OASL 2'-5'-oligoadenylate synthetase-like 0.0272427
RPL7A ribosomal protein L7a 0.0272406
WAC WW domain containing adaptor with coiled-coil 0.0271979
ERRFI1 ERBB receptor feedback inhibitor 1 0.0271027
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.0270746
USP6NL USP6 N-terminal like 0.0268923
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0267312
HDLBP high density lipoprotein binding protein 0.0267093
TSC22D1 TSC22 domain family, member 1 0.0265402
ANKRD11 ankyrin repeat domain 11 0.0265061
BHLHE40 basic helix-loop-helix family, member e40 0.0264047
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0262895
DNM2 dynamin 2 0.026253
CSNK1A1 casein kinase 1, alpha 1 0.0261139
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0260878
LOC102724023 ES1 protein homolog, mitochondrial 0.0260713
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.0260644
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0260242
JUN jun proto-oncogene 0.0259818
RIGI RNA sensor RIG-I 0.025784
JAG1 jagged 1 0.0255654
EIF4B eukaryotic translation initiation factor 4B 0.0254244
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0253874

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.173759
NPSR1 neuropeptide S receptor 1 -0.149662
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.146276
NALF1 NALCN channel auxiliary factor 1 -0.10559
GMDS GDP-mannose 4,6-dehydratase -0.105031
GPHN gephyrin -0.0941983
TMSB10 thymosin beta 10 -0.075467
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0731602
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0708048
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0702144
RPS6 ribosomal protein S6 -0.0699303
ALCAM activated leukocyte cell adhesion molecule -0.0647797
EHBP1 EH domain binding protein 1 -0.0514094
PDE4D phosphodiesterase 4D, cAMP-specific -0.0507746
PERP PERP, TP53 apoptosis effector -0.0494291
HMGA1 high mobility group AT-hook 1 -0.0494054
S100A6 S100 calcium binding protein A6 -0.049149
BIRC6 baculoviral IAP repeat containing 6 -0.0472498
RPLP0 ribosomal protein, large, P0 -0.0465613
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0455864
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0437217
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0434823
PDIA3 protein disulfide isomerase family A, member 3 -0.0428827
RPL35A ribosomal protein L35a -0.0426103
MON2 MON2 homolog (S. cerevisiae) -0.0405919
RPLP1 ribosomal protein, large, P1 -0.0405529
RPS8 ribosomal protein S8 -0.0399156
CADPS Ca++-dependent secretion activator -0.039155
CCND1 cyclin D1 -0.0389061
GCC2 GRIP and coiled-coil domain containing 2 -0.0387955
RPL23 ribosomal protein L23 -0.0379012
RPL34 ribosomal protein L34 -0.037308
RPL12 ribosomal protein L12 -0.0367994
FHIT fragile histidine triad -0.0366418
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0363636
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0361096
AGR2 anterior gradient 2 -0.0356537
RPL7 ribosomal protein L7 -0.0355843
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0349605
GOLGA4 golgin A4 -0.0349238
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0348999
EIF5B eukaryotic translation initiation factor 5B -0.0345877
AKAP9 A kinase (PRKA) anchor protein 9 -0.0345771
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0340277
MBD5 methyl-CpG binding domain protein 5 -0.0332049
GREB1L growth regulation by estrogen in breast cancer-like -0.0327326
SAMD5 sterile alpha motif domain containing 5 -0.0325893
PCDHB16 protocadherin beta 16 -0.0325798
S100A10 S100 calcium binding protein A10 -0.0322979
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0321802
PTBP3 polypyrimidine tract binding protein 3 -0.0318552
FERMT1 fermitin family member 1 -0.031842
CENPF centromere protein F, 350/400kDa -0.0317513
RPL11 ribosomal protein L11 -0.0313021
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0308686
PKP4 plakophilin 4 -0.0305316
PTPRK protein tyrosine phosphatase, receptor type, K -0.0303503
SMYD3 SET and MYND domain containing 3 -0.0303484
MECOM MDS1 and EVI1 complex locus -0.030108
RFX7 regulatory factor X, 7 -0.0299892
LSAMP limbic system-associated membrane protein -0.029911
SAMD12 sterile alpha motif domain containing 12 -0.029862
SERBP1 SERPINE1 mRNA binding protein 1 -0.0297297
SERINC5 serine incorporator 5 -0.0296519
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0295708
THSD4 thrombospondin, type I, domain containing 4 -0.0294101
RPS19 ribosomal protein S19 -0.0291934
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0286424
TAS2R14 taste receptor, type 2, member 14 -0.028615
MUC17 mucin 17, cell surface associated -0.02842
CCSER1 coiled-coil serine-rich protein 1 -0.028353
SPIDR scaffolding protein involved in DNA repair -0.0283466
RPS24 ribosomal protein S24 -0.0283141
CDK6 cyclin-dependent kinase 6 -0.0278201
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.02774
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0274201
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0274183
ZBTB20 zinc finger and BTB domain containing 20 -0.0274065
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0273839
PATJ PATJ crumbs cell polarity complex component -0.0270684
VDAC1 voltage-dependent anion channel 1 -0.026759
TNS4 tensin 4 -0.0264333
FRMD5 FERM domain containing 5 -0.0262104
DLG1 discs, large homolog 1 (Drosophila) -0.0261224
RPL27A ribosomal protein L27a -0.0260741
SLC35F3 solute carrier family 35, member F3 -0.025963
CD46 CD46 molecule, complement regulatory protein -0.0259425
ARID5B AT rich interactive domain 5B (MRF1-like) -0.025933
MGST1 microsomal glutathione S-transferase 1 -0.0258553
HMGB1 high mobility group box 1 -0.0257584
RABGAP1L RAB GTPase activating protein 1-like -0.0257194
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0257096
RPL36 ribosomal protein L36 -0.0256314
PTPRR protein tyrosine phosphatase, receptor type, R -0.0256076
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.0252736
AHR aryl hydrocarbon receptor -0.0250182
ARHGAP6 Rho GTPase activating protein 6 -0.0249
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0248644
MAML2 mastermind-like 2 (Drosophila) -0.0246046
JMJD1C jumonji domain containing 1C -0.0245824