Delamanid_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Delamanid perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Delamanid_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.128116
SMAD3 SMAD family member 3 0.113791
MT2A metallothionein 2A 0.0886487
VEGFA vascular endothelial growth factor A 0.0780859
DSCAM Down syndrome cell adhesion molecule 0.0750918
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0624129
VIM vimentin 0.0616619
AKAP12 A kinase (PRKA) anchor protein 12 0.0576758
CTNND1 catenin (cadherin-associated protein), delta 1 0.0538457
EEF2 eukaryotic translation elongation factor 2 0.0534365
ARHGAP5 Rho GTPase activating protein 5 0.0524598
NPC1 Niemann-Pick disease, type C1 0.0509057
RPS19 ribosomal protein S19 0.0505556
RPL7A ribosomal protein L7a 0.0453338
DOCK5 dedicator of cytokinesis 5 0.0444547
ADM adrenomedullin 0.0436131
RPL4 ribosomal protein L4 0.0430222
RPS6 ribosomal protein S6 0.0420988
RAB27B RAB27B, member RAS oncogene family 0.0396128
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0382676
TMSB4X thymosin beta 4, X-linked 0.0361476
GNA12 guanine nucleotide binding protein (G protein) alpha 12 0.0344299
CLTC clathrin, heavy chain (Hc) 0.0329947
SREBF2 sterol regulatory element binding transcription factor 2 0.0327383
RPL23 ribosomal protein L23 0.0325806
SETD5 SET domain containing 5 0.0325403
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0319898
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.031059
PTMA prothymosin, alpha 0.0302076
EGFR epidermal growth factor receptor 0.0302016
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0298612
HIPK2 homeodomain interacting protein kinase 2 0.0297554
OGA O-GlcNAcase 0.029722
CALR calreticulin 0.0295004
SEC23A Sec23 homolog A (S. cerevisiae) 0.0294076
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0289654
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0288583
FLNB filamin B, beta 0.0284834
SRRM2 serine/arginine repetitive matrix 2 0.0280968
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0280173
ANKRD36 ankyrin repeat domain 36 0.0277056
CNOT12 CCR4-NOT transcription complex subunit 12 0.0274706
BACE2 beta-site APP-cleaving enzyme 2 0.0270032
GLCCI1 glucocorticoid induced 1 0.0267744
RPS17 ribosomal protein S17 0.0267721
MMP2 matrix metallopeptidase 2 0.0258055
SDC4 syndecan 4 0.0257891
GSK3B glycogen synthase kinase 3 beta 0.0255508
EIF4H eukaryotic translation initiation factor 4H 0.0253498
EIF1 eukaryotic translation initiation factor 1 0.0250109
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0250083
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.024963
BHLHE40 basic helix-loop-helix family, member e40 0.0245575
THOC2 THO complex 2 0.0245428
RPL34 ribosomal protein L34 0.0244668
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0238602
DUSP5 dual specificity phosphatase 5 0.0237722
AGFG1 ArfGAP with FG repeats 1 0.0237043
GOLGA4 golgin A4 0.0233494
DAAM1 dishevelled associated activator of morphogenesis 1 0.0230516
NAV2 neuron navigator 2 0.0228944
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0228908
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0228136
RBM25 RNA binding motif protein 25 0.0226672
EHBP1L1 EH domain binding protein 1-like 1 0.0226549
RNF149 ring finger protein 149 0.0226074
MYH9 myosin, heavy chain 9, non-muscle 0.02257
TPR translocated promoter region, nuclear basket protein 0.0224383
ACTG1 actin gamma 1 0.0223503
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0222875
ARRDC3 arrestin domain containing 3 0.022109
TMED9 transmembrane emp24 protein transport domain containing 9 0.0220211
ANGPTL4 angiopoietin-like 4 0.0219135
PRRC2C proline-rich coiled-coil 2C 0.0218799
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0217869
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.0216808
HLA-C major histocompatibility complex, class I, C 0.0216676
PCNX1 pecanex 1 0.021587
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.021469
LUZP1 leucine zipper protein 1 0.0212644
GIGYF2 GRB10 interacting GYF protein 2 0.0212504
RPL9 ribosomal protein L9 0.0212008
CPNE1 copine I 0.0210899
RPL12 ribosomal protein L12 0.0210882
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0209981
KSR1 kinase suppressor of ras 1 0.0208487
BRD4 bromodomain containing 4 0.0208468
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0207445
ITCH itchy E3 ubiquitin protein ligase 0.0206253
ANXA10 annexin A10 0.0205749
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0202151
HLA-B major histocompatibility complex, class I, B 0.0202005
SAMD4A sterile alpha motif domain containing 4A 0.0200301
SPAG5 sperm associated antigen 5 0.0199639
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0199521
FNBP4 formin binding protein 4 0.0196647
FAM20C family with sequence similarity 20, member C 0.0196595
CEP250 centrosomal protein 250kDa 0.0196568
ARHGAP42 Rho GTPase activating protein 42 0.019592
ZEB2 zinc finger E-box binding homeobox 2 0.0194346

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.175395
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.120201
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.106613
FNDC3B fibronectin type III domain containing 3B -0.0898847
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0787404
NAMPT nicotinamide phosphoribosyltransferase -0.0744204
FN1 fibronectin 1 -0.0739735
GRB10 growth factor receptor-bound protein 10 -0.0695959
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0630833
RBM39 RNA binding motif protein 39 -0.0629312
DDIT3 DNA-damage-inducible transcript 3 -0.0617489
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.06017
GPC6 glypican 6 -0.059348
DPYD dihydropyrimidine dehydrogenase -0.0590228
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0581018
RAD51B RAD51 paralog B -0.0577474
SDK1 sidekick cell adhesion molecule 1 -0.0553862
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0543583
DLG1 discs, large homolog 1 (Drosophila) -0.0513453
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0509954
SOD2 superoxide dismutase 2, mitochondrial -0.0502482
NCOA7 nuclear receptor coactivator 7 -0.0498073
DST dystonin -0.0497522
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0496524
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.049265
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0491876
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0460081
PCBP2 poly(rC) binding protein 2 -0.0456519
VMP1 vacuole membrane protein 1 -0.0446683
MEF2A myocyte enhancer factor 2A -0.044511
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0442429
JMJD1C jumonji domain containing 1C -0.04415
MAML2 mastermind-like 2 (Drosophila) -0.0439011
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0427815
EGR1 early growth response 1 -0.0416152
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0404548
NRG1 neuregulin 1 -0.0397299
ELL2 elongation factor, RNA polymerase II, 2 -0.0396288
PARD3 par-3 family cell polarity regulator -0.0394686
PSD3 pleckstrin and Sec7 domain containing 3 -0.0390918
PDIA3 protein disulfide isomerase family A, member 3 -0.0390801
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0388288
CDH13 cadherin 13 -0.0386236
ZNF292 zinc finger protein 292 -0.0384415
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0381531
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0370476
MSRB3 methionine sulfoxide reductase B3 -0.0366834
ZSWIM6 zinc finger, SWIM-type containing 6 -0.036224
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0361989
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0352896
MAML3 mastermind-like 3 (Drosophila) -0.0349224
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0349014
USP3 ubiquitin specific peptidase 3 -0.0347889
ASPH aspartate beta-hydroxylase -0.0345741
KDM3A lysine (K)-specific demethylase 3A -0.0337938
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.0334721
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0334039
CANX calnexin -0.0331842
HMGA2 high mobility group AT-hook 2 -0.0326518
LRMDA leucine rich melanocyte differentiation associated -0.0324928
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0322947
ARF4 ADP-ribosylation factor 4 -0.0321841
IGFBP3 insulin-like growth factor binding protein 3 -0.0320227
EHBP1 EH domain binding protein 1 -0.0317856
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0317673
SAMD9 sterile alpha motif domain containing 9 -0.0316538
MECOM MDS1 and EVI1 complex locus -0.031514
VCL vinculin -0.0313118
RIOK3 RIO kinase 3 -0.0312511
TRA2A transformer 2 alpha homolog (Drosophila) -0.0310167
NDRG1 N-myc downstream regulated 1 -0.0307718
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0305606
GLIS3 GLIS family zinc finger 3 -0.0302627
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0301643
BLZF1 basic leucine zipper nuclear factor 1 -0.0301595
FAM13A family with sequence similarity 13, member A -0.030159
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0298487
EXOC4 exocyst complex component 4 -0.0298087
RAB1A RAB1A, member RAS oncogene family -0.0297645
CD44 CD44 molecule (Indian blood group) -0.0295769
ETV6 ets variant 6 -0.0293159
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0292954
EZR ezrin -0.0291476
HBP1 HMG-box transcription factor 1 -0.0288802
STC1 stanniocalcin 1 -0.0288676
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0287685
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0286749
TXNRD1 thioredoxin reductase 1 -0.0286585
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0286538
ENO1 enolase 1, (alpha) -0.0285743
YME1L1 YME1-like 1 ATPase -0.0285468
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0283172
ZEB1 zinc finger E-box binding homeobox 1 -0.0282642
ATXN1 ataxin 1 -0.0281729
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0278065
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0277181
PHF21A PHD finger protein 21A -0.0273385
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0272682
RLF rearranged L-myc fusion -0.0272485
KDM2A lysine (K)-specific demethylase 2A -0.0272101