| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Delamanid perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Delamanid_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FAM13A | family with sequence similarity 13, member A | 0.139107 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.136967 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.131499 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.105302 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0972484 |
| PDE10A | phosphodiesterase 10A | 0.0959396 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0948068 |
| CA8 | carbonic anhydrase VIII | 0.087736 |
| KRT17 | keratin 17, type I | 0.0829255 |
| SPAG9 | sperm associated antigen 9 | 0.0805009 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.079813 |
| RNF145 | ring finger protein 145 | 0.0781822 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0752059 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0747596 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0743966 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0729118 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0711409 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0701827 |
| OGA | O-GlcNAcase | 0.0684409 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0667067 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0657042 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0605037 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0593054 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0592862 |
| NGLY1 | N-glycanase 1 | 0.0585245 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0582291 |
| MCL1 | myeloid cell leukemia 1 | 0.0572848 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0572797 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0563505 |
| ANLN | anillin, actin binding protein | 0.0557255 |
| CA12 | carbonic anhydrase XII | 0.0549708 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0542683 |
| FNIP1 | folliculin interacting protein 1 | 0.0539294 |
| COLEC11 | collectin sub-family member 11 | 0.0514703 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0514473 |
| CENPF | centromere protein F, 350/400kDa | 0.0510218 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0494955 |
| KIF13B | kinesin family member 13B | 0.0477198 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0466383 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0462596 |
| TPD52 | tumor protein D52 | 0.0461825 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.046143 |
| YTHDC1 | YTH domain containing 1 | 0.0456236 |
| PHF3 | PHD finger protein 3 | 0.0454025 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0452264 |
| KYNU | kynureninase | 0.0448463 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0447029 |
| DST | dystonin | 0.0444378 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0443987 |
| APP | amyloid beta (A4) precursor protein | 0.0440125 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0439013 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0439001 |
| PTK2 | protein tyrosine kinase 2 | 0.0435619 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0435062 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0431721 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.043149 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0428277 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | 0.0425778 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0417809 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0416456 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0415192 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.0412859 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0410501 |
| ADNP | activity-dependent neuroprotector homeobox | 0.0408533 |
| ZNF207 | zinc finger protein 207 | 0.0402454 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0398195 |
| DTNA | dystrobrevin, alpha | 0.0395106 |
| SLMAP | sarcolemma associated protein | 0.0392065 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.039004 |
| JUN | jun proto-oncogene | 0.0387248 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0387019 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0386576 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0385648 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0383168 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0375769 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0374596 |
| RHEB | Ras homolog enriched in brain | 0.0373227 |
| CUL3 | cullin 3 | 0.0367164 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0355531 |
| PTEN | phosphatase and tensin homolog | 0.035422 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0350204 |
| USP3 | ubiquitin specific peptidase 3 | 0.0343489 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0339521 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0338907 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0335118 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0327775 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.032658 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0326463 |
| MKI67 | marker of proliferation Ki-67 | 0.0324587 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0311987 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0310008 |
| RAD21 | RAD21 homolog (S. pombe) | 0.030994 |
| RND3 | Rho family GTPase 3 | 0.030859 |
| SNX14 | sorting nexin 14 | 0.0306381 |
| ACVR1 | activin A receptor, type I | 0.0305045 |
| SEC63 | SEC63 homolog (S. cerevisiae) | 0.0304173 |
| CSNK1E | casein kinase 1, epsilon | 0.0303158 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0302283 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0300751 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0300586 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.135892 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.122994 |
| GRB10 | growth factor receptor-bound protein 10 | -0.120653 |
| LMO7 | LIM domain 7 | -0.113452 |
| LAMB3 | laminin, beta 3 | -0.112701 |
| ATOSA | atos homolog A | -0.11237 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.109663 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.104041 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0948128 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0826265 |
| PARD3 | par-3 family cell polarity regulator | -0.0788797 |
| AHNAK | AHNAK nucleoprotein | -0.0744913 |
| ABHD17C | abhydrolase domain containing 17C | -0.0737626 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0732203 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.072441 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0723991 |
| LAMC2 | laminin, gamma 2 | -0.0693286 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0682692 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0677806 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0670746 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0663674 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0655739 |
| DOCK4 | dedicator of cytokinesis 4 | -0.065123 |
| PRELID2 | PRELI domain containing 2 | -0.0628139 |
| MYOF | myoferlin | -0.0623485 |
| NEBL | nebulette | -0.061828 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0616637 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0601481 |
| GOLGB1 | golgin B1 | -0.0599536 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0598298 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0597017 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0577288 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0576702 |
| NBEA | neurobeachin | -0.0575335 |
| SVIL | supervillin | -0.0557041 |
| HOOK3 | hook microtubule-tethering protein 3 | -0.0554386 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0548848 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0547407 |
| TXNRD1 | thioredoxin reductase 1 | -0.0543448 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0535451 |
| MAPK6 | mitogen-activated protein kinase 6 | -0.0532371 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0530776 |
| HLA-B | major histocompatibility complex, class I, B | -0.0528906 |
| KIAA1217 | KIAA1217 | -0.0517918 |
| TMEM41B | transmembrane protein 41B | -0.051403 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0505396 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0496433 |
| XRN1 | 5'-3' exoribonuclease 1 | -0.0483957 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0476651 |
| PERP | PERP, TP53 apoptosis effector | -0.0472889 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0471823 |
| FMN1 | formin 1 | -0.047014 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0469975 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.046767 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0462384 |
| MYO5A | myosin VA (heavy chain 12, myoxin) | -0.0462354 |
| KIAA1671 | KIAA1671 | -0.0457616 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0448739 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0445233 |
| RCOR1 | REST corepressor 1 | -0.0444806 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0441051 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0433266 |
| TANK | TRAF family member-associated NFKB activator | -0.0432243 |
| DOCK9 | dedicator of cytokinesis 9 | -0.0431524 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0422062 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0420604 |
| SMYD3 | SET and MYND domain containing 3 | -0.0418931 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0417685 |
| ZNF638 | zinc finger protein 638 | -0.0416538 |
| RUFY1 | RUN and FYVE domain containing 1 | -0.0413627 |
| CDC42 | cell division cycle 42 | -0.0411991 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.040865 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0405911 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0405236 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0402812 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0402304 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0401211 |
| DSG2 | desmoglein 2 | -0.0399163 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0392063 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0381871 |
| PHF21A | PHD finger protein 21A | -0.0381855 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0380953 |
| RIGI | RNA sensor RIG-I | -0.0379785 |
| FOXO1 | forkhead box O1 | -0.0377276 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0374962 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0374898 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0372643 |
| CDK12 | cyclin-dependent kinase 12 | -0.0371946 |
| RBM47 | RNA binding motif protein 47 | -0.0363803 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0359474 |
| SDC4 | syndecan 4 | -0.0358467 |
| RREB1 | ras responsive element binding protein 1 | -0.0357774 |
| AUTS2 | autism susceptibility candidate 2 | -0.0357652 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.035605 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0355761 |
| MUC16 | mucin 16, cell surface associated | -0.0343451 |
| RNF213 | ring finger protein 213 | -0.0342541 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0340165 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0338923 |
| B2M | beta-2-microglobulin | -0.0338772 |
