Delamanid_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Delamanid perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Delamanid_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.174865
EEF2 eukaryotic translation elongation factor 2 0.1685
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.10392
GRAMD1B GRAM domain containing 1B 0.0796961
SMAD3 SMAD family member 3 0.0644139
NCAPD2 non-SMC condensin I complex, subunit D2 0.0613881
RPL7A ribosomal protein L7a 0.0568146
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.055916
HSPA8 heat shock 70kDa protein 8 0.0552369
MYH9 myosin, heavy chain 9, non-muscle 0.0547267
MACF1 microtubule-actin crosslinking factor 1 0.0542263
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0504151
SETD5 SET domain containing 5 0.0496145
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0491596
ACTN1 actinin, alpha 1 0.0490002
EGR1 early growth response 1 0.0485073
YBX3 Y box binding protein 3 0.0484066
COPA coatomer protein complex, subunit alpha 0.0483152
ERRFI1 ERBB receptor feedback inhibitor 1 0.0482493
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0470396
FTH1 ferritin, heavy polypeptide 1 0.0460063
DOCK5 dedicator of cytokinesis 5 0.0455003
RAB7A RAB7A, member RAS oncogene family 0.0453914
EIF4B eukaryotic translation initiation factor 4B 0.0450567
FLNA filamin A, alpha 0.0446854
SRRM2 serine/arginine repetitive matrix 2 0.0445405
NTSR1 neurotensin receptor 1 (high affinity) 0.0437526
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.042189
RPL3 ribosomal protein L3 0.0415657
HOOK2 hook microtubule-tethering protein 2 0.0414997
MKI67 marker of proliferation Ki-67 0.0413711
ACTG1 actin gamma 1 0.0407985
KMT2D lysine (K)-specific methyltransferase 2D 0.0406794
PLEC plectin 0.0401911
CTTN cortactin 0.0398621
RPL4 ribosomal protein L4 0.0394665
CCNL1 cyclin L1 0.0393589
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0390644
RPN1 ribophorin I 0.0386382
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0384684
KRT18 keratin 18, type I 0.0382118
CAPRIN2 caprin family member 2 0.0381341
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0378189
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0374244
ATP11A ATPase, class VI, type 11A 0.0372033
STK4 serine/threonine kinase 4 0.0368416
EIF3D eukaryotic translation initiation factor 3, subunit D 0.0363702
ANKRD36 ankyrin repeat domain 36 0.0363065
ANKRD11 ankyrin repeat domain 11 0.0355109
THRAP3 thyroid hormone receptor associated protein 3 0.034727
FLOT1 flotillin 1 0.0346524
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0341587
ANO6 anoctamin 6 0.0337539
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0337163
FMNL2 formin-like 2 0.0336727
GON4L gon-4-like (C. elegans) 0.0334126
SAMD4A sterile alpha motif domain containing 4A 0.0330312
NOTCH2 notch 2 0.0326656
WWTR1 WW domain containing transcription regulator 1 0.0324504
CSNK1A1 casein kinase 1, alpha 1 0.0318341
HELZ helicase with zinc finger 0.031096
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.0306545
SHB Src homology 2 domain containing adaptor protein B 0.0305891
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0303817
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0301448
IQGAP3 IQ motif containing GTPase activating protein 3 0.0299444
CUL4A cullin 4A 0.0298181
DCTN1 dynactin 1 0.0296997
NFE2L1 nuclear factor, erythroid 2-like 1 0.0296903
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0296507
MARCHF4 membrane associated ring-CH-type finger 4 0.0295478
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0293039
TMEM41B transmembrane protein 41B 0.0292137
UBAP2L ubiquitin associated protein 2-like 0.0292092
CTIF CBP80/20-dependent translation initiation factor 0.0289336
ELL2 elongation factor, RNA polymerase II, 2 0.0285926
BRD2 bromodomain containing 2 0.028146
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0278503
ADAM17 ADAM metallopeptidase domain 17 0.0277855
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0277294
PRPF8 pre-mRNA processing factor 8 0.0276577
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0276304
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.027513
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0274926
KDM6B lysine (K)-specific demethylase 6B 0.0274422
TXNRD1 thioredoxin reductase 1 0.027126
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0270791
LOXL2 lysyl oxidase-like 2 0.0265568
PTK2 protein tyrosine kinase 2 0.0265072
ANKRD36B ankyrin repeat domain 36B 0.0264224
EIF4H eukaryotic translation initiation factor 4H 0.0262595
WIPF2 WAS/WASL interacting protein family, member 2 0.0262493
CLTC clathrin, heavy chain (Hc) 0.0255209
SNX9 sorting nexin 9 0.0254915
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0253796
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.025328
COPG1 coatomer protein complex, subunit gamma 1 0.0252832
ZBTB25 zinc finger and BTB domain containing 25 0.0252669
ZC3H13 zinc finger CCCH-type containing 13 0.0252574
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0250539

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.13057
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.122239
TFPI2 tissue factor pathway inhibitor 2 -0.10046
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.093537
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0645559
CANX calnexin -0.0531792
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0513998
TMSB10 thymosin beta 10 -0.0490954
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0487809
RBM39 RNA binding motif protein 39 -0.0487463
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0483106
PFN1 profilin 1 -0.0436631
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0436487
TPI1 triosephosphate isomerase 1 -0.041986
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0402801
NIPBL Nipped-B homolog (Drosophila) -0.0399359
MED13L mediator complex subunit 13-like -0.0399155
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0390461
CSDE1 cold shock domain containing E1, RNA-binding -0.0386313
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0381154
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0378803
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0375286
PDE4D phosphodiesterase 4D, cAMP-specific -0.0370061
IFIH1 interferon induced with helicase C domain 1 -0.0364783
RPLP0 ribosomal protein, large, P0 -0.0364443
RPS12 ribosomal protein S12 -0.0359495
MYL12B myosin, light chain 12B, regulatory -0.0357187
VIM vimentin -0.0356555
NCOA7 nuclear receptor coactivator 7 -0.0356326
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0355563
RPS8 ribosomal protein S8 -0.0352985
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.034416
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0342156
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0340214
RPS15 ribosomal protein S15 -0.0336494
RIMS2 regulating synaptic membrane exocytosis 2 -0.0335185
PKM pyruvate kinase, muscle -0.0334159
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0318952
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.031747
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0316098
RPLP1 ribosomal protein, large, P1 -0.0315872
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0314541
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0312806
SBF2 SET binding factor 2 -0.0311683
BZW1 basic leucine zipper and W2 domains 1 -0.0307231
TAS2R14 taste receptor, type 2, member 14 -0.0302945
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0292771
UBB ubiquitin B -0.0291262
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0290902
NOP58 NOP58 ribonucleoprotein -0.0290773
HMGA1 high mobility group AT-hook 1 -0.029012
ZNF292 zinc finger protein 292 -0.0289645
RPS24 ribosomal protein S24 -0.0286625
VCL vinculin -0.0282826
TUBA1B tubulin, alpha 1b -0.0282343
ADGRG6 adhesion G protein-coupled receptor G6 -0.0281814
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0281576
CENPF centromere protein F, 350/400kDa -0.0280957
TLK1 tousled-like kinase 1 -0.0276939
PLSCR1 phospholipid scramblase 1 -0.0270971
SINHCAF SIN3-HDAC complex associated factor -0.0269386
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0268593
BBX bobby sox homolog (Drosophila) -0.026807
ZBTB20 zinc finger and BTB domain containing 20 -0.0264705
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0264335
FNDC3B fibronectin type III domain containing 3B -0.0264254
PREPL prolyl endopeptidase-like -0.0263323
TCF12 transcription factor 12 -0.0262549
TWF1 twinfilin actin binding protein 1 -0.0260339
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0258676
NUP155 nucleoporin 155kDa -0.0258035
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0257559
USP34 ubiquitin specific peptidase 34 -0.0256155
PDIA6 protein disulfide isomerase family A, member 6 -0.0254571
RPS21 ribosomal protein S21 -0.0251614
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -0.0250189
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0249775
GSTP1 glutathione S-transferase pi 1 -0.0248991
CAMKMT calmodulin-lysine N-methyltransferase -0.0248269
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0246686
DEK DEK proto-oncogene -0.0246108
EXOC4 exocyst complex component 4 -0.0246057
H1-3 H1.3 linker histone, cluster member -0.024603
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 -0.0244985
TRA2A transformer 2 alpha homolog (Drosophila) -0.0244859
BIRC2 baculoviral IAP repeat containing 2 -0.024379
CCT3 chaperonin containing TCP1, subunit 3 (gamma) -0.0241306
PHF20 PHD finger protein 20 -0.0238625
EIF2A eukaryotic translation initiation factor 2A, 65kDa -0.0238253
MATR3 matrin 3 -0.0238219
MBD5 methyl-CpG binding domain protein 5 -0.0236422
BSG basigin (Ok blood group) -0.0236108
VDAC1 voltage-dependent anion channel 1 -0.0234512
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0233974
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0233538
TAPBP TAP binding protein (tapasin) -0.0233515
PDE10A phosphodiesterase 10A -0.023227
TPT1 tumor protein, translationally-controlled 1 -0.0227853
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0225122
WDR70 WD repeat domain 70 -0.0221183