Delamanid_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Delamanid perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Delamanid_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.160389
ACTG1 actin gamma 1 0.155384
FTL ferritin, light polypeptide 0.108142
EXT1 exostosin glycosyltransferase 1 0.0797765
PTMA prothymosin, alpha 0.075106
FN1 fibronectin 1 0.0720588
HLA-B major histocompatibility complex, class I, B 0.068942
PLEC plectin 0.0634485
AKAP13 A kinase (PRKA) anchor protein 13 0.0610936
CALR calreticulin 0.0528382
SDC4 syndecan 4 0.0520441
CTSB cathepsin B 0.0514302
RPL9 ribosomal protein L9 0.0508041
RPL35A ribosomal protein L35a 0.0499522
DUSP10 dual specificity phosphatase 10 0.0490341
TMSB4X thymosin beta 4, X-linked 0.0484672
RPL7A ribosomal protein L7a 0.0467652
SAMD4A sterile alpha motif domain containing 4A 0.0464202
RPL4 ribosomal protein L4 0.0462854
VEGFA vascular endothelial growth factor A 0.0461089
LAMB3 laminin, beta 3 0.0440593
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0434825
CTNND1 catenin (cadherin-associated protein), delta 1 0.0428379
UBE2H ubiquitin-conjugating enzyme E2H 0.0425984
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0412122
IGFBP3 insulin-like growth factor binding protein 3 0.0408686
EIF1 eukaryotic translation initiation factor 1 0.0408078
PPARD peroxisome proliferator-activated receptor delta 0.0401452
FBXO32 F-box protein 32 0.0381398
BHLHE40 basic helix-loop-helix family, member e40 0.0362184
RBM25 RNA binding motif protein 25 0.0352767
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0348328
HLA-A major histocompatibility complex, class I, A 0.0345932
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0344786
MYO1E myosin IE 0.0341284
SMAD3 SMAD family member 3 0.0334313
SEC23A Sec23 homolog A (S. cerevisiae) 0.032505
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0324716
RCOR1 REST corepressor 1 0.0322473
RPS23 ribosomal protein S23 0.0321976
SETD5 SET domain containing 5 0.0313788
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0306403
FBXO34 F-box protein 34 0.0304362
RAB7A RAB7A, member RAS oncogene family 0.0303871
ERBIN erbb2 interacting protein 0.0301061
RPL23 ribosomal protein L23 0.0299538
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.0297176
RPS17 ribosomal protein S17 0.0290819
EEF2 eukaryotic translation elongation factor 2 0.0285724
RPL31 ribosomal protein L31 0.0280186
AHNAK2 AHNAK nucleoprotein 2 0.0279038
GPATCH8 G patch domain containing 8 0.0277462
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.027715
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0276933
CRABP2 cellular retinoic acid binding protein 2 0.0272168
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0270685
FLNA filamin A, alpha 0.0269686
KLC1 kinesin light chain 1 0.0266884
FNIP1 folliculin interacting protein 1 0.0266819
RBM47 RNA binding motif protein 47 0.0263981
ARHGAP5 Rho GTPase activating protein 5 0.0262558
WDR20 WD repeat domain 20 0.0261928
BCL2L1 BCL2-like 1 0.0261602
PLAUR plasminogen activator, urokinase receptor 0.0260843
WSB1 WD repeat and SOCS box containing 1 0.0257981
DTNA dystrobrevin, alpha 0.025675
TIMP2 TIMP metallopeptidase inhibitor 2 0.0256533
ANKRD11 ankyrin repeat domain 11 0.0255026
KDM2A lysine (K)-specific demethylase 2A 0.0253201
RPL37A ribosomal protein L37a 0.0252257
PGBD5 piggyBac transposable element derived 5 0.0250172
SOX4 SRY (sex determining region Y)-box 4 0.0249245
PRRC2C proline-rich coiled-coil 2C 0.0248692
TMEM165 transmembrane protein 165 0.0247053
CTBP2 C-terminal binding protein 2 0.0243891
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.023856
CLTC clathrin, heavy chain (Hc) 0.0236117
TJP2 tight junction protein 2 0.0233757
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0233036
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0233023
VGLL3 vestigial-like family member 3 0.0229429
MYO5B myosin VB 0.0229379
MYO6 myosin VI 0.0228834
CSNK1A1 casein kinase 1, alpha 1 0.0228554
MCU mitochondrial calcium uniporter 0.0224486
MYH9 myosin, heavy chain 9, non-muscle 0.0221868
RPS29 ribosomal protein S29 0.021625
EEF1G eukaryotic translation elongation factor 1 gamma 0.0215675
UBAP1 ubiquitin associated protein 1 0.0215314
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0212747
RPS25 ribosomal protein S25 0.0210412
ENO2 enolase 2 (gamma, neuronal) 0.0210291
RPS13 ribosomal protein S13 0.0208925
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0208754
KMT2E lysine (K)-specific methyltransferase 2E 0.0208713
LAMC2 laminin, gamma 2 0.0208555
VCL vinculin 0.0208458
TPT1 tumor protein, translationally-controlled 1 0.0208407
RPL15 ribosomal protein L15 0.0207968
ANKRD17 ankyrin repeat domain 17 0.0207569

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.172259
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.13165
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.120442
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.103179
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0946984
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0853046
ENO1 enolase 1, (alpha) -0.0836173
HMGA1 high mobility group AT-hook 1 -0.0758571
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0690906
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0678551
TSC22D2 TSC22 domain family, member 2 -0.0671256
ASPH aspartate beta-hydroxylase -0.0664703
FNDC3B fibronectin type III domain containing 3B -0.0633684
NDRG1 N-myc downstream regulated 1 -0.0590592
CCND1 cyclin D1 -0.0576587
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0561262
NAMPT nicotinamide phosphoribosyltransferase -0.0553604
S100A6 S100 calcium binding protein A6 -0.0515171
CANX calnexin -0.0510234
TM4SF1 transmembrane 4 L six family member 1 -0.0503477
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.04755
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0461289
TFG TRK-fused gene -0.0448161
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0436128
TXNRD1 thioredoxin reductase 1 -0.041661
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0414126
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0412293
SQSTM1 sequestosome 1 -0.0412224
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0405459
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0404756
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0399545
RLF rearranged L-myc fusion -0.0399446
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0396336
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0392387
CD2AP CD2-associated protein -0.0390606
RYBP RING1 and YY1 binding protein -0.0387677
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0383892
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0376103
QKI QKI, KH domain containing, RNA binding -0.0370091
TOP2A topoisomerase (DNA) II alpha 170kDa -0.036524
FAM162A family with sequence similarity 162, member A -0.0359588
HMGB2 high mobility group box 2 -0.0359411
DSTN destrin (actin depolymerizing factor) -0.0359159
LDHA lactate dehydrogenase A -0.0352366
MXD1 MAX dimerization protein 1 -0.0346851
PKM pyruvate kinase, muscle -0.0343113
RIOK3 RIO kinase 3 -0.0330708
CD46 CD46 molecule, complement regulatory protein -0.0324402
ZNF292 zinc finger protein 292 -0.0313223
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0310296
PGK1 phosphoglycerate kinase 1 -0.0310286
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0304813
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0302952
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0296107
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.0295948
RNF145 ring finger protein 145 -0.0294283
ADAM9 ADAM metallopeptidase domain 9 -0.0291191
IFRD1 interferon-related developmental regulator 1 -0.0285757
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0284334
IL6ST interleukin 6 signal transducer -0.0282956
BZW1 basic leucine zipper and W2 domains 1 -0.0280965
FOSL1 FOS-like antigen 1 -0.0278808
NAP1L1 nucleosome assembly protein 1-like 1 -0.0270954
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0267288
S100A10 S100 calcium binding protein A10 -0.0257599
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0255663
AREG amphiregulin -0.0253267
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0252015
DEK DEK proto-oncogene -0.0249557
FHIT fragile histidine triad -0.024935
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0248385
MSMO1 methylsterol monooxygenase 1 -0.0247396
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0245672
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0244568
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0242231
DSPP dentin sialophosphoprotein -0.0239741
TAGLN2 transgelin 2 -0.0238274
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.023138
TFRC transferrin receptor -0.0230398
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0230083
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0229175
CAV1 caveolin 1, caveolae protein, 22kDa -0.0226697
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.022623
EREG epiregulin -0.0225876
FAM13A family with sequence similarity 13, member A -0.0225623
KRT19 keratin 19, type I -0.0225121
MBNL1 muscleblind-like splicing regulator 1 -0.0223315
AZIN1 antizyme inhibitor 1 -0.0221233
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0220068
PDIA3 protein disulfide isomerase family A, member 3 -0.0219714
LMNA lamin A/C -0.0219248
TOP1 topoisomerase (DNA) I -0.021851
EMP1 epithelial membrane protein 1 -0.0217831
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0216348
LMAN1 lectin, mannose-binding, 1 -0.0215252
EZR ezrin -0.0213285
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0212492
GRB10 growth factor receptor-bound protein 10 -0.021248
PEG10 paternally expressed 10 -0.0209741
STEAP4 STEAP family member 4 -0.0206767