Delamanid_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Delamanid perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Delamanid_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.479614
FTH1 ferritin, heavy polypeptide 1 0.172526
EEF2 eukaryotic translation elongation factor 2 0.15925
MCL1 myeloid cell leukemia 1 0.144029
IGFBP3 insulin-like growth factor binding protein 3 0.102007
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0817268
DDIT4 DNA-damage-inducible transcript 4 0.0683123
FLNB filamin B, beta 0.0649048
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0600461
CALR calreticulin 0.0559245
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0547254
RPL3 ribosomal protein L3 0.0542293
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0490353
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0479152
PDGFA platelet-derived growth factor alpha polypeptide 0.046823
FLNA filamin A, alpha 0.0466151
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0464672
MYOF myoferlin 0.0451272
NCOR2 nuclear receptor corepressor 2 0.0445895
SAMD4A sterile alpha motif domain containing 4A 0.0445433
PM20D1 peptidase M20 domain containing 1 0.044127
ESYT2 extended synaptotagmin-like protein 2 0.0437769
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0429561
SRRM2 serine/arginine repetitive matrix 2 0.0428873
LIMCH1 LIM and calponin homology domains 1 0.0428596
HSPA8 heat shock 70kDa protein 8 0.0421019
TGFBI transforming growth factor, beta-induced, 68kDa 0.0415419
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.04029
MSN moesin 0.0399411
TPM3 tropomyosin 3 0.0398498
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0392963
SMOC1 SPARC related modular calcium binding 1 0.0389888
FAM13A family with sequence similarity 13, member A 0.0387185
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0384523
TMSB4X thymosin beta 4, X-linked 0.0367762
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0367708
TBXT T-box transcription factor T 0.0365942
COPA coatomer protein complex, subunit alpha 0.0360368
CD109 CD109 molecule 0.0356989
TRIO trio Rho guanine nucleotide exchange factor 0.034965
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0349016
ITPRID2 ITPR interacting domain containing 2 0.0348062
RPL7A ribosomal protein L7a 0.0346607
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.0340912
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0340876
MYH9 myosin, heavy chain 9, non-muscle 0.0339839
EZR ezrin 0.0337329
CTBP2 C-terminal binding protein 2 0.033533
DST dystonin 0.0334566
NFE2L1 nuclear factor, erythroid 2-like 1 0.0327593
PCBP3 poly(rC) binding protein 3 0.032582
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0321983
TNIP1 TNFAIP3 interacting protein 1 0.0319193
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0317664
EIF4B eukaryotic translation initiation factor 4B 0.0316436
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0308788
CTSL cathepsin L 0.0305966
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0304817
PDLIM5 PDZ and LIM domain 5 0.0302516
ANXA2 annexin A2 0.0293808
B2M beta-2-microglobulin 0.029273
IGFBP6 insulin-like growth factor binding protein 6 0.0292105
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0287762
SFTPA2 surfactant protein A2 0.028697
COL4A6 collagen, type IV, alpha 6 0.0285178
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.028371
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0280654
HELZ helicase with zinc finger 0.0278988
KMT2E lysine (K)-specific methyltransferase 2E 0.027768
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0277355
CHD1L chromodomain helicase DNA binding protein 1-like 0.02769
UBA6 ubiquitin-like modifier activating enzyme 6 0.0276148
RPH3AL rabphilin 3A-like (without C2 domains) 0.0275475
EIF4H eukaryotic translation initiation factor 4H 0.027547
STC2 stanniocalcin 2 0.0265493
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0262785
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.02626
APLP2 amyloid beta (A4) precursor-like protein 2 0.0261692
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.025757
LAMA5 laminin, alpha 5 0.0256477
HOOK2 hook microtubule-tethering protein 2 0.025547
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.025365
ZEB2 zinc finger E-box binding homeobox 2 0.024775
ASPH aspartate beta-hydroxylase 0.0245077
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0244505
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0242375
GRAMD1B GRAM domain containing 1B 0.0239043
PRRC2C proline-rich coiled-coil 2C 0.023886
TMX4 thioredoxin-related transmembrane protein 4 0.0238129
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0232512
RPN1 ribophorin I 0.0232236
LAMA1 laminin, alpha 1 0.0231782
ANXA1 annexin A1 0.0229194
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0229172
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.022887
NDRG1 N-myc downstream regulated 1 0.0224326
PCBP2 poly(rC) binding protein 2 0.0223097
EEF1G eukaryotic translation elongation factor 1 gamma 0.0221125
CTIF CBP80/20-dependent translation initiation factor 0.021935
DNER delta/notch-like EGF repeat containing 0.0218632

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.234584
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.123678
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.101517
TPT1 tumor protein, translationally-controlled 1 -0.0965845
PDE4D phosphodiesterase 4D, cAMP-specific -0.0947302
RPLP1 ribosomal protein, large, P1 -0.090774
VIM vimentin -0.0751814
RPS24 ribosomal protein S24 -0.0725515
RPLP0 ribosomal protein, large, P0 -0.0678678
NAP1L1 nucleosome assembly protein 1-like 1 -0.0631476
RPS6 ribosomal protein S6 -0.060487
FTL ferritin, light polypeptide -0.0555529
RPL34 ribosomal protein L34 -0.0540695
TFPI2 tissue factor pathway inhibitor 2 -0.0537237
TXNRD1 thioredoxin reductase 1 -0.0534963
RPS8 ribosomal protein S8 -0.0503909
TMSB10 thymosin beta 10 -0.0490509
SMYD3 SET and MYND domain containing 3 -0.0469566
RPS27A ribosomal protein S27a -0.0400676
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0394958
RPLP2 ribosomal protein, large, P2 -0.0391372
S100A6 S100 calcium binding protein A6 -0.0388587
RPL35A ribosomal protein L35a -0.0376757
RPL36A ribosomal protein L36a -0.0372033
RPL31 ribosomal protein L31 -0.0360771
RPS23 ribosomal protein S23 -0.0357747
RPL26 ribosomal protein L26 -0.0351018
RPS21 ribosomal protein S21 -0.0346963
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0343018
RPS12 ribosomal protein S12 -0.0340036
RPL37 ribosomal protein L37 -0.0338483
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0336919
RPS16 ribosomal protein S16 -0.0334967
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0333499
RPL12 ribosomal protein L12 -0.0330116
PDE10A phosphodiesterase 10A -0.0329193
NALF1 NALCN channel auxiliary factor 1 -0.0325095
RPS13 ribosomal protein S13 -0.0324052
RPS25 ribosomal protein S25 -0.0317565
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0307953
RPL39 ribosomal protein L39 -0.0305951
RPS28 ribosomal protein S28 -0.0303714
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0301269
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0295887
RPL38 ribosomal protein L38 -0.0285745
RPS2 ribosomal protein S2 -0.0280591
S100A10 S100 calcium binding protein A10 -0.0277255
RPL37A ribosomal protein L37a -0.0276852
RPS27 ribosomal protein S27 -0.0275821
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0273628
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0271187
IARS1 isoleucyl-tRNA synthetase 1 -0.0270855
RPL11 ribosomal protein L11 -0.0263536
RPL27A ribosomal protein L27a -0.0258493
PRKN parkin RBR E3 ubiquitin protein ligase -0.0257867
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0257406
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0256537
SRGN serglycin -0.0253969
TM4SF1 transmembrane 4 L six family member 1 -0.0249152
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0249037
CANX calnexin -0.0248217
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0241224
RACK1 receptor for activated C kinase 1 -0.022931
RPS29 ribosomal protein S29 -0.0227179
JMJD1C jumonji domain containing 1C -0.0224812
RPS19 ribosomal protein S19 -0.0224434
RPL9 ribosomal protein L9 -0.0222705
RPL35 ribosomal protein L35 -0.0222676
RPL10A ribosomal protein L10a -0.0220168
COL8A1 collagen, type VIII, alpha 1 -0.0218932
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0215941
MBD5 methyl-CpG binding domain protein 5 -0.0215228
RPL30 ribosomal protein L30 -0.021482
CLIP1 CAP-GLY domain containing linker protein 1 -0.0213067
RPS5 ribosomal protein S5 -0.0207254
RPL32 ribosomal protein L32 -0.0205767
VDAC1 voltage-dependent anion channel 1 -0.0203085
ASTN2 astrotactin 2 -0.0202715
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0199412
RSL1D1 ribosomal L1 domain containing 1 -0.0199113
RPS14 ribosomal protein S14 -0.0197046
EIF1 eukaryotic translation initiation factor 1 -0.0195448
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0194947
NCOA7 nuclear receptor coactivator 7 -0.0191933
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0191482
FOXC1 forkhead box C1 -0.0191412
HMGB1 high mobility group box 1 -0.0190488
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0190101
RPL5 ribosomal protein L5 -0.0188946
RAB10 RAB10, member RAS oncogene family -0.0187692
GNAS GNAS complex locus -0.0187405
RPS20 ribosomal protein S20 -0.0186526
RPL23 ribosomal protein L23 -0.0185859
CADM2 cell adhesion molecule 2 -0.0185385
MAML3 mastermind-like 3 (Drosophila) -0.0182589
NOP58 NOP58 ribonucleoprotein -0.0181999
KIAA0825 KIAA0825 -0.0177713
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0176651
TBCA tubulin folding cofactor A -0.0175435
COL5A2 collagen, type V, alpha 2 -0.0173257