Delamanid_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Delamanid perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Delamanid_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.489792
FN1 fibronectin 1 0.16743
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.121582
SMAD3 SMAD family member 3 0.0743062
CALR calreticulin 0.0686734
TMSB4X thymosin beta 4, X-linked 0.0663118
TRIO trio Rho guanine nucleotide exchange factor 0.0558588
FLNA filamin A, alpha 0.0558215
SFTPA2 surfactant protein A2 0.0499403
MYH9 myosin, heavy chain 9, non-muscle 0.0486927
VEGFA vascular endothelial growth factor A 0.0470819
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0445074
SDC4 syndecan 4 0.0427217
HLA-B major histocompatibility complex, class I, B 0.0423323
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.0396154
TMED9 transmembrane emp24 protein transport domain containing 9 0.039395
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0392432
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0386567
EEF2 eukaryotic translation elongation factor 2 0.0350555
EXT1 exostosin glycosyltransferase 1 0.0340737
PRRC2C proline-rich coiled-coil 2C 0.0320366
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0318551
TMEM156 transmembrane protein 156 0.0317271
PTMA prothymosin, alpha 0.0314064
ACTG1 actin gamma 1 0.0306816
CTBP2 C-terminal binding protein 2 0.0298668
BHLHE40 basic helix-loop-helix family, member e40 0.0289271
SRRM2 serine/arginine repetitive matrix 2 0.0285103
TPR translocated promoter region, nuclear basket protein 0.0284937
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0277847
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0277661
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0269431
RPN1 ribophorin I 0.0261724
DOCK5 dedicator of cytokinesis 5 0.0259261
PRPF8 pre-mRNA processing factor 8 0.0252093
TBC1D22A TBC1 domain family, member 22A 0.0250546
APP amyloid beta (A4) precursor protein 0.0249518
PELO pelota homolog (Drosophila) 0.0243197
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0230115
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0226803
RPL7A ribosomal protein L7a 0.0225685
HSPA8 heat shock 70kDa protein 8 0.0221946
SHB Src homology 2 domain containing adaptor protein B 0.0219454
HPCAL1 hippocalcin-like 1 0.0218477
ZC3H13 zinc finger CCCH-type containing 13 0.0214283
DDIT4 DNA-damage-inducible transcript 4 0.0210902
HIPK2 homeodomain interacting protein kinase 2 0.0205548
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0202896
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0201575
ZNF841 zinc finger protein 841 0.0200246
THRAP3 thyroid hormone receptor associated protein 3 0.0199355
UBAP2L ubiquitin associated protein 2-like 0.0198415
HLA-C major histocompatibility complex, class I, C 0.0197348
AHNAK2 AHNAK nucleoprotein 2 0.0197172
RPL4 ribosomal protein L4 0.0194436
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0188578
FAT1 FAT atypical cadherin 1 0.0187844
TSPYL2 TSPY-like 2 0.0187745
PLEC plectin 0.0186906
ADIPOR1 adiponectin receptor 1 0.0185083
FNIP1 folliculin interacting protein 1 0.0180767
SDE2 SDE2 telomere maintenance homolog (S. pombe) 0.0179645
RPL13A ribosomal protein L13a 0.0176121
CAB39 calcium binding protein 39 0.0175028
EIF4H eukaryotic translation initiation factor 4H 0.0174119
SEPTIN9 septin 9 0.0169701
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0169546
SEC23A Sec23 homolog A (S. cerevisiae) 0.0168388
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.0166978
EIF4B eukaryotic translation initiation factor 4B 0.016682
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0166811
RANBP2 RAN binding protein 2 0.016481
GOLM1 golgi membrane protein 1 0.0164478
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0163739
AFDN afadin, adherens junction formation factor 0.0163725
NCOR2 nuclear receptor corepressor 2 0.0163158
RPL3 ribosomal protein L3 0.0162564
AHDC1 AT hook, DNA binding motif, containing 1 0.0161218
KANSL3 KAT8 regulatory NSL complex subunit 3 0.0158553
EFNA5 ephrin-A5 0.0158135
NFE2L1 nuclear factor, erythroid 2-like 1 0.0156538
LRMDA leucine rich melanocyte differentiation associated 0.0154957
THBS1 thrombospondin 1 0.0154759
BAIAP2 BAI1-associated protein 2 0.015428
GOLGA7B golgin A7 family, member B 0.0153275
MACF1 microtubule-actin crosslinking factor 1 0.0152955
KIF1A kinesin family member 1A 0.0152395
RPS17 ribosomal protein S17 0.0151583
ZFYVE28 zinc finger, FYVE domain containing 28 0.0150451
WWTR1 WW domain containing transcription regulator 1 0.0150446
AOPEP aminopeptidase O (putative) 0.0149644
MCFD2 multiple coagulation factor deficiency 2 0.0148822
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0146652
COPG1 coatomer protein complex, subunit gamma 1 0.014646
PRRC2B proline-rich coiled-coil 2B 0.014551
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0144273
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0143984
CHD3 chromodomain helicase DNA binding protein 3 0.0143552
KDM3A lysine (K)-specific demethylase 3A 0.0143443
EGFR epidermal growth factor receptor 0.0142084

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.353599
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.103901
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0998999
NDRG1 N-myc downstream regulated 1 -0.0968108
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0922202
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0782078
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0764059
HILPDA hypoxia inducible lipid droplet-associated -0.0759764
TXNIP thioredoxin interacting protein -0.0713181
NAMPT nicotinamide phosphoribosyltransferase -0.0689569
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0683337
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0678299
CANX calnexin -0.0609157
FTL ferritin, light polypeptide -0.0544122
LOC102724023 ES1 protein homolog, mitochondrial -0.0510727
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0478572
SQSTM1 sequestosome 1 -0.0474724
CENPF centromere protein F, 350/400kDa -0.0469267
IFI27 interferon, alpha-inducible protein 27 -0.0451637
VCL vinculin -0.0424772
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0409548
ZNF292 zinc finger protein 292 -0.040599
ELL2 elongation factor, RNA polymerase II, 2 -0.0396101
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0393193
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0389443
PDIA3 protein disulfide isomerase family A, member 3 -0.0389095
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0386758
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0382766
S100A6 S100 calcium binding protein A6 -0.0368229
PGK1 phosphoglycerate kinase 1 -0.0357446
PKM pyruvate kinase, muscle -0.0356063
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0353358
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0352299
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0348576
RPS6 ribosomal protein S6 -0.0342871
PLIN2 perilipin 2 -0.0341518
VIM vimentin -0.034065
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0336575
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.033218
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0327543
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0326115
RYBP RING1 and YY1 binding protein -0.0323577
ENO1 enolase 1, (alpha) -0.0320169
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0317093
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0308784
SEPTIN7 septin 7 -0.0308257
HMGA1 high mobility group AT-hook 1 -0.030615
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0303204
TOP2A topoisomerase (DNA) II alpha 170kDa -0.028647
DSTN destrin (actin depolymerizing factor) -0.0284735
PFN1 profilin 1 -0.0279283
EGR1 early growth response 1 -0.0278648
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0277175
RPS20 ribosomal protein S20 -0.0271932
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0265252
POTEF POTE ankyrin domain family, member F -0.0257967
RIOK3 RIO kinase 3 -0.0255228
RPS24 ribosomal protein S24 -0.0250956
NOP58 NOP58 ribonucleoprotein -0.0250232
RPLP0 ribosomal protein, large, P0 -0.0249914
ADAM9 ADAM metallopeptidase domain 9 -0.0249653
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0246665
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0246228
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0244783
RNF145 ring finger protein 145 -0.0243711
STAU1 staufen double-stranded RNA binding protein 1 -0.0243264
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0237098
MAP1B microtubule-associated protein 1B -0.0236742
RPS27 ribosomal protein S27 -0.0234356
SPAG9 sperm associated antigen 9 -0.0233349
DNM1L dynamin 1-like -0.0233147
MBNL1 muscleblind-like splicing regulator 1 -0.0232373
BLZF1 basic leucine zipper nuclear factor 1 -0.0232151
WDR45B WD repeat domain 45B -0.0228999
RLF rearranged L-myc fusion -0.022274
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0221503
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0218402
TXNRD1 thioredoxin reductase 1 -0.0218034
EPS8 epidermal growth factor receptor pathway substrate 8 -0.021579
RPLP1 ribosomal protein, large, P1 -0.0211474
PDIA6 protein disulfide isomerase family A, member 6 -0.0210453
FBXO11 F-box protein 11 -0.0210183
SOD2 superoxide dismutase 2, mitochondrial -0.0209474
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0209301
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0209189
LDHA lactate dehydrogenase A -0.0208352
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0207073
RPS12 ribosomal protein S12 -0.0205482
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0203258
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0203038
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0203033
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0202941
RAB1A RAB1A, member RAS oncogene family -0.0200822
UBXN4 UBX domain protein 4 -0.0199617
ERRFI1 ERBB receptor feedback inhibitor 1 -0.019954
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0199537
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.019558
RACK1 receptor for activated C kinase 1 -0.0194782
AFF4 AF4/FMR2 family, member 4 -0.0194005
ARF1 ADP-ribosylation factor 1 -0.0193664