| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Demeclocycline perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Demeclocycline_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.23766 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.180043 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.148786 |
| AREG | amphiregulin | 0.102959 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0806053 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0799548 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0759144 |
| RTN4 | reticulon 4 | 0.0737728 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0731738 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0730592 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0639224 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0604386 |
| ADIPOR2 | adiponectin receptor 2 | 0.0582801 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0568777 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0558214 |
| TMEM41B | transmembrane protein 41B | 0.053572 |
| TPM3 | tropomyosin 3 | 0.0534662 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0523976 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0520324 |
| YBX3 | Y box binding protein 3 | 0.0516322 |
| ERBIN | erbb2 interacting protein | 0.0510359 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0508725 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0495676 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0495136 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.047899 |
| GOLGB1 | golgin B1 | 0.0476387 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0461731 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0456887 |
| RRM2 | ribonucleotide reductase M2 | 0.0455791 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0453204 |
| YAP1 | Yes-associated protein 1 | 0.0420453 |
| WWOX | WW domain containing oxidoreductase | 0.0419812 |
| IPO7 | importin 7 | 0.0419807 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.041967 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0406068 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0393737 |
| JMJD1C | jumonji domain containing 1C | 0.0393251 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0392804 |
| DST | dystonin | 0.0392707 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0392663 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.038434 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0377297 |
| SON | SON DNA binding protein | 0.0371591 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0371188 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.036408 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0345825 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0340853 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0340613 |
| XPO1 | exportin 1 | 0.0338638 |
| ZNF638 | zinc finger protein 638 | 0.0338581 |
| ANXA1 | annexin A1 | 0.0338041 |
| BRD2 | bromodomain containing 2 | 0.0337918 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0334768 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 0.0334025 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0333713 |
| RBM39 | RNA binding motif protein 39 | 0.0329886 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | 0.0328375 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0324246 |
| SPAG9 | sperm associated antigen 9 | 0.0324159 |
| CANX | calnexin | 0.0322504 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.032079 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0318016 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0317988 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0316277 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0314484 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0314086 |
| VMP1 | vacuole membrane protein 1 | 0.031026 |
| PRDX1 | peroxiredoxin 1 | 0.0309568 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | 0.0308621 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0306899 |
| CCDC88A | coiled-coil domain containing 88A | 0.0304896 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0304547 |
| CCNL1 | cyclin L1 | 0.030221 |
| PCBP2 | poly(rC) binding protein 2 | 0.0297364 |
| PCM1 | pericentriolar material 1 | 0.029579 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0295006 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0291035 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0290359 |
| MSH6 | mutS homolog 6 | 0.0290342 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0288032 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0286309 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0284632 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0283665 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | 0.0283202 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0283122 |
| PRRC2C | proline-rich coiled-coil 2C | 0.027848 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0278148 |
| DIAPH1 | diaphanous-related formin 1 | 0.0277467 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0277337 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.0277097 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0276499 |
| TPR | translocated promoter region, nuclear basket protein | 0.0273459 |
| INTS6 | integrator complex subunit 6 | 0.0272112 |
| RPS8 | ribosomal protein S8 | 0.0271665 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0271552 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0270725 |
| USP34 | ubiquitin specific peptidase 34 | 0.0268237 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0262146 |
| FTL | ferritin, light polypeptide | 0.0261657 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0261033 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EHBP1 | EH domain binding protein 1 | -0.0848564 |
| TMSB10 | thymosin beta 10 | -0.0746563 |
| ZNF804A | zinc finger protein 804A | -0.0697807 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0611489 |
| NHSL1 | NHS-like 1 | -0.055624 |
| RPS27A | ribosomal protein S27a | -0.0528842 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.048976 |
| VIM | vimentin | -0.0465966 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0458127 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0448494 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0438211 |
| UBC | ubiquitin C | -0.0436412 |
| SYT1 | synaptotagmin I | -0.0377111 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0348 |
| ACTG1 | actin gamma 1 | -0.03295 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0326962 |
| BCHE | butyrylcholinesterase | -0.032215 |
| PTMA | prothymosin, alpha | -0.0319202 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0310901 |
| RASAL2 | RAS protein activator like 2 | -0.0310757 |
| AHNAK | AHNAK nucleoprotein | -0.030606 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0298795 |
| CLDN1 | claudin 1 | -0.0295027 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0276348 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0270097 |
| LOC112694756 | uncharaterized LOC112694756 | -0.026294 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0258217 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0256183 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0242023 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0242004 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0240617 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0240108 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0236944 |
| CUX1 | cut-like homeobox 1 | -0.0229438 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0227585 |
| MGAT4C | MGAT4 family, member C | -0.0224775 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0220427 |
| RPS24 | ribosomal protein S24 | -0.0216193 |
| S100A6 | S100 calcium binding protein A6 | -0.0208027 |
| CDK17 | cyclin-dependent kinase 17 | -0.0205703 |
| KSR2 | kinase suppressor of ras 2 | -0.0201307 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0196539 |
| MKI67 | marker of proliferation Ki-67 | -0.0193887 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0185893 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0181505 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0181318 |
| GNAS | GNAS complex locus | -0.0181311 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0176114 |
| EGR1 | early growth response 1 | -0.017464 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0164862 |
| RPS16 | ribosomal protein S16 | -0.0164734 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0163633 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0162024 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | -0.0160964 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0160462 |
| ZFR | zinc finger RNA binding protein | -0.0159367 |
| PRR11 | proline rich 11 | -0.0156074 |
| GASK1B | golgi associated kinase 1B | -0.0154173 |
| FAM110C | family with sequence similarity 110, member C | -0.0153491 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0152801 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0151886 |
| WDR45B | WD repeat domain 45B | -0.0151718 |
| RNF13 | ring finger protein 13 | -0.0150555 |
| R3HDM2 | R3H domain containing 2 | -0.0149698 |
| TUBB | tubulin, beta class I | -0.0148444 |
| GRB2 | growth factor receptor-bound protein 2 | -0.0147184 |
| KHSRP | KH-type splicing regulatory protein | -0.0146301 |
| EPHA5 | EPH receptor A5 | -0.0144672 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0144439 |
| PCDH9 | protocadherin 9 | -0.0141472 |
| ZNF721 | zinc finger protein 721 | -0.0139081 |
| RPL19 | ribosomal protein L19 | -0.0138487 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.0138463 |
| NAV3 | neuron navigator 3 | -0.0138179 |
| CDC42SE2 | CDC42 small effector 2 | -0.0137261 |
| FSTL5 | follistatin-like 5 | -0.0136999 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0135638 |
| LMO7 | LIM domain 7 | -0.0135228 |
| CMIP | c-Maf inducing protein | -0.0134809 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0133183 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0132957 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0132955 |
| RPL6 | ribosomal protein L6 | -0.013119 |
| H1-0 | H1.0 linker histone | -0.0130117 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0129596 |
| ZDHHC2 | zinc finger, DHHC-type containing 2 | -0.0128757 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0126432 |
| RAB10 | RAB10, member RAS oncogene family | -0.012566 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0125577 |
| TMEM241 | transmembrane protein 241 | -0.0124274 |
| CALM3 | calmodulin 3 (phosphorylase kinase, delta) | -0.012368 |
| CCN2 | cellular communication network factor 2 | -0.0123083 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0122926 |
| PARD6B | par-6 family cell polarity regulator beta | -0.0121892 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0120841 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0120576 |
| RYK | receptor-like tyrosine kinase | -0.0120309 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0120198 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0120053 |
| KLHL24 | kelch-like family member 24 | -0.0118949 |
