| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Demeclocycline perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Demeclocycline_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.209869 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.140367 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.101027 |
| GOLGB1 | golgin B1 | 0.091971 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0872212 |
| NDRG1 | N-myc downstream regulated 1 | 0.0781197 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0764748 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0598047 |
| CALR | calreticulin | 0.0593016 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0590208 |
| ENO1 | enolase 1, (alpha) | 0.0589209 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0581543 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0540388 |
| CANX | calnexin | 0.053333 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0533305 |
| SQSTM1 | sequestosome 1 | 0.0507473 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0476187 |
| AHNAK | AHNAK nucleoprotein | 0.0468637 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0435518 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0413026 |
| RND3 | Rho family GTPase 3 | 0.0409111 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0405755 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0395671 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0390898 |
| FMNL2 | formin-like 2 | 0.0379541 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0365948 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0358241 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.0352971 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.034065 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0338562 |
| GANAB | glucosidase, alpha; neutral AB | 0.0332236 |
| COL3A1 | collagen, type III, alpha 1 | 0.0331304 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.032581 |
| STC1 | stanniocalcin 1 | 0.0324462 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0322095 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0320545 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0317053 |
| FAM107B | family with sequence similarity 107, member B | 0.0316165 |
| CCDC47 | coiled-coil domain containing 47 | 0.0315081 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0310409 |
| HM13 | histocompatibility (minor) 13 | 0.0301286 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0295268 |
| SP100 | SP100 nuclear antigen | 0.0294309 |
| ANXA1 | annexin A1 | 0.0293615 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0290183 |
| BRD2 | bromodomain containing 2 | 0.0281541 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0273553 |
| LARS1 | leucyl-tRNA synthetase 1 | 0.0272329 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0271193 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0265293 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0254691 |
| EFNA5 | ephrin-A5 | 0.025199 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0249663 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0248796 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0247969 |
| CDK13 | cyclin-dependent kinase 13 | 0.0246002 |
| XPOT | exportin, tRNA | 0.0245406 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0244961 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0235975 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0234146 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0231896 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.023159 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0230554 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 0.0229054 |
| CDH13 | cadherin 13 | 0.0229014 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0228503 |
| GOLGA4 | golgin A4 | 0.0226935 |
| ATXN1 | ataxin 1 | 0.0220629 |
| ASPH | aspartate beta-hydroxylase | 0.0219336 |
| LDHA | lactate dehydrogenase A | 0.0217521 |
| HDAC9 | histone deacetylase 9 | 0.021568 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0213433 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0212915 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | 0.0211612 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0211493 |
| RPS8 | ribosomal protein S8 | 0.0211197 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0208881 |
| JUN | jun proto-oncogene | 0.0206982 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0205698 |
| SSR1 | signal sequence receptor, alpha | 0.0202668 |
| TMF1 | TATA element modulatory factor 1 | 0.0197987 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0195891 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.019572 |
| MYO1E | myosin IE | 0.0195505 |
| PMM2 | phosphomannomutase 2 | 0.019468 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0194568 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0194439 |
| FNIP1 | folliculin interacting protein 1 | 0.0193874 |
| RSRP1 | arginine/serine-rich protein 1 | 0.0192669 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.019228 |
| TARS1 | threonyl-tRNA synthetase 1 | 0.0191528 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0189274 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0188447 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0187404 |
| TBX3 | T-box 3 | 0.0187067 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0187041 |
| SERINC1 | serine incorporator 1 | 0.0185183 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0184739 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0182236 |
| GLRX | glutaredoxin (thioltransferase) | 0.0180919 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A1 | collagen, type I, alpha 1 | -0.313077 |
| VIM | vimentin | -0.230393 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.200581 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.131797 |
| TMSB10 | thymosin beta 10 | -0.12613 |
| MT1X | metallothionein 1X | -0.0868888 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0809711 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0773506 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0755063 |
| ATP13A3 | ATPase type 13A3 | -0.0713911 |
| CALD1 | caldesmon 1 | -0.0666327 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0612826 |
| PTMA | prothymosin, alpha | -0.0580433 |
| FTL | ferritin, light polypeptide | -0.0544334 |
| VCAN | versican | -0.0543126 |
| TPM4 | tropomyosin 4 | -0.0536055 |
| COL1A2 | collagen, type I, alpha 2 | -0.0534011 |
| RPL35A | ribosomal protein L35a | -0.0514812 |
| POTEF | POTE ankyrin domain family, member F | -0.0511684 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0509378 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0494539 |
| PFN1 | profilin 1 | -0.0488436 |
| TMSB4X | thymosin beta 4, X-linked | -0.0485669 |
| TPM1 | tropomyosin 1 (alpha) | -0.0475293 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0468375 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0462171 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0451016 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.044699 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0443994 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0436287 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0435186 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0422845 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.040741 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0383452 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0381478 |
| CLIC4 | chloride intracellular channel 4 | -0.0375422 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0372795 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | -0.0369511 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.035614 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0354046 |
| QKI | QKI, KH domain containing, RNA binding | -0.0353401 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0350228 |
| MT2A | metallothionein 2A | -0.0347918 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0346039 |
| TAPBP | TAP binding protein (tapasin) | -0.0342378 |
| PKM | pyruvate kinase, muscle | -0.0339903 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0339037 |
| COL5A1 | collagen, type V, alpha 1 | -0.0335507 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0330831 |
| CNTN5 | contactin 5 | -0.0326269 |
| VEGFC | vascular endothelial growth factor C | -0.0324818 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.032353 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0323013 |
| AXL | AXL receptor tyrosine kinase | -0.032151 |
| RPL8 | ribosomal protein L8 | -0.0320401 |
| PTK2 | protein tyrosine kinase 2 | -0.0314588 |
| RPS6 | ribosomal protein S6 | -0.0314049 |
| SRPK2 | SRSF protein kinase 2 | -0.0309566 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0308867 |
| RNF145 | ring finger protein 145 | -0.0307822 |
| SBF2 | SET binding factor 2 | -0.0307595 |
| ZNF292 | zinc finger protein 292 | -0.0306441 |
| EGR1 | early growth response 1 | -0.0304401 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0304388 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0304311 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0303714 |
| RPL28 | ribosomal protein L28 | -0.0301109 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0299586 |
| FRMD4A | FERM domain containing 4A | -0.0297971 |
| SULF1 | sulfatase 1 | -0.0297089 |
| S100A9 | S100 calcium binding protein A9 | -0.0295908 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0293269 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0288498 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0286929 |
| FOSL1 | FOS-like antigen 1 | -0.0285901 |
| MAP1B | microtubule-associated protein 1B | -0.0284636 |
| S100A6 | S100 calcium binding protein A6 | -0.0282665 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0280447 |
| BNC2 | basonuclin 2 | -0.0279991 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0279009 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0278931 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | -0.0277671 |
| TENM3 | teneurin transmembrane protein 3 | -0.027579 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0275017 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0274185 |
| ITGAV | integrin, alpha V | -0.0274032 |
| BSG | basigin (Ok blood group) | -0.0273946 |
| NREP | neuronal regeneration related protein | -0.0272413 |
| USP3 | ubiquitin specific peptidase 3 | -0.0269056 |
| CCNL1 | cyclin L1 | -0.0267033 |
| TPI1 | triosephosphate isomerase 1 | -0.0266579 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0266392 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0264663 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0264066 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0261477 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0259635 |
| CADM1 | cell adhesion molecule 1 | -0.0258938 |
| SMIM44 | small integral membrane protein 44 | -0.0258261 |
| RPS19 | ribosomal protein S19 | -0.0254694 |
| TAGLN2 | transgelin 2 | -0.0254539 |
