| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Demeclocycline perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Demeclocycline_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.223581 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.197987 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.18531 |
| APOB | apolipoprotein B | 0.148176 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.138318 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.132977 |
| SVIL | supervillin | 0.127557 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.122926 |
| DSPP | dentin sialophosphoprotein | 0.0871213 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0805508 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0801227 |
| FAM107B | family with sequence similarity 107, member B | 0.0707784 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0707133 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0706412 |
| KYNU | kynureninase | 0.0650267 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0576645 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0556875 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0553538 |
| ATXN1 | ataxin 1 | 0.0537906 |
| FOXP1 | forkhead box P1 | 0.0531512 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0510787 |
| ENO1 | enolase 1, (alpha) | 0.0499618 |
| PEG3 | paternally expressed 3 | 0.047209 |
| AHR | aryl hydrocarbon receptor | 0.0457966 |
| FAT1 | FAT atypical cadherin 1 | 0.0444781 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0440698 |
| GK | glycerol kinase | 0.0439456 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0438911 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0413213 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0409731 |
| DUSP16 | dual specificity phosphatase 16 | 0.0408656 |
| TCIM | transcriptional and immune response regulator | 0.0408614 |
| INTS6 | integrator complex subunit 6 | 0.0404324 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0383301 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0375567 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0370649 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.036967 |
| DSTN | destrin (actin depolymerizing factor) | 0.0367995 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0366546 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0364438 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0352946 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0349133 |
| ZNF638 | zinc finger protein 638 | 0.0349018 |
| JMJD1C | jumonji domain containing 1C | 0.0348486 |
| PHF3 | PHD finger protein 3 | 0.0346553 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0342917 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0339567 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0334713 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0333787 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0333399 |
| CRY1 | cryptochrome circadian clock 1 | 0.0333272 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0332638 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0332438 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0326914 |
| CANX | calnexin | 0.0325101 |
| SKIL | SKI-like proto-oncogene | 0.0324627 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0324402 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0322656 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0312889 |
| VMP1 | vacuole membrane protein 1 | 0.0311358 |
| KRT23 | keratin 23, type I | 0.0307864 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0298294 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.029717 |
| LDHA | lactate dehydrogenase A | 0.0295656 |
| C3 | complement component 3 | 0.0292118 |
| MYO1E | myosin IE | 0.0288961 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0286618 |
| KIF21A | kinesin family member 21A | 0.0285575 |
| SEPTIN9 | septin 9 | 0.028401 |
| BPTF | bromodomain PHD finger transcription factor | 0.0277103 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0276371 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0271244 |
| MBNL3 | muscleblind-like splicing regulator 3 | 0.0269548 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0269161 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0264756 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0260002 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0259662 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0257156 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0254498 |
| SETX | senataxin | 0.0252502 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0252491 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0251565 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0250521 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0247729 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0246197 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0245478 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0244043 |
| VPS13D | vacuolar protein sorting 13 homolog D (S. cerevisiae) | 0.0240519 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0240038 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0239748 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0237461 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0237326 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 0.0237059 |
| A2M | alpha-2-macroglobulin | 0.023662 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0235578 |
| TLE4 | transducin-like enhancer of split 4 | 0.0235328 |
| LMO7 | LIM domain 7 | 0.0234564 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0234127 |
| IFRD1 | interferon-related developmental regulator 1 | 0.023349 |
| FUS | FUS RNA binding protein | 0.0232331 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.252233 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.112314 |
| HMGA1 | high mobility group AT-hook 1 | -0.0635821 |
| TMSB10 | thymosin beta 10 | -0.0625137 |
| APOA2 | apolipoprotein A-II | -0.052104 |
| NDRG1 | N-myc downstream regulated 1 | -0.0457577 |
| CP | ceruloplasmin (ferroxidase) | -0.044704 |
| RUNX1 | runt-related transcription factor 1 | -0.0443137 |
| RPS21 | ribosomal protein S21 | -0.0420567 |
| RPS6 | ribosomal protein S6 | -0.0408398 |
| RPS19 | ribosomal protein S19 | -0.0384482 |
| MT2A | metallothionein 2A | -0.0374503 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0366036 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0355927 |
| FERMT1 | fermitin family member 1 | -0.0350293 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0337371 |
| RPS24 | ribosomal protein S24 | -0.0328817 |
| RPL34 | ribosomal protein L34 | -0.0322565 |
| S100A9 | S100 calcium binding protein A9 | -0.0314446 |
| DTNA | dystrobrevin, alpha | -0.0311587 |
| MSI2 | musashi RNA-binding protein 2 | -0.0306619 |
| FLNB | filamin B, beta | -0.0299779 |
| ATP10A | ATPase, class V, type 10A | -0.0291319 |
| RNF213 | ring finger protein 213 | -0.0277825 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0270957 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.027028 |
| VEGFA | vascular endothelial growth factor A | -0.0269104 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0268167 |
| RNASET2 | ribonuclease T2 | -0.0264404 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0260037 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0256096 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0252344 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0242443 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0240553 |
| RPL26 | ribosomal protein L26 | -0.0239167 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0234501 |
| AGRN | agrin | -0.0232518 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | -0.0232498 |
| CDYL | chromodomain protein, Y-like | -0.0231395 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0229693 |
| RIGI | RNA sensor RIG-I | -0.0229382 |
| RPLP2 | ribosomal protein, large, P2 | -0.0228136 |
| HLA-A | major histocompatibility complex, class I, A | -0.0225944 |
| B2M | beta-2-microglobulin | -0.0225158 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0221951 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | -0.0221943 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0219011 |
| ACTN1 | actinin, alpha 1 | -0.0217889 |
| RBM25 | RNA binding motif protein 25 | -0.0217321 |
| APOE | apolipoprotein E | -0.0215413 |
| RPS3 | ribosomal protein S3 | -0.0215056 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0214366 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0213868 |
| RPL23 | ribosomal protein L23 | -0.0213227 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0209476 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0208986 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0207042 |
| RPL35A | ribosomal protein L35a | -0.0203241 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0201442 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0201195 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0200808 |
| DHFR | dihydrofolate reductase | -0.019972 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0196642 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0196459 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0194984 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0194553 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.019444 |
| S100P | S100 calcium binding protein P | -0.0193072 |
| FBXO11 | F-box protein 11 | -0.0192462 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0190381 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0186933 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.018685 |
| PARD3 | par-3 family cell polarity regulator | -0.0186272 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0186152 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0184729 |
| RPS14 | ribosomal protein S14 | -0.0184701 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0184187 |
| RPL31 | ribosomal protein L31 | -0.018292 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0180694 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0180089 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0179903 |
| MIDN | midnolin | -0.0176908 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | -0.0175132 |
| RPL9 | ribosomal protein L9 | -0.017421 |
| BSG | basigin (Ok blood group) | -0.0173674 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0173359 |
| GNAS | GNAS complex locus | -0.0173202 |
| ZFHX3 | zinc finger homeobox 3 | -0.0172809 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0169411 |
| ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18 | -0.0169393 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0168665 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | -0.0168266 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0166717 |
| RPL37A | ribosomal protein L37a | -0.0165142 |
| PLEKHA7 | pleckstrin homology domain containing, family A member 7 | -0.0164965 |
| TNS1 | tensin 1 | -0.0163664 |
| SEPTIN10 | septin 10 | -0.0162317 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.0161168 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0160325 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | -0.016022 |
