Demeclocycline_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Demeclocycline perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Demeclocycline_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.225849
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.148716
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0770828
LMO7 LIM domain 7 0.0721025
MYO1E myosin IE 0.0675502
EXT1 exostosin glycosyltransferase 1 0.0629994
VCL vinculin 0.0505096
FAT1 FAT atypical cadherin 1 0.0469197
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0454423
AHNAK AHNAK nucleoprotein 0.0430401
EPS8 epidermal growth factor receptor pathway substrate 8 0.0424965
KLF5 Kruppel-like factor 5 (intestinal) 0.0411533
GMDS GDP-mannose 4,6-dehydratase 0.039126
MBNL1 muscleblind-like splicing regulator 1 0.0374112
H1-0 H1.0 linker histone 0.0350332
PTPRK protein tyrosine phosphatase, receptor type, K 0.034693
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0343567
POF1B premature ovarian failure, 1B 0.0331383
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0326734
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0299306
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0299142
SVIL supervillin 0.0297898
AFF1 AF4/FMR2 family, member 1 0.0297233
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0296586
PDLIM5 PDZ and LIM domain 5 0.0288887
ANXA1 annexin A1 0.0263424
ECT2 epithelial cell transforming 2 0.0259477
MYO5B myosin VB 0.0251291
GDF15 growth differentiation factor 15 0.0248419
MED13 mediator complex subunit 13 0.0244085
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0242226
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0241979
FHIT fragile histidine triad 0.0237218
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0232521
ONECUT3 one cut homeobox 3 0.0228826
ARHGAP42 Rho GTPase activating protein 42 0.0219948
SMAD2 SMAD family member 2 0.0219136
FTH1 ferritin, heavy polypeptide 1 0.0215542
USP53 ubiquitin specific peptidase 53 0.0213964
PDE10A phosphodiesterase 10A 0.0212966
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0212081
CTBP2 C-terminal binding protein 2 0.0206855
PARD3B par-3 family cell polarity regulator beta 0.0205008
CEMIP cell migration inducing protein, hyaluronan binding 0.0203298
SLC38A2 solute carrier family 38, member 2 0.0202064
LURAP1L leucine rich adaptor protein 1-like 0.0200907
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0200154
C3ORF52 chromosome 3 open reading frame 52 0.0199673
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0198146
OSBPL10 oxysterol binding protein-like 10 0.0197325
ARF1 ADP-ribosylation factor 1 0.0194833
EPHA4 EPH receptor A4 0.0194216
SERINC5 serine incorporator 5 0.0194034
FOXP1 forkhead box P1 0.0191941
MAML3 mastermind-like 3 (Drosophila) 0.018756
KDM3A lysine (K)-specific demethylase 3A 0.0187226
SAMD5 sterile alpha motif domain containing 5 0.0180986
ETV6 ets variant 6 0.0180302
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0178448
MARCHF3 membrane associated ring-CH-type finger 3 0.0178297
DUSP16 dual specificity phosphatase 16 0.0175538
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.017552
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0175482
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0173529
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0173516
ZSWIM6 zinc finger, SWIM-type containing 6 0.0170346
RIGI RNA sensor RIG-I 0.0169698
TRPS1 trichorhinophalangeal syndrome I 0.0167781
TGFBR3 transforming growth factor, beta receptor III 0.0166335
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0165026
NEBL nebulette 0.0163714
MUC13 mucin 13, cell surface associated 0.0161586
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0160377
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0157885
RORA RAR-related orphan receptor A 0.0157489
SQSTM1 sequestosome 1 0.0155863
AKAP13 A kinase (PRKA) anchor protein 13 0.0155759
HDLBP high density lipoprotein binding protein 0.0155733
USP9X ubiquitin specific peptidase 9, X-linked 0.0154969
PDZD8 PDZ domain containing 8 0.0154788
ERRFI1 ERBB receptor feedback inhibitor 1 0.0154266
CD44 CD44 molecule (Indian blood group) 0.0150541
ABLIM1 actin binding LIM protein 1 0.0150382
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0150353
LAMA4 laminin, alpha 4 0.014797
NCOA7 nuclear receptor coactivator 7 0.0145293
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0143553
KLF6 Kruppel-like factor 6 0.0142061
ATF3 activating transcription factor 3 0.0140985
EGFR epidermal growth factor receptor 0.0140903
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0140751
APP amyloid beta (A4) precursor protein 0.0140482
IARS1 isoleucyl-tRNA synthetase 1 0.0140052
FUS FUS RNA binding protein 0.0139607
LPP LIM domain containing preferred translocation partner in lipoma 0.0138016
IGF1R insulin-like growth factor 1 receptor 0.0137833
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.0136518
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0136313
HBP1 HMG-box transcription factor 1 0.0136011
MARCHF6 membrane associated ring-CH-type finger 6 0.0132813

decreased expression

Symbol Name Standardized Value
MUC6 mucin 6, oligomeric mucus/gel-forming -0.204355
PTMA prothymosin, alpha -0.196903
RPS6 ribosomal protein S6 -0.132464
NDRG1 N-myc downstream regulated 1 -0.114312
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0945642
TNS4 tensin 4 -0.0935766
TMSB10 thymosin beta 10 -0.0913082
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0755697
GOLGA4 golgin A4 -0.0741995
NPSR1 neuropeptide S receptor 1 -0.0682927
RPS12 ribosomal protein S12 -0.0680739
RPS2 ribosomal protein S2 -0.067646
RPL37A ribosomal protein L37a -0.061468
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0613148
VEGFA vascular endothelial growth factor A -0.0565933
RPS8 ribosomal protein S8 -0.0562604
RPL9 ribosomal protein L9 -0.0533295
FLNB filamin B, beta -0.0532763
CALB1 calbindin 1, 28kDa -0.0515199
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0497324
ESYT2 extended synaptotagmin-like protein 2 -0.0486148
GCC2 GRIP and coiled-coil domain containing 2 -0.0486034
FTL ferritin, light polypeptide -0.0484915
TPM4 tropomyosin 4 -0.0473121
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0461508
AKAP9 A kinase (PRKA) anchor protein 9 -0.0450394
POTEF POTE ankyrin domain family, member F -0.0448993
PKM pyruvate kinase, muscle -0.0447628
SRRM2 serine/arginine repetitive matrix 2 -0.0437171
AREG amphiregulin -0.0436535
S100A6 S100 calcium binding protein A6 -0.0419895
RPL35A ribosomal protein L35a -0.0412997
KTN1 kinectin 1 (kinesin receptor) -0.0411436
RPS19 ribosomal protein S19 -0.0410221
RPS23 ribosomal protein S23 -0.0404775
RPS13 ribosomal protein S13 -0.0391623
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0385464
RPS29 ribosomal protein S29 -0.0385377
PPARG peroxisome proliferator-activated receptor gamma -0.037277
RPS3 ribosomal protein S3 -0.0369228
ITGB4 integrin, beta 4 -0.0365375
PTEN phosphatase and tensin homolog -0.0362397
FOSL1 FOS-like antigen 1 -0.0361815
MT2A metallothionein 2A -0.0359809
NCOR1 nuclear receptor corepressor 1 -0.0358079
KRT19 keratin 19, type I -0.0357396
FERMT1 fermitin family member 1 -0.0355118
RPL26 ribosomal protein L26 -0.0354583
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0349547
RPL31 ribosomal protein L31 -0.0349288
FAM13A family with sequence similarity 13, member A -0.0344511
NKTR natural killer cell triggering receptor -0.0337666
ABHD2 abhydrolase domain containing 2 -0.0335648
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0331761
SETD5 SET domain containing 5 -0.032806
TMF1 TATA element modulatory factor 1 -0.0327971
PRRC2C proline-rich coiled-coil 2C -0.0327209
KLF3 Kruppel-like factor 3 (basic) -0.032402
RPL5 ribosomal protein L5 -0.0321815
B2M beta-2-microglobulin -0.0321411
RPLP2 ribosomal protein, large, P2 -0.0317156
KIF5B kinesin family member 5B -0.0311566
ZNF292 zinc finger protein 292 -0.0311486
KMT2E lysine (K)-specific methyltransferase 2E -0.0308366
RPL36 ribosomal protein L36 -0.0306641
KRT18 keratin 18, type I -0.0304993
PDIA3 protein disulfide isomerase family A, member 3 -0.0303922
LDHA lactate dehydrogenase A -0.0301481
PLAUR plasminogen activator, urokinase receptor -0.0300412
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0298133
KDM7A lysine (K)-specific demethylase 7A -0.029231
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0290324
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0289598
RPL21 ribosomal protein L21 -0.0288859
TFF1 trefoil factor 1 -0.028854
RPS17 ribosomal protein S17 -0.028824
TPT1 tumor protein, translationally-controlled 1 -0.0286253
RPL7 ribosomal protein L7 -0.0284791
SRSF11 serine/arginine-rich splicing factor 11 -0.0283425
MON2 MON2 homolog (S. cerevisiae) -0.0281349
BIRC6 baculoviral IAP repeat containing 6 -0.0279962
RPS27 ribosomal protein S27 -0.0279861
RPS25 ribosomal protein S25 -0.0278755
SBF2 SET binding factor 2 -0.0278535
MUC17 mucin 17, cell surface associated -0.0277943
HMGA1 high mobility group AT-hook 1 -0.0275335
ANXA2 annexin A2 -0.0275057
RAB6A RAB6A, member RAS oncogene family -0.0274172
TFF3 trefoil factor 3 (intestinal) -0.0273715
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -0.0268981
RPL7A ribosomal protein L7a -0.0268957
DNM2 dynamin 2 -0.0267692
RPS14 ribosomal protein S14 -0.0265021
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0262966
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0261104
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0260529
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0260496
SCFD1 sec1 family domain containing 1 -0.0259105
PRSS3 protease, serine, 3 -0.0258815
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0256306