| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Demeclocycline perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Demeclocycline_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.161177 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.136318 |
| INTS6 | integrator complex subunit 6 | 0.124246 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.115976 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.108813 |
| SLTM | SAFB-like, transcription modulator | 0.103955 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0948219 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0936793 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.090952 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0900842 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0890546 |
| GRAMD1B | GRAM domain containing 1B | 0.0842976 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0842591 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0816055 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0754844 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0713776 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0679218 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0677482 |
| HOMER1 | homer scaffolding protein 1 | 0.0644898 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0622919 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0617954 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0586692 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0569201 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0555023 |
| ENO1 | enolase 1, (alpha) | 0.0544709 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0529033 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0524396 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0514595 |
| SMYD3 | SET and MYND domain containing 3 | 0.0506777 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0503597 |
| SMAD3 | SMAD family member 3 | 0.0494565 |
| MYOF | myoferlin | 0.0493721 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0492854 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0492791 |
| MCL1 | myeloid cell leukemia 1 | 0.0486337 |
| FAM13A | family with sequence similarity 13, member A | 0.0475549 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0461762 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0447395 |
| ATF6 | activating transcription factor 6 | 0.0446489 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0436459 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0421133 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0414732 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0408798 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0405828 |
| FUS | FUS RNA binding protein | 0.0404948 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0402143 |
| GPHN | gephyrin | 0.039988 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0397271 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0392296 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0389621 |
| SPAG9 | sperm associated antigen 9 | 0.0375537 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0368309 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0363003 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0360025 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.035617 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0355783 |
| MYO1E | myosin IE | 0.0348888 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0343475 |
| SIK3 | SIK family kinase 3 | 0.0330711 |
| FNDC3A | fibronectin type III domain containing 3A | 0.032739 |
| ANXA1 | annexin A1 | 0.0318268 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0312455 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0310774 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0307986 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0305442 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0304216 |
| NABP1 | nucleic acid binding protein 1 | 0.0302434 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0300705 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0299559 |
| RAD51B | RAD51 paralog B | 0.0298999 |
| ANKRD37 | ankyrin repeat domain 37 | 0.0297756 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0297437 |
| BMP6 | bone morphogenetic protein 6 | 0.029348 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0293361 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0290731 |
| GOLGB1 | golgin B1 | 0.0288539 |
| MT2A | metallothionein 2A | 0.0287501 |
| JMJD1C | jumonji domain containing 1C | 0.0285696 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0284956 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0282854 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0281194 |
| JUN | jun proto-oncogene | 0.0280628 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0280115 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0279082 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.027743 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0277253 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0272203 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.026821 |
| WWOX | WW domain containing oxidoreductase | 0.0263618 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0263139 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0262816 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0262651 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0262205 |
| CANX | calnexin | 0.0261571 |
| PYGL | phosphorylase, glycogen, liver | 0.0256638 |
| PTMA | prothymosin, alpha | 0.0256579 |
| MAP7 | microtubule-associated protein 7 | 0.0255346 |
| RPS3 | ribosomal protein S3 | 0.025438 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0249978 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.024851 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.202118 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.187871 |
| LAMC2 | laminin, gamma 2 | -0.107246 |
| OSMR | oncostatin M receptor | -0.0955221 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0879182 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0822629 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0794718 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0752222 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0707196 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0624613 |
| LAMA4 | laminin, alpha 4 | -0.0603548 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0544963 |
| NDRG1 | N-myc downstream regulated 1 | -0.0510491 |
| TMSB10 | thymosin beta 10 | -0.0505479 |
| TMEM165 | transmembrane protein 165 | -0.0504854 |
| EGR1 | early growth response 1 | -0.0467811 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0466468 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0452457 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.042699 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0404997 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0392123 |
| MKI67 | marker of proliferation Ki-67 | -0.0384895 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0378257 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0375156 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0369721 |
| CES1 | carboxylesterase 1 | -0.0346611 |
| MGAT4C | MGAT4 family, member C | -0.0345518 |
| RIN2 | Ras and Rab interactor 2 | -0.0334238 |
| NDE1 | nudE neurodevelopment protein 1 | -0.0333303 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.0331084 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0327708 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0319415 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0310669 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0310323 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0304777 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.03028 |
| H1-0 | H1.0 linker histone | -0.030059 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0295046 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0293744 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0286682 |
| PKM | pyruvate kinase, muscle | -0.0283944 |
| KRT8 | keratin 8, type II | -0.0282287 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.027934 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | -0.0265029 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | -0.0257343 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0255905 |
| NGLY1 | N-glycanase 1 | -0.0252854 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0248364 |
| CAB39 | calcium binding protein 39 | -0.0248354 |
| PGK1 | phosphoglycerate kinase 1 | -0.024611 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | -0.0242394 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0241104 |
| WDR45B | WD repeat domain 45B | -0.0238287 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0238073 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0231578 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | -0.0220369 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0216464 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0216294 |
| FRMD4B | FERM domain containing 4B | -0.0214715 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0210939 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0208151 |
| RSF1 | remodeling and spacing factor 1 | -0.0207423 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0206608 |
| PTEN | phosphatase and tensin homolog | -0.0200134 |
| RAP2B | RAP2B, member of RAS oncogene family | -0.0193252 |
| PERP | PERP, TP53 apoptosis effector | -0.019262 |
| RAB1A | RAB1A, member RAS oncogene family | -0.019197 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0191882 |
| TKT | transketolase | -0.0190917 |
| ABLIM1 | actin binding LIM protein 1 | -0.0187918 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0184792 |
| SBF2 | SET binding factor 2 | -0.0183426 |
| ADAR | adenosine deaminase, RNA-specific | -0.0178814 |
| PPP6R2 | protein phosphatase 6, regulatory subunit 2 | -0.0178429 |
| CCNL1 | cyclin L1 | -0.0177436 |
| TMEM41B | transmembrane protein 41B | -0.017655 |
| KRT19 | keratin 19, type I | -0.0176334 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0176179 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | -0.0174873 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0169858 |
| ASPH | aspartate beta-hydroxylase | -0.0169583 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0167459 |
| YEATS2 | YEATS domain containing 2 | -0.0166395 |
| PLEC | plectin | -0.0164176 |
| WASF2 | WAS protein family, member 2 | -0.0163133 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0162503 |
| S100A6 | S100 calcium binding protein A6 | -0.0162019 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0158394 |
| S100A11 | S100 calcium binding protein A11 | -0.0157611 |
| JUP | junction plakoglobin | -0.0156482 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0153472 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0153402 |
| CST3 | cystatin C | -0.0153338 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0150015 |
| FERMT1 | fermitin family member 1 | -0.0149349 |
| ESCO1 | establishment of sister chromatid cohesion N-acetyltransferase 1 | -0.0149303 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | -0.0148301 |
| RTN4 | reticulon 4 | -0.014715 |
| TLK1 | tousled-like kinase 1 | -0.0145408 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0145244 |
