| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Demeclocycline perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Demeclocycline_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SMAD3 | SMAD family member 3 | 0.118129 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.114096 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.112456 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.102071 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0768484 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0709473 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0647076 |
| INTS6 | integrator complex subunit 6 | 0.0631386 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0612234 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0610728 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0566295 |
| RAD51B | RAD51 paralog B | 0.0559945 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.05592 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0553798 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0553759 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0536225 |
| NAV2 | neuron navigator 2 | 0.0512853 |
| EFNA5 | ephrin-A5 | 0.0506968 |
| CD44 | CD44 molecule (Indian blood group) | 0.0472178 |
| PRELID2 | PRELI domain containing 2 | 0.0472077 |
| NTN4 | netrin 4 | 0.0467384 |
| ZNF638 | zinc finger protein 638 | 0.0465817 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0456184 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0439729 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.043719 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0434026 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0432037 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0427424 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0415462 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0403061 |
| PCBP2 | poly(rC) binding protein 2 | 0.0401857 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0399144 |
| HMGA2 | high mobility group AT-hook 2 | 0.0394141 |
| ASPH | aspartate beta-hydroxylase | 0.038919 |
| AHNAK | AHNAK nucleoprotein | 0.0383118 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0383109 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0379036 |
| TGM2 | transglutaminase 2 | 0.0378264 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0375824 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0373215 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0366674 |
| LOXL2 | lysyl oxidase-like 2 | 0.0366158 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0343882 |
| MYO10 | myosin X | 0.0343416 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0338937 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0334393 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0330969 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0330462 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.033012 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0327124 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0326492 |
| AADAC | arylacetamide deacetylase | 0.0324913 |
| FAM20C | family with sequence similarity 20, member C | 0.0313412 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0308776 |
| KSR1 | kinase suppressor of ras 1 | 0.0301249 |
| RHCG | Rh family, C glycoprotein | 0.0287919 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.028007 |
| IL1R1 | interleukin 1 receptor, type I | 0.0278771 |
| MIPOL1 | mirror-image polydactyly 1 | 0.0276249 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0274944 |
| KYNU | kynureninase | 0.0274695 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | 0.0273535 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0272347 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0271972 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.026939 |
| GPHN | gephyrin | 0.0269116 |
| WWOX | WW domain containing oxidoreductase | 0.0265487 |
| SEPTIN9 | septin 9 | 0.0262435 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0260271 |
| WLS | wntless Wnt ligand secretion mediator | 0.0258503 |
| ANO6 | anoctamin 6 | 0.0256887 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0253417 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0251954 |
| SP100 | SP100 nuclear antigen | 0.0251389 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.024381 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0241714 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0238614 |
| DST | dystonin | 0.0238202 |
| UTRN | utrophin | 0.0237805 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0235413 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.023459 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0233599 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.023207 |
| FKBP5 | FK506 binding protein 5 | 0.0230356 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.02288 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0228669 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.022644 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0222537 |
| SMYD3 | SET and MYND domain containing 3 | 0.0222262 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0222043 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0218787 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0214445 |
| PHF14 | PHD finger protein 14 | 0.0214264 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.02132 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0211444 |
| CEP250 | centrosomal protein 250kDa | 0.0210297 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.020959 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.020955 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0209117 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.020908 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.212631 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.197305 |
| VIM | vimentin | -0.117703 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.094666 |
| FTL | ferritin, light polypeptide | -0.0933017 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.090937 |
| FN1 | fibronectin 1 | -0.0843977 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0807447 |
| S100A6 | S100 calcium binding protein A6 | -0.0759634 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0727307 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0726878 |
| OSMR | oncostatin M receptor | -0.0704027 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0688411 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0671273 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0665901 |
| PTMA | prothymosin, alpha | -0.0635617 |
| STC1 | stanniocalcin 1 | -0.0630349 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0619846 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0587808 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.057883 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0577855 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0547142 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0543549 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0508336 |
| GLCCI1 | glucocorticoid induced 1 | -0.0485195 |
| MEF2A | myocyte enhancer factor 2A | -0.0478706 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0478174 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0469167 |
| NDRG1 | N-myc downstream regulated 1 | -0.046586 |
| RPS19 | ribosomal protein S19 | -0.0451321 |
| B2M | beta-2-microglobulin | -0.0438433 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.042848 |
| GOLGA4 | golgin A4 | -0.041523 |
| NRP1 | neuropilin 1 | -0.0414949 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0414346 |
| RPL35A | ribosomal protein L35a | -0.0404025 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.03944 |
| POTEF | POTE ankyrin domain family, member F | -0.0394027 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0383318 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0380526 |
| MTSS1 | metastasis suppressor 1 | -0.0372588 |
| LOX | lysyl oxidase | -0.0371172 |
| RPS21 | ribosomal protein S21 | -0.0365468 |
| HMGA1 | high mobility group AT-hook 1 | -0.036426 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0362362 |
| EGR1 | early growth response 1 | -0.0355739 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0352669 |
| RPLP1 | ribosomal protein, large, P1 | -0.0351067 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0347808 |
| TMEM165 | transmembrane protein 165 | -0.03445 |
| CDCP1 | CUB domain containing protein 1 | -0.0343793 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0340783 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0340203 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0337932 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0335518 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0334358 |
| CLMP | CXADR-like membrane protein | -0.033367 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.033245 |
| SNX9 | sorting nexin 9 | -0.0331967 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.03276 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0326408 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.032538 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0319045 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0317812 |
| MT2A | metallothionein 2A | -0.0312827 |
| VEGFA | vascular endothelial growth factor A | -0.0312507 |
| PRRX1 | paired related homeobox 1 | -0.0311085 |
| CDH13 | cadherin 13 | -0.0310808 |
| TMSB4X | thymosin beta 4, X-linked | -0.0310402 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0304727 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0299834 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0299264 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0298995 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0297453 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0294651 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0293712 |
| GNAS | GNAS complex locus | -0.02924 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0291389 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0287241 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0282439 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.028155 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0279027 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0278623 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0273729 |
| HLA-B | major histocompatibility complex, class I, B | -0.0272217 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0272188 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0269413 |
| RIOK3 | RIO kinase 3 | -0.0269251 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0268562 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | -0.0268125 |
| LOC112694756 | uncharaterized LOC112694756 | -0.026469 |
| MAP1B | microtubule-associated protein 1B | -0.0264651 |
| NAV3 | neuron navigator 3 | -0.0264377 |
| NRG1 | neuregulin 1 | -0.0263739 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0263233 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0261918 |
| RAI14 | retinoic acid induced 14 | -0.0261392 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0259373 |
| RPL34 | ribosomal protein L34 | -0.0257581 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0256364 |
