| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Demeclocycline perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Demeclocycline_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | 0.249407 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.153772 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0856434 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0798245 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0743536 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0701396 |
| WWOX | WW domain containing oxidoreductase | 0.0661695 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0656943 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0621421 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0615394 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0599736 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0558544 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0555378 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0547927 |
| FAM107B | family with sequence similarity 107, member B | 0.0521382 |
| BRD2 | bromodomain containing 2 | 0.0519172 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0515411 |
| PCBP2 | poly(rC) binding protein 2 | 0.0512847 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0512319 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0506055 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0487722 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0468093 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0452668 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0446988 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.044152 |
| PDE10A | phosphodiesterase 10A | 0.0414734 |
| RBM39 | RNA binding motif protein 39 | 0.0408816 |
| FUS | FUS RNA binding protein | 0.0392198 |
| FHIT | fragile histidine triad | 0.0391107 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0389034 |
| INTS6 | integrator complex subunit 6 | 0.0379111 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0377189 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0372105 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0371741 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0368184 |
| ZNF638 | zinc finger protein 638 | 0.0365 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0363679 |
| ATF6 | activating transcription factor 6 | 0.0351305 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0350018 |
| PTK2 | protein tyrosine kinase 2 | 0.0347161 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0346642 |
| HELZ | helicase with zinc finger | 0.0343139 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0342914 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0342876 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0338339 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0337351 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0335621 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0335561 |
| COPA | coatomer protein complex, subunit alpha | 0.0335031 |
| CTBP2 | C-terminal binding protein 2 | 0.0330983 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0325468 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0314077 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0310644 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.030986 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0306337 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0303486 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0301905 |
| RNF145 | ring finger protein 145 | 0.0299152 |
| USP36 | ubiquitin specific peptidase 36 | 0.0298684 |
| TOP1 | topoisomerase (DNA) I | 0.0298541 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0295102 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0294504 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0291405 |
| ZNF207 | zinc finger protein 207 | 0.0286802 |
| FMNL2 | formin-like 2 | 0.0286694 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0285833 |
| RCOR1 | REST corepressor 1 | 0.028561 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0283756 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0282506 |
| FTL | ferritin, light polypeptide | 0.0281993 |
| SIK3 | SIK family kinase 3 | 0.0281387 |
| CCNY | cyclin Y | 0.0281231 |
| CUL3 | cullin 3 | 0.0271073 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0269648 |
| DST | dystonin | 0.0269541 |
| ATXN1 | ataxin 1 | 0.0269226 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0268274 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.026771 |
| MYOF | myoferlin | 0.0267534 |
| GPHN | gephyrin | 0.0266117 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0263911 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0261753 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0261562 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0261201 |
| MED13 | mediator complex subunit 13 | 0.0260496 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0258934 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0256977 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0256772 |
| GOLGB1 | golgin B1 | 0.025649 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0254047 |
| RPS29 | ribosomal protein S29 | 0.025377 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0252797 |
| SMAD2 | SMAD family member 2 | 0.0251253 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0249335 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0249325 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0247323 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0246192 |
| NCKAP1 | NCK-associated protein 1 | 0.0242634 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0242479 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0240621 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.221905 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.172775 |
| VIM | vimentin | -0.122352 |
| TMSB10 | thymosin beta 10 | -0.111781 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.100607 |
| PYGL | phosphorylase, glycogen, liver | -0.085931 |
| GRAMD1B | GRAM domain containing 1B | -0.0847951 |
| IGF2 | insulin-like growth factor 2 | -0.0822754 |
| S100A6 | S100 calcium binding protein A6 | -0.0768031 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0766289 |
| TXNRD1 | thioredoxin reductase 1 | -0.0729172 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0686181 |
| OSMR | oncostatin M receptor | -0.0659938 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0625372 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.054823 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0541761 |
| TPM4 | tropomyosin 4 | -0.0521513 |
| EGR1 | early growth response 1 | -0.0499898 |
| STC1 | stanniocalcin 1 | -0.0499371 |
| ACTG1 | actin gamma 1 | -0.0458676 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0453204 |
| CAVIN1 | caveolae associated protein 1 | -0.0440342 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.043389 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0410481 |
| IER3 | immediate early response 3 | -0.0394801 |
| MT2A | metallothionein 2A | -0.0387165 |
| BICC1 | BicC family RNA binding protein 1 | -0.0347921 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0326616 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0323611 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0319933 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0309132 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0299672 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0297015 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0292605 |
| KLF6 | Kruppel-like factor 6 | -0.0291663 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0285975 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0281183 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0277525 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0275389 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0273541 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0272028 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0262653 |
| RACK1 | receptor for activated C kinase 1 | -0.0257116 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.025422 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0251282 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0247578 |
| SEPTIN10 | septin 10 | -0.0236431 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0236183 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0234484 |
| HDAC9 | histone deacetylase 9 | -0.0231413 |
| SNX14 | sorting nexin 14 | -0.0226911 |
| INHBA | inhibin, beta A | -0.0221452 |
| MYL12B | myosin, light chain 12B, regulatory | -0.022002 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0218642 |
| AK1 | adenylate kinase 1 | -0.0218123 |
| LAMC2 | laminin, gamma 2 | -0.0215107 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0213966 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0211198 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0211041 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0208595 |
| RPS21 | ribosomal protein S21 | -0.0207748 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.020667 |
| PCED1B | PC-esterase domain containing 1B | -0.0205325 |
| RPL4 | ribosomal protein L4 | -0.0203993 |
| CFDP1 | craniofacial development protein 1 | -0.0201557 |
| APP | amyloid beta (A4) precursor protein | -0.0200583 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0200559 |
| CLDN1 | claudin 1 | -0.0199262 |
| RPL30 | ribosomal protein L30 | -0.0198718 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0196975 |
| CDCP1 | CUB domain containing protein 1 | -0.0196557 |
| SRGN | serglycin | -0.0194004 |
| TMSB4X | thymosin beta 4, X-linked | -0.0192942 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.018995 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0189514 |
| RPLP0 | ribosomal protein, large, P0 | -0.0188536 |
| CD99 | CD99 molecule | -0.0184533 |
| RAD21 | RAD21 homolog (S. pombe) | -0.018383 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0181572 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0179449 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0179284 |
| FAM110C | family with sequence similarity 110, member C | -0.0178555 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0177772 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0176606 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0174305 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0173658 |
| CCL2 | chemokine (C-C motif) ligand 2 | -0.0170773 |
| PTMA | prothymosin, alpha | -0.0169163 |
| MKI67 | marker of proliferation Ki-67 | -0.0168107 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0166868 |
| RPL26 | ribosomal protein L26 | -0.0162779 |
| ERBIN | erbb2 interacting protein | -0.0162497 |
| IL6 | interleukin 6 | -0.0161735 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0161547 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0161053 |
| RAI1 | retinoic acid induced 1 | -0.0159785 |
| NAV3 | neuron navigator 3 | -0.0158744 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0158682 |
| GLIS3 | GLIS family zinc finger 3 | -0.0157987 |
| FLNB | filamin B, beta | -0.0157551 |
