| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Demeclocycline perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Demeclocycline_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.234073 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.109421 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0940904 |
| INTS6 | integrator complex subunit 6 | 0.0901916 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0812885 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0774797 |
| MCL1 | myeloid cell leukemia 1 | 0.0737741 |
| FMNL2 | formin-like 2 | 0.0710937 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0705011 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0644886 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0627916 |
| HOMER1 | homer scaffolding protein 1 | 0.0620889 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0556234 |
| SFPQ | splicing factor proline/glutamine-rich | 0.053579 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0535431 |
| PDLIM5 | PDZ and LIM domain 5 | 0.053159 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0516176 |
| AEBP2 | AE binding protein 2 | 0.049029 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0479121 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0465197 |
| BRD2 | bromodomain containing 2 | 0.045924 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.0459099 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0454974 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0448632 |
| YBX3 | Y box binding protein 3 | 0.0442172 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0409742 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0409548 |
| NABP1 | nucleic acid binding protein 1 | 0.0406368 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0393122 |
| VCL | vinculin | 0.037404 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0372512 |
| JMJD1C | jumonji domain containing 1C | 0.0371998 |
| TRIM59 | tripartite motif containing 59 | 0.0370296 |
| AFF3 | AF4/FMR2 family, member 3 | 0.036761 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0359855 |
| ANO6 | anoctamin 6 | 0.0345834 |
| NEK10 | NIMA-related kinase 10 | 0.0339926 |
| NRG1 | neuregulin 1 | 0.0327124 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0325714 |
| SETX | senataxin | 0.0321797 |
| ATP13A3 | ATPase type 13A3 | 0.0316515 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0309373 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0306876 |
| OSMR | oncostatin M receptor | 0.0304855 |
| TPM2 | tropomyosin 2 (beta) | 0.0302399 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0300357 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0294239 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0286418 |
| RCOR1 | REST corepressor 1 | 0.0283579 |
| CAPRIN2 | caprin family member 2 | 0.0281149 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.02777 |
| SVIL | supervillin | 0.0276282 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0274454 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.02718 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0268501 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0264618 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0260757 |
| PRKCE | protein kinase C, epsilon | 0.025884 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0257882 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0250782 |
| PUM1 | pumilio RNA-binding family member 1 | 0.024932 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0248711 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.0247923 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | 0.0247516 |
| ADIPOR2 | adiponectin receptor 2 | 0.0245162 |
| FUS | FUS RNA binding protein | 0.0243966 |
| DST | dystonin | 0.0241529 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0241306 |
| FARS2 | phenylalanyl-tRNA synthetase 2, mitochondrial | 0.0235967 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0235358 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0234642 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0234316 |
| GOLGB1 | golgin B1 | 0.0233292 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0233161 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0228201 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0226806 |
| MYO10 | myosin X | 0.0226441 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0226181 |
| DUSP16 | dual specificity phosphatase 16 | 0.0223307 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0221476 |
| FERMT2 | fermitin family member 2 | 0.0220739 |
| DIAPH2 | diaphanous-related formin 2 | 0.0219201 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0218106 |
| MAN1A2 | mannosidase, alpha, class 1A, member 2 | 0.0217603 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0217597 |
| VMP1 | vacuole membrane protein 1 | 0.021627 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0214391 |
| SRSF6 | serine/arginine-rich splicing factor 6 | 0.0211297 |
| TUT7 | terminal uridylyl transferase 7 | 0.0209214 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0208907 |
| CREM | cAMP responsive element modulator | 0.0207155 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0205792 |
| TEX14 | testis expressed 14 | 0.0204458 |
| HDAC9 | histone deacetylase 9 | 0.0204273 |
| R3HDM2 | R3H domain containing 2 | 0.0203844 |
| RSU1 | Ras suppressor protein 1 | 0.0203235 |
| JUN | jun proto-oncogene | 0.020295 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0200294 |
| NRDC | nardilysin convertase | 0.0199711 |
| WNT9A | wingless-type MMTV integration site family, member 9A | 0.0198215 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.174975 |
| PTMA | prothymosin, alpha | -0.11232 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0908862 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.085531 |
| TXNRD1 | thioredoxin reductase 1 | -0.0808727 |
| RAD51B | RAD51 paralog B | -0.068818 |
| TPI1 | triosephosphate isomerase 1 | -0.0671105 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0669737 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0649639 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.063947 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.061032 |
| VIM | vimentin | -0.0606727 |
| MKI67 | marker of proliferation Ki-67 | -0.0599325 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.059777 |
| TMSB10 | thymosin beta 10 | -0.0591151 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0543 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0542653 |
| BBX | bobby sox homolog (Drosophila) | -0.0513471 |
| ZFR | zinc finger RNA binding protein | -0.0508665 |
| ZNF292 | zinc finger protein 292 | -0.0474507 |
| CENPF | centromere protein F, 350/400kDa | -0.0473954 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0468681 |
| XPO1 | exportin 1 | -0.0454729 |
| RTN4 | reticulon 4 | -0.0441802 |
| ADAR | adenosine deaminase, RNA-specific | -0.0436863 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0431027 |
| EGR1 | early growth response 1 | -0.042539 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0424728 |
| SBF2 | SET binding factor 2 | -0.0406368 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.040426 |
| LDHB | lactate dehydrogenase B | -0.040357 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0398658 |
| PHIP | pleckstrin homology domain interacting protein | -0.0397228 |
| NCOR1 | nuclear receptor corepressor 1 | -0.039505 |
| BSG | basigin (Ok blood group) | -0.0384916 |
| GNAS | GNAS complex locus | -0.0382943 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0382901 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0377182 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0377009 |
| PGK1 | phosphoglycerate kinase 1 | -0.0376207 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.036881 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0367926 |
| TMEM165 | transmembrane protein 165 | -0.0367043 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0364329 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0357789 |
| PCNX1 | pecanex 1 | -0.0357642 |
| IGF2 | insulin-like growth factor 2 | -0.0356859 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0343133 |
| CCND2 | cyclin D2 | -0.0341379 |
| WDR45B | WD repeat domain 45B | -0.0337032 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0336853 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0336786 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0332443 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0332078 |
| AHNAK | AHNAK nucleoprotein | -0.0331024 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0329796 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0329694 |
| MAP4 | microtubule-associated protein 4 | -0.0328883 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0327783 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0326651 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0326268 |
| WASF2 | WAS protein family, member 2 | -0.0321845 |
| MATR3 | matrin 3 | -0.0318964 |
| RSF1 | remodeling and spacing factor 1 | -0.031296 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0312575 |
| PHF21A | PHD finger protein 21A | -0.0311865 |
| SIN3A | SIN3 transcription regulator family member A | -0.0305612 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.030517 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0303903 |
| ZNF217 | zinc finger protein 217 | -0.0299253 |
| MIS18BP1 | MIS18 binding protein 1 | -0.02985 |
| PFKP | phosphofructokinase, platelet | -0.0297515 |
| PKM | pyruvate kinase, muscle | -0.0297423 |
| TUBB | tubulin, beta class I | -0.0296619 |
| IGF2BP1 | insulin-like growth factor 2 mRNA binding protein 1 | -0.0296585 |
| GOLGA4 | golgin A4 | -0.0293878 |
| RPS21 | ribosomal protein S21 | -0.0293152 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0292115 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0290772 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.028843 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0285492 |
| RPL8 | ribosomal protein L8 | -0.0284668 |
| ENO1 | enolase 1, (alpha) | -0.0283641 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0283502 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0280605 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0280087 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0279768 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0278731 |
| CCDC88A | coiled-coil domain containing 88A | -0.02779 |
| LDHA | lactate dehydrogenase A | -0.0277806 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0273851 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0273469 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0272828 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0271534 |
| HMGA1 | high mobility group AT-hook 1 | -0.0271285 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0270458 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0268982 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0268668 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | -0.0268099 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0267281 |
