Demeclocycline_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Demeclocycline perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Demeclocycline_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.250063
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.161887
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.121234
FTL ferritin, light polypeptide 0.109076
TPT1 tumor protein, translationally-controlled 1 0.105054
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0968279
ZSWIM6 zinc finger, SWIM-type containing 6 0.0911135
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0844069
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0763134
CANX calnexin 0.0715448
SAMD4A sterile alpha motif domain containing 4A 0.0714059
EIF1 eukaryotic translation initiation factor 1 0.0713175
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0641535
APLP2 amyloid beta (A4) precursor-like protein 2 0.0612158
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0593522
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0570572
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0565323
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0529508
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0520581
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0517668
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0491959
NAP1L1 nucleosome assembly protein 1-like 1 0.0484066
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0482593
RPS8 ribosomal protein S8 0.0470282
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0469256
LAMB3 laminin, beta 3 0.0459499
ELL2 elongation factor, RNA polymerase II, 2 0.0456246
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0439957
RPS3 ribosomal protein S3 0.0438369
GOLGB1 golgin B1 0.0436379
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0414998
EFNA5 ephrin-A5 0.041077
FHIT fragile histidine triad 0.0401718
HMGB2 high mobility group box 2 0.0372942
RPL37A ribosomal protein L37a 0.0370344
ENO1 enolase 1, (alpha) 0.03686
SQSTM1 sequestosome 1 0.0367741
HSPA8 heat shock 70kDa protein 8 0.0360268
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0353497
BRD2 bromodomain containing 2 0.0353228
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0351404
RPS12 ribosomal protein S12 0.0348592
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0344044
ADM adrenomedullin 0.034252
INTS6 integrator complex subunit 6 0.0342082
RPL9 ribosomal protein L9 0.0340147
MT2A metallothionein 2A 0.0337358
TFPI2 tissue factor pathway inhibitor 2 0.0336735
SMAD3 SMAD family member 3 0.0330476
PRKCA protein kinase C, alpha 0.0326269
KIAA1217 KIAA1217 0.0318312
AHNAK AHNAK nucleoprotein 0.0318032
EEF2 eukaryotic translation elongation factor 2 0.0317105
RPL12 ribosomal protein L12 0.0314985
RPS29 ribosomal protein S29 0.0314064
SKP1 S-phase kinase-associated protein 1 0.0314054
TTC3 tetratricopeptide repeat domain 3 0.0309934
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0309245
MCL1 myeloid cell leukemia 1 0.0308435
SDC4 syndecan 4 0.0301285
UPP1 uridine phosphorylase 1 0.0299738
DTNA dystrobrevin, alpha 0.0296669
RPLP2 ribosomal protein, large, P2 0.0295494
CSNK1A1 casein kinase 1, alpha 1 0.0290247
ZBTB38 zinc finger and BTB domain containing 38 0.0286451
RPS27A ribosomal protein S27a 0.0285146
TJP1 tight junction protein 1 0.0285069
HDAC9 histone deacetylase 9 0.0283703
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0282156
SGMS2 sphingomyelin synthase 2 0.0280024
G0S2 G0/G1 switch 2 0.0277822
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.027573
PRRC2C proline-rich coiled-coil 2C 0.0274515
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0274168
EXT1 exostosin glycosyltransferase 1 0.0270103
RAD51B RAD51 paralog B 0.0269163
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0268476
DSPP dentin sialophosphoprotein 0.0265232
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0262697
RPS6 ribosomal protein S6 0.0262062
ANO6 anoctamin 6 0.0260272
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.026006
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0259624
TXNIP thioredoxin interacting protein 0.0257091
MX1 MX dynamin-like GTPase 1 0.0254316
RPS17 ribosomal protein S17 0.0254295
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0253651
RPLP0 ribosomal protein, large, P0 0.0252415
SET SET nuclear proto-oncogene 0.0251338
CTBP2 C-terminal binding protein 2 0.0251238
KDM2A lysine (K)-specific demethylase 2A 0.0251011
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0250285
TACSTD2 tumor-associated calcium signal transducer 2 0.0249378
RPL11 ribosomal protein L11 0.0248941
ARHGAP5 Rho GTPase activating protein 5 0.0248071
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0247823
SEC31A SEC31 homolog A (S. cerevisiae) 0.0243994
JUN jun proto-oncogene 0.0243479
CD44 CD44 molecule (Indian blood group) 0.0242275
USP53 ubiquitin specific peptidase 53 0.0240371

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.275571
POTEF POTE ankyrin domain family, member F -0.0875077
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0657202
NPEPPS aminopeptidase puromycin sensitive -0.0618955
HMGA1 high mobility group AT-hook 1 -0.0574429
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.050434
TMSB10 thymosin beta 10 -0.0499142
FAM3C family with sequence similarity 3, member C -0.0494096
LPP LIM domain containing preferred translocation partner in lipoma -0.0463858
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.042397
TFG TRK-fused gene -0.0408933
ADAM9 ADAM metallopeptidase domain 9 -0.0395726
LIMCH1 LIM and calponin homology domains 1 -0.0391995
LOC112694756 uncharaterized LOC112694756 -0.0385619
CD2AP CD2-associated protein -0.0384433
KMT2E lysine (K)-specific methyltransferase 2E -0.0375093
ITCH itchy E3 ubiquitin protein ligase -0.037025
TMSB4X thymosin beta 4, X-linked -0.0365166
PGK1 phosphoglycerate kinase 1 -0.0360038
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0358321
PKM pyruvate kinase, muscle -0.034491
S100A6 S100 calcium binding protein A6 -0.0339253
STRN3 striatin, calmodulin binding protein 3 -0.0336072
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0324001
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0315986
CCNL1 cyclin L1 -0.0314813
RNF145 ring finger protein 145 -0.0312777
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0312331
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0308707
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0304668
ARHGAP29 Rho GTPase activating protein 29 -0.0302193
FBXO32 F-box protein 32 -0.0298599
TMEM123 transmembrane protein 123 -0.0297327
MYH9 myosin, heavy chain 9, non-muscle -0.0290598
VEGFA vascular endothelial growth factor A -0.0288379
FTH1 ferritin, heavy polypeptide 1 -0.028193
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.0281862
EPCAM epithelial cell adhesion molecule -0.0280502
KRT8 keratin 8, type II -0.0278986
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0278363
LMAN1 lectin, mannose-binding, 1 -0.0276647
PLAU plasminogen activator, urokinase -0.0275982
ACTG1 actin gamma 1 -0.0270272
KRT7 keratin 7, type II -0.026974
IGFBP3 insulin-like growth factor binding protein 3 -0.0264582
LY6E lymphocyte antigen 6 complex, locus E -0.0263069
GRB10 growth factor receptor-bound protein 10 -0.0259445
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0258166
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.02553
FAM162A family with sequence similarity 162, member A -0.0252078
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0250702
PRRC1 proline-rich coiled-coil 1 -0.0249509
CPNE8 copine VIII -0.0247718
ZFP36L1 ZFP36 ring finger protein-like 1 -0.024584
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0243363
CDC73 cell division cycle 73 -0.0240957
MRPS6 mitochondrial ribosomal protein S6 -0.0240354
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0238524
ADAR adenosine deaminase, RNA-specific -0.0236704
COPA coatomer protein complex, subunit alpha -0.0236367
ATP5F1B ATP synthase F1 subunit beta -0.0234228
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.023174
MSMO1 methylsterol monooxygenase 1 -0.0231279
QKI QKI, KH domain containing, RNA binding -0.022192
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0219892
CD46 CD46 molecule, complement regulatory protein -0.0215231
F3 coagulation factor III (thromboplastin, tissue factor) -0.0213882
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0213772
USP3 ubiquitin specific peptidase 3 -0.0211548
MYO6 myosin VI -0.0210961
HLA-A major histocompatibility complex, class I, A -0.0208248
CTSD cathepsin D -0.0207987
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.020752
SOX4 SRY (sex determining region Y)-box 4 -0.0206029
CCND1 cyclin D1 -0.0203619
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0201666
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0199824
CAPN2 calpain 2, (m/II) large subunit -0.0197785
SETD5 SET domain containing 5 -0.0196276
PTBP3 polypyrimidine tract binding protein 3 -0.0195273
NRIP1 nuclear receptor interacting protein 1 -0.0194054
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0194034
GNAS GNAS complex locus -0.0192672
TRAM1 translocation associated membrane protein 1 -0.0192418
TAPBP TAP binding protein (tapasin) -0.0192298
PFN1 profilin 1 -0.0189935
WTAP Wilms tumor 1 associated protein -0.0189333
ACTN4 actinin, alpha 4 -0.0186708
PLEC plectin -0.0185266
CDK17 cyclin-dependent kinase 17 -0.0185036
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0183123
CD47 CD47 molecule -0.0180773
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0179037
FOSL1 FOS-like antigen 1 -0.017632
RASA2 RAS p21 protein activator 2 -0.0174859
FNDC3B fibronectin type III domain containing 3B -0.0174551
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0173763
MARCHF6 membrane associated ring-CH-type finger 6 -0.0172978
PIAS1 protein inhibitor of activated STAT, 1 -0.0172665
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0172551