| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Demeclocycline perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Demeclocycline_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | 0.18055 |
| DST | dystonin | 0.134439 |
| PDE10A | phosphodiesterase 10A | 0.126245 |
| GDA | guanine deaminase | 0.122739 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.115268 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0981582 |
| KYNU | kynureninase | 0.0951524 |
| GRAMD1B | GRAM domain containing 1B | 0.092381 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0817984 |
| COL5A2 | collagen, type V, alpha 2 | 0.0670007 |
| PDLIM5 | PDZ and LIM domain 5 | 0.066007 |
| FMNL2 | formin-like 2 | 0.0644681 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0593065 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.054898 |
| ASPH | aspartate beta-hydroxylase | 0.0510259 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0504516 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0476759 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.046374 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0439262 |
| TXNRD1 | thioredoxin reductase 1 | 0.0437784 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0428813 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0423403 |
| NEK7 | NIMA-related kinase 7 | 0.0419915 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0401312 |
| INTS6 | integrator complex subunit 6 | 0.037689 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0368285 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0356477 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0350135 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0347403 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0313876 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.031298 |
| VCL | vinculin | 0.0311338 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0301382 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.030112 |
| TNPO1 | transportin 1 | 0.0291318 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0286719 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0284914 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0279618 |
| CENPF | centromere protein F, 350/400kDa | 0.0275135 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0271822 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0268579 |
| SMAD2 | SMAD family member 2 | 0.0266677 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0264701 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0261696 |
| ATXN1 | ataxin 1 | 0.0249952 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0246757 |
| COL4A5 | collagen, type IV, alpha 5 | 0.0246684 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0241559 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0238602 |
| BDNF | brain-derived neurotrophic factor | 0.023805 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0237634 |
| FLRT2 | fibronectin leucine rich transmembrane protein 2 | 0.0233698 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0233223 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0220862 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0219858 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0219084 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0215216 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0214769 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.0213572 |
| COL4A6 | collagen, type IV, alpha 6 | 0.0213363 |
| PTEN | phosphatase and tensin homolog | 0.0212349 |
| LAMA1 | laminin, alpha 1 | 0.0209679 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0207105 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0206606 |
| DNER | delta/notch-like EGF repeat containing | 0.0205577 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 0.0199965 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0199276 |
| CTSC | cathepsin C | 0.0198843 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.019875 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0197052 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.019702 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0195767 |
| MALT1 | MALT1 paracaspase | 0.019563 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0195005 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0193352 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0192142 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0192054 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0191416 |
| ATXN7 | ataxin 7 | 0.019126 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0190812 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0190367 |
| TOP1 | topoisomerase (DNA) I | 0.0189818 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0189618 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0188741 |
| PLCB4 | phospholipase C, beta 4 | 0.0188697 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0188189 |
| MED13L | mediator complex subunit 13-like | 0.0187396 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0187231 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0187153 |
| EXOC6B | exocyst complex component 6B | 0.0186701 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0186571 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.018649 |
| BMP6 | bone morphogenetic protein 6 | 0.0185259 |
| NRDC | nardilysin convertase | 0.0184593 |
| GLCE | glucuronic acid epimerase | 0.0182683 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0181156 |
| NTN4 | netrin 4 | 0.0176142 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0168787 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0168454 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.0168186 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.246156 |
| FN1 | fibronectin 1 | -0.220401 |
| VIM | vimentin | -0.180761 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.170988 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.112877 |
| TMSB10 | thymosin beta 10 | -0.102012 |
| RPS6 | ribosomal protein S6 | -0.0909558 |
| PTMA | prothymosin, alpha | -0.0880748 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0869697 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0861235 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0740024 |
| RPLP1 | ribosomal protein, large, P1 | -0.0657563 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0628897 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0579292 |
| FTL | ferritin, light polypeptide | -0.0574884 |
| RPL35A | ribosomal protein L35a | -0.0523224 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.052218 |
| S100A6 | S100 calcium binding protein A6 | -0.0512913 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0511457 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.048573 |
| HLA-B | major histocompatibility complex, class I, B | -0.0485259 |
| STC1 | stanniocalcin 1 | -0.0480658 |
| RPS19 | ribosomal protein S19 | -0.0468984 |
| NCKAP5 | NCK-associated protein 5 | -0.0454102 |
| RPL31 | ribosomal protein L31 | -0.0450339 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.044797 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0438055 |
| RPL37A | ribosomal protein L37a | -0.0435344 |
| IL6 | interleukin 6 | -0.0433983 |
| CDH13 | cadherin 13 | -0.0418914 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0411948 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0400386 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0398568 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0392949 |
| CANX | calnexin | -0.0381449 |
| RPS23 | ribosomal protein S23 | -0.0380943 |
| RPS8 | ribosomal protein S8 | -0.0376278 |
| RPS27 | ribosomal protein S27 | -0.0375682 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0375588 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0372014 |
| RPL36A | ribosomal protein L36a | -0.0361776 |
| HLA-A | major histocompatibility complex, class I, A | -0.0360581 |
| RPL19 | ribosomal protein L19 | -0.0351931 |
| PYGL | phosphorylase, glycogen, liver | -0.0348035 |
| B2M | beta-2-microglobulin | -0.0343383 |
| RPL12 | ribosomal protein L12 | -0.0341544 |
| RPS24 | ribosomal protein S24 | -0.0336264 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.033247 |
| RPL34 | ribosomal protein L34 | -0.0329236 |
| RPS16 | ribosomal protein S16 | -0.0327388 |
| SLC16A6 | solute carrier family 16, member 6 | -0.0326769 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0322598 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.0321753 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0319834 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0319361 |
| RPL7A | ribosomal protein L7a | -0.0313319 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0312728 |
| RPS14 | ribosomal protein S14 | -0.0311113 |
| GNAS | GNAS complex locus | -0.030823 |
| NDRG1 | N-myc downstream regulated 1 | -0.030791 |
| TENM3 | teneurin transmembrane protein 3 | -0.0307317 |
| IER3 | immediate early response 3 | -0.0304922 |
| TBXT | T-box transcription factor T | -0.0298244 |
| RPL36 | ribosomal protein L36 | -0.0297506 |
| RPS27A | ribosomal protein S27a | -0.0295171 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0293834 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0290262 |
| EGR1 | early growth response 1 | -0.028753 |
| INHBA | inhibin, beta A | -0.0287193 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0286231 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0283935 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0279617 |
| TPM4 | tropomyosin 4 | -0.0277397 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0275132 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0274877 |
| CTSL | cathepsin L | -0.0273007 |
| RPS12 | ribosomal protein S12 | -0.0271743 |
| BMERB1 | bMERB domain containing 1 | -0.0270207 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0269817 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0269302 |
| RPL35 | ribosomal protein L35 | -0.0268485 |
| MCL1 | myeloid cell leukemia 1 | -0.0267122 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0266829 |
| RPL37 | ribosomal protein L37 | -0.0266721 |
| RPS29 | ribosomal protein S29 | -0.026599 |
| S100A10 | S100 calcium binding protein A10 | -0.0265941 |
| TMSB4X | thymosin beta 4, X-linked | -0.026565 |
| NBEAL1 | neurobeachin-like 1 | -0.0265472 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0263861 |
| RPS21 | ribosomal protein S21 | -0.0263735 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0263197 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0262271 |
| RPS3 | ribosomal protein S3 | -0.0261602 |
| RPLP2 | ribosomal protein, large, P2 | -0.026068 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0260657 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0260221 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0260019 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0256051 |
| LAMB1 | laminin, beta 1 | -0.0255885 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0253572 |
