| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Demeclocycline perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Demeclocycline_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GOLGB1 | golgin B1 | 0.161436 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.157077 |
| APP | amyloid beta (A4) precursor protein | 0.137982 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.131422 |
| SMAD3 | SMAD family member 3 | 0.11869 |
| FN1 | fibronectin 1 | 0.118409 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.117822 |
| COL6A3 | collagen, type VI, alpha 3 | 0.115853 |
| CD44 | CD44 molecule (Indian blood group) | 0.114936 |
| VMP1 | vacuole membrane protein 1 | 0.114398 |
| LAMA4 | laminin, alpha 4 | 0.110453 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.110243 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.10886 |
| PRRC2C | proline-rich coiled-coil 2C | 0.108528 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0974228 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0942047 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0927256 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0907847 |
| FAM13A | family with sequence similarity 13, member A | 0.0907434 |
| RBM39 | RNA binding motif protein 39 | 0.0882114 |
| INHBA | inhibin, beta A | 0.0873406 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0851955 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0822263 |
| RPS27A | ribosomal protein S27a | 0.0815308 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0814593 |
| FLNB | filamin B, beta | 0.0773975 |
| OGA | O-GlcNAcase | 0.0749674 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.071364 |
| FMNL2 | formin-like 2 | 0.0712996 |
| PRELID2 | PRELI domain containing 2 | 0.0698028 |
| BRD2 | bromodomain containing 2 | 0.068416 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0667893 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0666428 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0665497 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0661361 |
| EZR | ezrin | 0.0644433 |
| METTL15 | methyltransferase like 15 | 0.063671 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0621524 |
| VIM | vimentin | 0.0619686 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0615036 |
| INTS6 | integrator complex subunit 6 | 0.0590665 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0586092 |
| LMO7 | LIM domain 7 | 0.0564743 |
| RPLP2 | ribosomal protein, large, P2 | 0.0539981 |
| ITGA6 | integrin, alpha 6 | 0.0514018 |
| ERBIN | erbb2 interacting protein | 0.049794 |
| KIF5B | kinesin family member 5B | 0.049519 |
| DSPP | dentin sialophosphoprotein | 0.0488654 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0475012 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0469143 |
| GOLGA4 | golgin A4 | 0.0442664 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0422528 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0414348 |
| CANX | calnexin | 0.0410662 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0410331 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0406511 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0405419 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0403525 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0400428 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0400081 |
| ECT2 | epithelial cell transforming 2 | 0.0389363 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0379828 |
| GNAS | GNAS complex locus | 0.0376412 |
| RAD51B | RAD51 paralog B | 0.0371234 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0363716 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.036002 |
| CEP350 | centrosomal protein 350kDa | 0.0358585 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0358273 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0357422 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0352978 |
| MYO1E | myosin IE | 0.0352852 |
| NUCB2 | nucleobindin 2 | 0.034276 |
| CLASP1 | cytoplasmic linker associated protein 1 | 0.0328667 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0328152 |
| RPL34 | ribosomal protein L34 | 0.0324705 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0323391 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.032218 |
| RPS6 | ribosomal protein S6 | 0.0319693 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0319417 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | 0.031091 |
| EGFR | epidermal growth factor receptor | 0.0307357 |
| NF1 | neurofibromin 1 | 0.0301958 |
| CNKSR3 | CNKSR family member 3 | 0.0300421 |
| DST | dystonin | 0.0296032 |
| KCMF1 | potassium channel modulatory factor 1 | 0.028739 |
| ANO6 | anoctamin 6 | 0.0267474 |
| PTK2 | protein tyrosine kinase 2 | 0.0262488 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0244882 |
| RNF213 | ring finger protein 213 | 0.0244516 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.02353 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | 0.0229272 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0221522 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0220329 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0215418 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0215313 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0215288 |
| ATG7 | autophagy related 7 | 0.0205054 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0204859 |
| HDLBP | high density lipoprotein binding protein | 0.0193123 |
| SQSTM1 | sequestosome 1 | 0.0184191 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | -0.134817 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.13041 |
| IGF2 | insulin-like growth factor 2 | -0.117113 |
| MCL1 | myeloid cell leukemia 1 | -0.107861 |
| EXT1 | exostosin glycosyltransferase 1 | -0.10306 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.100936 |
| NAV2 | neuron navigator 2 | -0.100596 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0974608 |
| HMGA2 | high mobility group AT-hook 2 | -0.0932298 |
| CDH13 | cadherin 13 | -0.0874509 |
| ASPH | aspartate beta-hydroxylase | -0.0864481 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0854593 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0825697 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0808482 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0801782 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0784905 |
| SMYD3 | SET and MYND domain containing 3 | -0.0778289 |
| LAMB3 | laminin, beta 3 | -0.0728991 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0723922 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0720314 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.069574 |
| RPS19 | ribosomal protein S19 | -0.0695195 |
| ENO1 | enolase 1, (alpha) | -0.0664325 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0663512 |
| GIGYF2 | GRB10 interacting GYF protein 2 | -0.064767 |
| RPS8 | ribosomal protein S8 | -0.0643803 |
| STC1 | stanniocalcin 1 | -0.0610494 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0601845 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0596737 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0589126 |
| NDRG1 | N-myc downstream regulated 1 | -0.0577634 |
| RPL23 | ribosomal protein L23 | -0.0571968 |
| PARD3 | par-3 family cell polarity regulator | -0.0570376 |
| PKM | pyruvate kinase, muscle | -0.0550816 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0534765 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0525489 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0523217 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.052271 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0516403 |
| COL5A1 | collagen, type V, alpha 1 | -0.0485473 |
| HOOK3 | hook microtubule-tethering protein 3 | -0.0481377 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0468928 |
| RPS25 | ribosomal protein S25 | -0.046571 |
| MYOF | myoferlin | -0.0464903 |
| DIAPH2 | diaphanous-related formin 2 | -0.0460067 |
| ATP11A | ATPase, class VI, type 11A | -0.0452073 |
| EFNA5 | ephrin-A5 | -0.0448992 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.044388 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0443872 |
| ZNF609 | zinc finger protein 609 | -0.0429101 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0428204 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0423044 |
| RPLP1 | ribosomal protein, large, P1 | -0.0410834 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0410201 |
| RTN4 | reticulon 4 | -0.0408556 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0407154 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0406977 |
| RPS12 | ribosomal protein S12 | -0.0405259 |
| USP34 | ubiquitin specific peptidase 34 | -0.0391238 |
| RPS3 | ribosomal protein S3 | -0.038485 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0381408 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0366015 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0361419 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0359772 |
| AREG | amphiregulin | -0.0351075 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0346563 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0343997 |
| HYOU1 | hypoxia up-regulated 1 | -0.0343166 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.0342478 |
| GPATCH2 | G patch domain containing 2 | -0.0338498 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0325832 |
| FBXO11 | F-box protein 11 | -0.0315818 |
| BPTF | bromodomain PHD finger transcription factor | -0.0303757 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0300466 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0296505 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0296302 |
| RPL31 | ribosomal protein L31 | -0.0283518 |
| SYT1 | synaptotagmin I | -0.0274939 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.027371 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0263644 |
| TES | testin LIM domain protein | -0.026041 |
| ARGLU1 | arginine and glutamate rich 1 | -0.0254308 |
| MORF4L2 | mortality factor 4 like 2 | -0.0253049 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0251537 |
| MT2A | metallothionein 2A | -0.0246021 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0245016 |
| TMSB10 | thymosin beta 10 | -0.0243692 |
| EPN2 | epsin 2 | -0.0231161 |
| PPME1 | protein phosphatase methylesterase 1 | -0.0231102 |
| MED13L | mediator complex subunit 13-like | -0.0230729 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0230196 |
| ZNF638 | zinc finger protein 638 | -0.0229724 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.022446 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0220206 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0215448 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0211714 |
| TENM3 | teneurin transmembrane protein 3 | -0.0202113 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0200525 |
| RACK1 | receptor for activated C kinase 1 | -0.0200493 |
| VCL | vinculin | -0.0197967 |
