Demeclocycline_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Demeclocycline perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Demeclocycline_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.130266
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0975641
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0730221
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0699742
TXNRD1 thioredoxin reductase 1 0.0592359
AHNAK AHNAK nucleoprotein 0.0592205
MYH9 myosin, heavy chain 9, non-muscle 0.0584019
ANXA1 annexin A1 0.0573768
SMAD3 SMAD family member 3 0.0562878
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0490835
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.047824
NAP1L1 nucleosome assembly protein 1-like 1 0.0472909
RBM39 RNA binding motif protein 39 0.0469312
ANXA2 annexin A2 0.0447511
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0400256
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0398566
ANKRD28 ankyrin repeat domain 28 0.0371918
SET SET nuclear proto-oncogene 0.0368013
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0364935
SQSTM1 sequestosome 1 0.0354938
PEAK1 pseudopodium-enriched atypical kinase 1 0.0354402
CHD1 chromodomain helicase DNA binding protein 1 0.033556
COPB1 coatomer protein complex, subunit beta 1 0.0334916
TOP2B topoisomerase (DNA) II beta 180kDa 0.0332653
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0331829
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0330345
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0320724
XPO1 exportin 1 0.0314774
MIS18BP1 MIS18 binding protein 1 0.0312131
SEC23A Sec23 homolog A (S. cerevisiae) 0.0311895
TPX2 TPX2, microtubule-associated 0.0309137
PRRC2B proline-rich coiled-coil 2B 0.0306862
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0298552
WAC WW domain containing adaptor with coiled-coil 0.0297603
HELZ helicase with zinc finger 0.0297266
ZSWIM6 zinc finger, SWIM-type containing 6 0.0296879
PTGES2 prostaglandin E synthase 2 0.0289677
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0287704
RNF145 ring finger protein 145 0.0287331
HSPA8 heat shock 70kDa protein 8 0.0283544
CKAP5 cytoskeleton associated protein 5 0.0280523
SPAG9 sperm associated antigen 9 0.0280077
UBXN7 UBX domain protein 7 0.0277401
BRD2 bromodomain containing 2 0.0271591
GOLGB1 golgin B1 0.0269868
CENPF centromere protein F, 350/400kDa 0.0267482
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0266666
LCORL ligand dependent nuclear receptor corepressor-like 0.0264221
NUMA1 nuclear mitotic apparatus protein 1 0.0263992
OXSR1 oxidative stress responsive 1 0.026395
RARS1 arginyl-tRNA synthetase 1 0.0258914
FUS FUS RNA binding protein 0.0258731
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0257461
CENPE centromere protein E, 312kDa 0.0256164
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0255768
RAD23B RAD23 homolog B (S. cerevisiae) 0.0251935
EIF4A1 eukaryotic translation initiation factor 4A1 0.0248378
CPNE1 copine I 0.0247306
SON SON DNA binding protein 0.0245278
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0244271
PDE8A phosphodiesterase 8A 0.0242276
MRE11 MRE11 homolog, double strand break repair nuclease 0.0242187
ANLN anillin, actin binding protein 0.0241796
ETNK1 ethanolamine kinase 1 0.0241349
PSPC1 paraspeckle component 1 0.0240661
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0240403
CEP250 centrosomal protein 250kDa 0.0239677
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0238299
UBQLN1 ubiquilin 1 0.0237218
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0235409
OSBPL8 oxysterol binding protein-like 8 0.0233046
RAB10 RAB10, member RAS oncogene family 0.0232674
NAMPT nicotinamide phosphoribosyltransferase 0.0232446
ARRDC3 arrestin domain containing 3 0.0232262
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0231082
TUBB tubulin, beta class I 0.0229041
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0228135
RNF213 ring finger protein 213 0.0224854
SCRN1 secernin 1 0.0224818
RRBP1 ribosome binding protein 1 0.0223594
CAPRIN2 caprin family member 2 0.0223526
MLEC malectin 0.0223052
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0221734
KIF23 kinesin family member 23 0.021885
CTTN cortactin 0.0218644
NUP153 nucleoporin 153kDa 0.0218399
EED embryonic ectoderm development 0.0217688
RALY RALY heterogeneous nuclear ribonucleoprotein 0.021739
IPO7 importin 7 0.0215034
USP22 ubiquitin specific peptidase 22 0.0214124
PTTG1 pituitary tumor-transforming 1 0.0213895
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0212868
HPCAL1 hippocalcin-like 1 0.0211832
FNBP4 formin binding protein 4 0.0211706
NAP1L4 nucleosome assembly protein 1-like 4 0.0211621
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0210537
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0210384
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.020955
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0209304
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0208641

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.160559
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.157346
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.110777
IGF2 insulin-like growth factor 2 -0.108758
VIM vimentin -0.102618
FNDC3B fibronectin type III domain containing 3B -0.101335
IGFBP3 insulin-like growth factor binding protein 3 -0.0983769
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0980657
FTH1 ferritin, heavy polypeptide 1 -0.0977288
ZMYND8 zinc finger, MYND-type containing 8 -0.0892376
TPT1 tumor protein, translationally-controlled 1 -0.079152
NDRG1 N-myc downstream regulated 1 -0.0682359
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0652722
EGR1 early growth response 1 -0.062452
DST dystonin -0.0619501
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0615327
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0613758
ENO2 enolase 2 (gamma, neuronal) -0.061105
PTMA prothymosin, alpha -0.0604309
MT2A metallothionein 2A -0.0599607
HMGA2 high mobility group AT-hook 2 -0.0576878
ANGPTL4 angiopoietin-like 4 -0.0568163
RPLP1 ribosomal protein, large, P1 -0.0566989
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0559491
WARS1 tryptophanyl-tRNA synthetase 1 -0.0537868
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0535541
BASP1 brain abundant, membrane attached signal protein 1 -0.0501822
RAD51B RAD51 paralog B -0.049606
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.049262
PRR16 proline rich 16 -0.0491195
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0490851
SMYD3 SET and MYND domain containing 3 -0.0481501
UGCG UDP-glucose ceramide glucosyltransferase -0.0478354
PKM pyruvate kinase, muscle -0.0473729
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0471522
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0469575
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0467288
LDHA lactate dehydrogenase A -0.0467153
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.046508
S100A9 S100 calcium binding protein A9 -0.0458921
HILPDA hypoxia inducible lipid droplet-associated -0.04482
EXT1 exostosin glycosyltransferase 1 -0.0444489
FMN1 formin 1 -0.0442543
ANKRD12 ankyrin repeat domain 12 -0.0437236
SASH1 SAM and SH3 domain containing 1 -0.0431406
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0427444
RAI14 retinoic acid induced 14 -0.0425411
ATG7 autophagy related 7 -0.04247
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0423736
ZBTB20 zinc finger and BTB domain containing 20 -0.0421296
PRKCA protein kinase C, alpha -0.0419045
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0411497
IFIH1 interferon induced with helicase C domain 1 -0.0408489
RIGI RNA sensor RIG-I -0.0404821
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0402411
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0398845
DSE dermatan sulfate epimerase -0.0394378
ATXN1 ataxin 1 -0.0388624
AKAP12 A kinase (PRKA) anchor protein 12 -0.0387215
STXBP1 syntaxin binding protein 1 -0.0383997
EGFR epidermal growth factor receptor -0.0380983
MYO9B myosin IXB -0.0378673
DYNLRB1 dynein, light chain, roadblock-type 1 -0.0376953
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0376572
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0374984
HLA-A major histocompatibility complex, class I, A -0.0372974
ZNF609 zinc finger protein 609 -0.0364097
RPL35A ribosomal protein L35a -0.0361857
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0357717
NALCN sodium leak channel, non selective -0.0354417
BPTF bromodomain PHD finger transcription factor -0.0352377
MARCKS myristoylated alanine-rich protein kinase C substrate -0.035156
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0349711
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0349335
GPC6 glypican 6 -0.0349275
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0339531
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0339055
BRD4 bromodomain containing 4 -0.0338551
NT5E 5'-nucleotidase, ecto (CD73) -0.0335996
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0335676
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.033556
HLA-B major histocompatibility complex, class I, B -0.0333217
ZC3H12B zinc finger CCCH-type containing 12B -0.0330053
CD44 CD44 molecule (Indian blood group) -0.0330052
SH3KBP1 SH3-domain kinase binding protein 1 -0.0325434
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.032534
H3-3B H3.3 histone B -0.0325242
MAML2 mastermind-like 2 (Drosophila) -0.0323557
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0322735
ATM ATM serine/threonine kinase -0.0322623
FAM3C family with sequence similarity 3, member C -0.0322347
IER3 immediate early response 3 -0.0321315
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0320479
FNDC3A fibronectin type III domain containing 3A -0.0319682
AEBP2 AE binding protein 2 -0.031938
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0319231
CCDC91 coiled-coil domain containing 91 -0.0314376
FNIP1 folliculin interacting protein 1 -0.0312094
GPC5 glypican 5 -0.0311903
TAS2R14 taste receptor, type 2, member 14 -0.0311738