Demeclocycline_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Demeclocycline perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Demeclocycline_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMEM156 transmembrane protein 156 0.0838497
NRIP1 nuclear receptor interacting protein 1 0.059656
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0539658
OSMR oncostatin M receptor 0.0518543
NRP1 neuropilin 1 0.048017
NTN4 netrin 4 0.0418646
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0414462
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0373112
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0361948
NPAS2 neuronal PAS domain protein 2 0.0325296
SMAD3 SMAD family member 3 0.0318045
MCTP2 multiple C2 domains, transmembrane 2 0.0316403
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0311024
CAB39 calcium binding protein 39 0.0306758
RUNX2 runt-related transcription factor 2 0.0299325
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0290463
EREG epiregulin 0.0287093
SERINC1 serine incorporator 1 0.0286752
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0286131
LTBP1 latent transforming growth factor beta binding protein 1 0.0285565
ARHGAP5 Rho GTPase activating protein 5 0.0282788
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0267109
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0266884
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0264526
SVIL supervillin 0.0247188
SPRED1 sprouty-related, EVH1 domain containing 1 0.0244874
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0238177
PELO pelota homolog (Drosophila) 0.0237061
WWTR1 WW domain containing transcription regulator 1 0.0233338
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0232274
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0229128
AREG amphiregulin 0.0229016
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0225611
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0221515
NALF1 NALCN channel auxiliary factor 1 0.0215811
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0204714
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0204322
BICC1 BicC family RNA binding protein 1 0.0202145
LIFR leukemia inhibitory factor receptor alpha 0.0199782
HIPK2 homeodomain interacting protein kinase 2 0.0196555
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0193832
ZEB2 zinc finger E-box binding homeobox 2 0.0190023
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0189724
RBPMS RNA binding protein with multiple splicing 0.0189016
RAB31 RAB31, member RAS oncogene family 0.0188825
TXNRD1 thioredoxin reductase 1 0.0184789
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0182411
ZC3H12C zinc finger CCCH-type containing 12C 0.018088
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0178039
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0177391
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0175592
FHL2 four and a half LIM domains 2 0.0174656
STK24 serine/threonine kinase 24 0.0174503
TOP1 topoisomerase (DNA) I 0.017339
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0173031
FNDC3A fibronectin type III domain containing 3A 0.0172752
ANKRD28 ankyrin repeat domain 28 0.0172499
ARHGAP42 Rho GTPase activating protein 42 0.017114
DOCK5 dedicator of cytokinesis 5 0.0170521
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0167841
AHR aryl hydrocarbon receptor 0.0165466
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.016496
ADD3 adducin 3 (gamma) 0.0164786
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0163401
FOXO1 forkhead box O1 0.0161257
RDH10 retinol dehydrogenase 10 (all-trans) 0.0158797
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0156319
ITGB5 integrin, beta 5 0.0154439
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0152899
KLF12 Kruppel-like factor 12 0.0152604
DST dystonin 0.0148654
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0148028
TSHZ3 teashirt zinc finger homeobox 3 0.0146111
IFI44L interferon-induced protein 44-like 0.0146011
SLTM SAFB-like, transcription modulator 0.0145798
FBXL5 F-box and leucine-rich repeat protein 5 0.0143029
SON SON DNA binding protein 0.0142751
AOPEP aminopeptidase O (putative) 0.0142416
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0141609
CDCP1 CUB domain containing protein 1 0.014122
PLPP3 phospholipid phosphatase 3 0.01375
SYNJ2 synaptojanin 2 0.0136545
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0136077
MB21D2 Mab-21 domain containing 2 0.0135767
CAMKMT calmodulin-lysine N-methyltransferase 0.0135722
GRAMD1B GRAM domain containing 1B 0.0134566
DNMBP dynamin binding protein 0.0133783
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0133088
SEPTIN9 septin 9 0.013238
IL6ST interleukin 6 signal transducer 0.0132018
PTBP3 polypyrimidine tract binding protein 3 0.0131979
SOCS5 suppressor of cytokine signaling 5 0.0129854
SMYD3 SET and MYND domain containing 3 0.0129193
NOVA1 neuro-oncological ventral antigen 1 0.0128903
LAMA4 laminin, alpha 4 0.0128509
CCNJL cyclin J-like 0.0128205
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0127951
ATOSA atos homolog A 0.0127906
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 0.0125062
CD44 CD44 molecule (Indian blood group) 0.0124189

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.30789
PTMA prothymosin, alpha -0.202827
FN1 fibronectin 1 -0.180779
NRG1 neuregulin 1 -0.177644
NDRG1 N-myc downstream regulated 1 -0.124764
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.124013
HLA-B major histocompatibility complex, class I, B -0.112669
P4HB prolyl 4-hydroxylase, beta polypeptide -0.107517
SQSTM1 sequestosome 1 -0.106508
TMSB10 thymosin beta 10 -0.102553
VIM vimentin -0.0928153
PKM pyruvate kinase, muscle -0.0897676
FTL ferritin, light polypeptide -0.089277
TMSB4X thymosin beta 4, X-linked -0.0883887
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0861813
LOC102724023 ES1 protein homolog, mitochondrial -0.0780568
TRIO trio Rho guanine nucleotide exchange factor -0.0715924
ACTG1 actin gamma 1 -0.0699194
STC2 stanniocalcin 2 -0.0698986
RPS6 ribosomal protein S6 -0.0698344
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0698008
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0625639
S100A6 S100 calcium binding protein A6 -0.0622298
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0618598
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.060682
HILPDA hypoxia inducible lipid droplet-associated -0.0567465
IER3 immediate early response 3 -0.0566141
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0557139
IFI27 interferon, alpha-inducible protein 27 -0.0554692
RPL35A ribosomal protein L35a -0.0552063
RPLP1 ribosomal protein, large, P1 -0.0546209
GRB10 growth factor receptor-bound protein 10 -0.0545651
VEGFA vascular endothelial growth factor A -0.0521802
LIMCH1 LIM and calponin homology domains 1 -0.0509633
RPL31 ribosomal protein L31 -0.0476602
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0472633
EGR1 early growth response 1 -0.0470268
SFTPA2 surfactant protein A2 -0.0462447
CANX calnexin -0.0460713
LMNA lamin A/C -0.0455438
SOX4 SRY (sex determining region Y)-box 4 -0.0452486
GNAS GNAS complex locus -0.0449677
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0441178
ENO1 enolase 1, (alpha) -0.0422373
FTH1 ferritin, heavy polypeptide 1 -0.0422167
B2M beta-2-microglobulin -0.042079
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0418274
RPL37A ribosomal protein L37a -0.0413519
PLIN2 perilipin 2 -0.0413164
CADM1 cell adhesion molecule 1 -0.0410541
TPT1 tumor protein, translationally-controlled 1 -0.0409655
PGK1 phosphoglycerate kinase 1 -0.0405866
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0405459
IGFBP3 insulin-like growth factor binding protein 3 -0.0405232
RPS29 ribosomal protein S29 -0.0389491
ENO2 enolase 2 (gamma, neuronal) -0.0386866
MRPS6 mitochondrial ribosomal protein S6 -0.0380702
IGFBP5 insulin-like growth factor binding protein 5 -0.0376771
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0374647
RPS11 ribosomal protein S11 -0.0370173
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.037004
SEC31A SEC31 homolog A (S. cerevisiae) -0.0367367
RPS25 ribosomal protein S25 -0.0366466
RPS23 ribosomal protein S23 -0.0362104
NAMPT nicotinamide phosphoribosyltransferase -0.0356386
TENM4 teneurin transmembrane protein 4 -0.0356365
RPS3 ribosomal protein S3 -0.0350902
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0350649
RPS24 ribosomal protein S24 -0.034945
RPS16 ribosomal protein S16 -0.0347982
RAI14 retinoic acid induced 14 -0.0343565
CALU calumenin -0.0341306
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0340818
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0339338
LOC112694756 uncharaterized LOC112694756 -0.0339024
GOLGA4 golgin A4 -0.0335817
TPI1 triosephosphate isomerase 1 -0.0335639
KPNB1 karyopherin (importin) beta 1 -0.0334751
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0333465
S100A9 S100 calcium binding protein A9 -0.0332335
DDIT4 DNA-damage-inducible transcript 4 -0.032975
KDM3A lysine (K)-specific demethylase 3A -0.0329431
S100A10 S100 calcium binding protein A10 -0.0326628
RAB7A RAB7A, member RAS oncogene family -0.0326242
ZMYND8 zinc finger, MYND-type containing 8 -0.0320712
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0317268
PDE4D phosphodiesterase 4D, cAMP-specific -0.0312641
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.031252
ANKRD11 ankyrin repeat domain 11 -0.0312331
RACK1 receptor for activated C kinase 1 -0.0311601
RPS19 ribosomal protein S19 -0.0307345
LRRC23 leucine rich repeat containing 23 -0.0303846
MKI67 marker of proliferation Ki-67 -0.0303731
FBXO11 F-box protein 11 -0.0302028
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0301077
RPL8 ribosomal protein L8 -0.0300602
FLNB filamin B, beta -0.0300389
MORF4L2 mortality factor 4 like 2 -0.0300303
TAS2R14 taste receptor, type 2, member 14 -0.0293066
CTSD cathepsin D -0.0291558