Dental Caries Gene Set
Dataset
CTD Gene-Disease Associations
Category
disease or phenotype associations
Type
disease
Description
Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp. The three most prominent theories used to explain the etiology of the disease are that acids produced by bacteria lead to decalcification; that micro-organisms destroy the enamel protein; or that keratolytic micro-organisms produce chelates that lead to decalcification. (Experimental Factor Ontology , EFO_0003819 )
External Link
http://ctdbase.org/detail.go?type=disease&acc=MESH:D003731
Similar Terms
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Genes
30 genes/proteins associated with the disease Dental Caries from the curated CTD Gene-Disease Associations dataset.
Symbol
Name
Standardized Value
PRL
prolactin
1.29533
DRD2
dopamine receptor D2
1.2898
IL6
interleukin 6
1.26576
NPY
neuropeptide Y
1.25838
HSPA5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
1.22758
CYCS
cytochrome c, somatic
1.21337
NOS1
nitric oxide synthase 1 (neuronal)
1.21076
VEGFA
vascular endothelial growth factor A
1.19999
DDIT3
DNA-damage-inducible transcript 3
1.17959
OPRK1
opioid receptor, kappa 1
1.16302
HSPB1
heat shock 27kDa protein 1
1.15223
MAPK1
mitogen-activated protein kinase 1
1.14098
IL10
interleukin 10
1.12288
OPRM1
opioid receptor, mu 1
1.08231
DRD1
dopamine receptor D1
1.08091
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
1.08055
BAK1
BCL2-antagonist/killer 1
1.08055
PRKCD
protein kinase C, delta
1.04611
FAS
Fas cell surface death receptor
1.04427
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
1.04014
ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha
1.03715
CASP3
caspase 3, apoptosis-related cysteine peptidase
1.03159
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
1.03159
IL1B
interleukin 1, beta
1.03122
OPRD1
opioid receptor, delta 1
1.02336
AKT1
v-akt murine thymoma viral oncogene homolog 1
1.02114
MAP2K1
mitogen-activated protein kinase kinase 1
1.01739
HSPA8
heat shock 70kDa protein 8
1.01437
MAPK3
mitogen-activated protein kinase 3
1.01399
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
1.01286
