Dermatitis Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A skin disease characterized by itchy, erythematous, vesicular, weeping and crusting patches of skin. (Human Disease Ontology, DOID_2723)
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Genes

206 genes associated with the disease Dermatitis in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
SPIRE2 spire-type actin nucleation factor 2 2.044
AMACR alpha-methylacyl-CoA racemase 2.041
SLC45A2 solute carrier family 45, member 2 2.041
RXFP3 relaxin/insulin-like family peptide receptor 3 2.041
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 2.041
C1QTNF3 C1q and tumor necrosis factor related protein 3 2.041
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.039
LCE3E late cornified envelope 3E 2.038
CCNI2 cyclin I family, member 2 2.037
IL13 interleukin 13 2.037
KIF3A kinesin family member 3A 2.037
RAD50 RAD50 homolog (S. cerevisiae) 2.037
SEPTIN8 septin 8 2.037
IL4 interleukin 4 2.037
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 2.023
GAS8 growth arrest-specific 8 2.023
TUBB3 tubulin, beta 3 class III 2.023
DEF8 differentially expressed in FDCP 8 homolog (mouse) 2.023
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 2.023
TCF25 transcription factor 25 (basic helix-loop-helix) 2.023
LCE5A late cornified envelope 5A 2.019
CRCT1 cysteine-rich C-terminal 1 2.019
CRNN cornulin 2.012
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 2.007
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 2.007
CDK10 cyclin-dependent kinase 10 1.985
ZNF276 zinc finger protein 276 1.985
CHMP1A charged multivesicular body protein 1A 1.985
VPS9D1 VPS9 domain containing 1 1.985
SPATA2L spermatogenesis associated 2-like 1.985
SPATA33 spermatogenesis associated 33 1.985
FANCA Fanconi anemia, complementation group A 1.985
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.961
LRRC32 leucine rich repeat containing 32 1.95
EMSY EMSY transcriptional repressor, BRCA2 interacting 1.95
TSBP1 testis expressed basic protein 1 1.949
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 1.947
ARFRP1 ADP-ribosylation factor related protein 1 1.947
LIME1 Lck interacting transmembrane adaptor 1 1.947
SLC2A4RG SLC2A4 regulator 1.947
RTEL1 regulator of telomere elongation helicase 1 1.947
GMEB2 glucocorticoid modulatory element binding protein 2 1.947
STMN3 stathmin-like 3 1.947
ZGPAT zinc finger, CCCH-type with G patch domain 1.947
ZBTB46 zinc finger and BTB domain containing 46 1.947
FLG filaggrin 1.944
GLB1 galactosidase, beta 1 1.943
CCR4 chemokine (C-C motif) receptor 4 1.943
TMPPE transmembrane protein with metallophosphoesterase domain 1.943
CRTAP cartilage associated protein 1.943
IL18R1 interleukin 18 receptor 1 1.942
IL18RAP interleukin 18 receptor accessory protein 1.942
LCE3D late cornified envelope 3D 1.941
LCE2D late cornified envelope 2D 1.941
LCE3A late cornified envelope 3A 1.941
LCE3B late cornified envelope 3B 1.941
LCE3C late cornified envelope 3C 1.941
EIF3F eukaryotic translation initiation factor 3, subunit F 1.937
OR10A6 olfactory receptor, family 10, subfamily A, member 6 (gene/pseudogene) 1.937
TUB tubby bipartite transcription factor 1.937
NLRP10 NLR family, pyrin domain containing 10 1.937
OR10A3 olfactory receptor, family 10, subfamily A, member 3 1.937
BTNL2 butyrophilin-like 2 1.923
HLA-DRA major histocompatibility complex, class II, DR alpha 1.923
PPT2 palmitoyl-protein thioesterase 2 1.867
EGFL8 EGF-like-domain, multiple 8 1.867
FKBPL FK506 binding protein like 1.867
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 1.867
TNXB tenascin XB 1.867
AGER advanced glycosylation end product-specific receptor 1.867
ATF6B activating transcription factor 6 beta 1.867
PRRT1 proline-rich transmembrane protein 1 1.867
NOTCH4 notch 4 1.867
PBX2 pre-B-cell leukemia homeobox 2 1.867
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 1.867
GPSM3 G-protein signaling modulator 3 1.867
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 1.865
KAT5 K(lysine) acetyltransferase 5 1.865
OVOL1 ovo-like zinc finger 1 1.865
CFL1 cofilin 1 (non-muscle) 1.865
FIBP fibroblast growth factor (acidic) intracellular binding protein 1.865
AP5B1 adaptor-related protein complex 5, beta 1 subunit 1.865
MUS81 MUS81 structure-specific endonuclease subunit 1.865
RNASEH2C ribonuclease H2, subunit C 1.865
CTSW cathepsin W 1.865
SNX32 sorting nexin 32 1.865
IL33R interleukin 33 receptor 1.833
CCDC80 coiled-coil domain containing 80 1.805
SLC35A5 solute carrier family 35, member A5 1.805
ZNF365 zinc finger protein 365 1.804
CCDC85B coiled-coil domain containing 85B 1.793
HLA-B major histocompatibility complex, class I, B 1.788
HLA-C major histocompatibility complex, class I, C 1.788
EXOC2 exocyst complex component 2 1.763
DUSP22 dual specificity phosphatase 22 1.763
IRF4 interferon regulatory factor 4 1.763
IL5 interleukin 5 1.751
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 1.744
OCA2 oculocutaneous albinism II 1.744
OR2Z1 olfactory receptor, family 2, subfamily Z, member 1 1.736
ACTL9 actin-like 9 1.736
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 1.736
CLEC16A C-type lectin domain family 16, member A 1.723
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 1.708
PRORP protein only RNase P catalytic subunit 1.702
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma 1.702
SRP54 signal recognition particle 54kDa 1.702
FAM177A1 family with sequence similarity 177, member A1 1.702
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 1.61
RAG1 recombination activating gene 1 1.572
COMMD9 COMM domain containing 9 1.572
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 1.572
PRR5L proline rich 5 like 1.572
HELZ2 helicase with zinc finger 2, transcriptional coactivator 1.557
FLG2 filaggrin family member 2 1.543
ANKRD11 ankyrin repeat domain 11 1.487
ZNF778 zinc finger protein 778 1.487
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 1.414
SOWAHA sosondowah ankyrin repeat domain family member A 1.409
RPTN repetin 1.347
HRNR hornerin 1.347
CPNE7 copine VII 1.313
DPEP1 dipeptidase 1 (renal) 1.313
RPL13 ribosomal protein L13 1.313
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 1.307
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 1.294
IL6R interleukin 6 receptor 1.294
TDRD10 tudor domain containing 10 1.294
SHE Src homology 2 domain containing E 1.294
LCE2C late cornified envelope 2C 1.285
LCE4A late cornified envelope 4A 1.285
LCE2A late cornified envelope 2A 1.285
LCE2B late cornified envelope 2B 1.285
PAMR1 peptidase domain containing associated with muscle regeneration 1 1.278
CD44 CD44 molecule (Indian blood group) 1.278
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 1.278
ZNF652 zinc finger protein 652 1.217
KATNAL1 katanin p60 subunit A-like 1 1.169
CD207 CD207 molecule, langerin 1.129
CLEC4F C-type lectin domain family 4, member F 1.129
FIGLA folliculogenesis specific basic helix-loop-helix 1.129
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 1.129
VAX2 ventral anterior homeobox 2 1.129
PAQR8 progestin and adipoQ receptor family member VIII 1.111
EFHC1 EF-hand domain (C-terminal) containing 1 1.111
TRAM2 translocation associated membrane protein 2 1.111
PFDN4 prefoldin subunit 4 1.105
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 1.105
ATG3 autophagy related 3 1.074
SCN7A sodium channel, voltage gated, type VII alpha subunit 1.016
XIRP2 xin actin binding repeat containing 2 1.016
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 1.016
IKZF3 IKAROS family zinc finger 3 (Aiolos) 1.006
ZPBP2 zona pellucida binding protein 2 1.006
PGAP3 post-GPI attachment to proteins 3 1.006
GRB7 growth factor receptor-bound protein 7 1.006
ERBB2 erb-b2 receptor tyrosine kinase 2 1.006
MIEN1 migration and invasion enhancer 1 1.006
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 0.963
C4A complement component 4A (Rodgers blood group) 0.963
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.963
C4B complement component 4B (Chido blood group) 0.963
CAPSL calcyphosine-like 0.919
IL7R interleukin 7 receptor 0.919
SPEF2 sperm flagellar 2 0.919
UGT3A1 UDP glycosyltransferase 3 family, polypeptide A1 0.919
GRM5 glutamate receptor, metabotropic 5 0.865
NOX4 NADPH oxidase 4 0.865
TYR tyrosinase 0.865
HLA-DOB major histocompatibility complex, class II, DO beta 0.777
ANAPC1 anaphase promoting complex subunit 1 0.722
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 0.677
C4ORF36 chromosome 4 open reading frame 36 0.677
AFF1 AF4/FMR2 family, member 1 0.677
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 0.656
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.656
FBH1 F-box DNA helicase 1 0.65
RBM17 RNA binding motif protein 17 0.65
IL15RA interleukin 15 receptor, alpha 0.65
IL2RA interleukin 2 receptor, alpha 0.65
BCAS1 breast carcinoma amplified sequence 1 0.622
CIART circadian associated repressor of transcription 0.61
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.61
PRPF3 pre-mRNA processing factor 3 0.61
C1ORF54 chromosome 1 open reading frame 54 0.61
MRPS21 mitochondrial ribosomal protein S21 0.61
APH1A APH1A gamma secretase subunit 0.61
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.61
CA14 carbonic anhydrase XIV 0.61
UNC5B unc-5 homolog B (C. elegans) 0.602
STX2 syntaxin 2 0.592
ADGRD1 adhesion G protein-coupled receptor D1 0.592
RAN RAN, member RAS oncogene family 0.592
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 0.572
TEX261 testis expressed 261 0.564
HLA-G major histocompatibility complex, class I, G 0.561
HLA-F major histocompatibility complex, class I, F 0.561
MOG myelin oligodendrocyte glycoprotein 0.561
ZFP57 ZFP57 zinc finger protein 0.561
IL21 interleukin 21 0.56
CARD11 caspase recruitment domain family, member 11 0.56
IL2 interleukin 2 0.56
DMRTA1 DMRT-like family A1 0.557
UBASH3B ubiquitin associated and SH3 domain containing B 0.551
ADO 2-aminoethanethiol (cysteamine) dioxygenase 0.503
EGR2 early growth response 2 0.503