Dermatomyositis Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A myositis and is_a dermatitis that results_in inflammation located_in muscle and located_in skin. The disease may result from either a viral infection or an autoimmune reaction.|A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6) (Experimental Factor Ontology, EFO_0000398)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D003882
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Genes

65 genes/proteins associated with the disease Dermatomyositis from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
TNF tumor necrosis factor 2.88009
HLA-B major histocompatibility complex, class I, B 2.88009
C2 complement component 2 2.88009
IL1B interleukin 1, beta 2.88009
C9 complement component 9 2.88009
IL1A interleukin 1, alpha 2.88009
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.76013
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.64506
NOS2 nitric oxide synthase 2, inducible 1.57474
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.54232
TP53 tumor protein p53 1.48993
IFNG interferon, gamma 1.46568
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.43157
IL4 interleukin 4 1.40568
IL6 interleukin 6 1.3793
BAX BCL2-associated X protein 1.37303
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.3619
HSPA8 heat shock 70kDa protein 8 1.35473
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.34635
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.34314
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.3231
IGF1 insulin-like growth factor 1 (somatomedin C) 1.30421
CAT catalase 1.27286
MMP3 matrix metallopeptidase 3 1.25807
BCL2L1 BCL2-like 1 1.24056
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.23106
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.22821
FOXO1 forkhead box O1 1.21759
CCL2 chemokine (C-C motif) ligand 2 1.21468
RB1 retinoblastoma 1 1.21206
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.19509
FAS Fas cell surface death receptor 1.19047
TGFB1 transforming growth factor, beta 1 1.18326
S100A9 S100 calcium binding protein A9 1.18193
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.17794
DDIT3 DNA-damage-inducible transcript 3 1.167
HMOX1 heme oxygenase 1 1.1617
GPX2 glutathione peroxidase 2 1.16137
JUN jun proto-oncogene 1.15526
MMP2 matrix metallopeptidase 2 1.1529
NR1I3 nuclear receptor subfamily 1, group I, member 3 1.15256
CCNG1 cyclin G1 1.15189
CCND1 cyclin D1 1.15089
SOD2 superoxide dismutase 2, mitochondrial 1.14644
PARP1 poly (ADP-ribose) polymerase 1 1.14234
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.13518
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.11571
IGF1R insulin-like growth factor 1 receptor 1.10665
BCL2 B-cell CLL/lymphoma 2 1.10317
FASLG Fas ligand (TNF superfamily, member 6) 1.10033
FOS FBJ murine osteosarcoma viral oncogene homolog 1.09998
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.09332
GADD45A growth arrest and DNA-damage-inducible, alpha 1.09297
NQO1 NAD(P)H dehydrogenase, quinone 1 1.06008
UNG uracil-DNA glycosylase 1.05828
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.05573
MAPK1 mitogen-activated protein kinase 1 1.05498
EGR1 early growth response 1 1.05274
IL5 interleukin 5 1.05274
PTEN phosphatase and tensin homolog 1.05237
EDN1 endothelin 1 1.04051
MPO myeloperoxidase 1.0353
MUCL1 mucin-like 1 1.02933
VEGFA vascular endothelial growth factor A 1.02671
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.01928