| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group. (Chemical Entities of Biological Interest Ontology, CHEBI_47781) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/2995 |
| Similar Terms | |
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199 proteins with high or low expression in Desipramine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF600 | zinc finger protein 600 | 3.79 |
| TSPAN3 | tetraspanin 3 | 1.52 |
| CPE | carboxypeptidase E | 1.34 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 1.3 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 1.02 |
| KLHL5 | kelch-like family member 5 | 0.82 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | 0.76 |
| COL12A1 | collagen, type XII, alpha 1 | 0.73 |
| SREBF1 | sterol regulatory element binding transcription factor 1 | 0.72 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.72 |
| ZNF189 | zinc finger protein 189 | 0.7 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.7 |
| GALNT4 | polypeptide N-acetylgalactosaminyltransferase 4 | 0.69 |
| SSNA1 | Sjogren syndrome nuclear autoantigen 1 | 0.67 |
| CD63 | CD63 molecule | 0.65 |
| STYK1 | serine/threonine/tyrosine kinase 1 | 0.65 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.62 |
| FBXO17 | F-box protein 17 | 0.6 |
| DHFR | dihydrofolate reductase | 0.59 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.58 |
| USP18 | ubiquitin specific peptidase 18 | 0.58 |
| SNRNP35 | small nuclear ribonucleoprotein 35kDa (U11/U12) | 0.56 |
| FAM117A | family with sequence similarity 117, member A | 0.53 |
| MTF1 | metal-regulatory transcription factor 1 | 0.51 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | 0.51 |
| CCDC28A | coiled-coil domain containing 28A | 0.51 |
| SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | 0.5 |
| PAH | phenylalanine hydroxylase | 0.5 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.48 |
| RPL31 | ribosomal protein L31 | 0.48 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.48 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | 0.48 |
| DCHS1 | dachsous cadherin-related 1 | 0.47 |
| RCHY1 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase | 0.47 |
| PLPP2 | phospholipid phosphatase 2 | 0.47 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | 0.47 |
| KALRN | kalirin, RhoGEF kinase | 0.47 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.47 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.46 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.46 |
| CST6 | cystatin E/M | 0.45 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.44 |
| DENND4B | DENN/MADD domain containing 4B | 0.43 |
| HMCN1 | hemicentin 1 | 0.42 |
| PRRG1 | proline rich Gla (G-carboxyglutamic acid) 1 | 0.42 |
| FGFR4 | fibroblast growth factor receptor 4 | 0.42 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.42 |
| TET3 | tet methylcytosine dioxygenase 3 | 0.42 |
| MARK4 | MAP/microtubule affinity-regulating kinase 4 | 0.41 |
| STC2 | stanniocalcin 2 | 0.41 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.41 |
| FBLIM1 | filamin binding LIM protein 1 | 0.41 |
| PALB2 | partner and localizer of BRCA2 | 0.41 |
| COL18A1 | collagen, type XVIII, alpha 1 | 0.4 |
| TXN2 | thioredoxin 2 | 0.4 |
| ZNF513 | zinc finger protein 513 | 0.4 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 0.39 |
| MOSPD1 | motile sperm domain containing 1 | 0.39 |
| FAR1 | fatty acyl CoA reductase 1 | 0.39 |
| UBXN8 | UBX domain protein 8 | 0.39 |
| SUCO | SUN domain containing ossification factor | 0.39 |
| GRK5 | G protein-coupled receptor kinase 5 | 0.39 |
| ADCY10 | adenylate cyclase 10 (soluble) | 0.39 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | 0.39 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.39 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 0.38 |
| SPOPL | speckle-type POZ protein-like | 0.38 |
| SLC25A21 | solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 | 0.38 |
| ATG12 | autophagy related 12 | 0.38 |
| ATXN3 | ataxin 3 | 0.38 |
| ESPN | espin | 0.38 |
| UPRT | uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) | 0.38 |
| WWC3 | WWC family member 3 | 0.37 |
| ZIC2 | Zic family member 2 | 0.37 |
| LINS1 | lines homolog 1 | 0.37 |
| HHEX | hematopoietically expressed homeobox | 0.37 |
| ZBED6 | zinc finger, BED-type containing 6 | 0.37 |
| TET2 | tet methylcytosine dioxygenase 2 | 0.37 |
| EGFL7 | EGF-like-domain, multiple 7 | 0.36 |
| ELK4 | ELK4, ETS-domain protein (SRF accessory protein 1) | 0.36 |
| PDE7A | phosphodiesterase 7A | 0.36 |
| CEP85L | centrosomal protein 85kDa-like | 0.36 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | 0.36 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 0.36 |
| CRELD1 | cysteine-rich with EGF-like domains 1 | 0.36 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | 0.35 |
| FBXW8 | F-box and WD repeat domain containing 8 | 0.35 |
| TMEM104 | transmembrane protein 104 | 0.35 |
| GON7 | GON7 subunit of KEOPS complex | 0.35 |
| ZSCAN31 | zinc finger and SCAN domain containing 31 | 0.35 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | 0.35 |
| SUPT4H1 | suppressor of Ty 4 homolog 1 (S. cerevisiae) | 0.35 |
| MSMO1 | methylsterol monooxygenase 1 | 0.35 |
| TIGD1 | tigger transposable element derived 1 | 0.35 |
| KIAA0513 | KIAA0513 | 0.34 |
| FADS1 | fatty acid desaturase 1 | 0.34 |
| MSLN | mesothelin | 0.34 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.34 |
| HS6ST1 | heparan sulfate 6-O-sulfotransferase 1 | 0.34 |
| MICB | MHC class I polypeptide-related sequence B | 0.34 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | -2.55 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -1.39 |
| NAAA | N-acylethanolamine acid amidase | -0.83 |
| C11ORF95 | chromosome 11 open reading frame 95 | -0.76 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.74 |
| MRPL57 | mitochondrial ribosomal protein L57 | -0.66 |
| PPT1 | palmitoyl-protein thioesterase 1 | -0.65 |
| MRPL51 | mitochondrial ribosomal protein L51 | -0.58 |
| MRPL30 | mitochondrial ribosomal protein L30 | -0.57 |
| PPM1H | protein phosphatase, Mg2+/Mn2+ dependent, 1H | -0.55 |
| PSEN2 | presenilin 2 | -0.55 |
| MRPL37 | mitochondrial ribosomal protein L37 | -0.54 |
| CLN5 | ceroid-lipofuscinosis, neuronal 5 | -0.53 |
| CBX7 | chromobox homolog 7 | -0.53 |
| MT-CO1 | cytochrome c oxidase subunit I | -0.52 |
| ISL2 | ISL LIM homeobox 2 | -0.51 |
| MRPL28 | mitochondrial ribosomal protein L28 | -0.51 |
| MRAS | muscle RAS oncogene homolog | -0.5 |
| FGGY | FGGY carbohydrate kinase domain containing | -0.49 |
| MT-ND5 | NADH dehydrogenase, subunit 5 (complex I) | -0.48 |
| SLC25A44 | solute carrier family 25, member 44 | -0.48 |
| COPRS | coordinator of PRMT5, differentiation stimulator | -0.47 |
| MRPS18A | mitochondrial ribosomal protein S18A | -0.46 |
| MT-ATP6 | ATP synthase F0 subunit 6 | -0.46 |
| RITA1 | RBPJ interacting and tubulin associated 1 | -0.44 |
| SLC25A52 | solute carrier family 25, member 52 | -0.43 |
| TAPT1 | transmembrane anterior posterior transformation 1 | -0.43 |
| MT-CO2 | cytochrome c oxidase subunit II | -0.42 |
| MRPL13 | mitochondrial ribosomal protein L13 | -0.41 |
| MT-ND1 | NADH dehydrogenase, subunit 1 (complex I) | -0.41 |
| MRPL27 | mitochondrial ribosomal protein L27 | -0.41 |
| MYOM2 | myomesin 2 | -0.4 |
| NMU | neuromedin U | -0.4 |
| MRPL41 | mitochondrial ribosomal protein L41 | -0.39 |
| MRPL24 | mitochondrial ribosomal protein L24 | -0.39 |
| MRPL35 | mitochondrial ribosomal protein L35 | -0.39 |
| TMC6 | transmembrane channel-like 6 | -0.38 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.38 |
| MRPL17 | mitochondrial ribosomal protein L17 | -0.38 |
| MRPL22 | mitochondrial ribosomal protein L22 | -0.36 |
| MRPL52 | mitochondrial ribosomal protein L52 | -0.36 |
| GADD45GIP1 | growth arrest and DNA-damage-inducible, gamma interacting protein 1 | -0.36 |
| MRPL16 | mitochondrial ribosomal protein L16 | -0.36 |
| MRPL34 | mitochondrial ribosomal protein L34 | -0.35 |
| NDUFS5 | NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) | -0.35 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.35 |
| LAMP2 | lysosomal-associated membrane protein 2 | -0.35 |
| UQCRQ | ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa | -0.35 |
| MRPL58 | mitochondrial ribosomal protein L58 | -0.35 |
| MALSU1 | mitochondrial assembly of ribosomal large subunit 1 | -0.34 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.34 |
| MRPL15 | mitochondrial ribosomal protein L15 | -0.34 |
| MRPL4 | mitochondrial ribosomal protein L4 | -0.34 |
| MRPL32 | mitochondrial ribosomal protein L32 | -0.34 |
| BCDIN3D | BCDIN3 domain containing | -0.33 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | -0.33 |
| MRPS33 | mitochondrial ribosomal protein S33 | -0.33 |
| TRIM62 | tripartite motif containing 62 | -0.32 |
| MRPL39 | mitochondrial ribosomal protein L39 | -0.32 |
| NDUFA12 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 | -0.32 |
| NDUFA7 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa | -0.31 |
| ZFP90 | ZFP90 zinc finger protein | -0.31 |
| MRPL44 | mitochondrial ribosomal protein L44 | -0.31 |
| CCDC158 | coiled-coil domain containing 158 | -0.31 |
| MRPL55 | mitochondrial ribosomal protein L55 | -0.3 |
| CCDC112 | coiled-coil domain containing 112 | -0.3 |
| SYPL1 | synaptophysin-like 1 | -0.3 |
| UQCRC2 | ubiquinol-cytochrome c reductase core protein II | -0.3 |
| ZNF551 | zinc finger protein 551 | -0.29 |
| MRPL3 | mitochondrial ribosomal protein L3 | -0.29 |
| MRPL47 | mitochondrial ribosomal protein L47 | -0.29 |
| NDUFS4 | NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) | -0.29 |
| MTG1 | mitochondrial ribosome-associated GTPase 1 | -0.29 |
| MRPS21 | mitochondrial ribosomal protein S21 | -0.29 |
| COX6C | cytochrome c oxidase subunit VIc | -0.29 |
| ZNF460 | zinc finger protein 460 | -0.28 |
| MRPL9 | mitochondrial ribosomal protein L9 | -0.28 |
| MRPL2 | mitochondrial ribosomal protein L2 | -0.28 |
| CACUL1 | CDK2-associated, cullin domain 1 | -0.28 |
| IMPAD1 | inositol monophosphatase domain containing 1 | -0.28 |
| CDK11A | cyclin-dependent kinase 11A | -0.28 |
| TMEM179B | transmembrane protein 179B | -0.27 |
| SH3BP2 | SH3-domain binding protein 2 | -0.27 |
| DNASE1L1 | deoxyribonuclease I-like 1 | -0.27 |
| COX7A2L | cytochrome c oxidase subunit VIIa polypeptide 2 like | -0.27 |
| MRPL33 | mitochondrial ribosomal protein L33 | -0.27 |
| HOXA9 | homeobox A9 | -0.26 |
| MRPL45 | mitochondrial ribosomal protein L45 | -0.26 |
| SDHAF3 | succinate dehydrogenase complex assembly factor 3 | -0.26 |
| GTPBP10 | GTP-binding protein 10 (putative) | -0.26 |
| NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | -0.25 |
| LAMA2 | laminin, alpha 2 | -0.25 |
| MCFD2 | multiple coagulation factor deficiency 2 | -0.25 |
| ADAT3 | adenosine deaminase, tRNA-specific 3 | -0.25 |
| NDUFC2 | NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa | -0.25 |
| MRPL14 | mitochondrial ribosomal protein L14 | -0.25 |
| MRPS11 | mitochondrial ribosomal protein S11 | -0.25 |
| BTBD1 | BTB (POZ) domain containing 1 | -0.24 |
| CHCHD1 | coiled-coil-helix-coiled-coil-helix domain containing 1 | -0.24 |
