Desmosome Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores 2025
Category structural or functional annotations
Type cellular component
Description A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism. (Gene Ontology, GO_0030057)
External Link http://amigo.geneontology.org/amigo/term/GO:0030057
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Genes

23 proteins localized to the Desmosome cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

Symbol Name Standardized Value
KLHL24 kelch-like family member 24 5.0
PKP4 plakophilin 4 5.0
PKP2 plakophilin 2 5.0
PKP1 plakophilin 1 5.0
DSG2 desmoglein 2 5.0
DSG1 desmoglein 1 5.0
CDSN corneodesmosin 5.0
EVPL envoplakin 5.0
DSPP dentin sialophosphoprotein 5.0
JAM3 junctional adhesion molecule 3 5.0
JUP junction plakoglobin 5.0
KAZN kazrin, periplakin interacting protein 5.0
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 5.0
PNN pinin, desmosome associated protein 5.0
POF1B premature ovarian failure, 1B 5.0
PKP3 plakophilin 3 5.0
PERP PERP, TP53 apoptosis effector 4.0
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 4.0
DSG4 desmoglein 4 3.0
DSG3 desmoglein 3 3.0
DSC3 desmocollin 3 3.0
VCL vinculin 3.0
RCAN1 regulator of calcineurin 1 3.0