| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/125017 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in Desvenlafaxine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | 0.68 |
| CCDC15 | coiled-coil domain containing 15 | 0.67 |
| SBSN | suprabasin | 0.59 |
| PIP | prolactin-induced protein | 0.56 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.54 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 0.51 |
| SPTB | spectrin, beta, erythrocytic | 0.5 |
| TNK2 | tyrosine kinase, non-receptor, 2 | 0.49 |
| LSM11 | LSM11, U7 small nuclear RNA associated | 0.49 |
| ENKD1 | enkurin domain containing 1 | 0.48 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.45 |
| NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | 0.45 |
| HIST2H2BC | histone cluster 2, H2bc (pseudogene) | 0.42 |
| ZDHHC23 | zinc finger, DHHC-type containing 23 | 0.41 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.39 |
| RPL26 | ribosomal protein L26 | 0.37 |
| TANK | TRAF family member-associated NFKB activator | 0.37 |
| ZNRD1 | zinc ribbon domain containing 1 | 0.36 |
| PRKX | protein kinase, X-linked | 0.35 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 0.34 |
| ZNF552 | zinc finger protein 552 | 0.34 |
| FITM2 | fat storage-inducing transmembrane protein 2 | 0.33 |
| ZNF714 | zinc finger protein 714 | 0.32 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | 0.32 |
| OTC | ornithine carbamoyltransferase | 0.31 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.31 |
| SIVA1 | SIVA1, apoptosis-inducing factor | 0.31 |
| ZDHHC21 | zinc finger, DHHC-type containing 21 | 0.3 |
| ZNF460 | zinc finger protein 460 | 0.3 |
| PIGH | phosphatidylinositol glycan anchor biosynthesis, class H | 0.3 |
| ZNF397 | zinc finger protein 397 | 0.29 |
| ZNF780A | zinc finger protein 780A | 0.29 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.29 |
| ZNF394 | zinc finger protein 394 | 0.29 |
| HRAS | Harvey rat sarcoma viral oncogene homolog | 0.29 |
| PDE7A | phosphodiesterase 7A | 0.29 |
| C12ORF57 | chromosome 12 open reading frame 57 | 0.29 |
| PGGT1B | protein geranylgeranyltransferase type I, beta subunit | 0.28 |
| BORA | bora, aurora kinase A activator | 0.28 |
| SDHAF4 | succinate dehydrogenase complex assembly factor 4 | 0.28 |
| ANKRD12 | ankyrin repeat domain 12 | 0.28 |
| CC2D2A | coiled-coil and C2 domain containing 2A | 0.28 |
| TTN | titin | 0.27 |
| CTDSPL2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | 0.27 |
| NDFIP2 | Nedd4 family interacting protein 2 | 0.27 |
| PLCL2 | phospholipase C-like 2 | 0.27 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.26 |
| MT1F | metallothionein 1F | 0.26 |
| AAMDC | adipogenesis associated, Mth938 domain containing | 0.26 |
| TMEM120B | transmembrane protein 120B | 0.26 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | 0.26 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.26 |
| C12ORF66 | chromosome 12 open reading frame 66 | 0.26 |
| LAMA1 | laminin, alpha 1 | 0.26 |
| PXYLP1 | 2-phosphoxylose phosphatase 1 | 0.25 |
| ZBTB14 | zinc finger and BTB domain containing 14 | 0.25 |
| TRMT12 | tRNA methyltransferase 12 homolog (S. cerevisiae) | 0.25 |
| E2F7 | E2F transcription factor 7 | 0.25 |
| ADCY6 | adenylate cyclase 6 | 0.25 |
| SP100 | SP100 nuclear antigen | 0.25 |
| DERPC | DERPC proline and glycine rich nuclear protein | 0.24 |
| F8A1 | coagulation factor VIII-associated 1 | 0.24 |
| PTMA | prothymosin, alpha | 0.24 |
| KCTD6 | potassium channel tetramerization domain containing 6 | 0.24 |
| RNF138 | ring finger protein 138, E3 ubiquitin protein ligase | 0.24 |
| SLC16A7 | solute carrier family 16 (monocarboxylate transporter), member 7 | 0.23 |
| CENPP | centromere protein P | 0.23 |
| TOR3A | torsin family 3, member A | 0.23 |
| TRIML2 | tripartite motif family-like 2 | 0.23 |
| MAP2K5 | mitogen-activated protein kinase kinase 5 | 0.23 |
| MSANTD3 | Myb/SANT-like DNA-binding domain containing 3 | 0.23 |
| CALCOCO1 | calcium binding and coiled-coil domain 1 | 0.23 |
| ZNF721 | zinc finger protein 721 | 0.22 |
| TMEM38B | transmembrane protein 38B | 0.22 |
| TMEM177 | transmembrane protein 177 | 0.22 |
| THBS2 | thrombospondin 2 | 0.22 |
| ZNF771 | zinc finger protein 771 | 0.22 |
| TBRG1 | transforming growth factor beta regulator 1 | 0.22 |
| PDZD11 | PDZ domain containing 11 | 0.22 |
| HYLS1 | hydrolethalus syndrome 1 | 0.22 |
| SLC16A10 | solute carrier family 16 (aromatic amino acid transporter), member 10 | 0.22 |
| ZBTB4 | zinc finger and BTB domain containing 4 | 0.22 |
| DCAF4 | DDB1 and CUL4 associated factor 4 | 0.22 |
| LRRC28 | leucine rich repeat containing 28 | 0.22 |
| TPM2 | tropomyosin 2 (beta) | 0.21 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | 0.21 |
| TMEM104 | transmembrane protein 104 | 0.21 |
| CDC34 | cell division cycle 34 | 0.2 |
| USP53 | ubiquitin specific peptidase 53 | 0.2 |
| FBXO45 | F-box protein 45 | 0.2 |
| RWDD1 | RWD domain containing 1 | 0.2 |
| MYH13 | myosin, heavy chain 13, skeletal muscle | 0.2 |
| INO80B | INO80 complex subunit B | 0.2 |
| WDR20 | WD repeat domain 20 | 0.2 |
| ZNF600 | zinc finger protein 600 | 0.2 |
| DPH6 | diphthamine biosynthesis 6 | 0.19 |
| BRMS1 | breast cancer metastasis suppressor 1 | 0.19 |
| CCDC102A | coiled-coil domain containing 102A | 0.19 |
| EREG | epiregulin | 0.19 |
| C19ORF54 | chromosome 19 open reading frame 54 | 0.19 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ALPK3 | alpha-kinase 3 | -2.04 |
| CPN1 | carboxypeptidase N, polypeptide 1 | -1.43 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -1.3 |
| CCND3 | cyclin D3 | -1.15 |
| DOP1A | DOP1 leucine zipper like protein A | -1.15 |
| DCHS2 | dachsous cadherin-related 2 | -1.07 |
| FAM171A2 | family with sequence similarity 171, member A2 | -0.91 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.85 |
| TBC1D14 | TBC1 domain family, member 14 | -0.81 |
| ADCY10 | adenylate cyclase 10 (soluble) | -0.8 |
| ICK | intestinal cell (MAK-like) kinase | -0.8 |
| MCOLN2 | mucolipin 2 | -0.77 |
| RARG | retinoic acid receptor, gamma | -0.76 |
| OPA3 | optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) | -0.74 |
| NF1 | neurofibromin 1 | -0.67 |
| ARHGAP44 | Rho GTPase activating protein 44 | -0.65 |
| DOLK | dolichol kinase | -0.64 |
| CENPH | centromere protein H | -0.62 |
| C4ORF33 | chromosome 4 open reading frame 33 | -0.59 |
| KDELR3 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | -0.58 |
| TAZ | tafazzin | -0.57 |
| JUN | jun proto-oncogene | -0.56 |
| GAB1 | GRB2-associated binding protein 1 | -0.51 |
| KIAA0513 | KIAA0513 | -0.51 |
| NPHP3 | nephronophthisis 3 (adolescent) | -0.51 |
| TGFBR3 | transforming growth factor, beta receptor III | -0.51 |
| ASB7 | ankyrin repeat and SOCS box containing 7 | -0.5 |
| AMFR | autocrine motility factor receptor, E3 ubiquitin protein ligase | -0.49 |
| SORBS1 | sorbin and SH3 domain containing 1 | -0.48 |
| OBSL1 | obscurin-like 1 | -0.47 |
| COL1A1 | collagen, type I, alpha 1 | -0.47 |
| DENND3 | DENN/MADD domain containing 3 | -0.46 |
| RNF170 | ring finger protein 170 | -0.46 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | -0.46 |
| CTHRC1 | collagen triple helix repeat containing 1 | -0.45 |
| CLIC3 | chloride intracellular channel 3 | -0.44 |
| PEMT | phosphatidylethanolamine N-methyltransferase | -0.43 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.43 |
| AOC1 | amine oxidase, copper containing 1 | -0.42 |
| GON7 | GON7 subunit of KEOPS complex | -0.42 |
| SLC22A18 | solute carrier family 22, member 18 | -0.4 |
| PLEKHA6 | pleckstrin homology domain containing, family A member 6 | -0.4 |
| LAMA3 | laminin, alpha 3 | -0.4 |
| NOTCH3 | notch 3 | -0.39 |
| APLF | aprataxin and PNKP like factor | -0.39 |
| SASH1 | SAM and SH3 domain containing 1 | -0.39 |
| SHFL | shiftless antiviral inhibitor of ribosomal frameshifting | -0.38 |
| PLAUR | plasminogen activator, urokinase receptor | -0.38 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.38 |
| TMEM64 | transmembrane protein 64 | -0.38 |
| CBR1 | carbonyl reductase 1 | -0.38 |
| C18ORF32 | chromosome 18 open reading frame 32 | -0.37 |
| FOXO1 | forkhead box O1 | -0.37 |
| CYBA | cytochrome b-245, alpha polypeptide | -0.37 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.37 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | -0.37 |
| ARHGEF10L | Rho guanine nucleotide exchange factor (GEF) 10-like | -0.37 |
| C1ORF109 | chromosome 1 open reading frame 109 | -0.36 |
| ZNF451 | zinc finger protein 451 | -0.36 |
| TBC1D13 | TBC1 domain family, member 13 | -0.36 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | -0.36 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.35 |
| FAM120C | family with sequence similarity 120C | -0.35 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.35 |
| CHST3 | carbohydrate (chondroitin 6) sulfotransferase 3 | -0.35 |
| VAV1 | vav 1 guanine nucleotide exchange factor | -0.35 |
| NDRG1 | N-myc downstream regulated 1 | -0.34 |
| DGCR2 | DiGeorge syndrome critical region gene 2 | -0.34 |
| AFG1L | AFG1 like ATPase | -0.34 |
| FAM241B | family with sequence similarity 241 member B | -0.34 |
| OGFRL1 | opioid growth factor receptor-like 1 | -0.34 |
| CEP104 | centrosomal protein 104kDa | -0.33 |
| SPATA13 | spermatogenesis associated 13 | -0.33 |
| GAS2L1 | growth arrest-specific 2 like 1 | -0.33 |
| TFCP2L1 | transcription factor CP2-like 1 | -0.33 |
| TMEM63A | transmembrane protein 63A | -0.33 |
| SLC39A7 | solute carrier family 39 (zinc transporter), member 7 | -0.33 |
| TEN1 | TEN1 CST complex subunit | -0.33 |
| STRADA | STE20-related kinase adaptor alpha | -0.32 |
| CD58 | CD58 molecule | -0.32 |
| TMSB10 | thymosin beta 10 | -0.32 |
| TIPIN | TIMELESS interacting protein | -0.32 |
| DST | dystonin | -0.32 |
| FBXO31 | F-box protein 31 | -0.32 |
| MCPH1 | microcephalin 1 | -0.32 |
| STXBP6 | syntaxin binding protein 6 (amisyn) | -0.32 |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | -0.31 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.31 |
| GAS8 | growth arrest-specific 8 | -0.31 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.31 |
| CMTM4 | CKLF-like MARVEL transmembrane domain containing 4 | -0.31 |
| LAMC2 | laminin, gamma 2 | -0.3 |
| ENTR1 | endosome associated trafficking regulator 1 | -0.3 |
| C2ORF72 | chromosome 2 open reading frame 72 | -0.3 |
| PLD3 | phospholipase D family, member 3 | -0.3 |
| TTC8 | tetratricopeptide repeat domain 8 | -0.3 |
| MYH7B | myosin, heavy chain 7B, cardiac muscle, beta | -0.3 |
| TTC14 | tetratricopeptide repeat domain 14 | -0.3 |
